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Cheap flights from Florida Keys to South Carolina from $45

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florida Keys to South Carolina departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florida Keys to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 8:18 am
MIA
-
CLT
2h 18mnonstop
Frontier Logo
9:19 pm - 11:29 pm
CLT
-
MIA
2h 10mnonstop
$80Frontier
Fri, Jan 16 - Sun, Jan 25
Spirit Airlines Logo
10:06 am - 12:22 pm
MIA
-
CLT
2h 16mnonstop
Spirit Airlines Logo
7:00 am - 9:10 am
CLT
-
MIA
2h 10mnonstop
$81Spirit Airlines
Fri, Jan 9 - Sun, Jan 11
Frontier Logo
7:30 am - 9:47 am
MIA
-
CLT
2h 17mnonstop
Frontier Logo
9:37 pm - 11:49 pm
CLT
-
MIA
2h 12mnonstop
$88Frontier
Wed, Mar 25 - Fri, Mar 27
Multiple Airlines Logo
6:00 am - 8:18 am
MIA
-
CLT
2h 18mnonstop
Multiple Airlines Logo
3:15 pm - 11:59 pm
CLT
-
MIA
8h 44m1 stop
$95Multiple Airlines
Fri, Jan 16 - Sun, Jan 25
Multiple Airlines Logo
5:54 pm - 8:09 pm
MIA
-
CLT
2h 15mnonstop
Multiple Airlines Logo
1:30 pm - 3:43 pm
CLT
-
MIA
2h 13mnonstop
$99Multiple Airlines
Wed, Jan 7 - Thu, Jan 8
American Airlines Logo
10:10 pm - 11:59 pm
MIA
-
CHS
1h 49mnonstop
American Airlines Logo
8:10 pm - 10:05 pm
CHS
-
MIA
1h 55mnonstop
$107American Airlines
Fri, Feb 13 - Mon, Feb 16
American Airlines Logo
10:08 pm - 11:58 pm
MIA
-
CHS
1h 50mnonstop
American Airlines Logo
7:20 pm - 9:17 pm
CHS
-
MIA
1h 57mnonstop
$117American Airlines
Fri, Jan 16 - Mon, Jan 19
Southwest Logo
7:55 am - 12:50 pm
MIA
-
CHS
4h 55m1 stop
Southwest Logo
12:55 pm - 10:25 pm
CHS
-
MIA
9h 30m1 stop
$156Southwest
Fri, Jan 9 - Sun, Jan 11
Delta Logo
8:15 am - 2:06 pm
MIA
-
CHS
5h 51m1 stop
Delta Logo
3:28 pm - 9:41 pm
CHS
-
MIA
6h 13m1 stop
$157Delta
Wed, Jan 21 - Wed, Jan 28
Delta Logo
7:15 am - 11:29 am
MIA
-
SAV
4h 14m1 stop
Delta Logo
5:30 am - 9:26 am
SAV
-
MIA
3h 56m1 stop
$159Delta
Sat, Jan 24 - Sat, Jan 31

Frontier flights from Florida Keys to South Carolina

Our best Frontier deals on Florida Keys to South Carolina flight tickets
Frontier
Jan 9
MIA7:05 amMiami
2h 31m
CLT9:36 amCharlotte Douglas
Jan 11
CLT1:30 pmCharlotte Douglas
2h 13m
MIA3:43 pmMiami
$81
Find similar
Frontier
Mar 25
MIA7:30 amMiami
2h 17m
CLT9:47 amCharlotte Douglas
Mar 27
CLT9:37 pmCharlotte Douglas
2h 12m
MIA11:49 pmMiami
$88
Find similar
Frontier
Jan 22
MIA8:00 amMiami
2h 23m
CLT10:23 amCharlotte Douglas
Jan 24
CLT10:55 amCharlotte Douglas
8h 35m
1 stop
MIA7:30 pmMiami
$93
Find similar

