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Cheap flights from Knoxville to Des Moines from $134

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:00 am - 3:31 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
9h 31m1 stop Punta Gorda
Allegiant Air Logo
8:00 am - 10:23 amDSM  Des Moines-TYS Knoxville McGhee Tyson
25h 23m1 stop Sarasota Bradenton Intl
$343Allegiant Air
Mon, Dec 21 - Thu, Dec 24
Allegiant Air Logo
5:26 pm - 3:31 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
23h 05m1 stop Punta Gorda
Allegiant Air Logo
8:00 am - 10:23 amDSM  Des Moines-TYS Knoxville McGhee Tyson
25h 23m1 stop Sarasota Bradenton Intl
$344Allegiant Air
Thu, Dec 17 - Thu, Dec 24
Allegiant Air Logo
3:20 pm - 11:01 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 41m1 stop Tampa St. Petersburg
Allegiant Air Logo
8:00 am - 10:23 amDSM  Des Moines-TYS Knoxville McGhee Tyson
25h 23m1 stop Sarasota Bradenton Intl
$348Allegiant Air
Fri, Dec 18 - Thu, Dec 24
Allegiant Air Logo
9:27 pm - 10:22 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
25h 55m1 stop Orlando Sanford Intl
Allegiant Air Logo
8:00 am - 10:23 amDSM  Des Moines-TYS Knoxville McGhee Tyson
25h 23m1 stop Sarasota Bradenton Intl
$352Allegiant Air
Sat, Dec 19 - Thu, Dec 24
United Airlines Logo
5:57 pm - 9:23 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 26m1 stop Chicago O'Hare Intl
United Airlines Logo
5:00 am - 2:42 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
8h 42m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$445United Airlines
Sat, Dec 19 - Wed, Dec 30
United Airlines Logo
6:45 am - 10:32 amTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 47m1 stop Chicago O'Hare Intl
United Airlines Logo
6:05 am - 1:13 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 08m1 stop Chicago O'Hare Intl
$446United Airlines
Tue, Nov 24 - Sat, Nov 28
United Airlines Logo
11:20 am - 7:16 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 56m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
3:01 pm - 9:57 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
5h 56m1 stop Houston George Bush Intcntl
$448United Airlines
Sat, Nov 21 - Wed, Nov 25
American Airlines Logo
6:48 pm - 11:08 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 20m1 stop Dallas/Fort Worth
American Airlines Logo
7:58 pm - 11:02 amDSM  Des Moines-TYS Knoxville McGhee Tyson
14h 04m1 stop Chicago O'Hare Intl
$551American Airlines
Fri, Dec 25 - Mon, Dec 28
American Airlines Logo
8:01 pm - 11:58 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 57m1 stop Charlotte Douglas
American Airlines Logo
5:30 am - 2:36 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
8h 06m2 stops Chicago O'Hare Intl Charlotte Douglas
$575American Airlines
Thu, Dec 17 - Thu, Dec 24
American Airlines Logo
11:39 am - 6:58 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 19m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 4:16 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
9h 46m2 stops Chicago O'Hare Intl Charlotte Douglas
$585American Airlines
Fri, Dec 18 - Fri, Dec 25

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United Airlines flights from Knoxville to Des Moines

Our best United Airlines deals on Knoxville to Des Moines flight tickets
United Airlines
Dec 19
TYS5:57 pmKnoxville McGhee Tyson
4h 26m
1 stop
DSM9:23 pmDes Moines
Dec 30
DSM5:00 amDes Moines
8h 42m
2 stops
TYS2:42 pmKnoxville McGhee Tyson
$445
United Airlines
Nov 24
TYS6:45 amKnoxville McGhee Tyson
4h 47m
1 stop
DSM10:32 amDes Moines
Nov 28
DSM6:05 amDes Moines
6h 08m
1 stop
TYS1:13 pmKnoxville McGhee Tyson
$446
United Airlines
Nov 21
TYS11:20 amKnoxville McGhee Tyson
8h 56m
2 stops
DSM7:16 pmDes Moines
Nov 25
DSM3:01 pmDes Moines
5h 56m
1 stop
TYS9:57 pmKnoxville McGhee Tyson
$448

