What is the cheapest airline that flies from Knoxville McGhee Tyson to South America?

LATAM Airlines and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to South America

What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Knoxville according to our data. Delta is the first choice among our users, with 52% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?

Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of March 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$232 Cheap Flights from Knoxville to South America in 2026

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Knoxville to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

9:32 pm - 12:06 pm

TYS

CTG

15h 34m

1 stop

7:47 am - 8:35 pm

CTG

TYS

35h 48m

2 stops

$473Multiple Airlines

Thu, Apr 23 - Sat, May 2

9:32 pm - 12:06 pm

TYS

CTG

15h 34m

1 stop

9:52 pm - 11:06 am

CTG

TYS

36h 14m

2 stops

$510Multiple Airlines

Thu, Apr 23 - Thu, Apr 30

6:07 pm - 12:35 pm

TYS

CTG

19h 28m

2 stops

3:13 pm - 11:59 pm

CTG

TYS

7h 46m

1 stop

$567American Airlines

Sat, May 23 - Sat, May 30

7:46 pm - 12:35 pm

TYS

CTG

17h 49m

1 stop

3:13 pm - 11:59 pm

CTG

TYS

7h 46m

1 stop

$574American Airlines

Sat, May 23 - Sat, May 30

5:57 pm - 5:00 am

TYS

LIM

12h 03m

1 stop

12:10 am - 11:46 pm

LIM

TYS

22h 36m

2 stops

$665Delta

Tue, Jun 23 - Tue, Jul 7

3:20 pm - 5:00 am

TYS

LIM

14h 40m

2 stops

12:15 am - 6:15 pm

LIM

TYS

17h 00m

2 stops

$670Delta

Tue, Jun 23 - Mon, Jul 6

7:05 am - 8:21 pm

TYS

PEI

14h 16m

2 stops

5:15 am - 11:44 pm

PEI

TYS

17h 29m

2 stops

$684United Airlines

Tue, Apr 28 - Tue, May 5

7:20 pm - 5:00 am

TYS

LIM

10h 40m

1 stop

12:10 am - 11:46 pm

LIM

TYS

22h 36m

2 stops

$696LATAM Airlines

Mon, Jun 22 - Tue, Jul 7

4:00 pm - 5:00 am

TYS

LIM

14h 00m

1 stop

12:05 pm - 11:47 pm

LIM

TYS

10h 42m

1 stop

$725LATAM Airlines

Sun, Sep 6 - Sun, Sep 13

7:00 am - 8:20 pm

TYS

PEI

38h 20m

3 stops

5:15 am - 11:44 pm

PEI

TYS

17h 29m

2 stops

$1,153United Airlines

Fri, May 8 - Sun, May 10

LATAM Airlines flights from Knoxville to South America

Our best LATAM Airlines deals on Knoxville to South America flight tickets

LATAM Airlines

Jun 22

TYS7:20 pmKnoxville McGhee Tyson

10h 40m

1 stop

LIM5:00 amLima J Chavez Intl

Jul 7

LIM12:10 amLima J Chavez Intl

22h 36m

2 stops

TYS11:46 pmKnoxville McGhee Tyson

$696

LATAM Airlines

Sep 6

TYS4:00 pmKnoxville McGhee Tyson

14h 00m

1 stop

LIM5:00 amLima J Chavez Intl

Sep 13

LIM12:05 pmLima J Chavez Intl

10h 42m

1 stop

TYS11:47 pmKnoxville McGhee Tyson

$725

LATAM Airlines

May 23

TYS5:35 pmKnoxville McGhee Tyson

12h 25m

1 stop

LIM5:00 amLima J Chavez Intl

May 31

LIM3:50 pmLima J Chavez Intl

40h 44m

2 stops

TYS9:34 amKnoxville McGhee Tyson

$751

Delta flights from Knoxville to South America

Our best Delta deals on Knoxville to South America flight tickets

Delta

Sep 3

TYS5:30 amKnoxville McGhee Tyson

15h 05m

2 stops

CTG7:35 pmCartagena Rafael Nunez

Sep 14

CTG10:10 amCartagena Rafael Nunez

12h 37m

2 stops

TYS11:47 pmKnoxville McGhee Tyson

$609

Delta

Sep 3

TYS10:05 amKnoxville McGhee Tyson

14h 30m

2 stops

CTG11:35 pmCartagena Rafael Nunez

Sep 14

CTG10:10 amCartagena Rafael Nunez

12h 37m

2 stops

TYS11:47 pmKnoxville McGhee Tyson

$623

Delta

Jun 23

TYS5:57 pmKnoxville McGhee Tyson

12h 03m

1 stop

LIM5:00 amLima J Chavez Intl

Jul 7

LIM12:10 amLima J Chavez Intl

22h 36m

2 stops

TYS11:46 pmKnoxville McGhee Tyson

$665

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-12:06 pm

