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Cheap flights from Gainesville to Knoxville from $268

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Gainesville to Knoxville departing on 1/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Gainesville to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:03 pm - 4:49 pm
GNV
-
TYS
3h 46m1 stop
American Airlines Logo
8:09 am - 12:30 pm
TYS
-
GNV
4h 21m1 stop
$268American Airlines
Tue, Jan 20 - Tue, Jan 27
American Airlines Logo
5:00 pm - 9:21 pm
GNV
-
TYS
4h 21m1 stop
American Airlines Logo
3:00 pm - 11:57 pm
TYS
-
GNV
8h 57m2 stops
$273American Airlines
Tue, Jan 20 - Tue, Jan 27
American Airlines Logo
3:07 pm - 10:00 pm
GNV
-
TYS
6h 53m1 stop
American Airlines Logo
5:00 am - 10:57 am
TYS
-
GNV
5h 57m1 stop
$327American Airlines
Fri, Feb 20 - Sun, Feb 22
Delta Logo
7:00 pm - 11:45 pm
GNV
-
TYS
4h 45m1 stop
Delta Logo
5:40 am - 9:24 am
TYS
-
GNV
3h 44m1 stop
$403Delta
Fri, Jan 23 - Sun, Jan 25
Delta Logo
2:12 pm - 6:52 pm
GNV
-
TYS
4h 40m1 stop
Delta Logo
5:40 am - 9:24 am
TYS
-
GNV
3h 44m1 stop
$407Delta
Tue, Jan 6 - Sat, Jan 10
American Airlines Logo
5:45 pm - 11:40 pm
GNV
-
TYS
5h 55m1 stop
American Airlines Logo
7:39 pm - 11:59 pm
TYS
-
GNV
4h 20m1 stop
$417American Airlines
Mon, Mar 16 - Fri, Mar 20
Delta Logo
7:00 pm - 11:52 pm
GNV
-
TYS
4h 52m1 stop
Delta Logo
6:55 am - 12:26 pm
TYS
-
GNV
5h 31m1 stop
$433Delta
Fri, Feb 20 - Sun, Feb 22
Delta Logo
6:00 am - 10:31 am
GNV
-
TYS
4h 31m1 stop
Delta Logo
5:40 am - 9:24 am
TYS
-
GNV
3h 44m1 stop
$448Delta
Sat, Jan 3 - Sat, Jan 10
American Airlines Logo
6:00 am - 3:20 pm
GNV
-
TYS
9h 20m2 stops
American Airlines Logo
4:00 pm - 11:57 pm
TYS
-
GNV
7h 57m2 stops
$455American Airlines
Tue, Jan 20 - Tue, Jan 27
American Airlines Logo
5:00 pm - 9:21 pm
GNV
-
TYS
4h 21m1 stop
American Airlines Logo
5:14 pm - 11:30 pm
TYS
-
GNV
6h 16m1 stop
$462American Airlines
Fri, Jan 23 - Sun, Jan 25

American Airlines flights from Gainesville to Knoxville

Our best American Airlines deals on Gainesville to Knoxville flight tickets
American Airlines
Jan 20
GNV1:03 pmGainesville Regional
3h 46m
1 stop
TYS4:49 pmKnoxville McGhee Tyson
Jan 27
TYS8:09 amKnoxville McGhee Tyson
4h 21m
1 stop
GNV12:30 pmGainesville Regional
$268
Find similar
American Airlines
Jan 20
GNV5:00 pmGainesville Regional
4h 21m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
Jan 27
TYS3:00 pmKnoxville McGhee Tyson
8h 57m
2 stops
GNV11:57 pmGainesville Regional
$273
Find similar
American Airlines
Feb 13
GNV6:30 amGainesville Regional
4h 47m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Feb 15
TYS7:00 amKnoxville McGhee Tyson
3h 57m
1 stop
GNV10:57 amGainesville Regional
$327
Find similar

