Cheap flights from Iowa to St. Louis from $135

In general, November is the cheapest month to fly from Iowa to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of July is another great option to travel to St. Louis, with average flight prices from Iowa averaging around $0.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $364. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $420. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Iowa in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $365 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $408 per ticket.

Fly from Des Moines to Lambert-St Louis for the best Iowa - Lambert-St Louis flight prices

There is only 1 cabin class available to choose from on Iowa to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Iowa to St. Louis.

Frontier, Southwest, and United Airlines are the most popular carriers operating from Iowa to Lambert-St Louis

Southwest, United Airlines and American Airlines are the top three most popular airlines that fly to St. Louis from Iowa according to our data. Southwest is the first choice among our users, with 48% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 3 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

As of September 2026, 6 flights take off from Iowa and land in St. Louis each week. The most common flight departure day for this route is Tue, with 33% of weekly flights taking off on this day.

Flight times from Iowa to St. Louis vary, but if you’re flying out of Des Moines and flying into St. Louis (one of the most popular routes), then the duration is 3h 15m on average. Another popular route from Iowa to St. Louis is flying from Waterloo to St. Louis, which will take roughly 32h 16m. Keep in mind that layovers or delays could extend your travel time.