1 stop15h 34m

Cartagena Rafael Nunez

Sat 5/2

7:47 am-8:35 pm

2 stops35h 48m

$473

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-12:06 pm

1 stop15h 34m

Cartagena Rafael Nunez

Thu 4/30

9:52 pm-11:06 am

2 stops36h 14m

$510

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 5/23

6:07 pm-12:35 pm

2 stops19h 28m

Cartagena Rafael Nunez

Sat 5/30

3:13 pm-11:59 pm

1 stop7h 46m

$567

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 5/23

7:46 pm-12:35 pm

1 stop17h 49m

Cartagena Rafael Nunez

Sat 5/30

3:13 pm-11:59 pm

1 stop7h 46m

$574

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 6/23

5:57 pm-5:00 am

1 stop12h 03m

Lima J Chavez Intl

Tue 7/7

12:10 am-11:46 pm

2 stops22h 36m

$665

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 6/23

3:20 pm-5:00 am

2 stops14h 40m

Lima J Chavez Intl

Mon 7/6

12:15 am-6:15 pm

2 stops17h 00m

$670

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Tue 4/28

7:05 am-8:21 pm

2 stops14h 16m

Pereira Matecana

Tue 5/5

5:15 am-11:44 pm

2 stops17h 29m

$684

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 6/22

7:20 pm-5:00 am

1 stop10h 40m

Lima J Chavez Intl

Tue 7/7

12:10 am-11:46 pm

2 stops22h 36m

$696

Quickest round-trip

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sun 9/6

4:00 pm-5:00 am

1 stop14h 00m

Lima J Chavez Intl

Sun 9/13

12:05 pm-11:47 pm

1 stop10h 42m

$725

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Fri 5/8

7:00 am-8:20 pm

3 stops38h 20m

Pereira Matecana

Sun 5/10

5:15 am-11:44 pm

2 stops17h 29m

$1,153

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, August is the cheapest month to fly from Knoxville to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $488. If you aren’t able to travel during the month of August, then book flights to South America from Knoxville during February instead. Flights to South America in February, while not as cheap as those in August, still average around $614.

Can stopping save me money on Knoxville to South America flights?

You could potentially save up to 18% on your flight if you consider stops on a Knoxville to South America flight.

Cheap Knoxville to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South America

Fastest flight time	8h 43m
Direct flights	None

The fastest flight from Knoxville to South America takes 8h 43m

There are no direct flights from Knoxville to South America. There are no popular flight routes from Knoxville to South America.

Search flight deals

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South America?
Prices for flights from Knoxville McGhee Tyson Airport to South America refresh daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South America?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to South America as of March 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Knoxville to South America

Compare and see reviews for airlines that fly from Knoxville to South America with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $488	Free Cancellation	Rating 7.1 11,464 reviews	Search American Airlines flights
Delta	PriceFrom $614	Free Cancellation	Rating 7.9 8,291 reviews	Search Delta flights
LATAM Airlines	PriceFrom $622	Free Cancellation	Rating 7.4 1,918 reviews	Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to South America with flexible booking policies on momondo?

Yes. All flights to South America from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to South America?

Once all potential Knoxville to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.