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Cheap flights from Knoxville to Des Moines from $97

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
3:38 pm - 9:27 pm
TYS
-
DSM
6h 49m
1 stop
Allegiant Air Logo
10:57 am - 12:03 pm
DSM
-
TYS
24h 06m
1 stop
$251Allegiant Air
Thu, Jul 23 - Sun, Jul 26
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
Allegiant Air Logo
12:37 pm - 11:12 pm
DSM
-
TYS
9h 35m
1 stop
$254Allegiant Air
Sun, Aug 2 - Fri, Aug 7
Allegiant Air Logo
3:38 pm - 9:27 pm
TYS
-
DSM
6h 49m
1 stop
Allegiant Air Logo
10:57 am - 12:03 pm
DSM
-
TYS
24h 06m
1 stop
$256Allegiant Air
Thu, Jul 23 - Sun, Jul 26
Allegiant Air Logo
2:19 pm - 8:37 am
TYS
-
DSM
19h 18m
1 stop
Allegiant Air Logo
5:02 pm - 9:50 pm
DSM
-
TYS
27h 48m
1 stop
$260Allegiant Air
Wed, Jun 17 - Thu, Jun 25
Allegiant Air Logo
3:47 pm - 9:27 pm
TYS
-
DSM
6h 40m
1 stop
Allegiant Air Logo
7:18 pm - 10:53 pm
DSM
-
TYS
26h 35m
1 stop
$281Allegiant Air
Thu, Jun 4 - Fri, Jun 5
Allegiant Air Logo
8:00 am - 10:03 am
TYS
-
DSM
27h 03m
2 stops
Allegiant Air Logo
5:02 pm - 9:50 pm
DSM
-
TYS
27h 48m
1 stop
$306Allegiant Air
Wed, Jun 17 - Thu, Jun 25
American Airlines Logo
6:43 pm - 12:35 am
TYS
-
DSM
6h 52m
1 stop
American Airlines Logo
7:04 am - 3:42 pm
DSM
-
TYS
7h 38m
1 stop
$309American Airlines
Tue, Jun 30 - Fri, Jul 3
American Airlines Logo
7:59 pm - 12:17 am
TYS
-
DSM
5h 18m
1 stop
American Airlines Logo
4:48 pm - 11:56 pm
DSM
-
TYS
6h 08m
1 stop
$311American Airlines
Sun, May 24 - Thu, May 28
Delta Logo
5:25 pm - 8:41 pm
TYS
-
DSM
4h 16m
1 stop
Delta Logo
6:03 pm - 11:01 pm
DSM
-
TYS
3h 58m
1 stop
$323Delta
Tue, Jun 9 - Mon, Jun 15
Multiple Airlines Logo
7:15 am - 11:07 pm
TYS
-
DSM
16h 52m
2 stops
Multiple Airlines Logo
10:57 am - 12:03 pm
DSM
-
TYS
24h 06m
1 stop
$330Multiple Airlines
Thu, Jul 23 - Sun, Jul 26

United Airlines flights from Knoxville to Des Moines

Our best United Airlines deals on Knoxville to Des Moines flight tickets
United Airlines
Jun 30
TYS5:45 amKnoxville McGhee Tyson
9h 40m
2 stops
DSM2:25 pmDes Moines
Jul 3
DSM3:24 pmDes Moines
6h 10m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
$337
United Airlines
May 24
TYS5:45 amKnoxville McGhee Tyson
7h 28m
2 stops
DSM12:13 pmDes Moines
May 28
DSM6:00 amDes Moines
6h 18m
1 stop
TYS1:18 pmKnoxville McGhee Tyson
$404
United Airlines
May 16
TYS5:55 pmKnoxville McGhee Tyson
4h 40m
1 stop
DSM9:35 pmDes Moines
May 23
DSM11:23 amDes Moines
4h 28m
1 stop
TYS4:51 pmKnoxville McGhee Tyson
$440

