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Cheap flights from Gulfport to Knoxville from $209

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Gulfport to Knoxville departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Gulfport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 11:15 am
GPT
-
TYS
4h 15m
1 stop
American Airlines Logo
2:06 pm - 5:20 pm
TYS
-
GPT
4h 14m
1 stop
$314American Airlines
Sat, Apr 11 - Sat, Apr 18
Delta Logo
6:00 am - 11:17 am
GPT
-
TYS
4h 17m
1 stop
Delta Logo
5:40 am - 8:50 am
TYS
-
GPT
4h 10m
1 stop
$319Delta
Tue, Apr 7 - Sat, Apr 11
Delta Logo
2:40 pm - 7:01 pm
GPT
-
TYS
3h 21m
1 stop
Delta Logo
5:35 am - 9:24 am
TYS
-
GPT
4h 49m
1 stop
$328Delta
Wed, Apr 22 - Wed, Apr 29
Delta Logo
5:57 pm - 11:57 pm
GPT
-
TYS
5h 00m
1 stop
Delta Logo
5:40 am - 8:50 am
TYS
-
GPT
4h 10m
1 stop
$339Delta
Fri, Apr 3 - Wed, Apr 8
Delta Logo
2:46 pm - 7:27 pm
GPT
-
TYS
3h 41m
1 stop
Delta Logo
5:40 am - 8:50 am
TYS
-
GPT
4h 10m
1 stop
$389Delta
Thu, Apr 2 - Mon, Apr 6
Delta Logo
9:48 am - 4:13 pm
GPT
-
TYS
5h 25m
1 stop
Delta Logo
5:40 am - 9:24 am
TYS
-
GPT
4h 44m
1 stop
$407Delta
Sat, Apr 11 - Sat, Apr 18
United Airlines Logo
2:00 pm - 9:30 pm
GPT
-
TYS
6h 30m
1 stop
United Airlines Logo
7:15 am - 1:26 pm
TYS
-
GPT
7h 11m
1 stop
$408United Airlines
Sat, Aug 22 - Wed, Aug 26
Delta Logo
6:00 am - 11:17 am
GPT
-
TYS
4h 17m
1 stop
Delta Logo
5:54 pm - 10:13 pm
TYS
-
GPT
5h 19m
1 stop
$496Delta
Tue, Apr 21 - Tue, Apr 21
Multiple Airlines Logo
7:20 pm - 5:30 pm
GPT
-
TYS
21h 10m
1 stop
Multiple Airlines Logo
4:28 pm - 9:00 am
TYS
-
GPT
17h 32m
2 stops
$531Multiple Airlines
Sun, Apr 19 - Sun, Apr 26
United Airlines Logo
5:15 pm - 4:59 pm
GPT
-
TYS
22h 44m
2 stops
United Airlines Logo
7:15 am - 1:26 pm
TYS
-
GPT
7h 11m
1 stop
$543United Airlines
Sat, Aug 22 - Wed, Aug 26

United Airlines flights from Gulfport to Knoxville

Our best United Airlines deals on Gulfport to Knoxville flight tickets
United Airlines
Aug 22
GPT2:00 pmGulfport Biloxi Regional
6h 30m
1 stop
TYS9:30 pmKnoxville McGhee Tyson
Aug 26
TYS7:15 amKnoxville McGhee Tyson
7h 11m
1 stop
GPT1:26 pmGulfport Biloxi Regional
$408
United Airlines
Aug 22
GPT5:15 pmGulfport Biloxi Regional
22h 44m
2 stops
TYS4:59 pmKnoxville McGhee Tyson
Aug 26
TYS7:15 amKnoxville McGhee Tyson
7h 11m
1 stop
GPT1:26 pmGulfport Biloxi Regional
$543
United Airlines
Apr 22
GPT5:15 pmGulfport Biloxi Regional
28h 19m
2 stops
TYS10:34 pmKnoxville McGhee Tyson
Apr 29
TYS9:00 amKnoxville McGhee Tyson
5h 21m
1 stop
GPT1:21 pmGulfport Biloxi Regional
$582

American Airlines flights from Gulfport to Knoxville

Our best American Airlines deals on Gulfport to Knoxville flight tickets
American Airlines
Apr 11
GPT6:00 amGulfport Biloxi Regional
4h 15m
1 stop
TYS11:15 amKnoxville McGhee Tyson
Apr 18
TYS2:06 pmKnoxville McGhee Tyson
4h 14m
1 stop
GPT5:20 pmGulfport Biloxi Regional
$314
American Airlines
Apr 6
GPT4:29 pmGulfport Biloxi Regional
4h 25m
1 stop
TYS9:54 pmKnoxville McGhee Tyson
Apr 12
TYS11:40 amKnoxville McGhee Tyson
6h 53m
1 stop
GPT5:33 pmGulfport Biloxi Regional
$772
American Airlines
Apr 7
GPT6:06 amGulfport Biloxi Regional
7h 16m
1 stop
TYS2:22 pmKnoxville McGhee Tyson
Apr 11
TYS4:15 pmKnoxville McGhee Tyson
8h 43m
2 stops
GPT11:58 pmGulfport Biloxi Regional
$846

momondo Fare Finder

 
Customize your flight search to find flights from Gulfport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Gulfport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 4/11

6:00 am-11:15 am

1 stop4h 15m

Knoxville McGhee Tyson

Sat 4/18

2:06 pm-5:20 pm

1 stop4h 14m

$314

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Tue 4/7

6:00 am-11:17 am

1 stop4h 17m

Knoxville McGhee Tyson

Sat 4/11

5:40 am-8:50 am

1 stop4h 10m

$319

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Wed 4/22

2:40 pm-7:01 pm

1 stop3h 21m

Knoxville McGhee Tyson

Wed 4/29

5:35 am-9:24 am

1 stop4h 49m

$328

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Fri 4/3

5:57 pm-11:57 pm

1 stop5h 00m

Knoxville McGhee Tyson

Wed 4/8

5:40 am-8:50 am

1 stop4h 10m

$339
Quickest round-trip

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Thu 4/2

2:46 pm-7:27 pm

1 stop3h 41m

Knoxville McGhee Tyson

Mon 4/6

5:40 am-8:50 am

1 stop4h 10m

$389

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 4/11

9:48 am-4:13 pm

1 stop5h 25m

Knoxville McGhee Tyson

Sat 4/18

5:40 am-9:24 am

1 stop4h 44m

$407

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 8/22

2:00 pm-9:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 8/26

7:15 am-1:26 pm

1 stop7h 11m

$408

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Tue 4/21

6:00 am-11:17 am

1 stop4h 17m

Knoxville McGhee Tyson

Tue 4/21

5:54 pm-10:13 pm

1 stop5h 19m

$496

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sun 4/19

7:20 pm-5:30 pm

1 stop21h 10m

Knoxville McGhee Tyson

Sun 4/26

4:28 pm-9:00 am

2 stops17h 32m

$531

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 8/22

5:15 pm-4:59 pm

2 stops22h 44m

Knoxville McGhee Tyson

Wed 8/26

7:15 am-1:26 pm

1 stop7h 11m

$543

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Gulfport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Gulfport Biloxi Regional to Knoxville McGhee Tyson?

Delta, United Airlines, and American Airlines are the most popular carriers operating from Gulfport Biloxi Regional to Knoxville McGhee Tyson

What airlines fly to Knoxville?

Delta, American Airlines and Allegiant Air are the top three most popular airlines that fly to Knoxville from Gulfport according to our data. Delta is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 5 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When to book flights from Gulfport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Gulfport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Gulfport to Knoxville (GPT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Gulfport to Knoxville

Fastest flight time

3h 21m

Direct flights

None
The fastest flight from Gulfport to Knoxville takes 3h 21m
There are no direct flights from Gulfport to Knoxville. There are no popular flight routes from Gulfport to Knoxville.
Search flight deals

  • How far is Gulfport Biloxi Regional to Knoxville McGhee Tyson by plane?

    Gulfport Biloxi Regional and Knoxville McGhee Tyson are 488.2 mi apart from one another. Typically, this will take 3h 21m by plane in normal conditions.

  • When did momondo last update prices for flights from Gulfport Biloxi Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Gulfport Biloxi Regional Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Gulfport Biloxi Regional Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Gulfport Biloxi Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Gulfport Biloxi Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Gulfport to Knoxville?

Best airlines flying from Gulfport to Knoxville

Compare and see reviews for airlines that fly from Gulfport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $153Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights
DeltaPriceFrom $164Free CancellationRating
7.9
8,320 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Gulfport to Knoxville?

Finding the right flight to Knoxville from Gulfport is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Gulfport to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Gulfport on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Gulfport to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Gulfport. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Gulfport to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Gulfport are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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