What airlines fly to South America?

Delta, LATAM Airlines and American Airlines are the top three most popular airlines that fly to South America from Knoxville according to our data. Delta is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Knoxville McGhee Tyson to South America?

American Airlines, LATAM Airlines, and Avianca are the most popular carriers operating from Knoxville McGhee Tyson to South America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?

Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of May 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$305 Cheap Flights from Knoxville to South America in 2026

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Find the cheapest flights from Knoxville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 12:35 pm

TYS

CTG

7h 35m

1 stop

2:05 pm - 10:43 am

CTG

TYS

19h 38m

2 stops

$587American Airlines

Thu, Sep 3 - Mon, Sep 14

6:00 am - 2:15 pm

TYS

CTG

9h 15m

1 stop

2:05 pm - 10:25 am

CTG

TYS

19h 20m

2 stops

$597American Airlines

Thu, Sep 3 - Mon, Sep 14

12:55 pm - 12:55 am

TYS

LIM

13h 00m

2 stops

12:00 pm - 11:49 am

LIM

TYS

22h 49m

1 stop

$736Multiple Airlines

Mon, Jun 1 - Fri, Jun 12

5:40 am - 8:20 pm

TYS

LIM

15h 40m

2 stops

8:55 am - 11:52 pm

LIM

TYS

13h 57m

2 stops

$740Delta

Fri, Jul 3 - Wed, Jul 29

7:30 am - 9:35 pm

TYS

LIM

15h 05m

2 stops

8:15 am - 11:52 pm

LIM

TYS

14h 37m

2 stops

$750LATAM Airlines

Sun, Aug 16 - Thu, Aug 20

12:55 pm - 12:55 am

TYS

LIM

13h 00m

2 stops

12:00 pm - 11:49 am

LIM

TYS

22h 49m

1 stop

$756Multiple Airlines

Mon, Jun 1 - Fri, Jun 19

7:30 am - 11:35 pm

TYS

CTG

17h 05m

2 stops

5:30 am - 11:52 pm

CTG

TYS

17h 22m

2 stops

$774LATAM Airlines

Mon, Aug 24 - Thu, Aug 27

10:26 am - 10:00 pm

TYS

LIM

12h 34m

2 stops

12:05 am - 6:51 pm

LIM

TYS

17h 46m

2 stops

$783Delta

Mon, Jun 15 - Mon, Jul 27

9:15 am - 11:35 pm

TYS

PEI

39h 20m

2 stops

2:55 pm - 7:34 pm

PEI

TYS

27h 39m

2 stops

$902United Airlines

Mon, Oct 26 - Fri, Oct 30

6:00 am - 9:40 am

TYS

GRU

26h 40m

1 stop

10:20 pm - 4:58 pm

GRU

TYS

19h 38m

1 stop

$1,062United Airlines

Tue, Aug 4 - Mon, Aug 17

LATAM Airlines flights from Knoxville to South America

Our best LATAM Airlines deals on Knoxville to South America flight tickets

LATAM Airlines

Aug 16

TYS7:30 amKnoxville McGhee Tyson

15h 05m

2 stops

LIM9:35 pmLima J Chavez Intl

Aug 20

LIM8:15 amLima J Chavez Intl

14h 37m

2 stops

TYS11:52 pmKnoxville McGhee Tyson

$750

LATAM Airlines

Aug 24

TYS7:30 amKnoxville McGhee Tyson

17h 05m

2 stops

CTG11:35 pmCartagena Rafael Nunez

Aug 27

CTG5:30 amCartagena Rafael Nunez

17h 22m

2 stops

TYS11:52 pmKnoxville McGhee Tyson

$774

LATAM Airlines

Aug 16

TYS4:38 pmKnoxville McGhee Tyson

13h 22m

1 stop

LIM5:00 amLima J Chavez Intl

Aug 20

LIM12:05 pmLima J Chavez Intl

10h 47m

1 stop

TYS11:52 pmKnoxville McGhee Tyson

$808

Delta flights from Knoxville to South America

Our best Delta deals on Knoxville to South America flight tickets

Delta

Jul 3

TYS5:40 amKnoxville McGhee Tyson

15h 40m

2 stops

LIM8:20 pmLima J Chavez Intl

Jul 29

LIM8:55 amLima J Chavez Intl

13h 57m

2 stops

TYS11:52 pmKnoxville McGhee Tyson

$740

Delta

Jun 15

TYS10:26 amKnoxville McGhee Tyson

12h 34m

2 stops

LIM10:00 pmLima J Chavez Intl

Jul 27

LIM12:05 amLima J Chavez Intl

17h 46m

2 stops

TYS6:51 pmKnoxville McGhee Tyson

$783

Delta

Jul 3

TYS5:40 amKnoxville McGhee Tyson

15h 40m

2 stops

LIM8:20 pmLima J Chavez Intl

Jul 28

LIM12:05 pmLima J Chavez Intl

10h 47m

