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Cheap flights from Florence, South Carolina to Chicago from $355

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Chicago departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Florence, South Carolina to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:22 am - 10:51 am-
5h 29m
American Airlines Logo
7:30 am - 2:56 pm-
6h 26m
$355American Airlines
Tue, Sep 1 - Mon, Sep 7
American Airlines Logo
6:22 am - 10:51 am-
5h 29m
American Airlines Logo
7:30 am - 2:56 pm-
6h 26m
$402American Airlines
Tue, Sep 1 - Mon, Sep 7
American Airlines Logo
9:00 am - 2:20 pm-
6h 20m
American Airlines Logo
8:54 am - 2:12 pm-
4h 18m
$427American Airlines
Sat, Sep 5 - Sun, Sep 6
American Airlines Logo
2:35 pm - 8:03 pm-
6h 28m
American Airlines Logo
8:05 am - 2:09 pm-
5h 04m
$507American Airlines
Fri, Nov 27 - Tue, Dec 1
American Airlines Logo
5:15 am - 9:08 am-
4h 53m
American Airlines Logo
6:40 pm - 12:03 am-
4h 23m
$507American Airlines
Fri, Dec 11 - Tue, Dec 15
American Airlines Logo
2:35 pm - 8:04 pm-
6h 29m
American Airlines Logo
8:05 am - 3:09 pm-
6h 04m
$507American Airlines
Fri, Nov 6 - Mon, Nov 9
American Airlines Logo
3:22 pm - 9:57 pm-
7h 35m
American Airlines Logo
7:30 am - 2:56 pm-
6h 26m
$553American Airlines
Sat, Aug 15 - Wed, Aug 19
American Airlines Logo
6:22 am - 12:12 pm-
6h 50m
American Airlines Logo
7:30 am - 2:56 pm-
6h 26m
$584American Airlines
Tue, Sep 1 - Mon, Sep 7
American Airlines Logo
3:22 pm - 7:46 pm-
5h 24m
American Airlines Logo
5:49 pm - 10:59 pm-
4h 10m
$645American Airlines
Thu, Aug 27 - Mon, Aug 31

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American Airlines flights from Florence, South Carolina to Chicago

Our best American Airlines deals on Florence, South Carolina to Chicago flight tickets
American Airlines
Sep 1
FLO6:22 amFlorence
5h 29m
1 stop
ORD10:51 amChicago O'Hare Intl
Sep 7
ORD7:30 amChicago O'Hare Intl
6h 26m
1 stop
FLO2:56 pmFlorence
$355
American Airlines
Sep 1
FLO6:22 amFlorence
5h 29m
1 stop
ORD10:51 amChicago O'Hare Intl
Sep 7
ORD7:30 amChicago O'Hare Intl
6h 26m
1 stop
FLO2:56 pmFlorence
$402
American Airlines
Sep 5
FLO9:00 amFlorence
6h 20m
1 stop
ORD2:20 pmChicago O'Hare Intl
Sep 6
ORD8:54 amChicago O'Hare Intl
4h 18m
1 stop
FLO2:12 pmFlorence
$427

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 9/1

6:22 am-10:51 am

1 stop5h 29m

Chicago O'Hare Intl

Mon 9/7

7:30 am-2:56 pm

1 stop6h 26m

$355

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 9/1

6:22 am-10:51 am

1 stop5h 29m

Chicago O'Hare Intl

Mon 9/7

7:30 am-2:56 pm

1 stop6h 26m

$402

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 9/5

9:00 am-2:20 pm

1 stop6h 20m

Chicago O'Hare Intl

Sun 9/6

8:54 am-2:12 pm

1 stop4h 18m

$427

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 11/27

2:35 pm-8:03 pm

1 stop6h 28m

Chicago O'Hare Intl

Tue 12/1

8:05 am-2:09 pm

1 stop5h 04m

$507
Quickest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 12/11

5:15 am-9:08 am

1 stop4h 53m

Chicago O'Hare Intl

Tue 12/15

6:40 pm-12:03 am

1 stop4h 23m

$507

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 11/6

2:35 pm-8:04 pm

1 stop6h 29m

Chicago O'Hare Intl

Mon 11/9

8:05 am-3:09 pm

1 stop6h 04m

$507

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 8/15

3:22 pm-9:57 pm

1 stop7h 35m

Chicago O'Hare Intl

Wed 8/19

7:30 am-2:56 pm

1 stop6h 26m

$553

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 9/1

6:22 am-12:12 pm

2 stops6h 50m

Chicago O'Hare Intl

Mon 9/7

7:30 am-2:56 pm

1 stop6h 26m

$584

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 8/27

3:22 pm-7:46 pm

1 stop5h 24m

Chicago O'Hare Intl

Mon 8/31

5:49 pm-10:59 pm

1 stop4h 10m

$645

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Chicago from

How to get the cheapest flight ticket from Florence, South Carolina to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Chicago?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Chicago from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 6 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Chicago

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Chicago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Chicago (FLO to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Chicago

Fastest flight time

4h 53m

Direct flights

None
The fastest flight from Florence, South Carolina to Chicago takes 4h 53m
There are no direct flights from Florence, South Carolina to Chicago. There are no popular flight routes from Florence, South Carolina to Chicago.
Search flight deals

Frequently asked questions about flying from Florence, South Carolina to Chicago

  • How far is Florence to Chicago by plane?

    A flight from Florence to Chicago will travel around 680.6 mi. In terms of flight time, this usually takes a little over 4h 53m.

  • When did momondo last update prices for flights from Florence Airport to Chicago?

    Prices for flights from Florence Airport to Chicago are updated daily.

  • How old do you have to be to fly from Florence Airport to Chicago?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The travel and health documents you'll need for your trip to Chicago may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Portage
Benton Harbor
Lansing
Saint Joseph
Valparaiso
Schererville
Munster
Chesterton
Monticello
Crown Point
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Chicago?

Finding the right flight to Chicago from Florence is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Florence to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Florence to Chicago.

I’m not ready to book a flight from Florence to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Airports listed have a maximum distance of 78.5 mi from Chicago
Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport