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Cheap flights from Iowa to Roanoke from $222

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Roanoke departing on 3/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Iowa to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:02 pm - 10:26 pm
DSM
-
ROA
7h 24m
1 stop
American Airlines Logo
7:28 am - 11:30 am
ROA
-
DSM
5h 02m
1 stop
$268American Airlines
Wed, Apr 8 - Wed, Apr 15
Delta Logo
6:41 pm - 12:34 am
DSM
-
ROA
4h 53m
1 stop
Delta Logo
6:00 am - 11:03 am
ROA
-
DSM
6h 03m
1 stop
$269Delta
Sat, May 16 - Sat, May 23
American Airlines Logo
6:28 pm - 11:59 pm
CID
-
ROA
4h 31m
1 stop
American Airlines Logo
8:00 pm - 12:13 am
ROA
-
CID
5h 13m
1 stop
$269American Airlines
Mon, Mar 23 - Mon, Mar 30
American Airlines Logo
8:56 am - 5:33 pm
DSM
-
ROA
7h 37m
2 stops
American Airlines Logo
7:28 am - 1:46 pm
ROA
-
DSM
7h 18m
1 stop
$273American Airlines
Wed, Apr 8 - Wed, Apr 15
United Airlines Logo
2:04 pm - 8:40 pm
DSM
-
ROA
5h 36m
1 stop
United Airlines Logo
6:40 am - 1:23 pm
ROA
-
DSM
7h 43m
1 stop
$279United Airlines
Tue, Mar 10 - Sat, Mar 14
United Airlines Logo
8:00 am - 7:02 pm
DSM
-
ROA
10h 02m
2 stops
United Airlines Logo
6:40 am - 1:23 pm
ROA
-
DSM
7h 43m
1 stop
$284United Airlines
Tue, Mar 10 - Sat, Mar 14
American Airlines Logo
5:01 pm - 12:14 am
DSM
-
ROA
6h 13m
1 stop
American Airlines Logo
7:58 pm - 11:59 pm
ROA
-
DSM
5h 01m
1 stop
$289American Airlines
Sat, May 16 - Sat, May 23
Delta Logo
11:00 am - 4:17 pm
MLI
-
ROA
4h 17m
1 stop
Delta Logo
6:00 am - 10:20 am
ROA
-
MLI
5h 20m
1 stop
$304Delta
Sat, May 23 - Fri, May 29
American Airlines Logo
6:47 pm - 12:16 am
MLI
-
ROA
4h 29m
1 stop
American Airlines Logo
6:00 am - 10:56 am
ROA
-
MLI
5h 56m
1 stop
$338American Airlines
Sat, May 23 - Fri, May 29
United Airlines Logo
6:34 pm - 12:24 am
MLI
-
ROA
4h 50m
1 stop
United Airlines Logo
6:40 am - 9:59 am
ROA
-
MLI
4h 19m
1 stop
$339United Airlines
Sat, May 23 - Fri, May 29

United Airlines flights from Iowa to Roanoke

Our best United Airlines deals on Iowa to Roanoke flight tickets
United Airlines
Mar 10
DSM2:04 pmDes Moines
5h 36m
1 stop
ROA8:40 pmRoanoke
Mar 14
ROA6:40 amRoanoke
7h 43m
1 stop
DSM1:23 pmDes Moines
$279
United Airlines
Mar 10
DSM8:00 amDes Moines
10h 02m
2 stops
ROA7:02 pmRoanoke
Mar 14
ROA6:40 amRoanoke
7h 43m
1 stop
DSM1:23 pmDes Moines
$284
United Airlines
May 23
MLI6:34 pmMoline Quad-City
4h 50m
1 stop
ROA12:24 amRoanoke
May 29
ROA6:40 amRoanoke
4h 19m
1 stop
MLI9:59 amMoline Quad-City
$339