Delta flights from Gainesville to Knoxville

Our best Delta deals on Gainesville to Knoxville flight tickets
Delta
Jan 23
GNV7:00 pmGainesville Regional
4h 45m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
Jan 25
TYS5:40 amKnoxville McGhee Tyson
3h 44m
1 stop
GNV9:24 amGainesville Regional
$403
Find similar
Delta
Jan 6
GNV2:12 pmGainesville Regional
4h 40m
1 stop
TYS6:52 pmKnoxville McGhee Tyson
Jan 10
TYS5:40 amKnoxville McGhee Tyson
3h 44m
1 stop
GNV9:24 amGainesville Regional
$407
Find similar
Delta
Feb 20
GNV7:00 pmGainesville Regional
4h 52m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Feb 22
TYS6:55 amKnoxville McGhee Tyson
5h 31m
1 stop
GNV12:26 pmGainesville Regional
$433
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Gainesville to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Gainesville to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Tue 1/20

1:03 pm-4:49 pm

1 stop3h 46m

Knoxville McGhee Tyson

Tue 1/27

8:09 am-12:30 pm

1 stop4h 21m

$268

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Tue 1/20

5:00 pm-9:21 pm

1 stop4h 21m

Knoxville McGhee Tyson

Tue 1/27

3:00 pm-11:57 pm

2 stops8h 57m

$273

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Fri 2/20

3:07 pm-10:00 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sun 2/22

5:00 am-10:57 am

1 stop5h 57m

$327

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Fri 1/23

7:00 pm-11:45 pm

1 stop4h 45m

Knoxville McGhee Tyson

Sun 1/25

5:40 am-9:24 am

1 stop3h 44m

$403

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Tue 1/6

2:12 pm-6:52 pm

1 stop4h 40m

Knoxville McGhee Tyson

Sat 1/10

5:40 am-9:24 am

1 stop3h 44m

$407

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Mon 3/16

5:45 pm-11:40 pm

1 stop5h 55m

Knoxville McGhee Tyson

Fri 3/20

7:39 pm-11:59 pm

1 stop4h 20m

$417

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Fri 2/20

7:00 pm-11:52 pm

1 stop4h 52m

Knoxville McGhee Tyson

Sun 2/22

6:55 am-12:26 pm

1 stop5h 31m

$433

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Sat 1/3

6:00 am-10:31 am

1 stop4h 31m

Knoxville McGhee Tyson

Sat 1/10

5:40 am-9:24 am

1 stop3h 44m

$448

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Tue 1/20

6:00 am-3:20 pm

2 stops9h 20m

Knoxville McGhee Tyson

Tue 1/27

4:00 pm-11:57 pm

2 stops7h 57m

$455

GainesvilleKnoxville

GNV - TYS

GNVTYS

Gainesville Regional

Fri 1/23

5:00 pm-9:21 pm

1 stop4h 21m

Knoxville McGhee Tyson

Sun 1/25

5:14 pm-11:30 pm

1 stop6h 16m

$462

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Gainesville to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Gainesville, with most prices found around $248. If you aren’t able to travel during the month of September, then book flights to Knoxville from Gainesville during December instead. Flights to Knoxville in December, while not as cheap as those in September, still average around $258.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Gainesville to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $454. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Gainesville to Knoxville for around $664.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Gainesville to Knoxville when you can find flight prices for as low as $463. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $684.

What is the cheapest Gainesville Regional to Knoxville McGhee Tyson flight route?

Fly from Gainesville Regional to Knoxville McGhee Tyson for the best Gainesville Regional - Knoxville McGhee Tyson flight prices

What cabin class options are available on Gainesville Regional to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Gainesville Regional to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Gainesville to Knoxville flights?

You could potentially save up to 16% on your flight if you consider stops on a Gainesville to Knoxville flight.

When to book flights from Gainesville to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Gainesville to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Gainesville to Knoxville (GNV to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Gainesville to Knoxville

Fastest flight time

3h 00m

Direct flights

None
The fastest flight from Gainesville to Knoxville takes 3h 00m
There are no direct flights from Gainesville to Knoxville. There are no popular flight routes from Gainesville to Knoxville.
Search flight deals

  • How far is Gainesville Regional to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 445.3 mi away from Gainesville Regional. Flights usually cover this in 3h 00m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Gainesville Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Gainesville Regional Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Gainesville Regional Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Gainesville Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Gainesville Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Gainesville to Knoxville?

Best airlines flying from Gainesville to Knoxville

Compare and see reviews for airlines that fly from Gainesville to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,014 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Gainesville to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Gainesville.

Can I find flights from Gainesville to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Gainesville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Gainesville to Knoxville?

momondo helps you find the best flight between Gainesville and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Gainesville to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Gainesville to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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