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Cheap flights from Columbus Airport to Knoxville from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to Knoxville departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Columbus Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
10:31 am - 4:43 pm
CMH
-
TYS
6h 12m
1 stop
Delta Logo
5:10 pm - 10:27 pm
TYS
-
CMH
5h 17m
1 stop
$262Delta
Mon, Mar 23 - Tue, Mar 31
United Airlines Logo
6:10 am - 10:50 am
CMH
-
TYS
4h 40m
1 stop
United Airlines Logo
7:20 pm - 11:40 pm
TYS
-
CMH
4h 20m
1 stop
$263United Airlines
Thu, Apr 9 - Sat, Apr 11
Multiple Airlines Logo
12:25 pm - 9:47 pm
CMH
-
TYS
9h 22m
1 stop
Multiple Airlines Logo
3:29 pm - 11:42 am
TYS
-
CMH
20h 13m
2 stops
$276Multiple Airlines
Mon, Mar 23 - Mon, Mar 30
Multiple Airlines Logo
6:40 pm - 5:30 pm
CMH
-
TYS
22h 50m
1 stop
Multiple Airlines Logo
11:27 am - 11:15 am
TYS
-
CMH
23h 48m
2 stops
$281Multiple Airlines
Sun, Apr 12 - Sun, Apr 19
Southwest Logo
1:15 pm - 7:40 pm
CMH
-
TYS
6h 25m
2 stops
Southwest Logo
6:40 am - 12:00 pm
TYS
-
CMH
5h 20m
1 stop
$289Southwest
Tue, Apr 7 - Sat, Apr 11
United Airlines Logo
10:38 am - 5:04 pm
CMH
-
TYS
6h 26m
1 stop
United Airlines Logo
5:56 pm - 10:15 pm
TYS
-
CMH
4h 19m
1 stop
$290United Airlines
Fri, May 1 - Thu, May 7
Multiple Airlines Logo
4:15 pm - 12:51 pm
CMH
-
TYS
20h 36m
1 stop
Multiple Airlines Logo
9:16 pm - 1:56 pm
TYS
-
CMH
16h 40m
2 stops
$291Multiple Airlines
Tue, Mar 10 - Sat, Mar 14
Delta Logo
10:10 am - 2:33 pm
CMH
-
TYS
4h 23m
1 stop
Delta Logo
5:59 pm - 11:21 pm
TYS
-
CMH
5h 22m
1 stop
$294Delta
Wed, May 20 - Fri, May 22
Southwest Logo
1:15 pm - 8:20 pm
CMH
-
TYS
7h 05m
2 stops
Southwest Logo
6:40 am - 12:00 pm
TYS
-
CMH
5h 20m
1 stop
$296Southwest
Thu, Apr 9 - Sat, Apr 11
Multiple Airlines Logo
12:25 pm - 9:47 pm
CMH
-
TYS
9h 22m
1 stop
Multiple Airlines Logo
3:29 pm - 8:30 am
TYS
-
CMH
17h 01m
1 stop
$299Multiple Airlines
Mon, Mar 23 - Mon, Mar 30

Delta flights from Columbus Airport to Knoxville

Our best Delta deals on Columbus Airport to Knoxville flight tickets
Delta
Mar 23
CMH10:31 amColumbus
6h 12m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
Mar 31
TYS5:10 pmKnoxville McGhee Tyson
5h 17m
1 stop
CMH10:27 pmColumbus
$262
Delta
May 20
CMH10:10 amColumbus
4h 23m
1 stop
TYS2:33 pmKnoxville McGhee Tyson
May 22
TYS5:59 pmKnoxville McGhee Tyson
5h 22m
1 stop
CMH11:21 pmColumbus
$294
Delta
Apr 3
CMH10:31 amColumbus
6h 12m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
Apr 5
TYS5:40 amKnoxville McGhee Tyson
6h 24m
1 stop
CMH12:04 pmColumbus
$406

