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Cheap flights from Knoxville to South America from $390

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to South America departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:47 pm - 1:08 pmTYS-CTG
20h 21m1 stop
Multiple Airlines Logo
2:16 pm - 8:39 amCTG-TYS
18h 23m1 stop
$390Multiple Airlines
Find Deal
Wed, Jan 21 - Sat, Jan 31
Multiple Airlines Logo
4:47 pm - 1:08 pmTYS-CTG
20h 21m1 stop
Multiple Airlines Logo
2:16 pm - 8:39 amCTG-TYS
18h 23m1 stop
$402Multiple Airlines
Find Deal
Wed, Jan 21 - Sat, Jan 31
United Airlines Logo
6:45 am - 11:00 pmTYS-CTG
16h 15m2 stops
United Airlines Logo
3:02 pm - 11:44 pmCTG-TYS
32h 42m2 stops
$541United Airlines
Find Deal
Wed, Jan 21 - Sat, Jan 31
American Airlines Logo
6:51 pm - 3:30 pmTYS-CTG
20h 39m2 stops
American Airlines Logo
4:30 pm - 11:03 amCTG-TYS
18h 33m2 stops
$544American Airlines
Find Deal
Wed, Jan 21 - Sat, Jan 31
American Airlines Logo
5:36 pm - 1:30 pmTYS-CTG
19h 54m1 stop
American Airlines Logo
4:30 pm - 11:59 pmCTG-TYS
7h 29m1 stop
$550American Airlines
Find Deal
Wed, Jan 21 - Sat, Jan 31
United Airlines Logo
6:45 am - 11:00 pmTYS-CTG
16h 15m2 stops
United Airlines Logo
6:24 am - 11:44 pmCTG-TYS
17h 20m2 stops
$555United Airlines
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Thu, Jan 22 - Tue, Jan 27
Delta Logo
5:30 am - 2:17 pmTYS-CTG
8h 47m1 stop
Delta Logo
4:35 am - 11:45 pmCTG-TYS
19h 10m2 stops
$575Delta
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Thu, Jan 22 - Mon, Jan 26
Delta Logo
11:58 am - 12:31 amTYS-CTG
12h 33m2 stops
Delta Logo
4:35 am - 11:45 pmCTG-TYS
19h 10m2 stops
$581Delta
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Thu, Jan 22 - Mon, Jan 26
LATAM Airlines Logo
8:47 am - 10:30 amTYS-MVD
24h 43m2 stops
LATAM Airlines Logo
12:00 pm - 11:07 amMVD-TYS
24h 07m2 stops
$721LATAM Airlines
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Mon, Mar 23 - Tue, Mar 31
LATAM Airlines Logo
5:00 pm - 7:00 amTYS-SCL
13h 00m1 stop
LATAM Airlines Logo
9:35 pm - 11:44 pmSCL-TYS
26h 09m2 stops
$734LATAM Airlines
Find Deal
Wed, Mar 18 - Sun, Apr 5

LATAM Airlines flights from Knoxville to South America

Our best LATAM Airlines deals on Knoxville to South America flight tickets
LATAM Airlines
Mar 23
TYS8:47 amKnoxville McGhee Tyson
24h 43m
2 stops
MVD10:30 amMontevideo Carrasco
Mar 31
MVD12:00 pmMontevideo Carrasco
24h 07m
2 stops
TYS11:07 amKnoxville McGhee Tyson
$721
Find similar
LATAM Airlines
Mar 18
TYS5:00 pmKnoxville McGhee Tyson
13h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Apr 5
SCL9:35 pmSantiago Arturo Merino Benitez
26h 09m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
$734
Find similar
LATAM Airlines
Nov 30
TYS5:36 pmKnoxville McGhee Tyson
11h 24m
1 stop
LIM5:00 amLima J Chavez Intl
Dec 10
LIM11:40 pmLima J Chavez Intl
11h 06m
1 stop
TYS10:46 amKnoxville McGhee Tyson
$765
Find similar

