What is the cheapest airline that flies from Detroit to South Carolina?

Frontier, Spirit Airlines, and Southwest are the most popular carriers operating from Detroit to South Carolina

How many flights depart from Detroit to South Carolina on average per day?

As of November 2025, 23 flights take off from Detroit and land in South Carolina each day. The most common flight departure time for this route is 4:00PM, with 57% of daily flights taking off in the afternoon.

How many flights depart from Detroit to South Carolina on average per week?

The number of flights available between Detroit and South Carolina is 163 per week as of November 2025. The most frequent departure day is Thu, with 26% of weekly flights leaving on this day.

What airlines fly to South Carolina?

Delta, Spirit Airlines and American Airlines are the top three most popular airlines that fly to South Carolina from Detroit according to our data. Delta is the first choice among our users, with 48% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Detroit to South Carolina?

Prices for flights from Detroit to South Carolina were last updated today.

How many operators does momondo search for flights from Detroit to South Carolina?

There are 6 operators available for flights from Detroit to South Carolina as of November 2025.

How old do you have to be to fly from Detroit to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$39 Cheap Flights from Detroit to South Carolina in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Detroit to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:42 am - 5:06 pmDTW-CHS

6h 24m1 stop

6:13 pm - 11:59 pmCHS-DTW

5h 46m1 stop

$100Spirit Airlines

Find Deal

Wed, Nov 19 - Thu, Nov 20

10:42 am - 5:06 pmDTW-CHS

6h 24m1 stop

6:11 pm - 12:07 amCHS-DTW

5h 56m1 stop

$101Spirit Airlines

Find Deal

Tue, Nov 18 - Wed, Nov 19

6:30 am - 8:34 amDTW-CHS

2h 04mnonstop

9:29 am - 11:34 amCHS-DTW

2h 05mnonstop

$109Spirit Airlines

Find Deal

Thu, Jan 29 - Sun, Feb 1

2:28 pm - 10:21 pmDTW-SAV

7h 53m1 stop

1:18 pm - 7:44 amSAV-DTW

18h 26m1 stop

$145Multiple Airlines

Find Deal

Thu, Dec 4 - Mon, Dec 8

8:02 pm - 9:55 pmDTW-CLT

1h 53mnonstop

9:33 am - 11:30 amCLT-DTW

1h 57mnonstop

$149Delta

Find Deal

Wed, Dec 3 - Wed, Dec 10

7:17 pm - 9:05 amDTW-SAV

13h 48m1 stop

7:00 am - 10:17 amSAV-DTW

27h 17m1 stop

$152Multiple Airlines

Find Deal

Wed, Nov 19 - Sun, Nov 23

10:09 am - 12:12 pmDTW-CLT

2h 03mnonstop

9:30 am - 11:26 amCLT-DTW

1h 56mnonstop

$169Delta

Find Deal

Thu, Jan 29 - Sun, Feb 1

11:14 am - 1:13 pmDTW-CLT

1h 59mnonstop

9:12 am - 11:10 amCLT-DTW

1h 58mnonstop

$189American Airlines

Find Deal

Wed, Feb 18 - Sun, Feb 22

6:00 am - 9:59 amDTW-CAE

3h 59m1 stop

6:40 am - 1:40 pmCAE-DTW

7h 00m2 stops

$254American Airlines

Find Deal

Tue, Dec 2 - Sat, Dec 6

5:25 am - 10:40 amDTW-GSP

5h 15m1 stop

7:45 am - 2:55 pmGSP-DTW

7h 10m2 stops

$354Southwest

Find Deal

Tue, Jan 6 - Sat, Jan 10

American Airlines flights from Detroit to South Carolina

Our best American Airlines deals on Detroit to South Carolina flight tickets

American Airlines

Feb 18

DTW11:14 amDetroit Metropolitan Wayne County

1h 59m

CLT1:13 pmCharlotte Douglas

Feb 22

CLT9:12 amCharlotte Douglas

1h 58m

DTW11:10 amDetroit Metropolitan Wayne County

$189

Find similar

American Airlines

Dec 2

DTW6:00 amDetroit Metropolitan Wayne County

3h 59m

1 stop

CAE9:59 amColumbia Metropolitan

Dec 6

CAE6:40 amColumbia Metropolitan

7h 00m

2 stops

DTW1:40 pmDetroit Metropolitan Wayne County

$254

Find similar

American Airlines

Dec 18

DTW9:56 amDetroit Metropolitan Wayne County

4h 22m

1 stop

CAE2:18 pmColumbia Metropolitan

Dec 23

CAE7:59 pmColumbia Metropolitan

4h 45m

1 stop

DTW12:44 amDetroit Metropolitan Wayne County

