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Cheap flights from Harrisburg to Knoxville from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to Knoxville departing on 4/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Harrisburg to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:10 am - 10:31 am
MDT
-
TYS
4h 21m
1 stop
Delta Logo
5:24 pm - 10:50 pm
TYS
-
MDT
5h 26m
1 stop
$317Delta
Di, Mrz 10 - Fr, Mrz 13
United Airlines Logo
6:15 am - 10:49 am
MDT
-
TYS
4h 34m
1 stop
United Airlines Logo
6:45 am - 1:27 pm
TYS
-
MDT
6h 42m
1 stop
$319United Airlines
Di, Feb 24 - Sa, Feb 28
Multiple Airlines Logo
10:46 am - 6:31 pm
MDT
-
TYS
7h 45m
1 stop
Multiple Airlines Logo
2:06 pm - 10:32 am
TYS
-
MDT
20h 26m
1 stop
$327Multiple Airlines
Fr, Feb 27 - Mo, Mrz 2
United Airlines Logo
6:15 am - 1:15 pm
MDT
-
TYS
7h 00m
2 stops
United Airlines Logo
9:40 am - 1:56 pm
TYS
-
MDT
4h 16m
1 stop
$354United Airlines
Di, Feb 24 - Sa, Feb 28
Allegiant Air Logo
10:34 am - 8:17 pm
MDT
-
TYS
9h 43m
1 stop
Allegiant Air Logo
7:30 am - 5:26 pm
TYS
-
MDT
9h 56m
1 stop
$360Allegiant Air
Do, Apr 30 - Mo, Mai 4
Multiple Airlines Logo
10:46 am - 6:31 pm
MDT
-
TYS
7h 45m
1 stop
Multiple Airlines Logo
8:00 am - 10:32 am
TYS
-
MDT
26h 32m
2 stops
$380Multiple Airlines
Fr, Feb 27 - Mo, Mrz 2
Allegiant Air Logo
10:25 am - 9:57 pm
MDT
-
TYS
11h 32m
1 stop
Allegiant Air Logo
10:03 pm - 11:29 am
TYS
-
MDT
13h 26m
1 stop
$386Allegiant Air
Sa, Mai 23 - Mo, Mai 25
United Airlines Logo
6:15 am - 10:50 am
MDT
-
TYS
4h 35m
1 stop
United Airlines Logo
5:48 pm - 12:22 am
TYS
-
MDT
6h 34m
1 stop
$388United Airlines
Mi, Apr 1 - Mo, Apr 6
United Airlines Logo
2:07 pm - 8:37 pm
MDT
-
TYS
6h 30m
1 stop
United Airlines Logo
6:45 am - 1:27 pm
TYS
-
MDT
6h 42m
1 stop
$389United Airlines
Sa, Feb 28 - Mi, Mrz 4
Delta Logo
6:34 am - 11:08 am
MDT
-
TYS
4h 34m
1 stop
Delta Logo
6:55 am - 11:16 am
TYS
-
MDT
4h 21m
1 stop
$393Delta
Mi, Feb 25 - So, Mrz 1

Allegiant Air flights from Harrisburg to Knoxville

Our best Allegiant Air deals on Harrisburg to Knoxville flight tickets
Allegiant Air
Apr 30
MDT10:34 amHarrisburg
9h 43m
1 stop
TYS8:17 pmKnoxville McGhee Tyson
May 4
TYS7:30 amKnoxville McGhee Tyson
9h 56m
1 stop
MDT5:26 pmHarrisburg
$360
Allegiant Air
Feb 16
MDT5:25 pmHarrisburg
16h 43m
1 stop
TYS10:08 amKnoxville McGhee Tyson
Feb 19
TYS9:32 pmKnoxville McGhee Tyson
19h 03m
1 stop
MDT4:35 pmHarrisburg
$383
Allegiant Air
May 23
MDT10:25 amHarrisburg
11h 32m
1 stop
TYS9:57 pmKnoxville McGhee Tyson
May 25
TYS10:03 pmKnoxville McGhee Tyson
13h 26m
1 stop
MDT11:29 amHarrisburg
$386