Delta flights from Knoxville to South America

Our best Delta deals on Knoxville to South America flight tickets
Delta
Jan 22
TYS5:30 amKnoxville McGhee Tyson
8h 47m
1 stop
CTG2:17 pmCartagena Rafael Nunez
Jan 26
CTG4:35 amCartagena Rafael Nunez
19h 10m
2 stops
TYS11:45 pmKnoxville McGhee Tyson
$575
Find similar
Delta
Jan 22
TYS11:58 amKnoxville McGhee Tyson
12h 33m
2 stops
CTG12:31 amCartagena Rafael Nunez
Jan 26
CTG4:35 amCartagena Rafael Nunez
19h 10m
2 stops
TYS11:45 pmKnoxville McGhee Tyson
$581
Find similar
Delta
Mar 8
TYS7:20 pmKnoxville McGhee Tyson
18h 55m
1 stop
CTG1:15 pmCartagena Rafael Nunez
Mar 12
CTG2:30 pmCartagena Rafael Nunez
8h 14m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$598
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-1:08 pm

1 stop20h 21m

Cartagena Rafael Nunez

Sat 1/31

2:16 pm-8:39 am

1 stop18h 23m

$390

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-1:08 pm

1 stop20h 21m

Cartagena Rafael Nunez

Sat 1/31

2:16 pm-8:39 am

1 stop18h 23m

$402

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 1/21

6:45 am-11:00 pm

2 stops16h 15m

Cartagena Rafael Nunez

Sat 1/31

3:02 pm-11:44 pm

2 stops32h 42m

$541

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 1/21

6:51 pm-3:30 pm

2 stops20h 39m

Cartagena Rafael Nunez

Sat 1/31

4:30 pm-11:03 am

2 stops18h 33m

$544

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 1/21

5:36 pm-1:30 pm

1 stop19h 54m

Cartagena Rafael Nunez

Sat 1/31

4:30 pm-11:59 pm

1 stop7h 29m

$550

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

6:45 am-11:00 pm

2 stops16h 15m

Cartagena Rafael Nunez

Tue 1/27

6:24 am-11:44 pm

2 stops17h 20m

$555

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

5:30 am-2:17 pm

1 stop8h 47m

Cartagena Rafael Nunez

Mon 1/26

4:35 am-11:45 pm

2 stops19h 10m

$575

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

11:58 am-12:31 am

2 stops12h 33m

Cartagena Rafael Nunez

Mon 1/26

4:35 am-11:45 pm

2 stops19h 10m

$581

KnoxvilleMontevideo

TYS - MVD

TYSMVD

Knoxville McGhee Tyson

Mon 3/23

8:47 am-10:30 am

2 stops24h 43m

Montevideo Carrasco

Tue 3/31

12:00 pm-11:07 am

2 stops24h 07m

$721

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 3/18

5:00 pm-7:00 am

1 stop13h 00m

Santiago Arturo Merino Benitez

Sun 4/5

9:35 pm-11:44 pm

2 stops26h 09m

$734

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Knoxville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $630. If you aren’t able to travel during the month of September, then book flights to South America from Knoxville during February instead. Flights to South America in February, while not as cheap as those in September, still average around $685.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Knoxville to South America is on a Monday when prices can be found for as low as $627. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to South America for around $922.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Knoxville to South America flights are usually those with departure times at noon. Our users have found flights to South America at noon for as low as $688. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $776 on average. Flights to South America from Knoxville in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Knoxville to South America flights?

You could potentially save up to 18% on your flight if you consider stops on a Knoxville to South America flight.

Cheap Knoxville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South America

Direct flights

None
There are no direct flights from Knoxville to South America. There are no popular flight routes from Knoxville to South America.
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  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?

    Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to South America

Compare and see reviews for airlines that fly from Knoxville to South America with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $511Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $590Free CancellationRating
7.5
1,874 reviews
Search LATAM Airlines flights
DeltaPriceFrom $614Free CancellationRating
7.9
8,004 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to South America with flexible booking policies on momondo?

Yes. All flights to South America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to South America?

Once all potential Knoxville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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