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Cheap flights from Gainesville to Des Moines from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Gainesville to Des Moines departing on 5/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Gainesville to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:30 am - 1:11 pm
GNV
-
DSM
7h 41m
1 stop
American Airlines Logo
12:00 pm - 11:59 pm
DSM
-
GNV
10h 59m
2 stops
$446American Airlines
Fri, Apr 24 - Sat, Apr 25
American Airlines Logo
6:00 am - 4:31 pm
GNV
-
DSM
11h 31m
2 stops
American Airlines Logo
8:56 am - 7:33 pm
DSM
-
GNV
9h 37m
2 stops
$491American Airlines
Fri, Apr 24 - Sat, Apr 25
American Airlines Logo
6:30 am - 1:11 pm
GNV
-
DSM
7h 41m
1 stop
American Airlines Logo
7:05 am - 2:41 pm
DSM
-
GNV
6h 36m
1 stop
$516American Airlines
Fri, Apr 24 - Sat, Apr 25
American Airlines Logo
4:54 pm - 9:21 pm
GNV
-
DSM
5h 27m
1 stop
American Airlines Logo
12:28 pm - 11:59 pm
DSM
-
GNV
10h 31m
2 stops
$732American Airlines
Tue, Mar 10 - Sat, Mar 14
American Airlines Logo
6:00 am - 1:18 pm
GNV
-
DSM
8h 18m
2 stops
American Airlines Logo
12:28 pm - 11:59 pm
DSM
-
GNV
10h 31m
2 stops
$737American Airlines
Tue, Mar 10 - Sat, Mar 14
American Airlines Logo
4:15 pm - 11:42 pm
GNV
-
DSM
8h 27m
1 stop
American Airlines Logo
3:26 pm - 11:00 pm
DSM
-
GNV
6h 34m
1 stop
$769American Airlines
Tue, Mar 10 - Sat, Mar 14

American Airlines flights from Gainesville to Des Moines

Our best American Airlines deals on Gainesville to Des Moines flight tickets
American Airlines
Apr 24
GNV6:30 amGainesville Regional
7h 41m
1 stop
DSM1:11 pmDes Moines
Apr 25
DSM12:00 pmDes Moines
10h 59m
2 stops
GNV11:59 pmGainesville Regional
$446
American Airlines
Apr 24
GNV6:00 amGainesville Regional
11h 31m
2 stops
DSM4:31 pmDes Moines
Apr 25
DSM8:56 amDes Moines
9h 37m
2 stops
GNV7:33 pmGainesville Regional
$491
American Airlines
Apr 24
GNV6:30 amGainesville Regional
7h 41m
1 stop
DSM1:11 pmDes Moines
Apr 25
DSM7:05 amDes Moines
6h 36m
1 stop
GNV2:41 pmGainesville Regional
$516

momondo Fare Finder

 
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Fri 4/24

6:30 am-1:11 pm

1 stop7h 41m

Des Moines

Sat 4/25

12:00 pm-11:59 pm

2 stops10h 59m

$446

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Fri 4/24

6:00 am-4:31 pm

2 stops11h 31m

Des Moines

Sat 4/25

8:56 am-7:33 pm

2 stops9h 37m

$491

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Fri 4/24

6:30 am-1:11 pm

1 stop7h 41m

Des Moines

Sat 4/25

7:05 am-2:41 pm

1 stop6h 36m

$516

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 3/10

4:54 pm-9:21 pm

1 stop5h 27m

Des Moines

Sat 3/14

12:28 pm-11:59 pm

2 stops10h 31m

$732

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 3/10

6:00 am-1:18 pm

2 stops8h 18m

Des Moines

Sat 3/14

12:28 pm-11:59 pm

2 stops10h 31m

$737

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 3/10

4:15 pm-11:42 pm

1 stop8h 27m

Des Moines

Sat 3/14

3:26 pm-11:00 pm

1 stop6h 34m

$769

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Fri 5/8

5:14 pm-11:59 pm

1 stop7h 45m

$274

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 5/7

7:05 pm-10:32 pm

1 stop4h 27m

$284

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sat 5/9

1:11 pm-8:36 pm

2 stops8h 25m

$289

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 5/7

6:30 am-1:46 pm

2 stops8h 16m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Gainesville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Gainesville Regional to Des Moines?

Delta and American Airlines are the most popular carriers operating from Gainesville Regional to Des Moines

What airlines fly to Des Moines?

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to Des Moines from Gainesville according to our data. Allegiant Air is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 6 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Gainesville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Gainesville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Gainesville to Des Moines (GNV to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Gainesville to Des Moines

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Gainesville to Des Moines takes 4h 31m
There are no direct flights from Gainesville to Des Moines. There are no popular flight routes from Gainesville to Des Moines.
Search flight deals

  • How far is Gainesville Regional to Des Moines by plane?

    Gainesville Regional and Des Moines are 1037.9 mi apart from one another. By plane, this route typically takes 4h 31m.

  • When did momondo last update prices for flights from Gainesville Regional Airport to Des Moines Airport?

    Prices for flights from Gainesville Regional Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Gainesville Regional Airport to Des Moines Airport?

  • How old do you have to be to fly from Gainesville Regional Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Gainesville Regional Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Gainesville to Des Moines?

Best airlines flying from Gainesville to Des Moines

Compare and see reviews for airlines that fly from Gainesville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $394Free CancellationRating
7.1
11,345 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Gainesville to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Gainesville to Des Moines for you.

Can I find flights from Gainesville to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Gainesville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Gainesville to Des Moines?

Once all potential Gainesville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Gainesville to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Gainesville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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