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Cheap flights from Columbus Airport to Knoxville from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to Knoxville departing on 1/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbus Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
4:43 pm - 11:44 pm
CMH
-
TYS
7h 01m1 stop
United Airlines Logo
7:25 pm - 11:44 pm
TYS
-
CMH
4h 19m1 stop
$283United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
10:36 am - 8:37 pm
CMH
-
TYS
10h 01m2 stops
United Airlines Logo
6:45 am - 1:15 pm
TYS
-
CMH
6h 30m1 stop
$288United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
10:36 am - 8:37 pm
CMH
-
TYS
10h 01m2 stops
United Airlines Logo
6:45 am - 1:57 pm
TYS
-
CMH
7h 12m2 stops
$293United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
6:00 am - 10:49 am
CMH
-
TYS
4h 49m1 stop
United Airlines Logo
7:16 pm - 11:47 pm
TYS
-
CMH
4h 31m1 stop
$295United Airlines
Mon, Mar 2 - Mon, Mar 9
Multiple Airlines Logo
5:45 am - 8:39 am
CMH
-
TYS
26h 54m1 stop
Multiple Airlines Logo
4:47 pm - 9:40 am
TYS
-
CMH
16h 53m1 stop
$303Multiple Airlines
Sat, Jan 10 - Wed, Jan 14
United Airlines Logo
6:00 am - 10:57 am
CMH
-
TYS
4h 57m1 stop
United Airlines Logo
7:20 pm - 11:44 pm
TYS
-
CMH
4h 24m1 stop
$310United Airlines
Fri, Jan 16 - Mon, Jan 19
American Airlines Logo
7:43 am - 11:45 am
CMH
-
TYS
4h 02m1 stop
American Airlines Logo
2:19 pm - 8:31 pm
TYS
-
CMH
6h 12m1 stop
$317American Airlines
Fri, Jan 30 - Sun, Feb 1
Southwest Logo
1:45 pm - 8:05 pm
CMH
-
TYS
6h 20m2 stops
Southwest Logo
6:30 am - 12:00 pm
TYS
-
CMH
5h 30m1 stop
$332Southwest
Wed, Mar 18 - Fri, Mar 20
Multiple Airlines Logo
6:06 am - 8:39 am
CMH
-
TYS
26h 33m2 stops
Multiple Airlines Logo
4:47 pm - 9:40 am
TYS
-
CMH
16h 53m1 stop
$337Multiple Airlines
Sat, Jan 10 - Wed, Jan 14
Multiple Airlines Logo
6:06 am - 8:39 am
CMH
-
TYS
26h 33m3 stops
Multiple Airlines Logo
4:47 pm - 11:27 pm
TYS
-
CMH
6h 40m1 stop
$338Multiple Airlines
Sat, Jan 10 - Wed, Jan 14

American Airlines flights from Columbus Airport to Knoxville

Our best American Airlines deals on Columbus Airport to Knoxville flight tickets
American Airlines
Jan 30
CMH7:43 amColumbus
4h 02m
1 stop
TYS11:45 amKnoxville McGhee Tyson
Feb 1
TYS2:19 pmKnoxville McGhee Tyson
6h 12m
1 stop
CMH8:31 pmColumbus
$317
Find similar
American Airlines
Jan 12
CMH7:00 amColumbus
5h 46m
1 stop
TYS12:46 pmKnoxville McGhee Tyson
Jan 19
TYS6:00 amKnoxville McGhee Tyson
5h 49m
1 stop
CMH11:49 amColumbus
$363
Find similar
American Airlines
Jan 3
CMH10:02 amColumbus
5h 54m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
Jan 24
TYS10:11 amKnoxville McGhee Tyson
4h 04m
1 stop
CMH2:15 pmColumbus
$420
Find similar

