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Cheap flights from Indianapolis to Knoxville from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Indianapolis to Knoxville departing on 4/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Indianapolis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:54 pm - 7:29 pm
IND
-
TYS
4h 35m
1 stop
American Airlines Logo
5:06 pm - 9:24 pm
TYS
-
IND
4h 18m
1 stop
$221American Airlines
Tue, Apr 14 - Tue, Apr 21
Multiple Airlines Logo
5:43 pm - 2:58 pm
IND
-
TYS
21h 15m
1 stop
Multiple Airlines Logo
9:25 pm - 10:32 am
TYS
-
IND
13h 07m
2 stops
$245Multiple Airlines
Mon, Apr 27 - Thu, Apr 30
Southwest Logo
6:10 am - 2:20 pm
IND
-
TYS
8h 10m
2 stops
Southwest Logo
5:50 pm - 9:05 pm
TYS
-
IND
3h 15m
1 stop
$252Southwest
Tue, Apr 14 - Tue, Apr 21
Multiple Airlines Logo
5:43 pm - 2:58 pm
IND
-
TYS
21h 15m
1 stop
Multiple Airlines Logo
3:40 pm - 11:59 pm
TYS
-
IND
8h 19m
1 stop
$255Multiple Airlines
Mon, Apr 27 - Thu, Apr 30
Southwest Logo
6:10 am - 2:20 pm
IND
-
TYS
8h 10m
2 stops
Southwest Logo
8:15 am - 10:50 pm
TYS
-
IND
14h 35m
2 stops
$268Southwest
Tue, Apr 14 - Tue, Apr 21
Multiple Airlines Logo
5:30 pm - 4:04 pm
IND
-
TYS
22h 34m
1 stop
Multiple Airlines Logo
9:36 pm - 11:23 am
TYS
-
IND
13h 47m
2 stops
$277Multiple Airlines
Mon, Apr 6 - Thu, Apr 9
Multiple Airlines Logo
9:00 am - 1:16 pm
IND
-
TYS
28h 16m
1 stop
Multiple Airlines Logo
1:15 pm - 4:13 pm
TYS
-
IND
26h 58m
1 stop
$279Multiple Airlines
Thu, Apr 9 - Mon, Apr 13
American Airlines Logo
8:08 pm - 11:55 pm
IND
-
TYS
3h 47m
1 stop
American Airlines Logo
7:53 am - 3:18 pm
TYS
-
IND
7h 25m
1 stop
$286American Airlines
Mon, May 4 - Fri, May 8
Multiple Airlines Logo
8:23 am - 5:30 pm
IND
-
TYS
9h 07m
1 stop
Multiple Airlines Logo
1:15 pm - 11:11 am
TYS
-
IND
21h 56m
1 stop
$289Multiple Airlines
Fri, Apr 17 - Mon, Apr 20
Multiple Airlines Logo
6:00 am - 3:05 pm
IND
-
TYS
9h 05m
1 stop
Multiple Airlines Logo
12:55 pm - 12:51 pm
TYS
-
IND
23h 56m
1 stop
$291Multiple Airlines
Thu, May 14 - Sun, May 17

Southwest flights from Indianapolis to Knoxville

Our best Southwest deals on Indianapolis to Knoxville flight tickets
Southwest
Apr 14
IND6:10 amIndianapolis
8h 10m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
Apr 21
TYS5:50 pmKnoxville McGhee Tyson
3h 15m
1 stop
IND9:05 pmIndianapolis
$252
Southwest
Apr 14
IND6:10 amIndianapolis
8h 10m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
Apr 21
TYS8:15 amKnoxville McGhee Tyson
14h 35m
2 stops
IND10:50 pmIndianapolis
$268
Southwest
Apr 27
IND12:30 pmIndianapolis
7h 50m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
Apr 30
TYS8:05 amKnoxville McGhee Tyson
7h 55m
2 stops
IND4:00 pmIndianapolis
$332

