What is the cheapest airline that flies from Knoxville McGhee Tyson to South America?

Delta, United Airlines, and LATAM Airlines are the most popular carriers operating from Knoxville McGhee Tyson to South America

What airlines fly to South America?

Delta, LATAM Airlines and American Airlines are the top three most popular airlines that fly to South America from Knoxville according to our data. Delta is the first choice among our users, with 40% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?

Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of July 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$337 Cheap Flights from Knoxville to South America in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 3:36 pm

TYS

CTG

9h 36m

1 stop

4:37 pm - 11:03 am

CTG

TYS

18h 26m

2 stops

$617American Airlines

Sat, Nov 14 - Sat, Nov 21

5:19 pm - 1:35 pm

TYS

CTG

20h 16m

2 stops

2:35 pm - 10:33 am

CTG

TYS

19h 58m

2 stops

$627American Airlines

Sat, Nov 14 - Sat, Nov 21

6:05 am - 12:35 pm

TYS

CTG

7h 30m

1 stop

1:35 pm - 11:07 pm

CTG

TYS

8h 32m

1 stop

$631American Airlines

Thu, Sep 10 - Thu, Sep 17

6:00 am - 2:05 pm

TYS

CTG

8h 05m

1 stop

3:25 pm - 10:22 pm

CTG

TYS

6h 57m

1 stop

$662Delta

Sat, Nov 14 - Sat, Nov 21

10:28 am - 11:35 pm

TYS

CTG

14h 07m

2 stops

5:35 am - 11:55 pm

CTG

TYS

17h 20m

2 stops

$671Delta

Thu, Sep 3 - Mon, Sep 14

7:15 am - 7:35 am

TYS

PEI

25h 20m

2 stops

8:20 am - 12:50 pm

PEI

TYS

27h 30m

2 stops

$678Multiple Airlines

Sun, Aug 23 - Sun, Sep 13

12:23 pm - 9:55 pm

TYS

LIM

10h 32m

1 stop

12:15 am - 5:28 pm

LIM

TYS

16h 13m

2 stops

$701LATAM Airlines

Tue, Sep 15 - Mon, Sep 28

7:50 am - 8:20 pm

TYS

LIM

13h 30m

2 stops

12:15 am - 5:28 pm

LIM

TYS

16h 13m

2 stops

$701LATAM Airlines

Tue, Sep 15 - Mon, Sep 28

11:59 am - 8:30 pm

TYS

PEI

33h 31m

2 stops

2:55 pm - 5:54 pm

PEI

TYS

26h 59m

2 stops

$755United Airlines

Thu, Oct 29 - Mon, Nov 2

6:00 am - 5:00 am

TYS

LIM

23h 00m

1 stop

1:00 am - 6:38 pm

LIM

TYS

17h 38m

2 stops

$785Delta

Fri, Nov 6 - Fri, Nov 13

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LATAM Airlines flights from Knoxville to South America

