Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Des Moines from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 1/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:54 am - 7:34 pm
TYS
-
DSM
8h 40m1 stop
Delta Logo
7:34 am - 4:19 pm
DSM
-
TYS
7h 45m1 stop
$293Delta
jue., ene. 8 - mié., ene. 14
United Airlines Logo
6:45 am - 10:53 am
TYS
-
DSM
5h 08m1 stop
United Airlines Logo
3:24 pm - 8:37 pm
DSM
-
TYS
4h 13m1 stop
$301United Airlines
sáb., feb. 14 - mié., feb. 18
United Airlines Logo
2:21 pm - 9:41 pm
TYS
-
DSM
8h 20m2 stops
United Airlines Logo
3:24 pm - 8:37 pm
DSM
-
TYS
4h 13m1 stop
$306United Airlines
sáb., feb. 14 - mié., feb. 18
American Airlines Logo
8:24 am - 1:17 pm
TYS
-
DSM
5h 53m1 stop
American Airlines Logo
2:02 pm - 8:05 pm
DSM
-
TYS
5h 03m1 stop
$329American Airlines
jue., abr. 2 - dom., abr. 5
American Airlines Logo
9:13 am - 1:17 pm
TYS
-
DSM
5h 04m1 stop
American Airlines Logo
1:40 pm - 11:40 pm
DSM
-
TYS
9h 00m2 stops
$334American Airlines
jue., abr. 2 - dom., abr. 5
Southwest Logo
6:30 am - 12:10 pm
TYS
-
DSM
6h 40m2 stops
Southwest Logo
5:25 am - 12:55 pm
DSM
-
TYS
6h 30m2 stops
$357Southwest
jue., abr. 2 - dom., abr. 5
United Airlines Logo
11:10 am - 2:33 pm
TYS
-
DSM
4h 23m1 stop
United Airlines Logo
7:50 am - 1:24 pm
DSM
-
TYS
4h 34m1 stop
$359United Airlines
mar., ene. 6 - sáb., ene. 10
United Airlines Logo
5:29 pm - 9:50 pm
TYS
-
DSM
5h 21m1 stop
United Airlines Logo
7:50 am - 7:27 pm
DSM
-
TYS
10h 37m2 stops
$364United Airlines
mar., ene. 6 - sáb., ene. 10
American Airlines Logo
4:00 pm - 10:11 pm
TYS
-
DSM
7h 11m2 stops
American Airlines Logo
1:16 pm - 9:44 pm
DSM
-
TYS
7h 28m1 stop
$368American Airlines
jue., ene. 8 - mié., ene. 14
American Airlines Logo
8:09 am - 4:24 pm
TYS
-
DSM
9h 15m2 stops
American Airlines Logo
1:16 pm - 11:21 pm
DSM
-
TYS
9h 05m2 stops
$369American Airlines
mar., ene. 6 - sáb., ene. 10

American Airlines flights from Knoxville to Des Moines

Our best American Airlines deals on Knoxville to Des Moines flight tickets
American Airlines
Apr 2
TYS8:24 amKnoxville McGhee Tyson
5h 53m
1 stop
DSM1:17 pmDes Moines
Apr 5
DSM2:02 pmDes Moines
5h 03m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
$329
Find similar
American Airlines
Apr 2
TYS9:13 amKnoxville McGhee Tyson
5h 04m
1 stop
DSM1:17 pmDes Moines
Apr 5
DSM1:40 pmDes Moines
9h 00m
2 stops
TYS11:40 pmKnoxville McGhee Tyson
$334
Find similar
American Airlines
Jan 8
TYS4:00 pmKnoxville McGhee Tyson
7h 11m
2 stops
DSM10:11 pmDes Moines
Jan 14
DSM1:16 pmDes Moines
7h 28m
1 stop
TYS9:44 pmKnoxville McGhee Tyson
$368
Find similar

Southwest flights from Knoxville to Des Moines

Our best Southwest deals on Knoxville to Des Moines flight tickets
Southwest
Apr 2
TYS6:30 amKnoxville McGhee Tyson
6h 40m
2 stops
DSM12:10 pmDes Moines
Apr 5
DSM5:25 amDes Moines
6h 30m
2 stops
TYS12:55 pmKnoxville McGhee Tyson
$357
Find similar
Southwest
Apr 3
TYS3:45 pmKnoxville McGhee Tyson
8h 30m
2 stops
DSM11:15 pmDes Moines
Apr 5
DSM5:25 amDes Moines
6h 30m
2 stops
TYS12:55 pmKnoxville McGhee Tyson
$427
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 23, 2025.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 1/8

11:54 am-7:34 pm

1 stop8h 40m

Des Moines

mié. 1/14

7:34 am-4:19 pm

1 stop7h 45m

$293

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

sáb. 2/14

6:45 am-10:53 am

1 stop5h 08m

Des Moines

mié. 2/18

3:24 pm-8:37 pm

1 stop4h 13m

$301

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

sáb. 2/14

2:21 pm-9:41 pm

2 stops8h 20m

Des Moines

mié. 2/18

3:24 pm-8:37 pm

1 stop4h 13m

$306

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 4/2

8:24 am-1:17 pm

1 stop5h 53m

Des Moines

dom. 4/5

2:02 pm-8:05 pm

1 stop5h 03m

$329

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 4/2

9:13 am-1:17 pm

1 stop5h 04m

Des Moines

dom. 4/5

1:40 pm-11:40 pm

2 stops9h 00m

$334

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 4/2

6:30 am-12:10 pm

2 stops6h 40m

Des Moines

dom. 4/5

5:25 am-12:55 pm

2 stops6h 30m

$357

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mar. 1/6

11:10 am-2:33 pm

1 stop4h 23m

Des Moines

sáb. 1/10

7:50 am-1:24 pm

1 stop4h 34m

$359

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mar. 1/6

5:29 pm-9:50 pm

1 stop5h 21m

Des Moines

sáb. 1/10

7:50 am-7:27 pm

2 stops10h 37m

$364

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 1/8

4:00 pm-10:11 pm

2 stops7h 11m

Des Moines

mié. 1/14

1:16 pm-9:44 pm

1 stop7h 28m

$368

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mar. 1/6

8:09 am-4:24 pm

2 stops9h 15m

Des Moines

sáb. 1/10

1:16 pm-11:21 pm

2 stops9h 05m

$369

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then February is your next best option. Flight prices from Knoxville to Des Moines during February average around $278.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Knoxville to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $262. Flights from Knoxville to Des Moines on a Monday will generally be more expensive and average around $581. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Knoxville to Des Moines in the morning for as low as $320. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $338. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Fastest flight time

4h 21m

Direct flights

None
The fastest flight from Knoxville to Des Moines takes 4h 21m
There are no direct flights from Knoxville to Des Moines. There are no popular flight routes from Knoxville to Des Moines.
Search flight deals

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 4h 21m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?

Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
jue. 1/22
jue. 1/29
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States