Spirit Airlines flights from Florida Keys to South Carolina

Our best Spirit Airlines deals on Florida Keys to South Carolina flight tickets
Spirit Airlines
Feb 14
MIA10:05 amMiami
2h 15m
CLT12:20 pmCharlotte Douglas
Feb 18
CLT7:00 amCharlotte Douglas
2h 10m
MIA9:10 amMiami
$80
Find similar
Spirit Airlines
Jan 9
MIA10:06 amMiami
2h 16m
CLT12:22 pmCharlotte Douglas
Jan 11
CLT7:00 amCharlotte Douglas
2h 10m
MIA9:10 amMiami
$81
Find similar
Spirit Airlines
Jan 17
MIA10:06 amMiami
2h 16m
CLT12:22 pmCharlotte Douglas
Jan 20
CLT3:15 pmCharlotte Douglas
8h 44m
1 stop
MIA11:59 pmMiami
$98
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Florida Keys to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 1/16

6:00 am-8:18 am

Nonstop2h 18m

Charlotte Douglas

Sun 1/25

9:19 pm-11:29 pm

Nonstop2h 10m

$80

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 1/9

10:06 am-12:22 pm

Nonstop2h 16m

Charlotte Douglas

Sun 1/11

7:00 am-9:10 am

Nonstop2h 10m

$81

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Wed 3/25

7:30 am-9:47 am

Nonstop2h 17m

Charlotte Douglas

Fri 3/27

9:37 pm-11:49 pm

Nonstop2h 12m

$88

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 1/16

6:00 am-8:18 am

Nonstop2h 18m

Charlotte Douglas

Sun 1/25

3:15 pm-11:59 pm

1 stop8h 44m

$95

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Wed 1/7

5:54 pm-8:09 pm

Nonstop2h 15m

Charlotte Douglas

Thu 1/8

1:30 pm-3:43 pm

Nonstop2h 13m

$99

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 2/13

10:10 pm-11:59 pm

Nonstop1h 49m

Charleston

Mon 2/16

8:10 pm-10:05 pm

Nonstop1h 55m

$107

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 1/16

10:08 pm-11:58 pm

Nonstop1h 50m

Charleston

Mon 1/19

7:20 pm-9:17 pm

Nonstop1h 57m

$117

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 1/9

7:55 am-12:50 pm

1 stop4h 55m

Charleston

Sun 1/11

12:55 pm-10:25 pm

1 stop9h 30m

$156

MiamiCharleston

MIA - CHS

MIACHS

Miami

Wed 1/21

8:15 am-2:06 pm

1 stop5h 51m

Charleston

Wed 1/28

3:28 pm-9:41 pm

1 stop6h 13m

$157

MiamiSavannah

MIA - SAV

MIASAV

Miami

Sat 1/24

7:15 am-11:29 am

1 stop4h 14m

Savannah/Hilton Head

Sat 1/31

5:30 am-9:26 am

1 stop3h 56m

$159

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Florida Keys to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Florida Keys is in October. Flight prices, which tend to average around $178, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of October, then book flights to South Carolina from Florida Keys during January instead. Flights to South Carolina in January, while not as cheap as those in October, still average around $197.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $538. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $616.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Florida Keys to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $518. Try not to purchase tickets in the morning because they tend to be around $571. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Florida Keys when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $253 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Florida Keys for as low as $181 on momondo.

Can stopping save me money on Florida Keys to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Florida Keys to South Carolina.

Cheap Florida Keys to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florida Keys to South Carolina

Fastest flight time

1h 43m

Direct flights

Every day

Airports in South Carolina

57 airports
The fastest flight from Florida Keys to South Carolina takes 1h 43m
Direct flights go from Florida Keys to South Carolina every day.
There are 57 airports in South Carolina. From Florida Keys there are direct flights to Greenville (GSP), Savannah/Hilton Head (SAV), Charleston (CHS).
Search flight deals

  • When did momondo last update prices for flights from Florida Keys to South Carolina?

    Prices for flights from Florida Keys to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Florida Keys to South Carolina?

  • How old do you have to be to fly from Florida Keys to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florida Keys to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Florida Keys to South Carolina?

Best airlines flying from Florida Keys to South Carolina

Compare and see reviews for airlines that fly from Florida Keys to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $387Free CancellationRating
7.2
11,067 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Florida Keys to South Carolina?

It is quick and easy to find Florida Keys to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Florida Keys to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Florida Keys on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florida Keys to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Florida Keys. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Florida Keys to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florida Keys to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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