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Cheap flights from Harrisburg to Knoxville from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to Knoxville departing on 6/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Harrisburg to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:20 pm - 12:53 pm
MDT
-
TYS
17h 33m
1 stop
Allegiant Air Logo
9:32 pm - 5:26 pm
TYS
-
MDT
19h 54m
1 stop
$222Allegiant Air
Sun, Apr 19 - Thu, Apr 23
Multiple Airlines Logo
5:42 pm - 8:32 am
MDT
-
TYS
14h 50m
2 stops
Multiple Airlines Logo
10:05 pm - 11:29 am
TYS
-
MDT
13h 24m
1 stop
$271Multiple Airlines
Fri, Jul 3 - Mon, Jul 13
Allegiant Air Logo
9:08 pm - 10:57 pm
MDT
-
TYS
25h 49m
1 stop
Allegiant Air Logo
10:05 pm - 11:29 am
TYS
-
MDT
13h 24m
1 stop
$273Allegiant Air
Fri, Jul 3 - Mon, Jul 13
Allegiant Air Logo
7:20 pm - 12:53 pm
MDT
-
TYS
17h 33m
1 stop
Allegiant Air Logo
7:30 am - 5:26 pm
TYS
-
MDT
9h 56m
1 stop
$302Allegiant Air
Thu, Apr 30 - Mon, May 4
Allegiant Air Logo
8:03 pm - 1:09 pm
MDT
-
TYS
17h 06m
1 stop
Allegiant Air Logo
7:30 am - 5:26 pm
TYS
-
MDT
9h 56m
1 stop
$305Allegiant Air
Fri, May 1 - Mon, May 4
Allegiant Air Logo
8:03 pm - 1:09 pm
MDT
-
TYS
17h 06m
1 stop
Allegiant Air Logo
7:30 am - 5:26 pm
TYS
-
MDT
9h 56m
1 stop
$306Allegiant Air
Fri, May 1 - Mon, May 4
Delta Logo
12:25 pm - 6:17 pm
MDT
-
TYS
5h 52m
1 stop
Delta Logo
5:30 am - 11:36 am
TYS
-
MDT
6h 06m
1 stop
$309Delta
Wed, Aug 19 - Wed, Aug 26
United Airlines Logo
7:59 pm - 11:54 pm
MDT
-
TYS
3h 55m
1 stop
United Airlines Logo
7:19 pm - 11:30 pm
TYS
-
MDT
4h 11m
1 stop
$313United Airlines
Thu, Jul 2 - Mon, Jul 6
Multiple Airlines Logo
7:20 pm - 12:53 pm
MDT
-
TYS
17h 33m
1 stop
Multiple Airlines Logo
3:35 pm - 4:00 pm
TYS
-
MDT
24h 25m
2 stops
$332Multiple Airlines
Sun, Apr 19 - Thu, Apr 23
Allegiant Air Logo
10:10 am - 8:18 pm
MDT
-
TYS
10h 08m
1 stop
Allegiant Air Logo
9:08 pm - 11:29 am
TYS
-
MDT
14h 21m
1 stop
$333Allegiant Air
Fri, Aug 7 - Mon, Aug 10

Delta flights from Harrisburg to Knoxville

Our best Delta deals on Harrisburg to Knoxville flight tickets
Delta
Aug 19
MDT12:25 pmHarrisburg
5h 52m
1 stop
TYS6:17 pmKnoxville McGhee Tyson
Aug 26
TYS5:30 amKnoxville McGhee Tyson
6h 06m
1 stop
MDT11:36 amHarrisburg
$309
Delta
Apr 7
MDT4:40 pmHarrisburg
4h 26m
1 stop
TYS9:06 pmKnoxville McGhee Tyson
Apr 9
TYS5:10 pmKnoxville McGhee Tyson
6h 31m
1 stop
MDT11:41 pmHarrisburg
$634

United Airlines flights from Harrisburg to Knoxville

Our best United Airlines deals on Harrisburg to Knoxville flight tickets
United Airlines
Jul 2
MDT7:59 pmHarrisburg
3h 55m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
Jul 6
TYS7:19 pmKnoxville McGhee Tyson
4h 11m
1 stop
MDT11:30 pmHarrisburg
$313
United Airlines
Apr 29
MDT6:15 amHarrisburg
4h 35m
1 stop
TYS10:50 amKnoxville McGhee Tyson
May 5
TYS7:00 amKnoxville McGhee Tyson
6h 33m
1 stop
MDT1:33 pmHarrisburg
$379
United Airlines
Aug 19
MDT7:59 pmHarrisburg
3h 58m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
Aug 26
TYS6:30 amKnoxville McGhee Tyson
7h 33m
2 stops
MDT2:03 pmHarrisburg
$388

momondo Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 6, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 4/19

7:20 pm-12:53 pm

1 stop17h 33m

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-5:26 pm

1 stop19h 54m

$222

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 7/3

5:42 pm-8:32 am

2 stops14h 50m

Knoxville McGhee Tyson

Mon 7/13

10:05 pm-11:29 am

1 stop13h 24m

$271

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 7/3

9:08 pm-10:57 pm

1 stop25h 49m

Knoxville McGhee Tyson

Mon 7/13

10:05 pm-11:29 am

1 stop13h 24m

$273

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 4/30

7:20 pm-12:53 pm

1 stop17h 33m

Knoxville McGhee Tyson

Mon 5/4

7:30 am-5:26 pm

1 stop9h 56m

$302

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 5/1

8:03 pm-1:09 pm

1 stop17h 06m

Knoxville McGhee Tyson

Mon 5/4

7:30 am-5:26 pm

1 stop9h 56m

$305

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 5/1

8:03 pm-1:09 pm

1 stop17h 06m

Knoxville McGhee Tyson

Mon 5/4

7:30 am-5:26 pm

1 stop9h 56m

$306

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 8/19

12:25 pm-6:17 pm

1 stop5h 52m

Knoxville McGhee Tyson

Wed 8/26

5:30 am-11:36 am

1 stop6h 06m

$309
Quickest round-trip

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 7/2

7:59 pm-11:54 pm

1 stop3h 55m

Knoxville McGhee Tyson

Mon 7/6

7:19 pm-11:30 pm

1 stop4h 11m

$313

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 4/19

7:20 pm-12:53 pm

1 stop17h 33m

Knoxville McGhee Tyson

Thu 4/23

3:35 pm-4:00 pm

2 stops24h 25m

$332

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 8/7

10:10 am-8:18 pm

1 stop10h 08m

Knoxville McGhee Tyson

Mon 8/10

9:08 pm-11:29 am

1 stop14h 21m

$333

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Harrisburg to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Harrisburg and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Harrisburg, with most prices found around $271. If you aren’t able to travel during the month of January, then book flights to Knoxville from Harrisburg during February instead. Flights to Knoxville in February, while not as cheap as those in January, still average around $308.

When to book flights from Harrisburg to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Harrisburg to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harrisburg to Knoxville (MDT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to Knoxville

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Harrisburg to Knoxville takes 3h 55m
There are no direct flights from Harrisburg to Knoxville. There are no popular flight routes from Harrisburg to Knoxville.
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Frequently asked questions about flying from Harrisburg to Knoxville

  • How far is Harrisburg to Knoxville McGhee Tyson by plane?

    There are 484.3 mi between Harrisburg and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 3h 55m.

  • When did momondo last update prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harrisburg Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Harrisburg to Knoxville?

Best airlines flying from Harrisburg to Knoxville

Compare and see reviews for airlines that fly from Harrisburg to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
7.9
8,382 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,550 reviews
Search American Airlines flights
United AirlinesPriceFrom $281Free CancellationRating
7.4
9,546 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Harrisburg to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Harrisburg to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Harrisburg with this policy.

How can momondo help me find flights from Harrisburg to Knoxville?

momondo helps you find the best flight between Harrisburg and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Harrisburg to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Harrisburg to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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