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Cheap flights from Florida Keys to Knoxville from $76

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florida Keys to Knoxville departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florida Keys to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:19 am - 5:53 pm
MIA
-
TYS
7h 34m1 stop
Multiple Airlines Logo
1:39 pm - 4:40 pm
TYS
-
MIA
27h 01m1 stop
$153Multiple Airlines
Thu, Jan 15 - Sun, Jan 18
Allegiant Air Logo
5:41 pm - 7:56 pm
EYW
-
TYS
2h 15mnonstop
Allegiant Air Logo
9:00 am - 2:56 pm
TYS
-
EYW
5h 56m1 stop
$169Allegiant Air
Fri, Jan 16 - Sun, Jan 18
Multiple Airlines Logo
5:41 pm - 7:56 pm
EYW
-
TYS
2h 15mnonstop
Multiple Airlines Logo
1:39 pm - 9:09 am
TYS
-
EYW
19h 30m2 stops
$177Multiple Airlines
Fri, Jan 16 - Sun, Jan 18
Multiple Airlines Logo
5:01 am - 5:53 pm
MIA
-
TYS
12h 52m1 stop
Multiple Airlines Logo
1:39 pm - 6:50 pm
TYS
-
MIA
29h 11m1 stop
$178Multiple Airlines
Sun, Jan 18 - Sun, Jan 25
American Airlines Logo
9:34 pm - 11:59 pm
MIA
-
TYS
2h 25mnonstop
American Airlines Logo
6:20 am - 8:38 am
TYS
-
MIA
2h 18mnonstop
$179American Airlines
Thu, Jan 22 - Sun, Jan 25
Multiple Airlines Logo
6:00 am - 5:53 pm
MIA
-
TYS
11h 53m1 stop
Multiple Airlines Logo
1:39 pm - 6:50 pm
TYS
-
MIA
29h 11m1 stop
$180Multiple Airlines
Sun, Feb 1 - Sun, Feb 8
American Airlines Logo
9:34 pm - 11:59 pm
MIA
-
TYS
2h 25mnonstop
American Airlines Logo
6:20 am - 8:38 am
TYS
-
MIA
2h 18mnonstop
$182American Airlines
Thu, Jan 22 - Sun, Jan 25
Multiple Airlines Logo
10:19 am - 5:53 pm
MIA
-
TYS
7h 34m1 stop
Multiple Airlines Logo
1:39 pm - 2:15 pm
TYS
-
MIA
24h 36m2 stops
$185Multiple Airlines
Thu, Jan 15 - Sun, Jan 18
American Airlines Logo
4:37 pm - 11:59 pm
EYW
-
TYS
7h 22m1 stop
American Airlines Logo
12:17 pm - 6:01 pm
TYS
-
EYW
5h 44m1 stop
$251American Airlines
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
7:45 pm - 11:59 pm
EYW
-
TYS
4h 14m1 stop
American Airlines Logo
6:02 am - 10:58 am
TYS
-
EYW
4h 56m1 stop
$275American Airlines
Wed, Feb 11 - Sun, Feb 15

American Airlines flights from Florida Keys to Knoxville

Our best American Airlines deals on Florida Keys to Knoxville flight tickets
American Airlines
Jan 22
MIA9:34 pmMiami
2h 25m
TYS11:59 pmKnoxville McGhee Tyson
Jan 25
TYS6:20 amKnoxville McGhee Tyson
2h 18m
MIA8:38 amMiami
$179
Find similar
American Airlines
Jan 22
MIA9:34 pmMiami
2h 25m
TYS11:59 pmKnoxville McGhee Tyson
Jan 25
TYS6:20 amKnoxville McGhee Tyson
2h 18m
MIA8:38 amMiami
$182
Find similar
American Airlines
Jan 22
MIA4:03 pmMiami
6h 51m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
Jan 25
TYS6:20 amKnoxville McGhee Tyson
2h 18m
MIA8:38 amMiami
$215
Find similar