United Airlines flights from Columbus Airport to Knoxville

Our best United Airlines deals on Columbus Airport to Knoxville flight tickets
United Airlines
Feb 14
CMH4:43 pmColumbus
7h 01m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Feb 18
TYS7:25 pmKnoxville McGhee Tyson
4h 19m
1 stop
CMH11:44 pmColumbus
$283
Find similar
United Airlines
Feb 14
CMH10:36 amColumbus
10h 01m
2 stops
TYS8:37 pmKnoxville McGhee Tyson
Feb 18
TYS6:45 amKnoxville McGhee Tyson
6h 30m
1 stop
CMH1:15 pmColumbus
$288
Find similar
United Airlines
Feb 14
CMH10:36 amColumbus
10h 01m
2 stops
TYS8:37 pmKnoxville McGhee Tyson
Feb 18
TYS6:45 amKnoxville McGhee Tyson
7h 12m
2 stops
CMH1:57 pmColumbus
$293
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Columbus Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 2/14

4:43 pm-11:44 pm

1 stop7h 01m

Knoxville McGhee Tyson

Wed 2/18

7:25 pm-11:44 pm

1 stop4h 19m

$283

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 2/14

10:36 am-8:37 pm

2 stops10h 01m

Knoxville McGhee Tyson

Wed 2/18

6:45 am-1:15 pm

1 stop6h 30m

$288

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 2/14

10:36 am-8:37 pm

2 stops10h 01m

Knoxville McGhee Tyson

Wed 2/18

6:45 am-1:57 pm

2 stops7h 12m

$293

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 3/2

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Mon 3/9

7:16 pm-11:47 pm

1 stop4h 31m

$295

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 1/10

5:45 am-8:39 am

1 stop26h 54m

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-9:40 am

1 stop16h 53m

$303

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 1/16

6:00 am-10:57 am

1 stop4h 57m

Knoxville McGhee Tyson

Mon 1/19

7:20 pm-11:44 pm

1 stop4h 24m

$310

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 1/30

7:43 am-11:45 am

1 stop4h 02m

Knoxville McGhee Tyson

Sun 2/1

2:19 pm-8:31 pm

1 stop6h 12m

$317

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 3/18

1:45 pm-8:05 pm

2 stops6h 20m

Knoxville McGhee Tyson

Fri 3/20

6:30 am-12:00 pm

1 stop5h 30m

$332

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 1/10

6:06 am-8:39 am

2 stops26h 33m

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-9:40 am

1 stop16h 53m

$337

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 1/10

6:06 am-8:39 am

3 stops26h 33m

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-11:27 pm

1 stop6h 40m

$338

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Columbus Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Columbus Airport, with most prices found around $235. If you aren’t able to travel during the month of January, then book flights to Knoxville from Columbus Airport during July instead. Flights to Knoxville in July, while not as cheap as those in January, still average around $256.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Columbus Airport to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $253. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Columbus Airport to Knoxville for around $450.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Columbus Airport to Knoxville when you can find flight prices for as low as $258. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $386.

What is the cheapest Columbus to Knoxville McGhee Tyson flight route?

Fly from Columbus to Knoxville McGhee Tyson for the best Columbus - Knoxville McGhee Tyson flight prices

What cabin class options are available on Columbus to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Columbus to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

When to book flights from Columbus Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Columbus Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbus Airport to Knoxville (CMH to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to Knoxville

Fastest flight time

3h 56m

Direct flights

None
The fastest flight from Columbus Airport to Knoxville takes 3h 56m
There are no direct flights from Columbus Airport to Knoxville. There are no popular flight routes from Columbus Airport to Knoxville.
Search flight deals

  • How far is Columbus to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 284.5 mi away from Columbus. A reasonable flight in good conditions will take 3h 56m.

  • When did momondo last update prices for flights from Columbus Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Columbus Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbus Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Columbus Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbus Airport to Knoxville?

Best airlines flying from Columbus Airport to Knoxville

Compare and see reviews for airlines that fly from Columbus Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,061 reviews
Search American Airlines flights
DeltaPriceFrom $218Free CancellationRating
7.9
8,013 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to Knoxville with flexible booking policies on momondo?

Flights from Columbus to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Columbus to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Columbus.

I’m not ready to book a flight from Columbus to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Columbus to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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