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Cheap flights from Knoxville to Des Moines from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 11/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
3:44 pm - 9:32 pm
TYS
-
DSM
6h 48m
1 stop
Allegiant Air Logo
4:40 pm - 4:10 pm
DSM
-
TYS
22h 30m
1 stop
$239Allegiant Air
Thu, Jul 9 - Mon, Jul 13
Allegiant Air Logo
3:44 pm - 9:32 pm
TYS
-
DSM
6h 48m
1 stop
Allegiant Air Logo
5:30 pm - 3:30 pm
DSM
-
TYS
21h 00m
2 stops
$293Allegiant Air
Thu, Jul 9 - Mon, Jul 13
American Airlines Logo
6:32 pm - 12:01 am
TYS
-
DSM
6h 29m
1 stop
American Airlines Logo
4:48 pm - 11:51 pm
DSM
-
TYS
6h 03m
1 stop
$318American Airlines
Wed, Jul 22 - Fri, Jul 24
United Airlines Logo
7:00 am - 12:20 pm
TYS
-
DSM
6h 20m
1 stop
United Airlines Logo
5:00 am - 1:18 pm
DSM
-
TYS
7h 18m
1 stop
$319United Airlines
Mon, Aug 17 - Mon, Dec 14
American Airlines Logo
6:10 pm - 12:09 am
TYS
-
DSM
6h 59m
1 stop
American Airlines Logo
2:22 pm - 9:33 pm
DSM
-
TYS
6h 11m
1 stop
$338American Airlines
Tue, Jul 14 - Thu, Jul 16
Allegiant Air Logo
9:00 am - 11:55 am
TYS
-
DSM
27h 55m
1 stop
Allegiant Air Logo
3:54 pm - 8:43 pm
DSM
-
TYS
27h 49m
1 stop
$339Allegiant Air
Tue, Oct 6 - Sun, Oct 11
Allegiant Air Logo
10:05 pm - 3:24 pm
TYS
-
DSM
18h 19m
1 stop
Allegiant Air Logo
1:37 pm - 10:48 pm
DSM
-
TYS
8h 11m
1 stop
$342Allegiant Air
Mon, Jul 27 - Mon, Aug 3
Southwest Logo
5:45 pm - 10:10 pm
TYS
-
DSM
5h 25m
2 stops
Southwest Logo
7:05 am - 3:30 pm
DSM
-
TYS
7h 25m
1 stop
$353Southwest
Mon, Aug 17 - Mon, Dec 14
American Airlines Logo
6:10 pm - 12:09 am
TYS
-
DSM
6h 59m
1 stop
American Airlines Logo
5:00 am - 12:30 pm
DSM
-
TYS
6h 30m
1 stop
$358American Airlines
Sat, Jul 11 - Tue, Jul 14
Southwest Logo
12:45 pm - 10:50 pm
TYS
-
DSM
11h 05m
2 stops
Southwest Logo
6:10 am - 7:10 pm
DSM
-
TYS
12h 00m
1 stop
$369Southwest
Wed, Jul 22 - Fri, Jul 24

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American Airlines flights from Knoxville to Des Moines

Our best American Airlines deals on Knoxville to Des Moines flight tickets
American Airlines
Jul 22
TYS6:32 pmKnoxville McGhee Tyson
6h 29m
1 stop
DSM12:01 amDes Moines
Jul 24
DSM4:48 pmDes Moines
6h 03m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$318
American Airlines
Jul 14
TYS6:10 pmKnoxville McGhee Tyson
6h 59m
1 stop
DSM12:09 amDes Moines
Jul 16
DSM2:22 pmDes Moines
6h 11m
1 stop
TYS9:33 pmKnoxville McGhee Tyson
$338
American Airlines
Jul 11
TYS6:10 pmKnoxville McGhee Tyson
6h 59m
1 stop
DSM12:09 amDes Moines
Jul 14
DSM5:00 amDes Moines
6h 30m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
$358

United Airlines flights from Knoxville to Des Moines

Our best United Airlines deals on Knoxville to Des Moines flight tickets
United Airlines
Aug 17
TYS7:00 amKnoxville McGhee Tyson
6h 20m
1 stop
DSM12:20 pmDes Moines
Dec 14
DSM5:00 amDes Moines
7h 18m
1 stop
TYS1:18 pmKnoxville McGhee Tyson
$319
United Airlines
Jul 14
TYS6:00 amKnoxville McGhee Tyson
5h 17m
1 stop
DSM10:17 amDes Moines
Jul 16
DSM6:00 amDes Moines
7h 27m
2 stops
TYS2:27 pmKnoxville McGhee Tyson
$371
United Airlines
Jul 7
TYS1:54 pmKnoxville McGhee Tyson
5h 15m
1 stop
DSM6:09 pmDes Moines
Jul 11
DSM11:23 amDes Moines
11h 31m
2 stops
TYS11:54 pmKnoxville McGhee Tyson
$442

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/9

3:44 pm-9:32 pm

1 stop6h 48m

Des Moines

Mon 7/13

4:40 pm-4:10 pm

1 stop22h 30m

$239

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/9

3:44 pm-9:32 pm

1 stop6h 48m

Des Moines

Mon 7/13

5:30 pm-3:30 pm

2 stops21h 00m

$293
Quickest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 7/22

6:32 pm-12:01 am

1 stop6h 29m

Des Moines

Fri 7/24

4:48 pm-11:51 pm

1 stop6h 03m

$318

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 8/17

7:00 am-12:20 pm

1 stop6h 20m

Des Moines

Mon 12/14

5:00 am-1:18 pm

1 stop7h 18m

$319

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 7/14

6:10 pm-12:09 am

1 stop6h 59m

Des Moines

Thu 7/16

2:22 pm-9:33 pm

1 stop6h 11m

$338

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 10/6

9:00 am-11:55 am

1 stop27h 55m

Des Moines

Sun 10/11

3:54 pm-8:43 pm

1 stop27h 49m

$339

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 7/27

10:05 pm-3:24 pm

1 stop18h 19m

Des Moines

Mon 8/3

1:37 pm-10:48 pm

1 stop8h 11m

$342

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 8/17

5:45 pm-10:10 pm

2 stops5h 25m

Des Moines

Mon 12/14

7:05 am-3:30 pm

1 stop7h 25m

$353

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 7/11

6:10 pm-12:09 am

1 stop6h 59m

Des Moines

Tue 7/14

5:00 am-12:30 pm

1 stop6h 30m

$358

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 7/22

12:45 pm-10:50 pm

2 stops11h 05m

Des Moines

Fri 7/24

6:10 am-7:10 pm

1 stop12h 00m

$369

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then February is your next best option. Flight prices from Knoxville to Des Moines during February average around $226.

Can stopping save me money on Knoxville to Des Moines flights?

You could potentially save up to 52% on your flight if you consider stops on a Knoxville to Des Moines flight.

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Fastest flight time

4h 37m

Direct flights

None
The fastest flight from Knoxville to Des Moines takes 4h 37m
There are no direct flights from Knoxville to Des Moines. There are no popular flight routes from Knoxville to Des Moines.
Search flight deals

Frequently asked questions about flying from Knoxville to Des Moines

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 4h 37m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?

Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $226Free CancellationRating
7.1
11,769 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.8
8,453 reviews
Search Delta flights
United AirlinesPriceFrom $341Free CancellationRating
7.4
9,893 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Osceola
Urbandale
Newton
Johnston
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.

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