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Cheap flights from Harrisburg to Knoxville from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to Knoxville departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Harrisburg to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:16 pm - 9:47 pmMDT-TYS
6h 31m1 stop
American Airlines Logo
6:00 am - 12:01 pmTYS-MDT
6h 01m1 stop
$289American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
11:55 am - 4:07 pmMDT-TYS
4h 12m1 stop
American Airlines Logo
8:50 am - 2:51 pmTYS-MDT
6h 01m2 stops
$294American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
11:55 am - 8:27 pmMDT-TYS
8h 32m2 stops
American Airlines Logo
6:00 am - 2:51 pmTYS-MDT
8h 51m2 stops
$299American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
1:52 pm - 6:07 pmMDT-TYS
4h 15m1 stop
American Airlines Logo
5:42 am - 9:10 amTYS-MDT
3h 28m1 stop
$317American Airlines
Find Deal
Wed, Dec 24 - Sat, Dec 27
United Airlines Logo
6:15 am - 10:57 amMDT-TYS
4h 42m1 stop
United Airlines Logo
6:45 am - 2:15 pmTYS-MDT
7h 30m1 stop
$324United Airlines
Find Deal
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
3:03 pm - 8:56 pmMDT-TYS
5h 53m1 stop
American Airlines Logo
8:23 am - 2:38 pmTYS-MDT
6h 15m2 stops
$342American Airlines
Find Deal
Fri, Jan 16 - Sun, Jan 18
Delta Logo
6:25 pm - 11:46 pmMDT-TYS
5h 21m1 stop
Delta Logo
7:20 pm - 11:41 pmTYS-MDT
4h 21m1 stop
$398Delta
Find Deal
Fri, May 1 - Mon, May 4
United Airlines Logo
10:25 am - 11:59 pmMDT-TYS
13h 34m1 stop
United Airlines Logo
5:45 am - 9:35 amTYS-MDT
3h 50m1 stop
$478United Airlines
Find Deal
Fri, Nov 21 - Tue, Nov 25
Multiple Airlines Logo
4:28 pm - 3:16 pmMDT-TYS
22h 48m3 stops
Multiple Airlines Logo
5:37 pm - 8:27 amTYS-MDT
14h 50m1 stop
$513Multiple Airlines
Find Deal
Wed, Dec 24 - Sat, Dec 27
Multiple Airlines Logo
4:28 pm - 3:16 pmMDT-TYS
22h 48m3 stops
Multiple Airlines Logo
2:23 pm - 9:59 amTYS-MDT
19h 36m2 stops
$609Multiple Airlines
Find Deal
Wed, Dec 24 - Sat, Dec 27

American Airlines flights from Harrisburg to Knoxville

Our best American Airlines deals on Harrisburg to Knoxville flight tickets
American Airlines
Feb 21
MDT7:52 pmHarrisburg
4h 00m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Feb 25
TYS7:00 amKnoxville McGhee Tyson
5h 01m
1 stop
MDT12:01 pmHarrisburg
$289
Find similar
American Airlines
Feb 21
MDT11:55 amHarrisburg
4h 12m
1 stop
TYS4:07 pmKnoxville McGhee Tyson
Feb 25
TYS8:50 amKnoxville McGhee Tyson
6h 01m
2 stops
MDT2:51 pmHarrisburg
$294
Find similar
American Airlines
Feb 21
MDT11:55 amHarrisburg
8h 32m
2 stops
TYS8:27 pmKnoxville McGhee Tyson
Feb 25
TYS6:00 amKnoxville McGhee Tyson
8h 51m
2 stops
MDT2:51 pmHarrisburg
$299
Find similar

