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Cheap flights from Iowa to Charleston from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Charleston departing on 8/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Iowa to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:59 pm - 12:31 pm
DSM
-
CHS
18h 32m
1 stop
Multiple Airlines Logo
3:59 pm - 10:08 pm
CHS
-
DSM
7h 09m
1 stop
$248Multiple Airlines
Mon, Sep 14 - Fri, Sep 18
American Airlines Logo
4:57 pm - 11:59 pm
MLI
-
CHS
6h 02m
1 stop
American Airlines Logo
4:52 pm - 10:01 pm
CHS
-
MLI
6h 09m
1 stop
$271American Airlines
Sat, Oct 24 - Sat, Oct 31
United Airlines Logo
6:32 am - 2:04 pm
MLI
-
CHS
6h 32m
1 stop
United Airlines Logo
8:00 am - 12:37 pm
CHS
-
MLI
5h 37m
1 stop
$271United Airlines
Sat, Oct 10 - Sat, Oct 17
United Airlines Logo
2:05 pm - 7:40 pm
MLI
-
CHS
4h 35m
1 stop
United Airlines Logo
8:55 am - 12:32 pm
CHS
-
MLI
4h 37m
1 stop
$271United Airlines
Tue, Sep 15 - Sat, Sep 19
Delta Logo
11:00 am - 6:54 pm
MLI
-
CHS
6h 54m
1 stop
Delta Logo
12:15 pm - 4:22 pm
CHS
-
MLI
5h 07m
1 stop
$271Delta
Tue, Jan 5 - Sat, Jan 9
Delta Logo
5:55 am - 1:47 pm
MLI
-
CHS
6h 52m
1 stop
Delta Logo
10:30 am - 4:22 pm
CHS
-
MLI
6h 52m
1 stop
$271Delta
Wed, Jan 6 - Wed, Jan 13
American Airlines Logo
5:03 pm - 11:59 pm
MLI
-
CHS
5h 56m
1 stop
American Airlines Logo
7:16 am - 10:51 am
CHS
-
MLI
4h 35m
1 stop
$271American Airlines
Wed, Oct 28 - Sat, Oct 31
Multiple Airlines Logo
5:44 pm - 12:31 pm
OMA
-
CHS
17h 47m
1 stop
Multiple Airlines Logo
10:05 pm - 10:30 am
CHS
-
OMA
13h 25m
1 stop
$274Multiple Airlines
Mon, Nov 2 - Thu, Nov 5
Southwest Logo
8:40 am - 7:25 pm
OMA
-
CHS
9h 45m
2 stops
Southwest Logo
8:10 am - 4:05 pm
CHS
-
OMA
8h 55m
2 stops
$349Southwest
Sat, Sep 19 - Wed, Sep 23
Southwest Logo
1:30 pm - 8:55 pm
OMA
-
CHS
6h 25m
2 stops
Southwest Logo
4:00 pm - 11:40 pm
CHS
-
OMA
8h 40m
2 stops
$349Southwest
Mon, Nov 2 - Thu, Nov 5

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Southwest flights from Iowa to Charleston

Our best Southwest deals on Iowa to Charleston flight tickets
Southwest
Oct 28
DSM5:35 amDes Moines
7h 00m
2 stops
CHS1:35 pmCharleston
Nov 2
CHS4:00 pmCharleston
8h 00m
2 stops
DSM11:00 pmDes Moines
$335
Southwest
Sep 19
OMA8:40 amOmaha Eppley Airfield
9h 45m
2 stops
CHS7:25 pmCharleston
Sep 23
CHS8:10 amCharleston
8h 55m
2 stops
OMA4:05 pmOmaha Eppley Airfield
$349
Southwest
Sep 5
OMA12:50 pmOmaha Eppley Airfield
5h 05m
1 stop
CHS6:55 pmCharleston
Sep 10
CHS8:40 amCharleston
8h 30m
2 stops
OMA4:10 pmOmaha Eppley Airfield
$367

