Cheap flights from Detroit to South Carolina from $79

The cheapest month to fly to South Carolina from Detroit is in January. Flight prices, which tend to average around $351, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Detroit during October instead. Flights to South Carolina in October, while not as cheap as those in January, still average around $355.

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $348. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $484.

Our data shows that the cheapest Detroit to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $299. Try not to purchase tickets in the afternoon because they tend to be around $415. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $416 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit for as low as $319 on momondo.

There are 4 cabin classes available to choose from on Detroit to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Frontier, and Delta are the most popular carriers operating from Detroit to South Carolina

Delta, American Airlines and Southwest are the top three most popular airlines that fly to South Carolina from Detroit according to our data. Delta is the first choice among our users, with 74% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of August 2026, 42 flights take off from Detroit and land in South Carolina each day. The most common flight departure time for this route is 4:00PM, with 37% of daily flights taking off in the afternoon.

The number of flights available between Detroit and South Carolina is 294 per week as of August 2026. The most frequent departure day is Fri, with 18% of weekly flights leaving on this day.