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Cheap flights from Iowa to St. Louis from $66

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to St. Louis departing on 3/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Iowa to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:44 pm - 11:44 pm
DSM
-
STL
4h 00m
1 stop
American Airlines Logo
6:50 pm - 11:42 pm
STL
-
DSM
4h 52m
1 stop
$181American Airlines
Mon, Mar 9 - Wed, Mar 11
Southwest Logo
4:20 pm - 12:05 am
DSM
-
STL
7h 45m
2 stops
Southwest Logo
2:15 pm - 8:50 pm
STL
-
DSM
6h 35m
1 stop
$196Southwest
Mon, Mar 9 - Wed, Mar 11
Delta Logo
5:20 pm - 11:58 pm
DSM
-
STL
6h 38m
1 stop
Delta Logo
6:00 am - 10:48 am
STL
-
DSM
4h 48m
1 stop
$197Delta
Mon, Mar 9 - Wed, Mar 11
Southwest Logo
4:20 pm - 12:05 am
DSM
-
STL
7h 45m
2 stops
Southwest Logo
3:10 pm - 10:05 pm
STL
-
DSM
6h 55m
2 stops
$201Southwest
Mon, Mar 9 - Wed, Mar 11
American Airlines Logo
5:40 am - 10:03 am
OMA
-
STL
4h 23m
1 stop
American Airlines Logo
6:57 pm - 12:15 am
STL
-
OMA
5h 18m
1 stop
$201American Airlines
Sun, Mar 1 - Fri, Mar 6
American Airlines Logo
7:44 pm - 11:48 pm
DSM
-
STL
4h 04m
1 stop
American Airlines Logo
5:12 am - 10:34 am
STL
-
DSM
5h 22m
1 stop
$205American Airlines
Thu, Feb 19 - Mon, Feb 23
Delta Logo
6:55 am - 11:48 am
DSM
-
STL
4h 53m
1 stop
Delta Logo
5:29 pm - 9:10 pm
STL
-
DSM
3h 41m
1 stop
$237Delta
Sat, Mar 21 - Sat, Mar 28
Frontier Logo
5:00 pm - 9:26 pm
OMA
-
STL
28h 26m
2 stops
Frontier Logo
8:12 pm - 8:08 pm
STL
-
OMA
23h 56m
1 stop
$255Frontier
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
6:21 pm - 10:27 pm
OMA
-
STL
28h 06m
1 stop
Multiple Airlines Logo
4:51 pm - 9:30 am
STL
-
OMA
16h 39m
1 stop
$316Multiple Airlines
Mon, Feb 23 - Wed, Feb 25
Frontier Logo
9:03 pm - 9:49 am
OMA
-
STL
12h 46m
1 stop
Frontier Logo
10:47 pm - 8:18 pm
STL
-
OMA
21h 31m
2 stops
$332Frontier
Sun, Mar 8 - Sun, Mar 15

American Airlines flights from Iowa to St. Louis

Our best American Airlines deals on Iowa to St. Louis flight tickets
American Airlines
Mar 9
DSM7:44 pmDes Moines
4h 00m
1 stop
STL11:44 pmLambert-St Louis
Mar 11
STL6:50 pmLambert-St Louis
4h 52m
1 stop
DSM11:42 pmDes Moines
$181
American Airlines
Feb 19
DSM7:44 pmDes Moines
4h 04m
1 stop
STL11:48 pmLambert-St Louis
Feb 23
STL5:12 amLambert-St Louis
5h 22m
1 stop
DSM10:34 amDes Moines
$205
American Airlines
Apr 10
DSM12:00 pmDes Moines
4h 41m
1 stop
STL4:41 pmLambert-St Louis
Apr 13
STL5:46 amLambert-St Louis
4h 43m
1 stop
DSM10:29 amDes Moines
$243

