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Cheap flights from Indianapolis to Knoxville from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Indianapolis to Knoxville departing on 10/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Indianapolis to Knoxville

Cheap round-trip flights

Delta Logo
6:05 am - 10:17 amIND-TYS
4h 12m1 stop
Delta Logo
5:30 am - 9:00 amTYS-IND
3h 30m1 stop
$238Delta
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Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
1:03 pm - 8:43 pmIND-TYS
7h 40m1 stop
American Airlines Logo
6:50 pm - 10:26 pmTYS-IND
3h 36m1 stop
$239American Airlines
Find Deal
Wed, Feb 11 - Sun, Feb 15
Delta Logo
6:05 am - 10:17 amIND-TYS
4h 12m1 stop
Delta Logo
7:30 am - 11:15 amTYS-IND
3h 45m1 stop
$249Delta
Find Deal
Sat, Feb 21 - Wed, Feb 25
Delta Logo
6:51 pm - 11:44 pmIND-TYS
4h 53m1 stop
Delta Logo
5:45 am - 8:57 amTYS-IND
3h 12m1 stop
$254Delta
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Fri, Sep 26 - Sun, Sep 28
Multiple Airlines Logo
6:20 pm - 10:33 amIND-TYS
16h 13m1 stop
Multiple Airlines Logo
6:15 pm - 7:52 amTYS-IND
13h 37m1 stop
$255Multiple Airlines
Find Deal
Mon, Oct 20 - Fri, Oct 24
Allegiant Air Logo
12:13 pm - 7:53 amIND-TYS
19h 40m1 stop
Allegiant Air Logo
5:44 pm - 1:17 pmTYS-IND
19h 33m2 stops
$260Allegiant Air
Find Deal
Thu, Oct 2 - Sun, Oct 5
United Airlines Logo
4:36 pm - 10:50 pmIND-TYS
6h 14m1 stop
United Airlines Logo
8:50 am - 3:21 pmTYS-IND
6h 31m1 stop
$284United Airlines
Find Deal
Tue, Oct 14 - Thu, Oct 16
American Airlines Logo
10:15 am - 4:38 pmIND-TYS
6h 23m1 stop
American Airlines Logo
5:05 am - 9:28 amTYS-IND
4h 23m1 stop
$293American Airlines
Find Deal
Sat, Nov 22 - Fri, Nov 28
United Airlines Logo
6:00 am - 10:10 amIND-TYS
4h 10m1 stop
United Airlines Logo
10:51 am - 3:21 pmTYS-IND
4h 30m1 stop
$304United Airlines
Find Deal
Tue, Oct 7 - Fri, Oct 10
Allegiant Air Logo
12:13 pm - 7:53 amIND-TYS
19h 40m1 stop
Allegiant Air Logo
3:22 pm - 11:38 pmTYS-IND
8h 16m1 stop
$306Allegiant Air
Find Deal
Thu, Oct 2 - Sun, Oct 5

American Airlines flights from Indianapolis to Knoxville

Our best American Airlines deals on Indianapolis to Knoxville flight tickets
American Airlines
Feb 11
IND1:03 pmIndianapolis
7h 40m
1 stop
TYS8:43 pmKnoxville McGhee Tyson
Feb 15
TYS6:50 pmKnoxville McGhee Tyson
3h 36m
1 stop
IND10:26 pmIndianapolis
$239
Find similar
American Airlines
Sep 18
IND6:27 amIndianapolis
7h 42m
1 stop
TYS2:09 pmKnoxville McGhee Tyson
Sep 22
TYS5:19 pmKnoxville McGhee Tyson
5h 51m
1 stop
IND11:10 pmIndianapolis
$269
Find similar
American Airlines
Sep 18
IND6:27 amIndianapolis
7h 42m
1 stop
TYS2:09 pmKnoxville McGhee Tyson
Sep 20
TYS7:45 pmKnoxville McGhee Tyson
3h 25m
1 stop
IND11:10 pmIndianapolis
$279
Find similar

