Cheap flights from Detroit to South Carolina from $100
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to South Carolina departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Fly from
Fly to
Route
Depart
Return
DetroitCharleston
DTW Detroit Metropolitan Wayne County - CHS Charleston
DTWCHS
Detroit Metropolitan Wayne County
Fri 10/30
6:53 pm-9:38 am
2 stops38h 45m
Charleston
Wed 11/11
7:54 pm-11:37 pm
1 stop27h 43m
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Tue 1/12
5:15 am-10:00 am
1 stop4h 45m
Myrtle Beach Intl
Sat 1/16
6:30 pm-10:45 pm
1 stop4h 15m
DetroitCharleston
DTW Detroit Metropolitan Wayne County - CHS Charleston
DTWCHS
Detroit Metropolitan Wayne County
Thu 11/12
4:50 pm-10:20 pm
1 stop5h 30m
Charleston
Sat 11/14
5:35 pm-10:05 pm
1 stop4h 30m
DetroitCharleston
DTW Detroit Metropolitan Wayne County - CHS Charleston
DTWCHS
Detroit Metropolitan Wayne County
Sat 10/31
4:35 pm-9:38 am
1 stop17h 03m
Charleston
Wed 11/4
7:54 pm-11:37 pm
1 stop27h 43m
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Sat 12/5
8:40 am-10:41 am
Nonstop2h 01m
Myrtle Beach Intl
Sat 12/12
11:26 am-1:30 pm
Nonstop2h 04m
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Sat 11/7
8:25 am-10:20 am
Nonstop1h 55m
Myrtle Beach Intl
Wed 11/11
11:30 am-1:30 pm
Nonstop2h 00m
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Tue 11/3
5:55 am-11:32 am
1 stop5h 37m
Myrtle Beach Intl
Tue 11/10
5:03 pm-11:28 pm
1 stop6h 25m
DetroitMyrtle Beach
DTW Detroit Metropolitan Wayne County - MYR Myrtle Beach Intl
DTWMYR
Detroit Metropolitan Wayne County
Tue 11/3
7:43 am-11:32 am
1 stop3h 49m
Myrtle Beach Intl
Tue 11/10
12:12 pm-4:11 pm
1 stop3h 59m
DetroitColumbia
DTW Detroit Metropolitan Wayne County - CAE Columbia Metropolitan
DTWCAE
Detroit Metropolitan Wayne County
Fri 10/30
10:13 am-2:17 pm
1 stop4h 04m
Columbia Metropolitan
Sat 10/31
10:37 am-3:27 pm
1 stop4h 50m
DetroitColumbia
DTW Detroit Metropolitan Wayne County - CAE Columbia Metropolitan
DTWCAE
Detroit Metropolitan Wayne County
Fri 10/30
4:10 pm-9:02 pm
1 stop4h 52m
Columbia Metropolitan
Sun 11/1
7:54 pm-11:59 pm
1 stop4h 05m
See travel insights to South Carolina from
How to get the cheapest flight ticket from Detroit to South Carolina
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to South Carolina?
The cheapest month to fly to South Carolina from Detroit is in January. Flight prices, which tend to average around $346, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Detroit during December instead. Flights to South Carolina in December, while not as cheap as those in January, still average around $390.
What is the cheapest day to depart on your flight to South Carolina?
Our data shows that Saturday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $364. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $522.
What is the cheapest time of day to depart on your flight to South Carolina?
Our data shows that the cheapest Detroit to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $299. Try not to purchase tickets in the afternoon because they tend to be around $440. Of course, these prices can vary depending on the time of year and what airport you fly to.
What is the cheapest Detroit to South Carolina flight route?
Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit - South Carolina flight prices
How far in advance should I book a flight from Detroit to South Carolina?
You are more likely to see cheaper flights to South Carolina from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $432 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit for as low as $366 on momondo.
What cabin class options are available on Detroit to South Carolina flights?
There are 4 cabin classes available to choose from on Detroit to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.
What is the cheapest airline that flies from Detroit to South Carolina?
Southwest, Delta, and American Airlines are the most popular carriers operating from Detroit to South Carolina
What airlines fly to South Carolina?
Delta, American Airlines and Southwest are the top three most popular airlines that fly to South Carolina from Detroit according to our data. Delta is the first choice among our users, with 73% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.
How many flights depart from Detroit to South Carolina on average per day?
As of October 2026, 13 flights take off from Detroit and land in South Carolina each day. The most common flight departure time for this route is 7:00PM, with 37% of daily flights taking off in the afternoon.
How many flights depart from Detroit to South Carolina on average per week?
The number of flights available between Detroit and South Carolina is 93 per week as of October 2026. The most frequent departure day is Fri, with 31% of weekly flights leaving on this day.
Cheap Detroit to South Carolina flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Detroit to South Carolina
Frequently asked questions about flying from Detroit to South Carolina
When did momondo last update prices for flights from Detroit to South Carolina?
Prices for flights from Detroit to South Carolina were last updated today.
How many operators does momondo search for flights from Detroit to South Carolina?
There are 4 operators available for flights from Detroit to South Carolina as of October 2026.
How old do you have to be to fly from Detroit to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Detroit to South Carolina?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Detroit to South Carolina is Boeing 717-200 (28.83% of total bookings). The next most popular plane models are Canadair (Bombardier) Regional Jet 900 (26.38%), Airbus A320-100/200 (23.93%), and Canadair (Bombardier) Regional Jet 700 (7.77%).
Best airlines flying from Detroit to South Carolina
Compare and see reviews for airlines that fly from Detroit to South Carolina with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $235 | Free Cancellation | Rating 7.9 4,212 reviews | |||
| PriceFrom $248 | Free Cancellation | Rating 7.0 12,128 reviews | |||
| PriceFrom $283 | Free Cancellation | Rating 7.4 10,285 reviews | |||
| PriceFrom $299 | Free Cancellation | Rating 7.8 8,628 reviews |
Why use momondo?
Why should I use momondo to find a flight deal from Detroit to South Carolina?
To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Detroit.
Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?
Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.
How can momondo help me find flights from Detroit to South Carolina?
momondo helps you find the best flight between Detroit and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.
I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?
Price alerts on flights to South Carolina from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.