Our best LATAM Airlines deals on Knoxville to South America flight tickets

LATAM Airlines

Aug 25

TYS7:30 amKnoxville McGhee Tyson

13h 50m

2 stops

LIM8:20 pmLima J Chavez Intl

Sep 1

LIM12:05 pmLima J Chavez Intl

10h 47m

1 stop

TYS11:52 pmKnoxville McGhee Tyson

$710

LATAM Airlines

Nov 6

TYS4:11 pmKnoxville McGhee Tyson

12h 49m

2 stops

LIM5:00 amLima J Chavez Intl

Nov 13

LIM1:00 amLima J Chavez Intl

16h 24m

2 stops

TYS5:24 pmKnoxville McGhee Tyson

$716

LATAM Airlines

Aug 25

TYS7:30 amKnoxville McGhee Tyson

15h 05m

2 stops

LIM9:35 pmLima J Chavez Intl

Sep 1

LIM8:55 amLima J Chavez Intl

13h 57m

2 stops

TYS11:52 pmKnoxville McGhee Tyson

$725

American Airlines flights from Knoxville to South America

Our best American Airlines deals on Knoxville to South America flight tickets

American Airlines

Nov 14

TYS6:00 amKnoxville McGhee Tyson

9h 36m

1 stop

CTG3:36 pmCartagena Rafael Nunez

Nov 21

CTG4:37 pmCartagena Rafael Nunez

18h 26m

2 stops

TYS11:03 amKnoxville McGhee Tyson

$617

American Airlines

Nov 14

TYS5:19 pmKnoxville McGhee Tyson

20h 16m

2 stops

CTG1:35 pmCartagena Rafael Nunez

Nov 21

CTG2:35 pmCartagena Rafael Nunez

19h 58m

2 stops

TYS10:33 amKnoxville McGhee Tyson

$627

American Airlines

Sep 10

TYS6:05 amKnoxville McGhee Tyson

7h 30m

1 stop

CTG12:35 pmCartagena Rafael Nunez

Sep 17

CTG1:35 pmCartagena Rafael Nunez

8h 32m

1 stop

TYS11:07 pmKnoxville McGhee Tyson

$631

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 11/14

6:00 am-3:36 pm

1 stop9h 36m

Cartagena Rafael Nunez

Sat 11/21

4:37 pm-11:03 am

2 stops18h 26m

$617

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 11/14

5:19 pm-1:35 pm

2 stops20h 16m

Cartagena Rafael Nunez

Sat 11/21

2:35 pm-10:33 am

2 stops19h 58m

$627

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 9/10

6:05 am-12:35 pm

1 stop7h 30m

Cartagena Rafael Nunez

Thu 9/17

1:35 pm-11:07 pm

1 stop8h 32m

$631

Quickest round-trip

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 11/14

6:00 am-2:05 pm

1 stop8h 05m

Cartagena Rafael Nunez

Sat 11/21

3:25 pm-10:22 pm

1 stop6h 57m

$662

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 9/3

10:28 am-11:35 pm

2 stops14h 07m

Cartagena Rafael Nunez

Mon 9/14

5:35 am-11:55 pm

2 stops17h 20m

$671

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Sun 8/23

7:15 am-7:35 am

2 stops25h 20m

Pereira Matecana

Sun 9/13

8:20 am-12:50 pm

2 stops27h 30m

$678

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 9/15

12:23 pm-9:55 pm

1 stop10h 32m

Lima J Chavez Intl

Mon 9/28

12:15 am-5:28 pm

2 stops16h 13m

$701

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 9/15

7:50 am-8:20 pm

2 stops13h 30m

Lima J Chavez Intl

Mon 9/28

12:15 am-5:28 pm

2 stops16h 13m

$701

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Thu 10/29

11:59 am-8:30 pm

2 stops33h 31m

Pereira Matecana

Mon 11/2

2:55 pm-5:54 pm

2 stops26h 59m

$755

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Fri 11/6

6:00 am-5:00 am

1 stop23h 00m

Lima J Chavez Intl

Fri 11/13

1:00 am-6:38 pm

2 stops17h 38m

$785

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, April is the cheapest month to fly from Knoxville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you aren’t able to travel during the month of April, then book flights to South America from Knoxville during August instead. Flights to South America in August, while not as cheap as those in April, still average around $488.

Can stopping save me money on Knoxville to South America flights?

You could potentially save up to 20% on your flight if you consider stops on a Knoxville to South America flight.

Cheap Knoxville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South America

Fastest flight time	6h 25m
Direct flights	None

The fastest flight from Knoxville to South America takes 6h 25m

There are no direct flights from Knoxville to South America. There are no popular flight routes from Knoxville to South America.

Search flight deals

Frequently asked questions about flying from Knoxville to South America

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?
Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of July 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to South America

Compare and see reviews for airlines that fly from Knoxville to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $431	Free Cancellation	Rating 7.8 8,486 reviews	Search Delta flights
American Airlines	PriceFrom $488	Free Cancellation	Rating 7.1 11,839 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $622	Free Cancellation	Rating 7.4 1,968 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to South America with flexible booking policies on momondo?

Yes. All flights to South America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to South America?

Once all potential Knoxville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.