Allegiant Air flights from Indianapolis to Knoxville

Our best Allegiant Air deals on Indianapolis to Knoxville flight tickets
Allegiant Air
Oct 2
IND12:13 pmIndianapolis
19h 40m
1 stop
TYS7:53 amKnoxville McGhee Tyson
Oct 5
TYS5:44 pmKnoxville McGhee Tyson
19h 33m
2 stops
IND1:17 pmIndianapolis
$260
Find similar
Allegiant Air
Oct 2
IND12:13 pmIndianapolis
19h 40m
1 stop
TYS7:53 amKnoxville McGhee Tyson
Oct 5
TYS3:22 pmKnoxville McGhee Tyson
8h 16m
1 stop
IND11:38 pmIndianapolis
$306
Find similar
Allegiant Air
Oct 3
IND6:00 amIndianapolis
15h 04m
1 stop
TYS9:04 pmKnoxville McGhee Tyson
Oct 5
TYS5:44 pmKnoxville McGhee Tyson
19h 33m
2 stops
IND1:17 pmIndianapolis
$317
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Indianapolis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Indianapolis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Sat 2/21

6:05 am-10:17 am

1 stop4h 12m

Knoxville McGhee Tyson

Wed 2/25

5:30 am-9:00 am

1 stop3h 30m

$238

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Wed 2/11

1:03 pm-8:43 pm

1 stop7h 40m

Knoxville McGhee Tyson

Sun 2/15

6:50 pm-10:26 pm

1 stop3h 36m

$239

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Sat 2/21

6:05 am-10:17 am

1 stop4h 12m

Knoxville McGhee Tyson

Wed 2/25

7:30 am-11:15 am

1 stop3h 45m

$249

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Fri 9/26

6:51 pm-11:44 pm

1 stop4h 53m

Knoxville McGhee Tyson

Sun 9/28

5:45 am-8:57 am

1 stop3h 12m

$254

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Mon 10/20

6:20 pm-10:33 am

1 stop16h 13m

Knoxville McGhee Tyson

Fri 10/24

6:15 pm-7:52 am

1 stop13h 37m

$255

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Thu 10/2

12:13 pm-7:53 am

1 stop19h 40m

Knoxville McGhee Tyson

Sun 10/5

5:44 pm-1:17 pm

2 stops19h 33m

$260

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Tue 10/14

4:36 pm-10:50 pm

1 stop6h 14m

Knoxville McGhee Tyson

Thu 10/16

8:50 am-3:21 pm

1 stop6h 31m

$284

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Sat 11/22

10:15 am-4:38 pm

1 stop6h 23m

Knoxville McGhee Tyson

Fri 11/28

5:05 am-9:28 am

1 stop4h 23m

$293

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Tue 10/7

6:00 am-10:10 am

1 stop4h 10m

Knoxville McGhee Tyson

Fri 10/10

10:51 am-3:21 pm

1 stop4h 30m

$304

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Thu 10/2

12:13 pm-7:53 am

1 stop19h 40m

Knoxville McGhee Tyson

Sun 10/5

3:22 pm-11:38 pm

1 stop8h 16m

$306

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Indianapolis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Indianapolis, with most prices found around $254. If you aren’t able to travel during the month of June, then book flights to Knoxville from Indianapolis during January instead. Flights to Knoxville in January, while not as cheap as those in June, still average around $258.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Indianapolis to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $217. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Indianapolis to Knoxville for around $484.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Indianapolis to Knoxville when you can find flight prices for as low as $195. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $296.

When to book flights from Indianapolis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Indianapolis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Indianapolis to Knoxville (IND to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to Knoxville

Direct flights

None
There are no direct flights from Indianapolis to Knoxville. There are no popular flight routes from Indianapolis to Knoxville.
Search flight deals

  • How far is Indianapolis to Knoxville McGhee Tyson by plane?

    The straight-line distance from Indianapolis to Knoxville McGhee Tyson is 289.8 mi. A reasonable flight in good conditions will take 3h 50m.

  • When did momondo last update prices for flights from Indianapolis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Indianapolis Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Indianapolis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Indianapolis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Indianapolis to Knoxville?

Best airlines flying from Indianapolis to Knoxville

Compare and see reviews for airlines that fly from Indianapolis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $208Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $217Free CancellationRating
7.9
7,957 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Indianapolis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Indianapolis to Knoxville?

momondo helps you find the best flight between Indianapolis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Indianapolis to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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