American Airlines flights from Iowa to Charleston

Our best American Airlines deals on Iowa to Charleston flight tickets
American Airlines
Oct 28
MLI6:00 amMoline Quad-City
8h 40m
2 stops
CHS3:40 pmCharleston
Oct 31
CHS7:16 amCharleston
4h 35m
1 stop
MLI10:51 amMoline Quad-City
$276
American Airlines
Sep 29
LSE12:26 pmLa Crosse
5h 45m
1 stop
CHS7:11 pmCharleston
Oct 3
CHS7:18 amCharleston
5h 04m
1 stop
LSE11:22 amLa Crosse
$280
American Airlines
Oct 28
MLI11:21 amMoline Quad-City
6h 42m
2 stops
CHS7:03 pmCharleston
Oct 31
CHS6:45 amCharleston
10h 42m
2 stops
MLI4:27 pmMoline Quad-City
$281

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 3, 2026.
Use the filters below to find and compare flights from Iowa to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 9/14

4:59 pm-12:31 pm

1 stop18h 32m

Charleston

Fri 9/18

3:59 pm-10:08 pm

1 stop7h 09m

$248

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Sat 10/24

4:57 pm-11:59 pm

1 stop6h 02m

Charleston

Sat 10/31

4:52 pm-10:01 pm

1 stop6h 09m

$271

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Sat 10/10

6:32 am-2:04 pm

1 stop6h 32m

Charleston

Sat 10/17

8:00 am-12:37 pm

1 stop5h 37m

$271
Quickest round-trip

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Tue 9/15

2:05 pm-7:40 pm

1 stop4h 35m

Charleston

Sat 9/19

8:55 am-12:32 pm

1 stop4h 37m

$271

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Tue 1/5

11:00 am-6:54 pm

1 stop6h 54m

Charleston

Sat 1/9

12:15 pm-4:22 pm

1 stop5h 07m

$271

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Wed 1/6

5:55 am-1:47 pm

1 stop6h 52m

Charleston

Wed 1/13

10:30 am-4:22 pm

1 stop6h 52m

$271

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Wed 10/28

5:03 pm-11:59 pm

1 stop5h 56m

Charleston

Sat 10/31

7:16 am-10:51 am

1 stop4h 35m

$271

OmahaCharleston

OMA - CHS

OMACHS

Omaha Eppley Airfield

Mon 11/2

5:44 pm-12:31 pm

1 stop17h 47m

Charleston

Thu 11/5

10:05 pm-10:30 am

1 stop13h 25m

$274

OmahaCharleston

OMA - CHS

OMACHS

Omaha Eppley Airfield

Sat 9/19

8:40 am-7:25 pm

2 stops9h 45m

Charleston

Wed 9/23

8:10 am-4:05 pm

2 stops8h 55m

$349

OmahaCharleston

OMA - CHS

OMACHS

Omaha Eppley Airfield

Mon 11/2

1:30 pm-8:55 pm

2 stops6h 25m

Charleston

Thu 11/5

4:00 pm-11:40 pm

2 stops8h 40m

$349

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Iowa to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Iowa is in January. Flight prices, which tend to average around $312, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Charleston, with average flight prices from Iowa averaging around $313.

Can stopping save me money on Iowa to Charleston flights?

You could potentially save up to 30% on your flight if you consider stops on a Iowa to Charleston flight.

Cheap Iowa to Charleston flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Charleston

Fastest flight time

4h 35m

Direct flights

None
The fastest flight from Iowa to Charleston takes 4h 35m
There are no direct flights from Iowa to Charleston. There are no popular flight routes from Iowa to Charleston.
Search flight deals

Frequently asked questions about flying from Iowa to Charleston

  • When did momondo last update prices for flights from Iowa to Charleston Airport?

    Prices for flights from Iowa to Charleston Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Iowa to Charleston Airport?

  • How old do you have to be to fly from Iowa to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Iowa to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The necessary travel and health documents for your Charleston Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Charleston

Compare and see reviews for airlines that fly from Iowa to Charleston with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
10,058 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,842 reviews
Search American Airlines flights
DeltaPriceFrom $269Free CancellationRating
7.8
8,483 reviews
Search Delta flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
North Charleston
Summerville
Isle of Palms
Mount Pleasant
Kiawah Island
Walterboro
Santee
Goose Creek
Edisto Island
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Charleston?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Iowa to Charleston. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Iowa to Charleston with flexible booking policies on momondo?

All flight searches from Iowa to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Charleston?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Charleston from Iowa.

I’m not ready to book a flight from Iowa to Charleston right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Charleston now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Charleston and let you know when they change.

An easier way to manage your Charleston trip

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