United Airlines flights from Harrisburg to Knoxville

Our best United Airlines deals on Harrisburg to Knoxville flight tickets
United Airlines
Nov 7
MDT6:15 amHarrisburg
4h 33m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Nov 12
TYS5:45 amKnoxville McGhee Tyson
3h 50m
1 stop
MDT9:35 amHarrisburg
$319
Find similar
United Airlines
Jan 16
MDT6:15 amHarrisburg
4h 42m
1 stop
TYS10:57 amKnoxville McGhee Tyson
Jan 18
TYS6:45 amKnoxville McGhee Tyson
7h 30m
1 stop
MDT2:15 pmHarrisburg
$324
Find similar
United Airlines
Nov 7
MDT6:15 amHarrisburg
10h 53m
2 stops
TYS5:08 pmKnoxville McGhee Tyson
Nov 12
TYS6:45 amKnoxville McGhee Tyson
7h 13m
2 stops
MDT1:58 pmHarrisburg
$329
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 2/21

3:16 pm-9:47 pm

1 stop6h 31m

Knoxville McGhee Tyson

Wed 2/25

6:00 am-12:01 pm

1 stop6h 01m

$289

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 2/21

11:55 am-4:07 pm

1 stop4h 12m

Knoxville McGhee Tyson

Wed 2/25

8:50 am-2:51 pm

2 stops6h 01m

$294

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 2/21

11:55 am-8:27 pm

2 stops8h 32m

Knoxville McGhee Tyson

Wed 2/25

6:00 am-2:51 pm

2 stops8h 51m

$299

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 12/24

1:52 pm-6:07 pm

1 stop4h 15m

Knoxville McGhee Tyson

Sat 12/27

5:42 am-9:10 am

1 stop3h 28m

$317

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 1/16

6:15 am-10:57 am

1 stop4h 42m

Knoxville McGhee Tyson

Sun 1/18

6:45 am-2:15 pm

1 stop7h 30m

$324

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 1/16

3:03 pm-8:56 pm

1 stop5h 53m

Knoxville McGhee Tyson

Sun 1/18

8:23 am-2:38 pm

2 stops6h 15m

$342

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 5/1

6:25 pm-11:46 pm

1 stop5h 21m

Knoxville McGhee Tyson

Mon 5/4

7:20 pm-11:41 pm

1 stop4h 21m

$398

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 11/21

10:25 am-11:59 pm

1 stop13h 34m

Knoxville McGhee Tyson

Tue 11/25

5:45 am-9:35 am

1 stop3h 50m

$478

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 12/24

4:28 pm-3:16 pm

3 stops22h 48m

Knoxville McGhee Tyson

Sat 12/27

5:37 pm-8:27 am

1 stop14h 50m

$513

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 12/24

4:28 pm-3:16 pm

3 stops22h 48m

Knoxville McGhee Tyson

Sat 12/27

2:23 pm-9:59 am

2 stops19h 36m

$609

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Harrisburg to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from Harrisburg, with most prices found around $288. If you aren’t able to travel during the month of May, then book flights to Knoxville from Harrisburg during April instead. Flights to Knoxville in April, while not as cheap as those in May, still average around $320.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Harrisburg to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $271. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Harrisburg to Knoxville for around $422.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Harrisburg to Knoxville when you can find flight prices for as low as $310. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $428.

When to book flights from Harrisburg to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Harrisburg to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harrisburg to Knoxville (MDT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to Knoxville

Direct flights

None
There are no direct flights from Harrisburg to Knoxville. There are no popular flight routes from Harrisburg to Knoxville.
Search flight deals

  • How far is Harrisburg to Knoxville McGhee Tyson by plane?

    There are 484.3 mi between Harrisburg and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 3h 34m.

  • When did momondo last update prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harrisburg Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Harrisburg to Knoxville?

Best airlines flying from Harrisburg to Knoxville

Compare and see reviews for airlines that fly from Harrisburg to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
7.9
8,001 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Harrisburg to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Harrisburg to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Harrisburg with this policy.

How can momondo help me find flights from Harrisburg to Knoxville?

momondo helps you find the best flight between Harrisburg and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Harrisburg to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Harrisburg to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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