$265

Find similar

Spirit Airlines flights from Detroit to South Carolina

Our best Spirit Airlines deals on Detroit to South Carolina flight tickets

Spirit Airlines

Nov 19

DTW10:42 amDetroit Metropolitan Wayne County

6h 24m

1 stop

CHS5:06 pmCharleston

Nov 20

CHS6:13 pmCharleston

5h 46m

1 stop

DTW11:59 pmDetroit Metropolitan Wayne County

$100

Find similar

Spirit Airlines

Nov 18

DTW10:42 amDetroit Metropolitan Wayne County

6h 24m

1 stop

CHS5:06 pmCharleston

Nov 19

CHS6:11 pmCharleston

5h 56m

1 stop

DTW12:07 amDetroit Metropolitan Wayne County

$101

Find similar

Spirit Airlines

Jan 29

DTW6:30 amDetroit Metropolitan Wayne County

2h 04m

CHS8:34 amCharleston

Feb 1

CHS9:29 amCharleston

2h 05m

DTW11:34 amDetroit Metropolitan Wayne County

$109

Find similar

Fly from

Fly to

Route

Depart

Return

Price

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Wed 11/19

10:42 am-5:06 pm

1 stop6h 24m

Charleston

Thu 11/20

6:13 pm-11:59 pm

1 stop5h 46m

$100

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Tue 11/18

10:42 am-5:06 pm

1 stop6h 24m

Charleston

Wed 11/19

6:11 pm-12:07 am

1 stop5h 56m

$101

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Thu 1/29

6:30 am-8:34 am

Nonstop2h 04m

Charleston

Sun 2/1

9:29 am-11:34 am

Nonstop2h 05m

$109

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Thu 12/4

2:28 pm-10:21 pm

1 stop7h 53m

Savannah/Hilton Head

Mon 12/8

1:18 pm-7:44 am

1 stop18h 26m

$145

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 12/3

8:02 pm-9:55 pm

Nonstop1h 53m

Charlotte Douglas

Wed 12/10

9:33 am-11:30 am

Nonstop1h 57m

$149

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Wed 11/19

7:17 pm-9:05 am

1 stop13h 48m

Savannah/Hilton Head

Sun 11/23

7:00 am-10:17 am

1 stop27h 17m

$152

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 1/29

10:09 am-12:12 pm

Nonstop2h 03m

Charlotte Douglas

Sun 2/1

9:30 am-11:26 am

Nonstop1h 56m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 2/18

11:14 am-1:13 pm

Nonstop1h 59m

Charlotte Douglas

Sun 2/22

9:12 am-11:10 am

Nonstop1h 58m

$189

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Tue 12/2

6:00 am-9:59 am

1 stop3h 59m

Columbia Metropolitan

Sat 12/6

6:40 am-1:40 pm

2 stops7h 00m

$254

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Tue 1/6

5:25 am-10:40 am

1 stop5h 15m

Greenville

Sat 1/10

7:45 am-2:55 pm

2 stops7h 10m

$354

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Detroit is in September. Flight prices, which tend to average around $219, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Detroit during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $239.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $301. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $483.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Detroit to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $310. Try not to purchase tickets at noon because they tend to be around $414. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Detroit to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit for as low as $265 on momondo.

What cabin class options are available on Detroit to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to South Carolina flights?

You could potentially save up to 40% on your flight if you consider stops on a Detroit to South Carolina flight.

Cheap Detroit to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to South Carolina

Best Price Found	$110
Fastest flight time	1h 40m
Direct flights	Every day
Airports in South Carolina	3 airports

The best one-way flight to South Carolina from Detroit in the past 72 hours is $110. The best round-trip flight deal from Detroit to South Carolina found on momondo in the last 72 hours is $299.

