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Cheap flights from Detroit to South Carolina from $58

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to South Carolina departing on 10/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to South Carolina

Cheap round-trip flights

Spirit Airlines Logo
2:57 pm - 11:36 pmDTW-CLT
8h 39m1 stop
Spirit Airlines Logo
6:00 am - 3:14 pmCLT-DTW
9h 14m1 stop
$116Spirit Airlines
Find Deal
Sat, Oct 4 - Tue, Oct 7
Spirit Airlines Logo
5:20 pm - 11:36 pmDTW-CLT
6h 16m1 stop
Spirit Airlines Logo
6:00 am - 3:14 pmCLT-DTW
9h 14m1 stop
$117Spirit Airlines
Find Deal
Wed, Oct 1 - Tue, Oct 7
Logo
5:23 pm - 11:29 pmDTW-CLT
6h 06m1 stop
Logo
8:55 am - 12:54 pmCLT-DTW
3h 59m1 stop
$131
Find Deal
Wed, Oct 15 - Mon, Oct 20
Logo
5:20 pm - 11:36 pmDTW-CLT
6h 16m1 stop
Logo
7:55 pm - 8:00 amCLT-DTW
12h 05m1 stop
$142
Find Deal
Tue, Sep 30 - Fri, Oct 3
Delta Logo
2:08 pm - 3:55 pmDTW-CLT
1h 47mnonstop
Delta Logo
12:56 pm - 2:40 pmCLT-DTW
1h 44mnonstop
$151Delta
Find Deal
Wed, Oct 15 - Wed, Oct 22
Delta Logo
7:05 am - 8:54 amDTW-CLT
1h 49mnonstop
Delta Logo
5:30 am - 9:25 amCLT-DTW
3h 55m1 stop
$161Delta
Find Deal
Wed, Oct 15 - Wed, Oct 22
Southwest Logo
1:35 pm - 6:05 pmDTW-SAV
4h 30m1 stop
Southwest Logo
5:35 pm - 10:35 pmSAV-DTW
5h 00m1 stop
$187Southwest
Find Deal
Sat, Nov 1 - Wed, Nov 5
American Airlines Logo
6:00 am - 9:37 amDTW-MYR
3h 37m1 stop
American Airlines Logo
6:00 am - 12:07 pmMYR-DTW
6h 07m1 stop
$199American Airlines
Find Deal
Tue, Oct 7 - Tue, Oct 14
American Airlines Logo
5:30 am - 11:29 amDTW-SAV
5h 59m1 stop
American Airlines Logo
5:00 am - 11:18 amSAV-DTW
6h 18m1 stop
$199American Airlines
Find Deal
Tue, Oct 14 - Thu, Oct 23
Southwest Logo
1:15 pm - 9:25 pmDTW-GSP
8h 10m2 stops
Southwest Logo
8:00 am - 12:20 pmGSP-DTW
4h 20m1 stop
$366Southwest
Find Deal
Thu, Oct 2 - Sat, Oct 4

Spirit Airlines flights from Detroit to South Carolina

Our best Spirit Airlines deals on Detroit to South Carolina flight tickets
Spirit Airlines
Oct 4
DTW2:57 pmDetroit Metropolitan Wayne County
8h 39m
1 stop
CLT11:36 pmCharlotte Douglas
Oct 7
CLT6:00 amCharlotte Douglas
9h 14m
1 stop
DTW3:14 pmDetroit Metropolitan Wayne County
$116
Find similar
Spirit Airlines
Oct 1
DTW5:20 pmDetroit Metropolitan Wayne County
6h 16m
1 stop
CLT11:36 pmCharlotte Douglas
Oct 7
CLT6:00 amCharlotte Douglas
9h 14m
1 stop
DTW3:14 pmDetroit Metropolitan Wayne County
$117
Find similar
Spirit Airlines
Sep 27
DTW5:20 pmDetroit Metropolitan Wayne County
6h 16m
1 stop
CLT11:36 pmCharlotte Douglas
Sep 30
CLT5:45 amCharlotte Douglas
9h 37m
1 stop
DTW3:22 pmDetroit Metropolitan Wayne County
$118
Find similar