United Airlines flights from Columbus Airport to Knoxville

Our best United Airlines deals on Columbus Airport to Knoxville flight tickets
United Airlines
Apr 9
CMH6:10 amColumbus
4h 40m
1 stop
TYS10:50 amKnoxville McGhee Tyson
Apr 11
TYS7:20 pmKnoxville McGhee Tyson
4h 20m
1 stop
CMH11:40 pmColumbus
$263
United Airlines
May 1
CMH10:38 amColumbus
6h 26m
1 stop
TYS5:04 pmKnoxville McGhee Tyson
May 7
TYS5:56 pmKnoxville McGhee Tyson
4h 19m
1 stop
CMH10:15 pmColumbus
$290
United Airlines
May 2
CMH10:36 amColumbus
3h 58m
1 stop
TYS2:34 pmKnoxville McGhee Tyson
May 6
TYS7:18 pmKnoxville McGhee Tyson
4h 26m
1 stop
CMH11:44 pmColumbus
$304

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Columbus Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 3/23

10:31 am-4:43 pm

1 stop6h 12m

Knoxville McGhee Tyson

Tue 3/31

5:10 pm-10:27 pm

1 stop5h 17m

$262

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 4/9

6:10 am-10:50 am

1 stop4h 40m

Knoxville McGhee Tyson

Sat 4/11

7:20 pm-11:40 pm

1 stop4h 20m

$263

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 3/23

12:25 pm-9:47 pm

1 stop9h 22m

Knoxville McGhee Tyson

Mon 3/30

3:29 pm-11:42 am

2 stops20h 13m

$276

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sun 4/12

6:40 pm-5:30 pm

1 stop22h 50m

Knoxville McGhee Tyson

Sun 4/19

11:27 am-11:15 am

2 stops23h 48m

$281

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 4/7

1:15 pm-7:40 pm

2 stops6h 25m

Knoxville McGhee Tyson

Sat 4/11

6:40 am-12:00 pm

1 stop5h 20m

$289

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 5/1

10:38 am-5:04 pm

1 stop6h 26m

Knoxville McGhee Tyson

Thu 5/7

5:56 pm-10:15 pm

1 stop4h 19m

$290

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 3/10

4:15 pm-12:51 pm

1 stop20h 36m

Knoxville McGhee Tyson

Sat 3/14

9:16 pm-1:56 pm

2 stops16h 40m

$291

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 5/20

10:10 am-2:33 pm

1 stop4h 23m

Knoxville McGhee Tyson

Fri 5/22

5:59 pm-11:21 pm

1 stop5h 22m

$294

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 4/9

1:15 pm-8:20 pm

2 stops7h 05m

Knoxville McGhee Tyson

Sat 4/11

6:40 am-12:00 pm

1 stop5h 20m

$296

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 3/23

12:25 pm-9:47 pm

1 stop9h 22m

Knoxville McGhee Tyson

Mon 3/30

3:29 pm-8:30 am

1 stop17h 01m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Columbus Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Columbus Airport, with most prices found around $256. If you aren’t able to travel during the month of July, then book flights to Knoxville from Columbus Airport during May instead. Flights to Knoxville in May, while not as cheap as those in July, still average around $268.

When to book flights from Columbus Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbus Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbus Airport to Knoxville (CMH to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to Knoxville

Fastest flight time

3h 53m

Direct flights

None
The fastest flight from Columbus Airport to Knoxville takes 3h 53m
There are no direct flights from Columbus Airport to Knoxville. There are no popular flight routes from Columbus Airport to Knoxville.
Search flight deals

  • How far is Columbus to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 284.5 mi away from Columbus. A reasonable flight in good conditions will take 3h 53m.

  • When did momondo last update prices for flights from Columbus Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbus Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbus Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Columbus Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbus Airport to Knoxville?

Best airlines flying from Columbus Airport to Knoxville

Compare and see reviews for airlines that fly from Columbus Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,352 reviews
Search American Airlines flights
DeltaPriceFrom $218Free CancellationRating
7.9
8,237 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to Knoxville with flexible booking policies on momondo?

Flights from Columbus to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Columbus to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Columbus.

I’m not ready to book a flight from Columbus to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbus to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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