What airlines fly to South America?

LATAM Airlines, Delta and American Airlines are the top three most popular airlines that fly to South America from Knoxville according to our data. LATAM Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Knoxville McGhee Tyson to South America?

United Airlines, American Airlines, and LATAM Airlines are the most popular carriers operating from Knoxville McGhee Tyson to South America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?

Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of September 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$321 Cheap Flights from Knoxville to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 3:36 pmTYS Knoxville McGhee Tyson-CTG Cartagena Rafael Nunez

9h 36m1 stop Miami

2:35 pm - 11:59 pmCTG Cartagena Rafael Nunez-TYS Knoxville McGhee Tyson

9h 24m1 stop Miami

$512American Airlines

Sat, Nov 7 - Sat, Nov 14

5:19 pm - 1:35 pmTYS Knoxville McGhee Tyson-CTG Cartagena Rafael Nunez

20h 16m2 stops Charlotte Douglas Miami

4:37 pm - 11:59 pmCTG Cartagena Rafael Nunez-TYS Knoxville McGhee Tyson

7h 22m1 stop Miami

$517American Airlines

Sat, Nov 7 - Sat, Nov 14

5:32 pm - 1:35 pmTYS Knoxville McGhee Tyson-CTG Cartagena Rafael Nunez

20h 03m2 stops Dallas/Fort Worth Miami

4:37 pm - 8:48 amCTG Cartagena Rafael Nunez-TYS Knoxville McGhee Tyson

16h 11m2 stops Miami Charlotte Douglas

$517American Airlines

Sat, Nov 7 - Sat, Nov 14

7:35 pm - 2:50 pmTYS Knoxville McGhee Tyson-CTG Cartagena Rafael Nunez

19h 15m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

4:00 pm - 1:20 pmCTG Cartagena Rafael Nunez-TYS Knoxville McGhee Tyson

21h 20m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$597United Airlines

Wed, Dec 30 - Tue, Jan 12

7:35 pm - 2:50 pmTYS Knoxville McGhee Tyson-CTG Cartagena Rafael Nunez

19h 15m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

4:00 pm - 12:05 amCTG Cartagena Rafael Nunez-TYS Knoxville McGhee Tyson

8h 05m1 stop Washington, D.C. Dulles Intl

$597United Airlines

Wed, Dec 30 - Tue, Jan 12

7:22 pm - 12:15 pmTYS Knoxville McGhee Tyson-BOG Bogotá El Dorado

16h 53m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

9:00 am - 6:27 pmBOG Bogotá El Dorado-TYS Knoxville McGhee Tyson

9h 27m1 stop Atlanta Hartsfield-Jackson

$638Delta

Mon, Nov 9 - Mon, Nov 16

7:22 pm - 12:15 pmTYS Knoxville McGhee Tyson-BOG Bogotá El Dorado

16h 53m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

8:35 am - 11:59 pmBOG Bogotá El Dorado-TYS Knoxville McGhee Tyson

15h 24m2 stops Miami Atlanta Hartsfield-Jackson

$643Delta

Mon, Nov 9 - Mon, Nov 16

7:00 am - 12:30 amTYS Knoxville McGhee Tyson-UIO Quito Mariscal Sucr

17h 30m1 stop Houston George Bush Intcntl

1:35 am - 6:23 pmUIO Quito Mariscal Sucr-TYS Knoxville McGhee Tyson

16h 48m1 stop Houston George Bush Intcntl

$646United Airlines

Sat, Feb 6 - Fri, Feb 12

7:09 am - 7:25 pmTYS Knoxville McGhee Tyson-LIM Lima J Chavez Intl

12h 16m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

12:10 pm - 10:12 pmLIM Lima J Chavez Intl-TYS Knoxville McGhee Tyson

10h 02m1 stop Atlanta Hartsfield-Jackson

$779LATAM Airlines

Fri, Nov 6 - Sat, Nov 14

6:23 pm - 5:00 amTYS Knoxville McGhee Tyson-LIM Lima J Chavez Intl

10h 37m1 stop Atlanta Hartsfield-Jackson

12:10 pm - 10:12 pmLIM Lima J Chavez Intl-TYS Knoxville McGhee Tyson

10h 02m1 stop Atlanta Hartsfield-Jackson

$779LATAM Airlines

Fri, Nov 6 - Sat, Nov 14

Cheap last minute flights

Enter your travel dates to find the best prices.

