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Cheap flights from Massachusetts to Florence from $279

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Massachusetts to Florence departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Massachusetts to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:15 pm - 5:21 pm
BOS
-
FLO
5h 06m
1 stop
American Airlines Logo
6:20 pm - 10:40 pm
FLO
-
BOS
4h 20m
1 stop
$279American Airlines
Tue, Mar 10 - Wed, Mar 18
American Airlines Logo
3:49 pm - 11:08 pm
BOS
-
FLO
7h 19m
2 stops
American Airlines Logo
5:16 am - 10:05 am
FLO
-
BOS
4h 49m
1 stop
$284American Airlines
Tue, Mar 10 - Wed, Mar 18
American Airlines Logo
9:00 am - 5:21 pm
BOS
-
FLO
8h 21m
2 stops
American Airlines Logo
6:20 pm - 11:59 pm
FLO
-
BOS
5h 39m
2 stops
$289American Airlines
Tue, Mar 10 - Wed, Mar 18
American Airlines Logo
5:30 pm - 11:57 pm
BOS
-
FLO
6h 27m
1 stop
American Airlines Logo
6:15 am - 12:46 pm
FLO
-
BOS
6h 31m
1 stop
$299American Airlines
Thu, Mar 26 - Tue, Mar 31
American Airlines Logo
5:30 pm - 11:57 pm
BOS
-
FLO
6h 27m
1 stop
American Airlines Logo
6:15 am - 3:16 pm
FLO
-
BOS
9h 01m
2 stops
$304American Airlines
Thu, Mar 26 - Tue, Mar 31
American Airlines Logo
12:26 pm - 5:50 pm
BOS
-
FLO
5h 24m
1 stop
American Airlines Logo
6:20 pm - 10:51 pm
FLO
-
BOS
4h 31m
1 stop
$319American Airlines
Thu, Mar 5 - Mon, Mar 9
American Airlines Logo
10:56 am - 5:50 pm
BOS
-
FLO
6h 54m
1 stop
American Airlines Logo
6:20 pm - 11:59 pm
FLO
-
BOS
5h 39m
2 stops
$324American Airlines
Thu, Mar 5 - Mon, Mar 9
American Airlines Logo
8:00 am - 5:50 pm
BOS
-
FLO
9h 50m
2 stops
American Airlines Logo
6:20 pm - 11:59 pm
FLO
-
BOS
5h 39m
2 stops
$329American Airlines
Thu, Mar 5 - Mon, Mar 9
American Airlines Logo
8:00 am - 2:11 pm
BOS
-
FLO
6h 11m
1 stop
American Airlines Logo
2:36 pm - 8:00 pm
FLO
-
BOS
5h 24m
1 stop
$349American Airlines
Wed, May 27 - Tue, Jun 2
American Airlines Logo
6:00 am - 2:11 pm
BOS
-
FLO
8h 11m
2 stops
American Airlines Logo
2:36 pm - 8:00 pm
FLO
-
BOS
5h 24m
1 stop
$354American Airlines
Wed, May 27 - Sat, May 30

American Airlines flights from Massachusetts to Florence, South Carolina

Our best American Airlines deals on Massachusetts to Florence, South Carolina flight tickets
American Airlines
Mar 10
BOS12:15 pmBoston Logan Intl
5h 06m
1 stop
FLO5:21 pmFlorence
Mar 18
FLO6:20 pmFlorence
4h 20m
1 stop
BOS10:40 pmBoston Logan Intl
$279
American Airlines
Mar 10
BOS3:49 pmBoston Logan Intl
7h 19m
2 stops
FLO11:08 pmFlorence
Mar 18
FLO5:16 amFlorence
4h 49m
1 stop
BOS10:05 amBoston Logan Intl
$284
American Airlines
Mar 10
BOS9:00 amBoston Logan Intl
8h 21m
2 stops
FLO5:21 pmFlorence
Mar 18
FLO6:20 pmFlorence
5h 39m
2 stops
BOS11:59 pmBoston Logan Intl
$289

momondo Fare Finder

 
Customize your flight search to find flights from Massachusetts to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Massachusetts to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 3/10

12:15 pm-5:21 pm

1 stop5h 06m

Florence

Wed 3/18

6:20 pm-10:40 pm

1 stop4h 20m

$279

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 3/10

3:49 pm-11:08 pm

2 stops7h 19m

Florence

Wed 3/18

5:16 am-10:05 am

1 stop4h 49m

$284

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 3/10

9:00 am-5:21 pm

2 stops8h 21m

Florence

Wed 3/18

6:20 pm-11:59 pm

2 stops5h 39m

$289

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 3/26

5:30 pm-11:57 pm

1 stop6h 27m

Florence

Tue 3/31

6:15 am-12:46 pm

1 stop6h 31m

$299

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 3/26

5:30 pm-11:57 pm

1 stop6h 27m

Florence

Tue 3/31

6:15 am-3:16 pm

2 stops9h 01m

$304

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 3/5

12:26 pm-5:50 pm

1 stop5h 24m

Florence

Mon 3/9

6:20 pm-10:51 pm

1 stop4h 31m

$319

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 3/5

10:56 am-5:50 pm

1 stop6h 54m

Florence

Mon 3/9

6:20 pm-11:59 pm

2 stops5h 39m

$324

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 3/5

8:00 am-5:50 pm

2 stops9h 50m

Florence

Mon 3/9

6:20 pm-11:59 pm

2 stops5h 39m

$329

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 5/27

8:00 am-2:11 pm

1 stop6h 11m

Florence

Tue 6/2

2:36 pm-8:00 pm

1 stop5h 24m

$349

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 5/27

6:00 am-2:11 pm

2 stops8h 11m

Florence

Sat 5/30

2:36 pm-8:00 pm

1 stop5h 24m

$354

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Massachusetts to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Spirit Airlines and Delta are the top three most popular airlines that fly to Florence, South Carolina from Massachusetts according to our data. American Airlines is the first choice among our users, with 31% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Massachusetts to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Massachusetts to Florence, South Carolina

Fastest flight time

4h 18m

Direct flights

None
The fastest flight from Massachusetts to Florence, South Carolina takes 4h 18m
There are no direct flights from Massachusetts to Florence, South Carolina. There are no popular flight routes from Massachusetts to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Massachusetts to Florence Airport?

    Prices for flights from Massachusetts to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Massachusetts to Florence Airport?

  • How old do you have to be to fly from Massachusetts to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Massachusetts to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Massachusetts to Florence, South Carolina

Compare and see reviews for airlines that fly from Massachusetts to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $279Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Massachusetts to Florence?

Finding the right flight to Florence from Massachusetts is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Massachusetts to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Massachusetts on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Massachusetts to Florence?

Once you have performed a search for Massachusetts to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Massachusetts to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Massachusetts. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florence, South Carolina trip

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