United Airlines flights from Harrisburg to Knoxville

Our best United Airlines deals on Harrisburg to Knoxville flight tickets
United Airlines
Feb 19
MDT6:15 amHarrisburg
4h 34m
1 stop
TYS10:49 amKnoxville McGhee Tyson
Feb 21
TYS2:21 pmKnoxville McGhee Tyson
4h 19m
1 stop
MDT6:40 pmHarrisburg
$299
United Airlines
Feb 19
MDT6:15 amHarrisburg
7h 00m
2 stops
TYS1:15 pmKnoxville McGhee Tyson
Feb 21
TYS6:45 amKnoxville McGhee Tyson
6h 42m
1 stop
MDT1:27 pmHarrisburg
$304
United Airlines
Feb 19
MDT6:15 amHarrisburg
7h 00m
2 stops
TYS1:15 pmKnoxville McGhee Tyson
Feb 21
TYS6:45 amKnoxville McGhee Tyson
7h 11m
2 stops
MDT1:56 pmHarrisburg
$309

momondo Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated Februar 12, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Di 3/10

6:10 am-10:31 am

1 stop4h 21m

Knoxville McGhee Tyson

Fr 3/13

5:24 pm-10:50 pm

1 stop5h 26m

$317

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Di 2/24

6:15 am-10:49 am

1 stop4h 34m

Knoxville McGhee Tyson

Sa 2/28

6:45 am-1:27 pm

1 stop6h 42m

$319

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fr 2/27

10:46 am-6:31 pm

1 stop7h 45m

Knoxville McGhee Tyson

Mo 3/2

2:06 pm-10:32 am

1 stop20h 26m

$327

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Di 2/24

6:15 am-1:15 pm

2 stops7h 00m

Knoxville McGhee Tyson

Sa 2/28

9:40 am-1:56 pm

1 stop4h 16m

$354

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Do 4/30

10:34 am-8:17 pm

1 stop9h 43m

Knoxville McGhee Tyson

Mo 5/4

7:30 am-5:26 pm

1 stop9h 56m

$360

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fr 2/27

10:46 am-6:31 pm

1 stop7h 45m

Knoxville McGhee Tyson

Mo 3/2

8:00 am-10:32 am

2 stops26h 32m

$380

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sa 5/23

10:25 am-9:57 pm

1 stop11h 32m

Knoxville McGhee Tyson

Mo 5/25

10:03 pm-11:29 am

1 stop13h 26m

$386

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Mi 4/1

6:15 am-10:50 am

1 stop4h 35m

Knoxville McGhee Tyson

Mo 4/6

5:48 pm-12:22 am

1 stop6h 34m

$388

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sa 2/28

2:07 pm-8:37 pm

1 stop6h 30m

Knoxville McGhee Tyson

Mi 3/4

6:45 am-1:27 pm

1 stop6h 42m

$389

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Mi 2/25

6:34 am-11:08 am

1 stop4h 34m

Knoxville McGhee Tyson

So 3/1

6:55 am-11:16 am

1 stop4h 21m

$393

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Harrisburg to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Harrisburg and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Harrisburg, with most prices found around $280. If you aren’t able to travel during the month of January, then book flights to Knoxville from Harrisburg during May instead. Flights to Knoxville in May, while not as cheap as those in January, still average around $288.

When to book flights from Harrisburg to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Harrisburg to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harrisburg to Knoxville (MDT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to Knoxville

Fastest flight time

4h 21m

Direct flights

None
The fastest flight from Harrisburg to Knoxville takes 4h 21m
There are no direct flights from Harrisburg to Knoxville. There are no popular flight routes from Harrisburg to Knoxville.
Search flight deals

  • How far is Harrisburg to Knoxville McGhee Tyson by plane?

    There are 484.3 mi between Harrisburg and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 4h 21m.

  • When did momondo last update prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Harrisburg Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harrisburg Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Harrisburg to Knoxville?

Best airlines flying from Harrisburg to Knoxville

Compare and see reviews for airlines that fly from Harrisburg to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
7.9
8,180 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,271 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Harrisburg to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Harrisburg to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Harrisburg with this policy.

How can momondo help me find flights from Harrisburg to Knoxville?

momondo helps you find the best flight between Harrisburg and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Harrisburg to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Harrisburg to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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