6:13 pm - 8:15 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

13h 02m1 stop Atlanta Hartsfield-Jackson

5:10 am - 11:59 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

19h 49m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,237LATAM Airlines

Wed, Sep 30 - Fri, Oct 9

6:13 pm - 8:15 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

13h 02m1 stop Atlanta Hartsfield-Jackson

8:20 am - 11:59 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

16h 39m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,237LATAM Airlines

Wed, Sep 30 - Fri, Oct 9

6:13 pm - 8:15 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

13h 02m1 stop Atlanta Hartsfield-Jackson

8:50 am - 11:59 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

16h 09m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,237LATAM Airlines

Wed, Sep 30 - Fri, Oct 9

3:45 pm - 11:25 pmTYS Knoxville McGhee Tyson-UIO Quito Mariscal Sucr

8h 40m1 stop Houston George Bush Intcntl

12:35 am - 11:17 amUIO Quito Mariscal Sucr-TYS Knoxville McGhee Tyson

9h 42m1 stop Houston George Bush Intcntl

$1,295Copa Airlines

Tue, Sep 29 - Wed, Sep 30

12:05 pm - 11:25 pmTYS Knoxville McGhee Tyson-UIO Quito Mariscal Sucr

12h 20m1 stop Houston George Bush Intcntl

12:35 am - 5:08 pmUIO Quito Mariscal Sucr-TYS Knoxville McGhee Tyson

15h 33m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,299Copa Airlines

Tue, Sep 29 - Wed, Sep 30

9:45 am - 11:25 pmTYS Knoxville McGhee Tyson-UIO Quito Mariscal Sucr

14h 40m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

12:35 am - 2:42 pmUIO Quito Mariscal Sucr-TYS Knoxville McGhee Tyson

13h 07m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$1,299Multiple Airlines

Tue, Sep 29 - Wed, Sep 30

10:26 am - 5:40 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

18h 14m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl

8:55 pm - 8:08 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

24h 13m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,397Delta

Wed, Sep 30 - Fri, Oct 9

6:13 pm - 8:15 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

13h 02m1 stop Atlanta Hartsfield-Jackson

8:55 pm - 8:08 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

24h 13m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$1,397Delta

Wed, Sep 30 - Fri, Oct 9

7:00 am - 8:00 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

24h 00m1 stop Miami

9:30 pm - 1:09 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

16h 39m1 stop Miami

$1,437American Airlines

Wed, Sep 30 - Fri, Oct 9

7:00 am - 8:00 amTYS Knoxville McGhee Tyson-SCL Santiago Arturo Merino Benitez

24h 00m1 stop Miami

9:30 pm - 1:09 pmSCL Santiago Arturo Merino Benitez-TYS Knoxville McGhee Tyson

16h 39m1 stop Miami

$1,542American Airlines

Wed, Sep 30 - Fri, Oct 9

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Delta flights from Knoxville to South America

