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Cheap flights from Florence, South Carolina to Chicago from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Chicago departing on 6/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:20 am - 10:44 am
FLO
-
ORD
6h 24m
1 stop
American Airlines Logo
3:26 pm - 9:47 pm
ORD
-
FLO
5h 21m
1 stop
$339American Airlines
Sat, May 16 - Wed, May 20
American Airlines Logo
5:20 am - 8:30 am
FLO
-
ORD
4h 10m
1 stop
American Airlines Logo
8:39 am - 3:32 pm
ORD
-
FLO
5h 53m
1 stop
$380American Airlines
Fri, May 15 - Tue, May 19
American Airlines Logo
2:35 pm - 7:48 pm
FLO
-
ORD
6h 13m
1 stop
American Airlines Logo
7:58 am - 2:10 pm
ORD
-
FLO
5h 12m
1 stop
$382American Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
4:16 pm - 10:17 pm
FLO
-
ORD
7h 01m
2 stops
American Airlines Logo
3:26 pm - 10:42 pm
ORD
-
FLO
6h 16m
1 stop
$385American Airlines
Fri, May 15 - Tue, May 19
American Airlines Logo
5:05 am - 9:02 am
FLO
-
ORD
4h 57m
1 stop
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
$387American Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
5:20 am - 8:30 am
FLO
-
ORD
4h 10m
1 stop
American Airlines Logo
4:17 pm - 9:47 pm
ORD
-
FLO
4h 30m
1 stop
$421American Airlines
Thu, May 14 - Mon, May 18
American Airlines Logo
5:05 am - 9:02 am
FLO
-
ORD
4h 57m
1 stop
American Airlines Logo
6:55 am - 2:10 pm
ORD
-
FLO
6h 15m
1 stop
$437American Airlines
Thu, May 21 - Mon, May 25
American Airlines Logo
5:20 am - 10:44 am
FLO
-
ORD
6h 24m
1 stop
American Airlines Logo
6:55 am - 2:10 pm
ORD
-
FLO
6h 15m
1 stop
$439American Airlines
Sun, May 17 - Thu, May 21
American Airlines Logo
5:05 am - 10:47 am
FLO
-
ORD
6h 42m
1 stop
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
$442American Airlines
Thu, May 21 - Mon, May 25
American Airlines Logo
5:20 am - 8:30 am
FLO
-
ORD
4h 10m
1 stop
American Airlines Logo
6:40 am - 2:10 pm
ORD
-
FLO
6h 30m
2 stops
$444American Airlines
Sun, May 17 - Thu, May 21

American Airlines flights from Florence, South Carolina to Chicago

Our best American Airlines deals on Florence, South Carolina to Chicago flight tickets
American Airlines
May 16
FLO5:20 amFlorence
6h 24m
1 stop
ORD10:44 amChicago O'Hare Intl
May 20
ORD3:26 pmChicago O'Hare Intl
5h 21m
1 stop
FLO9:47 pmFlorence
$339
American Airlines
May 15
FLO5:20 amFlorence
4h 10m
1 stop
ORD8:30 amChicago O'Hare Intl
May 19
ORD8:39 amChicago O'Hare Intl
5h 53m
1 stop
FLO3:32 pmFlorence
$380
American Airlines
May 28
FLO2:35 pmFlorence
6h 13m
1 stop
ORD7:48 pmChicago O'Hare Intl
May 31
ORD7:58 amChicago O'Hare Intl
5h 12m
1 stop
FLO2:10 pmFlorence
$382

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 3, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 5/16

5:20 am-10:44 am

1 stop6h 24m

Chicago O'Hare Intl

Wed 5/20

3:26 pm-9:47 pm

1 stop5h 21m

$339

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 5/15

5:20 am-8:30 am

1 stop4h 10m

Chicago O'Hare Intl

Tue 5/19

8:39 am-3:32 pm

1 stop5h 53m

$380

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/28

2:35 pm-7:48 pm

1 stop6h 13m

Chicago O'Hare Intl

Sun 5/31

7:58 am-2:10 pm

1 stop5h 12m

$382

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 5/15

4:16 pm-10:17 pm

2 stops7h 01m

Chicago O'Hare Intl

Tue 5/19

3:26 pm-10:42 pm

1 stop6h 16m

$385

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/28

5:05 am-9:02 am

1 stop4h 57m

Chicago O'Hare Intl

Sun 5/31

5:00 am-2:10 pm

2 stops8h 10m

$387
Quickest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/14

5:20 am-8:30 am

1 stop4h 10m

Chicago O'Hare Intl

Mon 5/18

4:17 pm-9:47 pm

1 stop4h 30m

$421

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/21

5:05 am-9:02 am

1 stop4h 57m

Chicago O'Hare Intl

Mon 5/25

6:55 am-2:10 pm

1 stop6h 15m

$437

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 5/17

5:20 am-10:44 am

1 stop6h 24m

Chicago O'Hare Intl

Thu 5/21

6:55 am-2:10 pm

1 stop6h 15m

$439

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 5/21

5:05 am-10:47 am

1 stop6h 42m

Chicago O'Hare Intl

Mon 5/25

5:00 am-2:10 pm

2 stops8h 10m

$442

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sun 5/17

5:20 am-8:30 am

1 stop4h 10m

Chicago O'Hare Intl

Thu 5/21

6:40 am-2:10 pm

2 stops6h 30m

$444

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Florence, South Carolina to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Florence to Chicago?

American Airlines is the most popular carrier operating from Florence to Chicago

What airlines fly to Chicago?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Chicago from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 6 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Chicago

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Chicago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Chicago (FLO to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Chicago

Fastest flight time

6h 13m

Direct flights

None
The fastest flight from Florence, South Carolina to Chicago takes 6h 13m
There are no direct flights from Florence, South Carolina to Chicago. There are no popular flight routes from Florence, South Carolina to Chicago.
Search flight deals

Frequently asked questions about flying from Florence, South Carolina to Chicago

  • How far is Florence to Chicago by plane?

    A flight from Florence to Chicago will travel around 680.6 mi. In terms of flight time, this usually takes a little over 6h 13m.

  • When did momondo last update prices for flights from Florence Airport to Chicago?

    Prices for flights from Florence Airport to Chicago are updated daily.

  • How many operators does momondo search for flights from Florence Airport to Chicago?

  • How old do you have to be to fly from Florence Airport to Chicago?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The travel and health documents you'll need for your trip to Chicago may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Florence, South Carolina to Chicago

Compare and see reviews for airlines that fly from Florence, South Carolina to Chicago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $176Free CancellationRating
7.1
11,672 reviews
Search American Airlines flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
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Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Chicago?

Finding the right flight to Chicago from Florence is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Florence to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Florence to Chicago.

I’m not ready to book a flight from Florence to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Airports listed have a maximum distance of 78.5 mi from Chicago
Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport