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Cheap flights from Gainesville to Des Moines from $348

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Gainesville to Des Moines departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Gainesville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:21 pm - 11:58 pm
GNV
-
DSM
7h 37m
1 stop
American Airlines Logo
7:04 am - 1:20 pm
DSM
-
GNV
5h 16m
1 stop
$605American Airlines
Thu, Jul 2 - Mon, Jul 6
American Airlines Logo
7:00 am - 12:56 pm
GNV
-
DSM
6h 56m
1 stop
American Airlines Logo
1:35 pm - 12:16 am
DSM
-
GNV
9h 41m
2 stops
$716American Airlines
Thu, Jul 2 - Mon, Jul 6
American Airlines Logo
1:48 pm - 10:04 pm
GNV
-
DSM
9h 16m
2 stops
American Airlines Logo
1:35 pm - 12:16 am
DSM
-
GNV
9h 41m
2 stops
$775American Airlines
Thu, Jul 2 - Mon, Jul 6

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American Airlines flights from Gainesville to Des Moines

Our best American Airlines deals on Gainesville to Des Moines flight tickets
American Airlines
Jul 2
GNV5:21 pmGainesville Regional
7h 37m
1 stop
DSM11:58 pmDes Moines
Jul 6
DSM7:04 amDes Moines
5h 16m
1 stop
GNV1:20 pmGainesville Regional
$605
American Airlines
Jul 2
GNV7:00 amGainesville Regional
6h 56m
1 stop
DSM12:56 pmDes Moines
Jul 6
DSM1:35 pmDes Moines
9h 41m
2 stops
GNV12:16 amGainesville Regional
$716
American Airlines
Jul 2
GNV1:48 pmGainesville Regional
9h 16m
2 stops
DSM10:04 pmDes Moines
Jul 6
DSM1:35 pmDes Moines
9h 41m
2 stops
GNV12:16 amGainesville Regional
$775

momondo Fare Finder

 
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 7/2

5:21 pm-11:58 pm

1 stop7h 37m

Des Moines

Mon 7/6

7:04 am-1:20 pm

1 stop5h 16m

$605

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 7/2

7:00 am-12:56 pm

1 stop6h 56m

Des Moines

Mon 7/6

1:35 pm-12:16 am

2 stops9h 41m

$716

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 7/2

1:48 pm-10:04 pm

2 stops9h 16m

Des Moines

Mon 7/6

1:35 pm-12:16 am

2 stops9h 41m

$775
Cheapest one-way
Quickest one-way

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Mon 10/5

5:18 pm-11:07 pm

1 stop6h 49m

$348

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Mon 10/5

1:58 pm-8:11 pm

2 stops7h 13m

$403

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Gainesville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Gainesville Regional to Des Moines?

American Airlines is the most popular carrier operating from Gainesville Regional to Des Moines

What airlines fly to Des Moines?

Allegiant Air, Delta and American Airlines are the top three most popular airlines that fly to Des Moines from Gainesville according to our data. Allegiant Air is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 5 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Gainesville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Gainesville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Gainesville to Des Moines (GNV to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Gainesville to Des Moines

Fastest flight time

6h 40m

Direct flights

None
The fastest flight from Gainesville to Des Moines takes 6h 40m
There are no direct flights from Gainesville to Des Moines. There are no popular flight routes from Gainesville to Des Moines.
Search flight deals

Frequently asked questions about flying from Gainesville to Des Moines

  • How far is Gainesville Regional to Des Moines by plane?

    Gainesville Regional and Des Moines are 1037.9 mi apart from one another. By plane, this route typically takes 6h 40m.

  • When did momondo last update prices for flights from Gainesville Regional Airport to Des Moines Airport?

    Prices for flights from Gainesville Regional Airport to Des Moines Airport were last updated today.

  • How old do you have to be to fly from Gainesville Regional Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Gainesville Regional Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Osceola
Urbandale
Newton
Johnston
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Gainesville to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Gainesville to Des Moines for you.

Can I find flights from Gainesville to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Gainesville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Gainesville to Des Moines?

Once all potential Gainesville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Gainesville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Gainesville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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