Our best Delta deals on Knoxville to South America flight tickets

Delta

Nov 9

TYS7:22 pmKnoxville McGhee Tyson

16h 53m

2 stops

BOG12:15 pmBogotá El Dorado

Nov 16

BOG9:00 amBogotá El Dorado

9h 27m

1 stop

TYS6:27 pmKnoxville McGhee Tyson

$638

Delta

Nov 9

TYS7:22 pmKnoxville McGhee Tyson

16h 53m

2 stops

BOG12:15 pmBogotá El Dorado

Nov 16

BOG8:35 amBogotá El Dorado

15h 24m

2 stops

TYS11:59 pmKnoxville McGhee Tyson

$643

Delta

Oct 9

TYS5:40 amKnoxville McGhee Tyson

9h 00m

1 stop

BOG1:40 pmBogotá El Dorado

Oct 17

BOG2:55 pmBogotá El Dorado

17h 39m

1 stop

TYS9:34 amKnoxville McGhee Tyson

$678

American Airlines flights from Knoxville to South America

Our best American Airlines deals on Knoxville to South America flight tickets

American Airlines

Nov 7

TYS6:00 amKnoxville McGhee Tyson

9h 36m

1 stop

CTG3:36 pmCartagena Rafael Nunez

Nov 14

CTG2:35 pmCartagena Rafael Nunez

9h 24m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

$512

American Airlines

Nov 7

TYS5:19 pmKnoxville McGhee Tyson

20h 16m

2 stops

CTG1:35 pmCartagena Rafael Nunez

Nov 14

CTG4:37 pmCartagena Rafael Nunez

7h 22m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

$517

American Airlines

Nov 13

TYS7:16 pmKnoxville McGhee Tyson

18h 19m

1 stop

CTG1:35 pmCartagena Rafael Nunez

Nov 26

CTG2:35 pmCartagena Rafael Nunez

18h 14m

2 stops

TYS8:49 amKnoxville McGhee Tyson

$608

momondo Fare Finder

Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

KnoxvilleCartagena

TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez

TYSCTG

Knoxville McGhee Tyson

Sat 11/7

6:00 am-3:36 pm

1 stop9h 36m

Cartagena Rafael Nunez

Sat 11/14

2:35 pm-11:59 pm

1 stop9h 24m

$512

KnoxvilleCartagena

TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez

TYSCTG

Knoxville McGhee Tyson

Sat 11/7

5:19 pm-1:35 pm

2 stops20h 16m

Cartagena Rafael Nunez

Sat 11/14

4:37 pm-11:59 pm

1 stop7h 22m

$517

KnoxvilleCartagena

TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez

TYSCTG

Knoxville McGhee Tyson

Sat 11/7

5:32 pm-1:35 pm

2 stops20h 03m

Cartagena Rafael Nunez

Sat 11/14

4:37 pm-8:48 am

2 stops16h 11m

$517

KnoxvilleCartagena

TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez

TYSCTG

Knoxville McGhee Tyson

Wed 12/30

7:35 pm-2:50 pm

2 stops19h 15m

Cartagena Rafael Nunez

Tue 1/12

4:00 pm-1:20 pm

2 stops21h 20m

$597

KnoxvilleCartagena

TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez

TYSCTG

Knoxville McGhee Tyson

Wed 12/30

7:35 pm-2:50 pm

2 stops19h 15m

Cartagena Rafael Nunez

Tue 1/12

4:00 pm-12:05 am

1 stop8h 05m

$597

KnoxvilleBogotá

TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado

TYSBOG

Knoxville McGhee Tyson

Mon 11/9

7:22 pm-12:15 pm

2 stops16h 53m

Bogotá El Dorado

Mon 11/16

9:00 am-6:27 pm

1 stop9h 27m

$638

KnoxvilleBogotá

TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado

TYSBOG

Knoxville McGhee Tyson

Mon 11/9

7:22 pm-12:15 pm

2 stops16h 53m

Bogotá El Dorado

Mon 11/16

8:35 am-11:59 pm

2 stops15h 24m

$643

KnoxvilleQuito

TYS Knoxville McGhee Tyson - UIO Quito Mariscal Sucr

TYSUIO

Knoxville McGhee Tyson

Sat 2/6

7:00 am-12:30 am

1 stop17h 30m

Quito Mariscal Sucr

Fri 2/12

1:35 am-6:23 pm

1 stop16h 48m

$646

KnoxvilleLima

TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl

TYSLIM

Knoxville McGhee Tyson

Fri 11/6

7:09 am-7:25 pm

2 stops12h 16m

Lima J Chavez Intl

Sat 11/14

12:10 pm-10:12 pm

1 stop10h 02m

$779

KnoxvilleLima

TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl

TYSLIM

Knoxville McGhee Tyson

Fri 11/6

6:23 pm-5:00 am

1 stop10h 37m

Lima J Chavez Intl

Sat 11/14

12:10 pm-10:12 pm

1 stop10h 02m

$779

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, April is the cheapest month to fly from Knoxville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you aren’t able to travel during the month of April, then book flights to South America from Knoxville during March instead. Flights to South America in March, while not as cheap as those in April, still average around $0.

Can stopping save me money on Knoxville to South America flights?

You could potentially save up to 15% on your flight if you consider stops on a Knoxville to South America flight.

Cheap Knoxville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South America

Best Price Found	$321
Fastest flight time	10h 37m
Direct flights	None

The best one-way flight to South America from Knoxville in the past 72 hours is $321. The best round-trip flight deal from Knoxville to South America found on momondo in the last 72 hours is $512.

The fastest flight from Knoxville to South America takes 10h 37m

There are no direct flights from Knoxville to South America. There are no popular flight routes from Knoxville to South America.

Search flight deals

Frequently asked questions about flying from Knoxville to South America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?
Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of September 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to South America

Compare and see reviews for airlines that fly from Knoxville to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $393	Free Cancellation	Rating 7.8 8,606 reviews	Search Delta flights
American Airlines	PriceFrom $488	Free Cancellation	Rating 7.0 12,097 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $619	Free Cancellation	Rating 7.4 1,977 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to South America with flexible booking policies on momondo?

Yes. All flights to South America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to South America?

Once all potential Knoxville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.