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Cheap flights from Detroit to South Carolina from $44

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to South Carolina departing on 2/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
5:00 am - 2:42 pm
DTW
-
MYR
9h 42m1 stop
Spirit Airlines Logo
10:00 am - 12:19 am
MYR
-
DTW
14h 19m1 stop
$119Spirit Airlines
Wed, Feb 4 - Wed, Feb 11
Spirit Airlines Logo
5:00 am - 4:10 pm
DTW
-
CHS
11h 10m1 stop
Spirit Airlines Logo
5:05 pm - 12:19 am
CHS
-
DTW
7h 14m1 stop
$121Spirit Airlines
Mon, Jan 26 - Fri, Jan 30
Spirit Airlines Logo
5:00 am - 4:10 pm
DTW
-
CHS
11h 10m1 stop
Spirit Airlines Logo
5:05 pm - 12:19 am
CHS
-
DTW
7h 14m1 stop
$122Spirit Airlines
Thu, Feb 5 - Mon, Feb 9
Multiple Airlines Logo
2:06 pm - 7:17 pm
DTW
-
CLT
5h 11m1 stop
Multiple Airlines Logo
3:12 pm - 9:54 pm
CLT
-
DTW
6h 42m1 stop
$143Multiple Airlines
Thu, Feb 12 - Thu, Feb 19
Multiple Airlines Logo
9:18 am - 7:17 pm
DTW
-
CLT
9h 59m1 stop
Multiple Airlines Logo
3:12 pm - 9:54 pm
CLT
-
DTW
6h 42m1 stop
$144Multiple Airlines
Sun, Feb 15 - Wed, Feb 18
Delta Logo
7:05 am - 9:07 am
DTW
-
CLT
2h 02mnonstop
Delta Logo
5:25 am - 9:30 am
CLT
-
DTW
4h 05m1 stop
$149Delta
Thu, Feb 12 - Wed, Feb 18
Frontier Logo
9:04 pm - 8:03 am
DTW
-
CLT
10h 59m1 stop
Frontier Logo
9:28 pm - 9:52 am
CLT
-
DTW
12h 24m1 stop
$150Frontier
Wed, Mar 18 - Sat, Mar 28
Delta Logo
2:20 pm - 9:20 pm
DTW
-
CAE
7h 00m1 stop
Delta Logo
7:13 pm - 12:43 am
CAE
-
DTW
5h 30m1 stop
$269Delta
Fri, Mar 13 - Sun, Mar 15
American Airlines Logo
5:24 pm - 12:20 pm
DTW
-
HHH
18h 56m2 stops
American Airlines Logo
3:29 pm - 11:33 am
HHH
-
DTW
20h 04m2 stops
$284American Airlines
Wed, Jan 28 - Fri, Jan 30
American Airlines Logo
10:40 am - 5:44 pm
DTW
-
HHH
7h 04m2 stops
American Airlines Logo
4:31 pm - 10:16 pm
HHH
-
DTW
5h 45m1 stop
$288American Airlines
Sat, Feb 14 - Sat, Feb 21

Delta flights from Detroit to South Carolina

Our best Delta deals on Detroit to South Carolina flight tickets
Delta
Feb 12
DTW7:05 amDetroit Metropolitan Wayne County
2h 02m
CLT9:07 amCharlotte Douglas
Feb 18
CLT5:25 amCharlotte Douglas
4h 05m
1 stop
DTW9:30 amDetroit Metropolitan Wayne County
$149
Delta
Feb 4
DTW7:45 pmDetroit Metropolitan Wayne County
1h 47m
CLT9:32 pmCharlotte Douglas
Feb 9
CLT6:00 amCharlotte Douglas
1h 52m
DTW7:52 amDetroit Metropolitan Wayne County
$159
Delta
Feb 13
DTW2:15 pmDetroit Metropolitan Wayne County
1h 50m
CLT4:05 pmCharlotte Douglas
Feb 24
CLT1:11 pmCharlotte Douglas
1h 52m
DTW3:03 pmDetroit Metropolitan Wayne County
$169