Southwest flights from Iowa to St. Louis

Our best Southwest deals on Iowa to St. Louis flight tickets
Southwest
Mar 9
DSM4:20 pmDes Moines
7h 45m
2 stops
STL12:05 amLambert-St Louis
Mar 11
STL2:15 pmLambert-St Louis
6h 35m
1 stop
DSM8:50 pmDes Moines
$196
Southwest
Mar 9
DSM4:20 pmDes Moines
7h 45m
2 stops
STL12:05 amLambert-St Louis
Mar 11
STL3:10 pmLambert-St Louis
6h 55m
2 stops
DSM10:05 pmDes Moines
$201
Southwest
Apr 3
DSM5:35 amDes Moines
3h 25m
1 stop
STL9:00 amLambert-St Louis
Apr 6
STL2:30 pmLambert-St Louis
7h 50m
1 stop
DSM10:20 pmDes Moines
$239

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Iowa to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 3/9

7:44 pm-11:44 pm

1 stop4h 00m

Lambert-St Louis

Wed 3/11

6:50 pm-11:42 pm

1 stop4h 52m

$181

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 3/9

4:20 pm-12:05 am

2 stops7h 45m

Lambert-St Louis

Wed 3/11

2:15 pm-8:50 pm

1 stop6h 35m

$196

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 3/9

5:20 pm-11:58 pm

1 stop6h 38m

Lambert-St Louis

Wed 3/11

6:00 am-10:48 am

1 stop4h 48m

$197

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 3/9

4:20 pm-12:05 am

2 stops7h 45m

Lambert-St Louis

Wed 3/11

3:10 pm-10:05 pm

2 stops6h 55m

$201

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Sun 3/1

5:40 am-10:03 am

1 stop4h 23m

Lambert-St Louis

Fri 3/6

6:57 pm-12:15 am

1 stop5h 18m

$201

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/19

7:44 pm-11:48 pm

1 stop4h 04m

Lambert-St Louis

Mon 2/23

5:12 am-10:34 am

1 stop5h 22m

$205

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 3/21

6:55 am-11:48 am

1 stop4h 53m

Lambert-St Louis

Sat 3/28

5:29 pm-9:10 pm

1 stop3h 41m

$237

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Wed 3/4

5:00 pm-9:26 pm

2 stops28h 26m

Lambert-St Louis

Wed 3/11

8:12 pm-8:08 pm

1 stop23h 56m

$255

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Mon 2/23

6:21 pm-10:27 pm

1 stop28h 06m

Lambert-St Louis

Wed 2/25

4:51 pm-9:30 am

1 stop16h 39m

$316

OmahaSt. Louis

OMA - STL

OMASTL

Omaha Eppley Airfield

Sun 3/8

9:03 pm-9:49 am

1 stop12h 46m

Lambert-St Louis

Sun 3/15

10:47 pm-8:18 pm

2 stops21h 31m

$332

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Iowa to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $357. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $418. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Iowa in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $383 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $399 per ticket.

What is the cheapest Iowa to Lambert-St Louis flight route?

Fly from Burlington to Lambert-St Louis for the best Iowa - Lambert-St Louis flight prices

What cabin class options are available on Iowa to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Iowa to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Iowa to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Iowa to St. Louis.

Cheap Iowa to St. Louis flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to St. Louis

Best Price Found

$218

Fastest flight time

1h 05m

Direct flights

Mon, Wed, Thu, Fri, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Iowa in the past 72 hours is $218. The best round-trip flight deal from Iowa to St. Louis found on momondo in the last 72 hours is $105.
The fastest flight from Iowa to St. Louis takes 1h 05m
Direct flights go from Iowa to St. Louis on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in St. Louis. From Iowa there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • When did momondo last update prices for flights from Iowa to Lambert-St Louis Airport?

    Prices for flights from Iowa to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Iowa to Lambert-St Louis Airport?

  • How old do you have to be to fly from Iowa to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Iowa to St. Louis?

Best airlines flying from Iowa to St. Louis

Compare and see reviews for airlines that fly from Iowa to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,280 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Collinsville
St. Peters
Fenton
Wentzville
Alton
Farmington
Clayton
Edwardsville
Eureka
Festus
Litchfield
Glencoe
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to St. Louis?

Finding the right flight to St. Louis from Iowa is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to St. Louis quick and easy, saving you time and money.

Can I find flights from Iowa to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Iowa on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Iowa to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Iowa.

I’m not ready to book a flight from Iowa to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Iowa. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your St. Louis trip

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