1 stop

TYS11:52 pmKnoxville McGhee Tyson

$803

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 9/3

6:00 am-12:35 pm

1 stop7h 35m

Cartagena Rafael Nunez

Mon 9/14

2:05 pm-10:43 am

2 stops19h 38m

$587

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 9/3

6:00 am-2:15 pm

1 stop9h 15m

Cartagena Rafael Nunez

Mon 9/14

2:05 pm-10:25 am

2 stops19h 20m

$597

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 6/1

12:55 pm-12:55 am

2 stops13h 00m

Lima J Chavez Intl

Fri 6/12

12:00 pm-11:49 am

1 stop22h 49m

$736

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Fri 7/3

5:40 am-8:20 pm

2 stops15h 40m

Lima J Chavez Intl

Wed 7/29

8:55 am-11:52 pm

2 stops13h 57m

$740

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sun 8/16

7:30 am-9:35 pm

2 stops15h 05m

Lima J Chavez Intl

Thu 8/20

8:15 am-11:52 pm

2 stops14h 37m

$750

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 6/1

12:55 pm-12:55 am

2 stops13h 00m

Lima J Chavez Intl

Fri 6/19

12:00 pm-11:49 am

1 stop22h 49m

$756

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Mon 8/24

7:30 am-11:35 pm

2 stops17h 05m

Cartagena Rafael Nunez

Thu 8/27

5:30 am-11:52 pm

2 stops17h 22m

$774

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 6/15

10:26 am-10:00 pm

2 stops12h 34m

Lima J Chavez Intl

Mon 7/27

12:05 am-6:51 pm

2 stops17h 46m

$783

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Mon 10/26

9:15 am-11:35 pm

2 stops39h 20m

Pereira Matecana

Fri 10/30

2:55 pm-7:34 pm

2 stops27h 39m

$902

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Tue 8/4

6:00 am-9:40 am

1 stop26h 40m

Sao Paulo Guarulhos Intl

Mon 8/17

10:20 pm-4:58 pm

1 stop19h 38m

$1,062

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, August is the cheapest month to fly from Knoxville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $488. If you aren’t able to travel during the month of August, then book flights to South America from Knoxville during February instead. Flights to South America in February, while not as cheap as those in August, still average around $494.

Can stopping save me money on Knoxville to South America flights?

You could potentially save up to 18% on your flight if you consider stops on a Knoxville to South America flight.

Cheap Knoxville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South America

Fastest flight time	8h 43m
Direct flights	None

The fastest flight from Knoxville to South America takes 8h 43m

There are no direct flights from Knoxville to South America. There are no popular flight routes from Knoxville to South America.

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Frequently asked questions about flying from Knoxville to South America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?
Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of May 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to South America

Compare and see reviews for airlines that fly from Knoxville to South America with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $488	Free Cancellation	Rating 7.1 11,655 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $622	Free Cancellation	Rating 7.4 1,924 reviews	Search LATAM Airlines flights
Delta	PriceFrom $696	Free Cancellation	Rating 7.9 8,453 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to South America with flexible booking policies on momondo?

Yes. All flights to South America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to South America?

Once all potential Knoxville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.