American Airlines flights from Iowa to Roanoke

Our best American Airlines deals on Iowa to Roanoke flight tickets
American Airlines
Apr 8
DSM2:02 pmDes Moines
7h 24m
1 stop
ROA10:26 pmRoanoke
Apr 15
ROA7:28 amRoanoke
5h 02m
1 stop
DSM11:30 amDes Moines
$268
American Airlines
Mar 23
CID6:28 pmCedar Rapids
4h 31m
1 stop
ROA11:59 pmRoanoke
Mar 30
ROA8:00 pmRoanoke
5h 13m
1 stop
CID12:13 amCedar Rapids
$269
American Airlines
Apr 8
DSM8:56 amDes Moines
7h 37m
2 stops
ROA5:33 pmRoanoke
Apr 15
ROA7:28 amRoanoke
7h 18m
1 stop
DSM1:46 pmDes Moines
$273

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 24, 2026.
Use the filters below to find and compare flights from Iowa to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 4/8

2:02 pm-10:26 pm

1 stop7h 24m

Roanoke

Wed 4/15

7:28 am-11:30 am

1 stop5h 02m

$268

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

6:41 pm-12:34 am

1 stop4h 53m

Roanoke

Sat 5/23

6:00 am-11:03 am

1 stop6h 03m

$269

Cedar RapidsRoanoke

CID - ROA

CIDROA

Cedar Rapids

Mon 3/23

6:28 pm-11:59 pm

1 stop4h 31m

Roanoke

Mon 3/30

8:00 pm-12:13 am

1 stop5h 13m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 4/8

8:56 am-5:33 pm

2 stops7h 37m

Roanoke

Wed 4/15

7:28 am-1:46 pm

1 stop7h 18m

$273

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 3/10

2:04 pm-8:40 pm

1 stop5h 36m

Roanoke

Sat 3/14

6:40 am-1:23 pm

1 stop7h 43m

$279

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 3/10

8:00 am-7:02 pm

2 stops10h 02m

Roanoke

Sat 3/14

6:40 am-1:23 pm

1 stop7h 43m

$284

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

5:01 pm-12:14 am

1 stop6h 13m

Roanoke

Sat 5/23

7:58 pm-11:59 pm

1 stop5h 01m

$289

MolineRoanoke

MLI - ROA

MLIROA

Moline Quad-City

Sat 5/23

11:00 am-4:17 pm

1 stop4h 17m

Roanoke

Fri 5/29

6:00 am-10:20 am

1 stop5h 20m

$304

MolineRoanoke

MLI - ROA

MLIROA

Moline Quad-City

Sat 5/23

6:47 pm-12:16 am

1 stop4h 29m

Roanoke

Fri 5/29

6:00 am-10:56 am

1 stop5h 56m

$338

MolineRoanoke

MLI - ROA

MLIROA

Moline Quad-City

Sat 5/23

6:34 pm-12:24 am

1 stop4h 50m

Roanoke

Fri 5/29

6:40 am-9:59 am

1 stop4h 19m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from Iowa to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Iowa to Roanoke?

American Airlines and United Airlines are the most popular carriers operating from Iowa to Roanoke

What airlines fly to Roanoke?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Roanoke from Iowa according to our data. American Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Roanoke. Keep in mind that there are 3 different airlines that fly to Roanoke on a routine basis, so you have a few additional options to choose from.

Cheap Iowa to Roanoke flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Roanoke

Fastest flight time

4h 25m

Direct flights

None
The fastest flight from Iowa to Roanoke takes 4h 25m
There are no direct flights from Iowa to Roanoke. There are no popular flight routes from Iowa to Roanoke.
Search flight deals

  • When did momondo last update prices for flights from Iowa to Roanoke Airport?

    Prices for flights from Iowa to Roanoke Airport were last updated today.

  • How many operators does momondo search for flights from Iowa to Roanoke Airport?

  • How old do you have to be to fly from Iowa to Roanoke Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Iowa to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The required travel and health documents for your Roanoke Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Roanoke Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Iowa to Roanoke

Compare and see reviews for airlines that fly from Iowa to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $235Free CancellationRating
7.1
11,345 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,237 reviews
Search Delta flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Salem
Christiansburg
Radford
Rocky Mount

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Roanoke?

It is quick and easy to find Iowa to Roanoke flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Roanoke that suits you.

Can I find flights from Iowa to Roanoke with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to Roanoke flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to Roanoke?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Iowa to Roanoke.

I’m not ready to book a flight from Iowa to Roanoke right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Roanoke now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Roanoke and let you know when they change.

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