Frontier flights from Detroit to South Carolina

Our best Frontier deals on Detroit to South Carolina flight tickets
Frontier
Mar 18
DTW9:04 pmDetroit Metropolitan Wayne County
10h 59m
1 stop
CLT8:03 amCharlotte Douglas
Mar 28
CLT9:28 pmCharlotte Douglas
12h 24m
1 stop
DTW9:52 amDetroit Metropolitan Wayne County
$150
Frontier
Feb 13
DTW11:01 amDetroit Metropolitan Wayne County
1h 51m
CLT12:52 pmCharlotte Douglas
Feb 20
CLT4:10 pmCharlotte Douglas
1h 58m
DTW6:08 pmDetroit Metropolitan Wayne County
$174
Frontier
Mar 19
DTW8:51 pmDetroit Metropolitan Wayne County
11h 12m
1 stop
CLT8:03 amCharlotte Douglas
Mar 28
CLT9:28 pmCharlotte Douglas
12h 24m
1 stop
DTW9:52 amDetroit Metropolitan Wayne County
$185

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Wed 2/4

5:00 am-2:42 pm

1 stop9h 42m

Myrtle Beach Intl

Wed 2/11

10:00 am-12:19 am

1 stop14h 19m

$119

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Mon 1/26

5:00 am-4:10 pm

1 stop11h 10m

Charleston

Fri 1/30

5:05 pm-12:19 am

1 stop7h 14m

$121

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Thu 2/5

5:00 am-4:10 pm

1 stop11h 10m

Charleston

Mon 2/9

5:05 pm-12:19 am

1 stop7h 14m

$122

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/12

2:06 pm-7:17 pm

1 stop5h 11m

Charlotte Douglas

Thu 2/19

3:12 pm-9:54 pm

1 stop6h 42m

$143

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sun 2/15

9:18 am-7:17 pm

1 stop9h 59m

Charlotte Douglas

Wed 2/18

3:12 pm-9:54 pm

1 stop6h 42m

$144

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 2/12

7:05 am-9:07 am

Nonstop2h 02m

Charlotte Douglas

Wed 2/18

5:25 am-9:30 am

1 stop4h 05m

$149

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 3/18

9:04 pm-8:03 am

1 stop10h 59m

Charlotte Douglas

Sat 3/28

9:28 pm-9:52 am

1 stop12h 24m

$150

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Fri 3/13

2:20 pm-9:20 pm

1 stop7h 00m

Columbia Metropolitan

Sun 3/15

7:13 pm-12:43 am

1 stop5h 30m

$269

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Wed 1/28

5:24 pm-12:20 pm

2 stops18h 56m

Hilton Head Island

Fri 1/30

3:29 pm-11:33 am

2 stops20h 04m

$284

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Sat 2/14

10:40 am-5:44 pm

2 stops7h 04m

Hilton Head Island

Sat 2/21

4:31 pm-10:16 pm

1 stop5h 45m

$288

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Detroit to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Detroit is in September. Flight prices, which tend to average around $219, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Detroit during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $234.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $299. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $434.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Detroit to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $303. Try not to purchase tickets in the afternoon because they tend to be around $360. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Detroit to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Charleston for the best Detroit - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $320 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit for as low as $216 on momondo.

What cabin class options are available on Detroit to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit to South Carolina.

Cheap Detroit to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to South Carolina

Best Price Found

$304

Fastest flight time

1h 39m

Direct flights

Every day

Airports in South Carolina

57 airports
The best one-way flight to South Carolina from Detroit in the past 72 hours is $304. The best round-trip flight deal from Detroit to South Carolina found on momondo in the last 72 hours is $299.
The fastest flight from Detroit to South Carolina takes 1h 39m
Direct flights go from Detroit to South Carolina every day.
There are 57 airports in South Carolina. From Detroit there are direct flights to Greenville (GSP), Myrtle Beach Intl (MYR), Charlotte Douglas (CLT), Augusta Bush Field (AGS) and 1 more.
Search flight deals

  • When did momondo last update prices for flights from Detroit to South Carolina?

    Prices for flights from Detroit to South Carolina were last updated today.

  • How many operators does momondo search for flights from Detroit to South Carolina?

  • How old do you have to be to fly from Detroit to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit to South Carolina?

Best airlines flying from Detroit to South Carolina

Compare and see reviews for airlines that fly from Detroit to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $76Free CancellationRating
6.3
8,296 reviews
Search Spirit Airlines flights
DeltaPriceFrom $160Free CancellationRating
7.9
8,033 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,111 reviews
Search American Airlines flights
SouthwestPriceFrom $207Free CancellationRating
8.0
4,253 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Detroit.

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to South Carolina?

momondo helps you find the best flight between Detroit and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South Carolina trip

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