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Cheap flights from Knoxville to Des Moines from $112

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:17 am - 1:50 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
7h 33m1 stop Washington, D.C. Reagan-National
American Airlines Logo
3:31 pm - 11:32 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 01m1 stop Dallas/Fort Worth
$303American Airlines
Thu, Oct 29 - Mon, Nov 2
Delta Logo
6:23 pm - 10:33 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 10m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:03 pm - 10:22 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 19m1 stop Atlanta Hartsfield-Jackson
$303Delta
Tue, Oct 13 - Tue, Oct 20
Delta Logo
5:40 am - 10:42 amTYS  Knoxville McGhee Tyson-DSM Des Moines
6h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:27 am - 5:38 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
5h 11m1 stop Atlanta Hartsfield-Jackson
$303Delta
Sat, Oct 24 - Sat, Oct 31
United Airlines Logo
1:35 pm - 9:23 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 48m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
9:36 am - 4:59 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 23m1 stop Chicago O'Hare Intl
$308United Airlines
Sat, Oct 24 - Sat, Oct 31
American Airlines Logo
6:05 pm - 10:45 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 40m1 stop Washington, D.C. Reagan-National
American Airlines Logo
4:12 pm - 11:18 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 06m1 stop Dallas/Fort Worth
$335American Airlines
Tue, Oct 13 - Tue, Oct 20
American Airlines Logo
6:10 pm - 10:39 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 29m1 stop Washington, D.C. Reagan-National
American Airlines Logo
11:28 am - 5:37 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
5h 09m1 stop Charlotte Douglas
$363American Airlines
Fri, Nov 13 - Sun, Nov 15
United Airlines Logo
4:53 pm - 11:52 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
7h 59m1 stop Denver Intl
United Airlines Logo
1:24 pm - 8:49 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 25m1 stop Chicago O'Hare Intl
$367United Airlines
Sat, Oct 10 - Wed, Oct 14
United Airlines Logo
10:42 am - 2:15 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 33m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 2:42 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 42m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$372United Airlines
Sat, Oct 10 - Wed, Oct 14
Southwest Logo
5:30 pm - 10:20 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 50m1 stop Denver Intl
Southwest Logo
5:25 am - 8:30 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
14h 05m2 stops Chicago Midway Nashville Intl
$384Southwest
Thu, Oct 29 - Mon, Nov 2
American Airlines Logo
6:05 pm - 10:45 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 40m1 stop Washington, D.C. Reagan-National
American Airlines Logo
2:26 pm - 9:33 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 07m1 stop Washington, D.C. Reagan-National
$453American Airlines
Tue, Oct 13 - Thu, Oct 15

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Allegiant Air flights from Knoxville to Des Moines

Our best Allegiant Air deals on Knoxville to Des Moines flight tickets
Allegiant Air
Oct 1
TYS2:06 pmKnoxville McGhee Tyson
8h 25m
1 stop
DSM9:31 pmDes Moines
Oct 3
DSM9:00 amDes Moines
9h 52m
1 stop
TYS7:52 pmKnoxville McGhee Tyson
$342
Allegiant Air
Oct 1
TYS2:06 pmKnoxville McGhee Tyson
8h 25m
1 stop
DSM9:31 pmDes Moines
Oct 3
DSM9:00 amDes Moines
9h 52m
1 stop
TYS7:52 pmKnoxville McGhee Tyson
$349
Allegiant Air
Oct 1
TYS2:06 pmKnoxville McGhee Tyson
8h 25m
1 stop
DSM9:31 pmDes Moines
Oct 4
DSM1:37 pmDes Moines
19h 58m
1 stop
TYS10:35 amKnoxville McGhee Tyson
$365

American Airlines flights from Knoxville to Des Moines

Our best American Airlines deals on Knoxville to Des Moines flight tickets
American Airlines
Oct 13
TYS6:05 pmKnoxville McGhee Tyson
5h 40m
1 stop
DSM10:45 pmDes Moines
Oct 20
DSM4:12 pmDes Moines
6h 06m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
$335
American Airlines
Nov 13
TYS6:10 pmKnoxville McGhee Tyson
5h 29m
1 stop
DSM10:39 pmDes Moines
Nov 15
DSM11:28 amDes Moines
5h 09m
1 stop
TYS5:37 pmKnoxville McGhee Tyson
$363
American Airlines
Oct 13
TYS6:05 pmKnoxville McGhee Tyson
5h 40m
1 stop
DSM10:45 pmDes Moines
Oct 15
DSM2:26 pmDes Moines
6h 07m
1 stop
TYS9:33 pmKnoxville McGhee Tyson
$453

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

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Cheapest round-trip

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 10/29

7:17 am-1:50 pm

1 stop7h 33m

Des Moines

Mon 11/2

3:31 pm-11:32 pm

1 stop7h 01m

$303

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Tue 10/13

6:23 pm-10:33 pm

1 stop5h 10m

Des Moines

Tue 10/20

3:03 pm-10:22 pm

1 stop6h 19m

$303

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 10/24

5:40 am-10:42 am

1 stop6h 02m

Des Moines

Sat 10/31

11:27 am-5:38 pm

1 stop5h 11m

$303

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 10/24

1:35 pm-9:23 pm

2 stops8h 48m

Des Moines

Sat 10/31

9:36 am-4:59 pm

1 stop6h 23m

$308

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Tue 10/13

6:05 pm-10:45 pm

1 stop5h 40m

Des Moines

Tue 10/20

4:12 pm-11:18 pm

1 stop6h 06m

$335
Quickest round-trip

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Fri 11/13

6:10 pm-10:39 pm

1 stop5h 29m

Des Moines

Sun 11/15

11:28 am-5:37 pm

1 stop5h 09m

$363

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 10/10

4:53 pm-11:52 pm

1 stop7h 59m

Des Moines

Wed 10/14

1:24 pm-8:49 pm

1 stop6h 25m

$367

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Sat 10/10

10:42 am-2:15 pm

1 stop4h 33m

Des Moines

Wed 10/14

6:00 am-2:42 pm

2 stops7h 42m

$372

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Thu 10/29

5:30 pm-10:20 pm

1 stop5h 50m

Des Moines

Mon 11/2

5:25 am-8:30 pm

2 stops14h 05m

$384

KnoxvilleDes Moines

TYS Knoxville McGhee Tyson - DSM Des Moines

TYSDSM

Knoxville McGhee Tyson

Tue 10/13

6:05 pm-10:45 pm

1 stop5h 40m

Des Moines

Thu 10/15

2:26 pm-9:33 pm

1 stop6h 07m

$453

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then February is your next best option. Flight prices from Knoxville to Des Moines during February average around $226.

Can stopping save me money on Knoxville to Des Moines flights?

You could potentially save up to 35% on your flight if you consider stops on a Knoxville to Des Moines flight.

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Best Price Found

$112

Fastest flight time

5h 29m

Direct flights

None
The best one-way flight to Des Moines from Knoxville in the past 72 hours is $112. The best round-trip flight deal from Knoxville to Des Moines found on momondo in the last 72 hours is $303.
The fastest flight from Knoxville to Des Moines takes 5h 29m
There are no direct flights from Knoxville to Des Moines. There are no popular flight routes from Knoxville to Des Moines.
Search flight deals

Frequently asked questions about flying from Knoxville to Des Moines

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 5h 29m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?

Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $226Free CancellationRating
7.0
12,099 reviews
Search American Airlines flights
United AirlinesPriceFrom $284Free CancellationRating
7.4
10,242 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Newton
Boone
Johnston
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.

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