The fastest flight from Detroit to South Carolina takes 1h 40m

Direct flights go from Detroit to South Carolina every day.

There are 3 airports near South Carolina: Greenville (GSP), Myrtle Beach Intl (MYR), Charlotte Douglas (CLT)

Search flight deals

When did momondo last update prices for flights from Detroit to South Carolina?
Prices for flights from Detroit to South Carolina were last updated today.
How many operators does momondo search for flights from Detroit to South Carolina?
There are 6 operators available for flights from Detroit to South Carolina as of November 2025.
How old do you have to be to fly from Detroit to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Detroit to South Carolina?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Detroit to South Carolina is Airbus A320-100/200 (25.14% of total bookings). The next most popular plane models are Boeing 717-200 (22.16%), Canadair (Bombardier) Regional Jet 900 (19.98%), and Airbus A320 (sharklets) (9.18%).

Best airlines flying from Detroit to South Carolina

Compare and see reviews for airlines that fly from Detroit to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $76	Free Cancellation	Rating 6.3 8,122 reviews	Search Spirit Airlines flights
Delta	PriceFrom $159	Free Cancellation	Rating 7.9 8,001 reviews	Search Delta flights
American Airlines	PriceFrom $197	Free Cancellation	Rating 7.2 11,040 reviews	Search American Airlines flights
Southwest	PriceFrom $231	Free Cancellation	Rating 8.0 4,241 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Detroit.

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to South Carolina?

momondo helps you find the best flight between Detroit and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

Sat 12/6

Sat 12/13

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Flights to New Yorkfrom $44

Flights to Los Angelesfrom $49

Flights to Miamifrom $49

Flights to Chicagofrom $54

Flights to Orlandofrom $49

Flights to Las Vegasfrom $42

Flights to San Franciscofrom $57

Flights to Washington, D.C.from $49

Flights to Bostonfrom $49

Flights to Atlantafrom $40

Flights to Dallasfrom $59

Flights to Seattlefrom $58

Detroit flight routes

Flights from Detroit Metropolitan Wayne County to Baltimore/Washington

Flights from Detroit Metropolitan Wayne County to Nashville Intl

Flights from Detroit Metropolitan Wayne County to New York LaGuardia

Flights from Detroit Metropolitan Wayne County to Wilmington New Hanover County

Flights from Detroit Metropolitan Wayne County to Newark

Flights from Detroit Metropolitan Wayne County to Boston Logan Intl

Cheap flights from Detroit to South Carolina from $39

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to South Carolina departing on 12/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Detroit to South Carolina

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Cheap direct flights

American Airlines flights from Detroit to South Carolina

Our best American Airlines deals on Detroit to South Carolina flight tickets

Spirit Airlines flights from Detroit to South Carolina

Our best Spirit Airlines deals on Detroit to South Carolina flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.

See travel insights to South Carolina from

How to get the cheapest flight ticket from Detroit to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $301. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $483.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Detroit to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Detroit to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to South Carolina flights?

You could potentially save up to 40% on your flight if you consider stops on a Detroit to South Carolina flight.

What is the cheapest airline that flies from Detroit to South Carolina?

Frontier, Spirit Airlines, and Southwest are the most popular carriers operating from Detroit to South Carolina

What airlines fly to South Carolina?

How many flights depart from Detroit to South Carolina on average per day?

As of November 2025, 23 flights take off from Detroit and land in South Carolina each day. The most common flight departure time for this route is 4:00PM, with 57% of daily flights taking off in the afternoon.

How many flights depart from Detroit to South Carolina on average per week?

The number of flights available between Detroit and South Carolina is 163 per week as of November 2025. The most frequent departure day is Thu, with 26% of weekly flights leaving on this day.

Cheap Detroit to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Detroit to South Carolina?

How many operators does momondo search for flights from Detroit to South Carolina?

How old do you have to be to fly from Detroit to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Detroit to South Carolina?

Best airlines flying from Detroit to South Carolina

Compare and see reviews for airlines that fly from Detroit to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Detroit to South Carolina?

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo