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Cheap flights from Florence, South Carolina to Chicago from $357

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Chicago departing on 7/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Florence, South Carolina to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:17 am - 11:00 am
FLO
-
ORD
6h 43m
1 stop
American Airlines Logo
5:45 pm - 11:37 pm
ORD
-
FLO
4h 52m
1 stop
$357American Airlines
Wed, Jul 22 - Fri, Jul 24
American Airlines Logo
5:17 am - 11:00 am
FLO
-
ORD
6h 43m
1 stop
American Airlines Logo
6:30 am - 2:10 pm
ORD
-
FLO
6h 40m
1 stop
$359American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
6:22 am - 12:15 pm
FLO
-
ORD
6h 53m
1 stop
American Airlines Logo
7:30 am - 2:12 pm
ORD
-
FLO
5h 42m
1 stop
$391American Airlines
Fri, Aug 28 - Sun, Aug 30
American Airlines Logo
2:35 pm - 7:45 pm
FLO
-
ORD
6h 10m
1 stop
American Airlines Logo
8:00 am - 2:10 pm
ORD
-
FLO
5h 10m
1 stop
$405American Airlines
Wed, Jul 1 - Sun, Jul 5
American Airlines Logo
5:17 am - 9:02 am
FLO
-
ORD
4h 45m
1 stop
American Airlines Logo
9:00 am - 2:10 pm
ORD
-
FLO
4h 10m
1 stop
$575American Airlines
Fri, Jul 17 - Thu, Jul 23
American Airlines Logo
2:35 pm - 7:51 pm
FLO
-
ORD
6h 16m
1 stop
American Airlines Logo
5:00 am - 2:10 pm
ORD
-
FLO
8h 10m
2 stops
$581American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
2:35 pm - 7:51 pm
FLO
-
ORD
6h 16m
1 stop
American Airlines Logo
8:00 am - 2:10 pm
ORD
-
FLO
5h 10m
1 stop
$612American Airlines
Fri, Jul 17 - Thu, Jul 23
American Airlines Logo
5:05 am - 11:34 am
FLO
-
ORD
7h 29m
2 stops
American Airlines Logo
8:00 am - 2:10 pm
ORD
-
FLO
5h 10m
1 stop
$627American Airlines
Wed, Jul 1 - Sun, Jul 5
American Airlines Logo
5:17 am - 11:33 am
FLO
-
ORD
7h 16m
2 stops
American Airlines Logo
6:30 am - 2:10 pm
ORD
-
FLO
6h 40m
1 stop
$639American Airlines
Fri, Jul 24 - Mon, Jul 27
American Airlines Logo
3:22 pm - 7:46 pm
FLO
-
ORD
5h 24m
1 stop
American Airlines Logo
6:45 am - 2:12 pm
ORD
-
FLO
6h 27m
2 stops
$651American Airlines
Fri, Aug 28 - Sun, Aug 30

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American Airlines flights from Florence, South Carolina to Chicago

Our best American Airlines deals on Florence, South Carolina to Chicago flight tickets
American Airlines
Jul 22
FLO5:17 amFlorence
6h 43m
1 stop
ORD11:00 amChicago O'Hare Intl
Jul 24
ORD5:45 pmChicago O'Hare Intl
4h 52m
1 stop
FLO11:37 pmFlorence
$357
American Airlines
Jul 7
FLO5:17 amFlorence
6h 43m
1 stop
ORD11:00 amChicago O'Hare Intl
Jul 11
ORD6:30 amChicago O'Hare Intl
6h 40m
1 stop
FLO2:10 pmFlorence
$359
American Airlines
Aug 28
FLO6:22 amFlorence
6h 53m
1 stop
ORD12:15 pmChicago O'Hare Intl
Aug 30
ORD7:30 amChicago O'Hare Intl
5h 42m
1 stop
FLO2:12 pmFlorence
$391

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 7/22

5:17 am-11:00 am

1 stop6h 43m

Chicago O'Hare Intl

Fri 7/24

5:45 pm-11:37 pm

1 stop4h 52m

$357

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 7/7

5:17 am-11:00 am

1 stop6h 43m

Chicago O'Hare Intl

Sat 7/11

6:30 am-2:10 pm

1 stop6h 40m

$359

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 8/28

6:22 am-12:15 pm

1 stop6h 53m

Chicago O'Hare Intl

Sun 8/30

7:30 am-2:12 pm

1 stop5h 42m

$391

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 7/1

2:35 pm-7:45 pm

1 stop6h 10m

Chicago O'Hare Intl

Sun 7/5

8:00 am-2:10 pm

1 stop5h 10m

$405
Quickest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 7/17

5:17 am-9:02 am

1 stop4h 45m

Chicago O'Hare Intl

Thu 7/23

9:00 am-2:10 pm

1 stop4h 10m

$575

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 7/7

2:35 pm-7:51 pm

1 stop6h 16m

Chicago O'Hare Intl

Sat 7/11

5:00 am-2:10 pm

2 stops8h 10m

$581

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 7/17

2:35 pm-7:51 pm

1 stop6h 16m

Chicago O'Hare Intl

Thu 7/23

8:00 am-2:10 pm

1 stop5h 10m

$612

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 7/1

5:05 am-11:34 am

2 stops7h 29m

Chicago O'Hare Intl

Sun 7/5

8:00 am-2:10 pm

1 stop5h 10m

$627

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 7/24

5:17 am-11:33 am

2 stops7h 16m

Chicago O'Hare Intl

Mon 7/27

6:30 am-2:10 pm

1 stop6h 40m

$639

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 8/28

3:22 pm-7:46 pm

1 stop5h 24m

Chicago O'Hare Intl

Sun 8/30

6:45 am-2:12 pm

2 stops6h 27m

$651

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Chicago from

How to get the cheapest flight ticket from Florence, South Carolina to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Chicago?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Chicago from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 5 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Chicago

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Chicago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Chicago (FLO to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Chicago

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Florence, South Carolina to Chicago takes 4h 45m
There are no direct flights from Florence, South Carolina to Chicago. There are no popular flight routes from Florence, South Carolina to Chicago.
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Frequently asked questions about flying from Florence, South Carolina to Chicago

  • How far is Florence to Chicago by plane?

    A flight from Florence to Chicago will travel around 680.6 mi. In terms of flight time, this usually takes a little over 4h 45m.

  • When did momondo last update prices for flights from Florence Airport to Chicago?

    Prices for flights from Florence Airport to Chicago are updated daily.

  • How many operators does momondo search for flights from Florence Airport to Chicago?

  • How old do you have to be to fly from Florence Airport to Chicago?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The travel and health documents you'll need for your trip to Chicago may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Florence, South Carolina to Chicago

Compare and see reviews for airlines that fly from Florence, South Carolina to Chicago with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $176Free CancellationRating
7.1
11,703 reviews
Search American Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Florence to Chicago?

Finding the right flight to Chicago from Florence is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Chicago quick and easy, saving you time and money.

Can I find flights from Florence to Chicago with flexible booking policies on momondo?

Yes. All flights to Chicago from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Florence to Chicago.

I’m not ready to book a flight from Florence to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Florence to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Airports listed have a maximum distance of 78.5 mi from Chicago
Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport