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Cheap flights from Harrisburg to Knoxville from $220

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to Knoxville departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Harrisburg to Knoxville (MDT-TYS)

Cheap round-trip flights

American Airlines Logo
6:30 pm - 11:03 pmMDT-TYS
4h 33m1 stop
American Airlines Logo
4:49 pm - 11:59 pmTYS-MDT
7h 10m1 stop
$229American Airlines
Find Deal
Sat, Sep 27 - Mon, Sep 29
American Airlines Logo
4:30 pm - 11:03 pmMDT-TYS
6h 33m2 stops
American Airlines Logo
4:49 pm - 11:59 pmTYS-MDT
7h 10m1 stop
$234American Airlines
Find Deal
Sat, Sep 27 - Mon, Sep 29
Delta Logo
6:00 am - 10:28 amMDT-TYS
4h 28m1 stop
Delta Logo
6:15 am - 12:19 pmTYS-MDT
6h 04m1 stop
$268Delta
Find Deal
Sat, Oct 18 - Sat, Oct 25
Delta Logo
6:00 am - 10:28 amMDT-TYS
4h 28m1 stop
Delta Logo
12:47 pm - 11:08 pmTYS-MDT
10h 21m2 stops
$274Delta
Find Deal
Sat, Oct 18 - Sat, Oct 25
Delta Logo
6:10 am - 1:26 pmMDT-TYS
7h 16m2 stops
Delta Logo
7:30 am - 5:25 pmTYS-MDT
9h 55m2 stops
$278Delta
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
9:33 am - 1:48 pmMDT-TYS
4h 15m1 stop
American Airlines Logo
7:00 am - 11:40 amTYS-MDT
4h 40m1 stop
$283American Airlines
Find Deal
Sat, Oct 18 - Sat, Oct 25
United Airlines Logo
5:48 pm - 10:45 pmMDT-TYS
4h 57m1 stop
United Airlines Logo
9:55 am - 1:48 pmTYS-MDT
3h 53m1 stop
$299United Airlines
Find Deal
Tue, Sep 9 - Sat, Sep 13
United Airlines Logo
5:48 pm - 10:45 pmMDT-TYS
4h 57m1 stop
United Airlines Logo
7:00 am - 1:48 pmTYS-MDT
6h 48m2 stops
$304United Airlines
Find Deal
Tue, Sep 9 - Sat, Sep 13
Allegiant Air Logo
11:48 am - 7:53 amMDT-TYS
20h 05m1 stop
Allegiant Air Logo
5:34 pm - 5:12 pmTYS-MDT
23h 38m2 stops
$439Allegiant Air
Find Deal
Thu, Oct 16 - Sun, Oct 19
Allegiant Air Logo
4:57 pm - 10:19 pmMDT-TYS
5h 22m1 stop
Allegiant Air Logo
6:19 pm - 6:14 pmTYS-MDT
23h 55m1 stop
$455Allegiant Air
Find Deal
Thu, Sep 18 - Sun, Sep 21

United Airlines flights from Harrisburg to Knoxville

Our best United Airlines deals on Harrisburg to Knoxville flight tickets
United Airlines
Sep 9
MDT5:48 pmHarrisburg
4h 57m
1 stop
TYS10:45 pmKnoxville McGhee Tyson
Sep 13
TYS9:55 amKnoxville McGhee Tyson
3h 53m
1 stop
MDT1:48 pmHarrisburg
$299
Find similar
United Airlines
Sep 9
MDT5:48 pmHarrisburg
4h 57m
1 stop
TYS10:45 pmKnoxville McGhee Tyson
Sep 13
TYS7:00 amKnoxville McGhee Tyson
6h 48m
2 stops
MDT1:48 pmHarrisburg
$304
Find similar
United Airlines
Oct 18
MDT5:48 pmHarrisburg
5h 02m
1 stop
TYS10:50 pmKnoxville McGhee Tyson
Oct 25
TYS8:50 amKnoxville McGhee Tyson
8h 02m
1 stop
MDT4:52 pmHarrisburg
$309
Find similar

American Airlines flights from Harrisburg to Knoxville

Our best American Airlines deals on Harrisburg to Knoxville flight tickets
American Airlines
Sep 27
MDT6:30 pmHarrisburg
4h 33m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
Sep 29
TYS4:49 pmKnoxville McGhee Tyson
7h 10m
1 stop
MDT11:59 pmHarrisburg
$229
Find similar
American Airlines
Sep 27
MDT4:30 pmHarrisburg
6h 33m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Sep 29
TYS4:49 pmKnoxville McGhee Tyson
7h 10m
1 stop
MDT11:59 pmHarrisburg
$234
Find similar
American Airlines
Oct 18
MDT9:33 amHarrisburg
4h 15m
1 stop
TYS1:48 pmKnoxville McGhee Tyson
Oct 25
TYS7:00 amKnoxville McGhee Tyson
4h 40m
1 stop
MDT11:40 amHarrisburg
$283
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 9/27

6:30 pm-11:03 pm

1 stop4h 33m

Knoxville McGhee Tyson

Mon 9/29

4:49 pm-11:59 pm

1 stop7h 10m

$229

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 9/27

4:30 pm-11:03 pm

2 stops6h 33m

Knoxville McGhee Tyson

Mon 9/29

4:49 pm-11:59 pm

1 stop7h 10m

$234

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/18

6:00 am-10:28 am

1 stop4h 28m

Knoxville McGhee Tyson

Sat 10/25

6:15 am-12:19 pm

1 stop6h 04m

$268

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/18

6:00 am-10:28 am

1 stop4h 28m

Knoxville McGhee Tyson

Sat 10/25

12:47 pm-11:08 pm

2 stops10h 21m

$274

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 2/21

6:10 am-1:26 pm

2 stops7h 16m

Knoxville McGhee Tyson

Wed 2/25

7:30 am-5:25 pm

2 stops9h 55m

$278

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/18

9:33 am-1:48 pm

1 stop4h 15m

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:40 am

1 stop4h 40m

$283

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 9/9

5:48 pm-10:45 pm

1 stop4h 57m

Knoxville McGhee Tyson

Sat 9/13

9:55 am-1:48 pm

1 stop3h 53m

$299

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 9/9

5:48 pm-10:45 pm

1 stop4h 57m

Knoxville McGhee Tyson

Sat 9/13

7:00 am-1:48 pm

2 stops6h 48m

$304

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 10/16

11:48 am-7:53 am

1 stop20h 05m

Knoxville McGhee Tyson

Sun 10/19

5:34 pm-5:12 pm

2 stops23h 38m

$439

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 9/18

4:57 pm-10:19 pm

1 stop5h 22m

Knoxville McGhee Tyson

Sun 9/21

6:19 pm-6:14 pm

1 stop23h 55m

$455

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Harrisburg to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Harrisburg, with most prices found around $288. If you aren’t able to travel during the month of May, then book flights to Knoxville from Harrisburg during April instead. Flights to Knoxville in April, while not as cheap as those in May, still average around $328.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Harrisburg to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $271. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Harrisburg to Knoxville for around $422.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Harrisburg to Knoxville when you can find flight prices for as low as $310. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $428.

When to book flights from Harrisburg to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Harrisburg to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harrisburg to Knoxville (MDT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to Knoxville

Direct flights

None
There are no direct flights from Harrisburg to Knoxville. There are no popular flight routes from Harrisburg to Knoxville.
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  • How far is Harrisburg to Knoxville McGhee Tyson by plane?

    There are 484.3 mi between Harrisburg and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 3h 34m.

  • When did momondo last update prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harrisburg Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Harrisburg to Knoxville?

Best airlines flying from Harrisburg to Knoxville

Compare and see reviews for airlines that fly from Harrisburg to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Harrisburg to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Harrisburg to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Harrisburg with this policy.

How can momondo help me find flights from Harrisburg to Knoxville?

momondo helps you find the best flight between Harrisburg and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Harrisburg to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Harrisburg to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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