American Airlines flights from Indianapolis to Knoxville

Our best American Airlines deals on Indianapolis to Knoxville flight tickets
American Airlines
Apr 14
IND2:54 pmIndianapolis
4h 35m
1 stop
TYS7:29 pmKnoxville McGhee Tyson
Apr 21
TYS5:06 pmKnoxville McGhee Tyson
4h 18m
1 stop
IND9:24 pmIndianapolis
$221
American Airlines
May 4
IND8:08 pmIndianapolis
3h 47m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
May 8
TYS7:53 amKnoxville McGhee Tyson
7h 25m
1 stop
IND3:18 pmIndianapolis
$286
American Airlines
May 4
IND3:48 pmIndianapolis
5h 33m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
May 8
TYS7:53 amKnoxville McGhee Tyson
7h 25m
1 stop
IND3:18 pmIndianapolis
$337

momondo Fare Finder

 
Customize your flight search to find flights from Indianapolis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Indianapolis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Tue 4/14

2:54 pm-7:29 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 4/21

5:06 pm-9:24 pm

1 stop4h 18m

$221

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Mon 4/27

5:43 pm-2:58 pm

1 stop21h 15m

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-10:32 am

2 stops13h 07m

$245

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Tue 4/14

6:10 am-2:20 pm

2 stops8h 10m

Knoxville McGhee Tyson

Tue 4/21

5:50 pm-9:05 pm

1 stop3h 15m

$252

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Mon 4/27

5:43 pm-2:58 pm

1 stop21h 15m

Knoxville McGhee Tyson

Thu 4/30

3:40 pm-11:59 pm

1 stop8h 19m

$255

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Tue 4/14

6:10 am-2:20 pm

2 stops8h 10m

Knoxville McGhee Tyson

Tue 4/21

8:15 am-10:50 pm

2 stops14h 35m

$268

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Mon 4/6

5:30 pm-4:04 pm

1 stop22h 34m

Knoxville McGhee Tyson

Thu 4/9

9:36 pm-11:23 am

2 stops13h 47m

$277

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Thu 4/9

9:00 am-1:16 pm

1 stop28h 16m

Knoxville McGhee Tyson

Mon 4/13

1:15 pm-4:13 pm

1 stop26h 58m

$279

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Mon 5/4

8:08 pm-11:55 pm

1 stop3h 47m

Knoxville McGhee Tyson

Fri 5/8

7:53 am-3:18 pm

1 stop7h 25m

$286

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Fri 4/17

8:23 am-5:30 pm

1 stop9h 07m

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-11:11 am

1 stop21h 56m

$289

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Thu 5/14

6:00 am-3:05 pm

1 stop9h 05m

Knoxville McGhee Tyson

Sun 5/17

12:55 pm-12:51 pm

1 stop23h 56m

$291

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Indianapolis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Indianapolis and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Indianapolis, with most prices found around $238. If you aren’t able to travel during the month of July, then book flights to Knoxville from Indianapolis during November instead. Flights to Knoxville in November, while not as cheap as those in July, still average around $250.

When to book flights from Indianapolis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Indianapolis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Indianapolis to Knoxville (IND to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to Knoxville

Fastest flight time

3h 36m

Direct flights

None
The fastest flight from Indianapolis to Knoxville takes 3h 36m
There are no direct flights from Indianapolis to Knoxville. There are no popular flight routes from Indianapolis to Knoxville.
Search flight deals

  • How far is Indianapolis to Knoxville McGhee Tyson by plane?

    The straight-line distance from Indianapolis to Knoxville McGhee Tyson is 289.8 mi. A reasonable flight in good conditions will take 3h 36m.

  • When did momondo last update prices for flights from Indianapolis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Indianapolis Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Indianapolis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Indianapolis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Indianapolis to Knoxville?

Best airlines flying from Indianapolis to Knoxville

Compare and see reviews for airlines that fly from Indianapolis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $208Free CancellationRating
7.1
11,495 reviews
Search American Airlines flights
DeltaPriceFrom $217Free CancellationRating
7.9
8,331 reviews
Search Delta flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,483 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Indianapolis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Indianapolis to Knoxville?

momondo helps you find the best flight between Indianapolis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Indianapolis to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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