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Cheap flights from Knoxville to Des Moines from $229

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 7/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:00 am - 10:44 am
TYS
-
DSM
4h 44m
1 stop
United Airlines Logo
3:21 pm - 10:34 pm
DSM
-
TYS
6h 13m
1 stop
$303United Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
7:50 am - 11:30 am
TYS
-
DSM
4h 40m
1 stop
American Airlines Logo
11:09 am - 8:00 pm
DSM
-
TYS
7h 51m
2 stops
$308American Airlines
Wed, Apr 15 - Sat, Apr 18
Allegiant Air Logo
4:25 pm - 4:00 pm
TYS
-
DSM
24h 35m
1 stop
Allegiant Air Logo
11:00 am - 6:03 pm
DSM
-
TYS
6h 03m
1 stop
$310Allegiant Air
Wed, Apr 22 - Sat, Apr 25
United Airlines Logo
7:00 am - 10:44 am
TYS
-
DSM
4h 44m
1 stop
United Airlines Logo
3:04 pm - 11:41 pm
DSM
-
TYS
7h 37m
1 stop
$311United Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
American Airlines Logo
11:09 am - 8:00 pm
DSM
-
TYS
7h 51m
2 stops
$313American Airlines
Wed, Apr 15 - Sat, Apr 18
United Airlines Logo
5:15 pm - 10:43 pm
TYS
-
DSM
6h 28m
1 stop
United Airlines Logo
6:20 am - 3:09 pm
DSM
-
TYS
7h 49m
2 stops
$316United Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
American Airlines Logo
11:09 am - 8:00 pm
DSM
-
TYS
7h 51m
2 stops
$321American Airlines
Wed, Apr 22 - Sat, Apr 25
Allegiant Air Logo
7:30 am - 1:46 pm
TYS
-
DSM
7h 16m
1 stop
Allegiant Air Logo
2:36 pm - 12:25 pm
DSM
-
TYS
20h 49m
1 stop
$328Allegiant Air
Sun, Apr 5 - Thu, Apr 9
Allegiant Air Logo
8:30 am - 10:42 pm
TYS
-
DSM
15h 12m
2 stops
Allegiant Air Logo
8:30 am - 8:42 pm
DSM
-
TYS
11h 12m
1 stop
$342Allegiant Air
Fri, Apr 24 - Sun, Apr 26
United Airlines Logo
7:00 am - 12:29 pm
TYS
-
DSM
6h 29m
1 stop
United Airlines Logo
3:21 pm - 10:34 pm
DSM
-
TYS
6h 13m
1 stop
$357United Airlines
Fri, Apr 24 - Sun, Apr 26

United Airlines flights from Knoxville to Des Moines

Our best United Airlines deals on Knoxville to Des Moines flight tickets
United Airlines
Apr 22
TYS7:00 amKnoxville McGhee Tyson
4h 44m
1 stop
DSM10:44 amDes Moines
Apr 25
DSM3:21 pmDes Moines
6h 13m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
$303
United Airlines
Apr 22
TYS7:00 amKnoxville McGhee Tyson
4h 44m
1 stop
DSM10:44 amDes Moines
Apr 25
DSM3:04 pmDes Moines
7h 37m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$311
United Airlines
Apr 22
TYS5:15 pmKnoxville McGhee Tyson
6h 28m
1 stop
DSM10:43 pmDes Moines
Apr 25
DSM6:20 amDes Moines
7h 49m
2 stops
TYS3:09 pmKnoxville McGhee Tyson
$316

American Airlines flights from Knoxville to Des Moines

Our best American Airlines deals on Knoxville to Des Moines flight tickets
American Airlines
Apr 15
TYS7:50 amKnoxville McGhee Tyson
4h 40m
1 stop
DSM11:30 amDes Moines
Apr 18
DSM11:09 amDes Moines
7h 51m
2 stops
TYS8:00 pmKnoxville McGhee Tyson
$308
American Airlines
Apr 15
TYS5:00 amKnoxville McGhee Tyson
7h 30m
2 stops
DSM11:30 amDes Moines
Apr 18
DSM11:09 amDes Moines
7h 51m
2 stops
TYS8:00 pmKnoxville McGhee Tyson
$313
American Airlines
Apr 22
TYS5:00 amKnoxville McGhee Tyson
7h 30m
2 stops
DSM11:30 amDes Moines
Apr 25
DSM11:09 amDes Moines
7h 51m
2 stops
TYS8:00 pmKnoxville McGhee Tyson
$321

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/22

7:00 am-10:44 am

1 stop4h 44m

Des Moines

Sat 4/25

3:21 pm-10:34 pm

1 stop6h 13m

$303

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/15

7:50 am-11:30 am

1 stop4h 40m

Des Moines

Sat 4/18

11:09 am-8:00 pm

2 stops7h 51m

$308

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/22

4:25 pm-4:00 pm

1 stop24h 35m

Des Moines

Sat 4/25

11:00 am-6:03 pm

1 stop6h 03m

$310

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/22

7:00 am-10:44 am

1 stop4h 44m

Des Moines

Sat 4/25

3:04 pm-11:41 pm

1 stop7h 37m

$311

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/15

5:00 am-11:30 am

2 stops7h 30m

Des Moines

Sat 4/18

11:09 am-8:00 pm

2 stops7h 51m

$313

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/22

5:15 pm-10:43 pm

1 stop6h 28m

Des Moines

Sat 4/25

6:20 am-3:09 pm

2 stops7h 49m

$316

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/22

5:00 am-11:30 am

2 stops7h 30m

Des Moines

Sat 4/25

11:09 am-8:00 pm

2 stops7h 51m

$321

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 4/5

7:30 am-1:46 pm

1 stop7h 16m

Des Moines

Thu 4/9

2:36 pm-12:25 pm

1 stop20h 49m

$328

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 4/24

8:30 am-10:42 pm

2 stops15h 12m

Des Moines

Sun 4/26

8:30 am-8:42 pm

1 stop11h 12m

$342

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 4/24

7:00 am-12:29 pm

1 stop6h 29m

Des Moines

Sun 4/26

3:21 pm-10:34 pm

1 stop6h 13m

$357

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to Des Moines flights?

You could potentially save up to 15% on your flight if you consider stops on a Knoxville to Des Moines flight.

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Fastest flight time

4h 44m

Direct flights

None
The fastest flight from Knoxville to Des Moines takes 4h 44m
There are no direct flights from Knoxville to Des Moines. There are no popular flight routes from Knoxville to Des Moines.
Search flight deals

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 4h 44m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?

Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,491 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,320 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.

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