Delta flights from Florida Keys to Knoxville

Our best Delta deals on Florida Keys to Knoxville flight tickets
Delta
Jan 21
MIA5:50 amMiami
5h 18m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Jan 25
TYS5:40 amKnoxville McGhee Tyson
5h 00m
1 stop
MIA10:40 amMiami
$199
Find similar
Delta
Jan 8
MIA5:50 amMiami
4h 25m
1 stop
TYS10:15 amKnoxville McGhee Tyson
Feb 4
TYS5:40 amKnoxville McGhee Tyson
3h 46m
1 stop
MIA9:26 amMiami
$244
Find similar
Delta
Jan 28
MIA8:15 amMiami
5h 35m
1 stop
TYS1:50 pmKnoxville McGhee Tyson
Feb 1
TYS6:41 pmKnoxville McGhee Tyson
4h 07m
1 stop
MIA10:48 pmMiami
$249
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/15

10:19 am-5:53 pm

1 stop7h 34m

Knoxville McGhee Tyson

Sun 1/18

1:39 pm-4:40 pm

1 stop27h 01m

$153

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

5:41 pm-7:56 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Sun 1/18

9:00 am-2:56 pm

1 stop5h 56m

$169

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

5:41 pm-7:56 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Sun 1/18

1:39 pm-9:09 am

2 stops19h 30m

$177

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 1/18

5:01 am-5:53 pm

1 stop12h 52m

Knoxville McGhee Tyson

Sun 1/25

1:39 pm-6:50 pm

1 stop29h 11m

$178

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/22

9:34 pm-11:59 pm

Nonstop2h 25m

Knoxville McGhee Tyson

Sun 1/25

6:20 am-8:38 am

Nonstop2h 18m

$179

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 2/1

6:00 am-5:53 pm

1 stop11h 53m

Knoxville McGhee Tyson

Sun 2/8

1:39 pm-6:50 pm

1 stop29h 11m

$180

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/22

9:34 pm-11:59 pm

Nonstop2h 25m

Knoxville McGhee Tyson

Sun 1/25

6:20 am-8:38 am

Nonstop2h 18m

$182

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/15

10:19 am-5:53 pm

1 stop7h 34m

Knoxville McGhee Tyson

Sun 1/18

1:39 pm-2:15 pm

2 stops24h 36m

$185

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

4:37 pm-11:59 pm

1 stop7h 22m

Knoxville McGhee Tyson

Sun 1/18

12:17 pm-6:01 pm

1 stop5h 44m

$251

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 2/11

7:45 pm-11:59 pm

1 stop4h 14m

Knoxville McGhee Tyson

Sun 2/15

6:02 am-10:58 am

1 stop4h 56m

$275

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Florida Keys to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Florida Keys, with most prices found around $226. If you aren’t able to travel during the month of July, then book flights to Knoxville from Florida Keys during February instead. Flights to Knoxville in February, while not as cheap as those in July, still average around $241.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Florida Keys to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $331. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Florida Keys to Knoxville for around $687.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Florida Keys to Knoxville when you can find flight prices for as low as $383. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $409.

What is the cheapest Florida Keys to Knoxville McGhee Tyson flight route?

Fly from Key West to Knoxville McGhee Tyson for the best Florida Keys - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Florida Keys when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $367 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Florida Keys for as low as $252 on momondo.

What cabin class options are available on Florida Keys to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Florida Keys to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Florida Keys to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Florida Keys to Knoxville.

Cheap Florida Keys to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florida Keys to Knoxville

Fastest flight time

2h 16m

Direct flights

Every day

Airports in Knoxville

1 airport
The fastest flight from Florida Keys to Knoxville takes 2h 16m
Direct flights go from Florida Keys to Knoxville every day.
There is 1 airport in Knoxville. From Florida Keys there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • When did momondo last update prices for flights from Florida Keys to Knoxville McGhee Tyson Airport?

    Prices for flights from Florida Keys to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Florida Keys to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Florida Keys to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florida Keys to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Florida Keys to Knoxville?

Best airlines flying from Florida Keys to Knoxville

Compare and see reviews for airlines that fly from Florida Keys to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $253Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $298Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Florida Keys to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Florida Keys to Knoxville for you.

Can I find flights from Florida Keys to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Florida Keys on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florida Keys to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Florida Keys. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Florida Keys to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Florida Keys are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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