Cheap flights from Knoxville to Des Moines from $155
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
Discover deals from 900+ travel sites with momondo.
Save money when you book flights with momondo
Big names and deals
Big names and deals
Search 100s of travel sites to compare prices.Filter for what you want
Filter for what you want
Free Wi-Fi? Stopover? Instantly customize your results.Trusted and free
Trusted and free
We’re completely free to use - no hidden charges or fees.Price Alerts
Price Alerts
Not ready to book? to track prices.Find the cheapest flights from Knoxville to Des Moines
Cheap round-trip flights
Cheap one-way flights
Cheap last minute flights
Delta flights from Knoxville to Des Moines
Our best Delta deals on Knoxville to Des Moines flight tickets
American Airlines flights from Knoxville to Des Moines
Our best American Airlines deals on Knoxville to Des Moines flight tickets
See travel insights to Des Moines from
How to get the cheapest flight ticket from Knoxville to Des Moines
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to Des Moines?
If you’re not able to fly to Des Moines in August, then September is your next best option. Flight prices from Knoxville to Des Moines during September average around $268.
What is the cheapest day to depart on your flight to Des Moines?
The cheapest day to depart from Knoxville to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $262. Flights from Knoxville to Des Moines on a Monday will generally be more expensive and average around $581. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.
What is the cheapest airline that flies from Knoxville McGhee Tyson to Des Moines?
Delta and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Des Moines
What airlines fly to Des Moines?
American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Des Moines from Knoxville according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.
When to book flights from Knoxville to Des Moines
Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines
How far is Knoxville McGhee Tyson to Des Moines by plane?
There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 4h 09m.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?
The number of operators available for flights from Knoxville McGhee Tyson Airport to Des Moines Airport is 3 as of June 2025.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Knoxville to Des Moines?
Based on momondo bookings for flights between Knoxville and Des Moines, the leading airline is American Airlines, making up 66% of the total bookings. Other popular airlines include Delta with 22% and United Airlines with 12%.
Best airlines flying from Knoxville to Des Moines
Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $222 | Free Cancellation | Rating 8.0 7,964 reviews | |||
| PriceFrom $248 | Free Cancellation | Rating 7.2 10,000 reviews | |||
| PriceFrom $252 | Free Cancellation | Rating 7.4 8,810 reviews |
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Knoxville to Des Moines?
momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.
Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?
Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.
How can momondo help me find flights from Knoxville to Des Moines?
Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.
I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?
If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.