Cheap flights from Florida Keys to Knoxville from $82

The month of July is, on average, the cheapest month to fly to Knoxville from Florida Keys, with most prices found around $261. If you aren’t able to travel during the month of July, then book flights to Knoxville from Florida Keys during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $297.

The cheapest day to depart from Florida Keys to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $331. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Florida Keys to Knoxville for around $687.

At noon is the cheapest time of day to fly from Florida Keys to Knoxville when you can find flight prices for as low as $376. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $417.

Fly from Key West to Knoxville McGhee Tyson for the best Florida Keys - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Florida Keys when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $379 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Florida Keys for as low as $238 on momondo.

There is only 1 cabin class available to choose from on Florida Keys to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Southwest, and Allegiant Air are the most popular carriers operating from Florida Keys to Knoxville McGhee Tyson

Allegiant Air, Delta and American Airlines are the top three most popular airlines that fly to Knoxville from Florida Keys according to our data. Allegiant Air is the first choice among our users, with 51% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

As of February 2026, 2 flights take off from Florida Keys and land in Knoxville each day. The most common flight departure time for this route is 11:00AM, with 100% of daily flights taking off at noon.

As of February 2026, 19 flights take off from Florida Keys and land in Knoxville each week. The most common flight departure day for this route is Mon, with 21% of weekly flights taking off on this day.