Allegiant Air flights from Knoxville to Des Moines

Our best Allegiant Air deals on Knoxville to Des Moines flight tickets
Allegiant Air
Dec 21
TYS7:00 amKnoxville McGhee Tyson
9h 31m
1 stop
DSM3:31 pmDes Moines
Dec 24
DSM8:00 amDes Moines
25h 23m
1 stop
TYS10:23 amKnoxville McGhee Tyson
$343
Allegiant Air
Dec 17
TYS5:26 pmKnoxville McGhee Tyson
23h 05m
1 stop
DSM3:31 pmDes Moines
Dec 24
DSM8:00 amDes Moines
25h 23m
1 stop
TYS10:23 amKnoxville McGhee Tyson
$344
Allegiant Air
Dec 18
TYS3:20 pmKnoxville McGhee Tyson
8h 41m
1 stop
DSM11:01 pmDes Moines
Dec 24
DSM8:00 amDes Moines
25h 23m
1 stop
TYS10:23 amKnoxville McGhee Tyson
$348

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

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Cheapest round-trip

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Mon 12/21

7:00 am-3:31 pm

1 stop9h 31m

Des Moines

Thu 12/24

8:00 am-10:23 am

1 stop25h 23m

$343

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 12/17

5:26 pm-3:31 pm

1 stop23h 05m

Des Moines

Thu 12/24

8:00 am-10:23 am

1 stop25h 23m

$344

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Fri 12/18

3:20 pm-11:01 pm

1 stop8h 41m

Des Moines

Thu 12/24

8:00 am-10:23 am

1 stop25h 23m

$348

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 12/19

9:27 pm-10:22 pm

1 stop25h 55m

Des Moines

Thu 12/24

8:00 am-10:23 am

1 stop25h 23m

$352

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 12/19

5:57 pm-9:23 pm

1 stop4h 26m

Des Moines

Wed 12/30

5:00 am-2:42 pm

2 stops8h 42m

$445
Quickest round-trip

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Tue 11/24

6:45 am-10:32 am

1 stop4h 47m

Des Moines

Sat 11/28

6:05 am-1:13 pm

1 stop6h 08m

$446

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 11/21

11:20 am-7:16 pm

2 stops8h 56m

Des Moines

Wed 11/25

3:01 pm-9:57 pm

1 stop5h 56m

$448

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Fri 12/25

6:48 pm-11:08 pm

1 stop5h 20m

Des Moines

Mon 12/28

7:58 pm-11:02 am

1 stop14h 04m

$551

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 12/17

8:01 pm-11:58 pm

1 stop4h 57m

Des Moines

Thu 12/24

5:30 am-2:36 pm

2 stops8h 06m

$575

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Fri 12/18

11:39 am-6:58 pm

1 stop8h 19m

Des Moines

Fri 12/25

5:30 am-4:16 pm

2 stops9h 46m

$585

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Des Moines from

How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then February is your next best option. Flight prices from Knoxville to Des Moines during February average around $226.

Can stopping save me money on Knoxville to Des Moines flights?

You could potentially save up to 36% on your flight if you consider stops on a Knoxville to Des Moines flight.

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Best Price Found

$134

Fastest flight time

7h 27m

Direct flights

None
The best one-way flight to Des Moines from Knoxville in the past 72 hours is $134. The best round-trip flight deal from Knoxville to Des Moines found on momondo in the last 72 hours is $343.
The fastest flight from Knoxville to Des Moines takes 7h 27m
There are no direct flights from Knoxville to Des Moines. There are no popular flight routes from Knoxville to Des Moines.
Search flight deals

Frequently asked questions about flying from Knoxville to Des Moines

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 7h 27m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?

Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $226Free CancellationRating
7.0
12,223 reviews
Search American Airlines flights
United AirlinesPriceFrom $284Free CancellationRating
7.3
10,474 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Johnston
Boone
Newton
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.

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