Allegiant Air flights from Knoxville to Des Moines

Our best Allegiant Air deals on Knoxville to Des Moines flight tickets
Allegiant Air
Jul 23
TYS3:38 pmKnoxville McGhee Tyson
6h 49m
1 stop
DSM9:27 pmDes Moines
Jul 26
DSM10:57 amDes Moines
24h 06m
1 stop
TYS12:03 pmKnoxville McGhee Tyson
$251
Allegiant Air
Aug 2
TYS3:38 pmKnoxville McGhee Tyson
8h 09m
1 stop
DSM10:47 pmDes Moines
Aug 7
DSM12:37 pmDes Moines
9h 35m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
$254
Allegiant Air
Jul 23
TYS3:38 pmKnoxville McGhee Tyson
6h 49m
1 stop
DSM9:27 pmDes Moines
Jul 26
DSM10:57 amDes Moines
24h 06m
1 stop
TYS12:03 pmKnoxville McGhee Tyson
$256

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/23

3:38 pm-9:27 pm

1 stop6h 49m

Des Moines

Sun 7/26

10:57 am-12:03 pm

1 stop24h 06m

$251

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/2

3:38 pm-10:47 pm

1 stop8h 09m

Des Moines

Fri 8/7

12:37 pm-11:12 pm

1 stop9h 35m

$254

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/23

3:38 pm-9:27 pm

1 stop6h 49m

Des Moines

Sun 7/26

10:57 am-12:03 pm

1 stop24h 06m

$256

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 6/17

2:19 pm-8:37 am

1 stop19h 18m

Des Moines

Thu 6/25

5:02 pm-9:50 pm

1 stop27h 48m

$260

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 6/4

3:47 pm-9:27 pm

1 stop6h 40m

Des Moines

Fri 6/5

7:18 pm-10:53 pm

1 stop26h 35m

$281

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 6/17

8:00 am-10:03 am

2 stops27h 03m

Des Moines

Thu 6/25

5:02 pm-9:50 pm

1 stop27h 48m

$306

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 6/30

6:43 pm-12:35 am

1 stop6h 52m

Des Moines

Fri 7/3

7:04 am-3:42 pm

1 stop7h 38m

$309

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 5/24

7:59 pm-12:17 am

1 stop5h 18m

Des Moines

Thu 5/28

4:48 pm-11:56 pm

1 stop6h 08m

$311
Quickest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 6/9

5:25 pm-8:41 pm

1 stop4h 16m

Des Moines

Mon 6/15

6:03 pm-11:01 pm

1 stop3h 58m

$323

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/23

7:15 am-11:07 pm

2 stops16h 52m

Des Moines

Sun 7/26

10:57 am-12:03 pm

1 stop24h 06m

$330

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then February is your next best option. Flight prices from Knoxville to Des Moines during February average around $226.

Can stopping save me money on Knoxville to Des Moines flights?

You could potentially save up to 30% on your flight if you consider stops on a Knoxville to Des Moines flight.

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Fastest flight time

4h 16m

Direct flights

None
The fastest flight from Knoxville to Des Moines takes 4h 16m
There are no direct flights from Knoxville to Des Moines. There are no popular flight routes from Knoxville to Des Moines.
Search flight deals

Frequently asked questions about flying from Knoxville to Des Moines

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 4h 16m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?

Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $226Free CancellationRating
7.1
11,664 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,454 reviews
Search Delta flights
United AirlinesPriceFrom $341Free CancellationRating
7.4
9,711 reviews
Search United Airlines flights

  • United Airlines Flights From Knoxville to Des Moines

    United Airlines flies from Knoxville to Des Moines around 1 time per week, with 9,711 momondo users rating the airline 7.4/10. The cheapest United Airlines deal from Knoxville to Des Moines in the last 72 hours was $341 (round-trip), much lower than the average airfare cost of $404 for United Airlines flights on this route.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.

An easier way to manage your Des Moines trip

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