Frontier flights from Detroit to South Carolina

Our best Frontier deals on Detroit to South Carolina flight tickets
Frontier
Oct 3
DTW10:32 amDetroit Metropolitan Wayne County
10h 53m
1 stop
CLT9:25 pmCharlotte Douglas
Oct 6
CLT9:11 amCharlotte Douglas
11h 18m
1 stop
DTW8:29 pmDetroit Metropolitan Wayne County
$144
Find similar
Frontier
Sep 26
DTW10:32 amDetroit Metropolitan Wayne County
10h 53m
1 stop
CLT9:25 pmCharlotte Douglas
Sep 28
CLT9:11 amCharlotte Douglas
11h 18m
1 stop
DTW8:29 pmDetroit Metropolitan Wayne County
$146
Find similar
Frontier
Sep 19
DTW10:32 amDetroit Metropolitan Wayne County
10h 53m
1 stop
CLT9:25 pmCharlotte Douglas
Sep 22
CLT9:11 amCharlotte Douglas
11h 18m
1 stop
DTW8:29 pmDetroit Metropolitan Wayne County
$147
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 9, 2025.
Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sat 10/4

2:57 pm-11:36 pm

1 stop8h 39m

Charlotte Douglas

Tue 10/7

6:00 am-3:14 pm

1 stop9h 14m

$116

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 10/1

5:20 pm-11:36 pm

1 stop6h 16m

Charlotte Douglas

Tue 10/7

6:00 am-3:14 pm

1 stop9h 14m

$117

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 10/15

5:23 pm-11:29 pm

1 stop6h 06m

Charlotte Douglas

Mon 10/20

8:55 am-12:54 pm

1 stop3h 59m

$131

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Tue 9/30

5:20 pm-11:36 pm

1 stop6h 16m

Charlotte Douglas

Fri 10/3

7:55 pm-8:00 am

1 stop12h 05m

$142

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 10/15

2:08 pm-3:55 pm

Nonstop1h 47m

Charlotte Douglas

Wed 10/22

12:56 pm-2:40 pm

Nonstop1h 44m

$151

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 10/15

7:05 am-8:54 am

Nonstop1h 49m

Charlotte Douglas

Wed 10/22

5:30 am-9:25 am

1 stop3h 55m

$161

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Sat 11/1

1:35 pm-6:05 pm

1 stop4h 30m

Savannah/Hilton Head

Wed 11/5

5:35 pm-10:35 pm

1 stop5h 00m

$187

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Tue 10/7

6:00 am-9:37 am

1 stop3h 37m

Myrtle Beach Intl

Tue 10/14

6:00 am-12:07 pm

1 stop6h 07m

$199

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Tue 10/14

5:30 am-11:29 am

1 stop5h 59m

Savannah/Hilton Head

Thu 10/23

5:00 am-11:18 am

1 stop6h 18m

$199

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 10/2

1:15 pm-9:25 pm

2 stops8h 10m

Greenville

Sat 10/4

8:00 am-12:20 pm

1 stop4h 20m

$366

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Detroit to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Detroit is in September. Flight prices, which tend to average around $216, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Detroit during October instead. Flights to South Carolina in October, while not as cheap as those in September, still average around $229.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $304. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $387.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Detroit to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $310. Try not to purchase tickets at noon because they tend to be around $411. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Detroit to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit for as low as $270 on momondo.

What cabin class options are available on Detroit to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit to South Carolina.

Cheap Detroit to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to South Carolina

Best Price Found

$100

Fastest flight time

1h 35m

Direct flights

Every day

Airports in South Carolina

3 airports
The best one-way flight to South Carolina from Detroit in the past 72 hours is $100. The best round-trip flight deal from Detroit to South Carolina found on momondo in the last 72 hours is $159.
The fastest flight from Detroit to South Carolina takes 1h 35m
Direct flights go from Detroit to South Carolina every day.
There are 3 airports near South Carolina: Greenville (GSP), Myrtle Beach Intl (MYR), Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Detroit to South Carolina?

    Prices for flights from Detroit to South Carolina were last updated today.

  • How many operators does momondo search for flights from Detroit to South Carolina?

  • How old do you have to be to fly from Detroit to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit to South Carolina?

Best airlines flying from Detroit to South Carolina

Compare and see reviews for airlines that fly from Detroit to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $70Free CancellationRating
6.3
8,025 reviews
Search Spirit Airlines flights
DeltaPriceFrom $159Free CancellationRating
7.9
7,965 reviews
Search Delta flights
American AirlinesPriceFrom $187Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $231Free CancellationRating
8.0
4,250 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Detroit.

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to South Carolina?

momondo helps you find the best flight between Detroit and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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