Cheap flights from Harrisburg to Knoxville from $197
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to Knoxville departing on 11/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Fly from
Fly to
Route
Depart
Return
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 11/3
1:59 pm-8:49 pm
1 stop6h 50m
Knoxville McGhee Tyson
Wed 11/11
7:14 pm-11:21 pm
1 stop4h 07m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sat 11/14
6:15 am-11:30 am
1 stop5h 15m
Knoxville McGhee Tyson
Tue 11/17
1:56 pm-6:57 pm
1 stop5h 01m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sat 10/31
6:15 am-11:30 am
1 stop5h 15m
Knoxville McGhee Tyson
Mon 11/2
7:35 pm-11:44 pm
1 stop4h 09m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 1/12
10:25 am-2:47 pm
1 stop4h 22m
Knoxville McGhee Tyson
Sat 1/16
9:45 am-1:56 pm
1 stop4h 11m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Mon 11/2
6:13 am-10:20 am
1 stop4h 07m
Knoxville McGhee Tyson
Wed 11/11
6:10 pm-11:50 pm
1 stop5h 40m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Mon 11/2
6:13 am-10:20 am
1 stop4h 07m
Knoxville McGhee Tyson
Fri 11/13
5:10 pm-11:06 pm
1 stop5h 56m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sat 12/19
5:27 pm-9:57 pm
1 stop28h 30m
Knoxville McGhee Tyson
Thu 1/7
9:06 pm-6:54 pm
1 stop21h 48m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 10/20
11:02 am-5:36 pm
1 stop6h 34m
Knoxville McGhee Tyson
Mon 10/26
6:00 am-10:17 am
1 stop4h 17m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sun 12/20
9:14 pm-11:22 pm
1 stop26h 08m
Knoxville McGhee Tyson
Thu 1/7
9:06 pm-6:54 pm
1 stop21h 48m
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Wed 11/11
6:15 am-11:16 am
1 stop5h 01m
Knoxville McGhee Tyson
Sun 11/15
8:04 pm-12:16 am
1 stop4h 12m
See travel insights to Knoxville from
How to get the cheapest flight ticket from Harrisburg to Knoxville
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the typical price of a round-trip flight between Harrisburg and Knoxville?
Prices are currently low for flights on this route.
Typical prices usually range from $358 to $721.The lowest price recently found on this route was $319.
What is the cheapest airline that flies from Harrisburg to Knoxville McGhee Tyson?
American Airlines, Allegiant Air, and United Airlines are the most popular carriers operating from Harrisburg to Knoxville McGhee Tyson
What airlines fly to Knoxville?
American Airlines, Delta and Southwest are the top three most popular airlines that fly to Knoxville from Harrisburg according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 4 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.
Which airport is the most popular layover for flights between Harrisburg and Knoxville?
Washington, D.C. (IAD) was the most common stop: 75% of momondo users choosing 1-stop flights on this route connected there.
Which layover airport offers the lowest fares from Harrisburg to Knoxville?
Flights via Washington, D.C. (IAD) offer the lowest average round-trip price of $288.
Which layover airport has the shortest travel time from Harrisburg to Knoxville?
Flights connecting via Washington, D.C. (IAD) have the shortest average one-way travel time: 3h 55m.
Which layover airport has the shortest connection time from Harrisburg to Knoxville?
Charlotte (CLT) has the shortest average layover time for this route: 1h 13m.
When to book flights from Harrisburg to Knoxville
Cheap Harrisburg to Knoxville (MDT to TYS) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Harrisburg to Knoxville
Frequently asked questions about flying from Harrisburg to Knoxville
How far is Harrisburg to Knoxville McGhee Tyson by plane?
There are 484.3 mi between Harrisburg and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 4h 44m.
When did momondo last update prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport?
As of October 2026, there are 3 operators available to choose from for flights from Harrisburg Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Harrisburg Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harrisburg Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Harrisburg to Knoxville?
momondo data reveals that the most frequently booked airline on the route from Harrisburg to Knoxville is American Airlines, representing 56% of all bookings. The subsequent popular airlines are Delta at 23% and United Airlines at 21%.
Best airlines flying from Harrisburg to Knoxville
Compare and see reviews for airlines that fly from Harrisburg to Knoxville with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $228 | Free Cancellation | Rating 7.0 12,138 reviews | |||
| PriceFrom $281 | Free Cancellation | Rating 7.4 10,315 reviews | |||
| PriceFrom $298 | Free Cancellation | Rating 7.8 8,636 reviews |
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Harrisburg to Knoxville?
momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Harrisburg to Knoxville. Millions of users trust and use momondo every year so you are in good hands.
Can I find flights from Harrisburg to Knoxville with flexible booking policies on momondo?
Yes. momondo enables you to select and highlight flights to Knoxville from Harrisburg with this policy.
How can momondo help me find flights from Harrisburg to Knoxville?
momondo helps you find the best flight between Harrisburg and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.
I’m not ready to book a flight from Harrisburg to Knoxville right now. Can momondo alert me if prices change?
Yes. momondo can track prices for Harrisburg to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.