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Cheap flights from Gainesville to Des Moines from $377

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Gainesville to Des Moines departing on 5/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Gainesville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:38 am - 11:08 am
GNV
-
DSM
5h 30m
1 stop
Delta Logo
5:27 am - 12:22 pm
DSM
-
GNV
5h 55m
1 stop
$377Delta
Wed, May 20 - Wed, May 27
American Airlines Logo
6:00 am - 4:31 pm
GNV
-
DSM
11h 31m
2 stops
American Airlines Logo
4:48 pm - 11:46 pm
DSM
-
GNV
5h 58m
1 stop
$382American Airlines
Wed, May 20 - Wed, May 27
American Airlines Logo
3:07 pm - 11:59 pm
GNV
-
DSM
9h 52m
2 stops
American Airlines Logo
1:48 pm - 12:33 am
DSM
-
GNV
9h 45m
2 stops
$387American Airlines
Wed, May 20 - Wed, May 27
Delta Logo
6:38 am - 11:08 am
GNV
-
DSM
5h 30m
1 stop
Delta Logo
5:27 am - 12:22 pm
DSM
-
GNV
5h 55m
1 stop
$426Delta
Tue, May 12 - Wed, May 20
American Airlines Logo
6:05 am - 12:52 pm
GNV
-
DSM
7h 47m
1 stop
American Airlines Logo
5:44 am - 2:41 pm
DSM
-
GNV
7h 57m
2 stops
$431American Airlines
Tue, May 12 - Wed, May 20
American Airlines Logo
2:58 pm - 11:49 pm
GNV
-
DSM
9h 51m
2 stops
American Airlines Logo
5:44 am - 2:41 pm
DSM
-
GNV
7h 57m
2 stops
$436American Airlines
Tue, May 12 - Wed, May 20
Delta Logo
6:00 am - 11:05 am
GNV
-
DSM
6h 05m
1 stop
Delta Logo
2:33 pm - 10:44 pm
DSM
-
GNV
7h 11m
1 stop
$521Delta
Sat, May 2 - Fri, May 8
American Airlines Logo
7:05 am - 2:47 pm
GNV
-
DSM
8h 42m
1 stop
American Airlines Logo
12:06 pm - 11:59 pm
DSM
-
GNV
10h 53m
2 stops
$526American Airlines
Sat, May 2 - Fri, May 8
American Airlines Logo
6:30 am - 4:31 pm
GNV
-
DSM
11h 01m
2 stops
American Airlines Logo
1:25 pm - 11:59 pm
DSM
-
GNV
9h 34m
2 stops
$577American Airlines
Sat, May 2 - Fri, May 8
American Airlines Logo
6:30 am - 1:46 pm
GNV
-
DSM
8h 16m
2 stops
American Airlines Logo
12:06 pm - 11:59 pm
DSM
-
GNV
10h 53m
2 stops
$582American Airlines
Sat, May 2 - Fri, May 8

Delta flights from Gainesville to Des Moines

Our best Delta deals on Gainesville to Des Moines flight tickets
Delta
May 20
GNV6:38 amGainesville Regional
5h 30m
1 stop
DSM11:08 amDes Moines
May 27
DSM5:27 amDes Moines
5h 55m
1 stop
GNV12:22 pmGainesville Regional
$377
Delta
May 12
GNV6:38 amGainesville Regional
5h 30m
1 stop
DSM11:08 amDes Moines
May 20
DSM5:27 amDes Moines
5h 55m
1 stop
GNV12:22 pmGainesville Regional
$426
Delta
May 2
GNV6:00 amGainesville Regional
6h 05m
1 stop
DSM11:05 amDes Moines
May 8
DSM2:33 pmDes Moines
7h 11m
1 stop
GNV10:44 pmGainesville Regional
$521

American Airlines flights from Gainesville to Des Moines

Our best American Airlines deals on Gainesville to Des Moines flight tickets
American Airlines
May 20
GNV6:00 amGainesville Regional
11h 31m
2 stops
DSM4:31 pmDes Moines
May 27
DSM4:48 pmDes Moines
5h 58m
1 stop
GNV11:46 pmGainesville Regional
$382
American Airlines
May 20
GNV3:07 pmGainesville Regional
9h 52m
2 stops
DSM11:59 pmDes Moines
May 27
DSM1:48 pmDes Moines
9h 45m
2 stops
GNV12:33 amGainesville Regional
$387
American Airlines
May 12
GNV6:05 amGainesville Regional
7h 47m
1 stop
DSM12:52 pmDes Moines
May 20
DSM5:44 amDes Moines
7h 57m
2 stops
GNV2:41 pmGainesville Regional
$431

momondo Fare Finder

 
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Wed 5/20

6:38 am-11:08 am

1 stop5h 30m

Des Moines

Wed 5/27

5:27 am-12:22 pm

1 stop5h 55m

$377

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Wed 5/20

6:00 am-4:31 pm

2 stops11h 31m

Des Moines

Wed 5/27

4:48 pm-11:46 pm

1 stop5h 58m

$382

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Wed 5/20

3:07 pm-11:59 pm

2 stops9h 52m

Des Moines

Wed 5/27

1:48 pm-12:33 am

2 stops9h 45m

$387

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/12

6:38 am-11:08 am

1 stop5h 30m

Des Moines

Wed 5/20

5:27 am-12:22 pm

1 stop5h 55m

$426

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/12

6:05 am-12:52 pm

1 stop7h 47m

Des Moines

Wed 5/20

5:44 am-2:41 pm

2 stops7h 57m

$431

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/12

2:58 pm-11:49 pm

2 stops9h 51m

Des Moines

Wed 5/20

5:44 am-2:41 pm

2 stops7h 57m

$436

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sat 5/2

6:00 am-11:05 am

1 stop6h 05m

Des Moines

Fri 5/8

2:33 pm-10:44 pm

1 stop7h 11m

$521

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sat 5/2

7:05 am-2:47 pm

1 stop8h 42m

Des Moines

Fri 5/8

12:06 pm-11:59 pm

2 stops10h 53m

$526

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sat 5/2

6:30 am-4:31 pm

2 stops11h 01m

Des Moines

Fri 5/8

1:25 pm-11:59 pm

2 stops9h 34m

$577

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sat 5/2

6:30 am-1:46 pm

2 stops8h 16m

Des Moines

Fri 5/8

12:06 pm-11:59 pm

2 stops10h 53m

$582

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Gainesville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Gainesville Regional to Des Moines?

Delta and American Airlines are the most popular carriers operating from Gainesville Regional to Des Moines

What airlines fly to Des Moines?

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to Des Moines from Gainesville according to our data. Allegiant Air is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 5 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Gainesville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Gainesville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Gainesville to Des Moines (GNV to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Gainesville to Des Moines

Fastest flight time

4h 27m

Direct flights

None
The fastest flight from Gainesville to Des Moines takes 4h 27m
There are no direct flights from Gainesville to Des Moines. There are no popular flight routes from Gainesville to Des Moines.
Search flight deals

Frequently asked questions about flying from Gainesville to Des Moines

  • How far is Gainesville Regional to Des Moines by plane?

    Gainesville Regional and Des Moines are 1037.9 mi apart from one another. By plane, this route typically takes 4h 27m.

  • When did momondo last update prices for flights from Gainesville Regional Airport to Des Moines Airport?

    Prices for flights from Gainesville Regional Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Gainesville Regional Airport to Des Moines Airport?

  • How old do you have to be to fly from Gainesville Regional Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Gainesville Regional Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Gainesville to Des Moines?

Best airlines flying from Gainesville to Des Moines

Compare and see reviews for airlines that fly from Gainesville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $394Free CancellationRating
7.1
11,647 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Gainesville to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Gainesville to Des Moines for you.

Can I find flights from Gainesville to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Gainesville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Gainesville to Des Moines?

Once all potential Gainesville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Gainesville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Gainesville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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