Cheap flights from Detroit to South America from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to South America departing on 5/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
5:42 pm - 12:26 pm
DTW
-
CTG
19h 44m
1 stop
Spirit Airlines Logo
1:31 pm - 11:53 pm
CTG
-
DTW
9h 22m
1 stop
$367Spirit Airlines
Sun, May 10 - Thu, May 14
Spirit Airlines Logo
6:00 am - 12:26 pm
DTW
-
CTG
7h 26m
1 stop
Spirit Airlines Logo
1:31 pm - 7:52 am
CTG
-
DTW
17h 21m
2 stops
$368Spirit Airlines
Mon, May 11 - Fri, May 15
Multiple Airlines Logo
5:42 pm - 12:26 pm
DTW
-
CTG
19h 44m
1 stop
Multiple Airlines Logo
1:31 pm - 7:52 am
CTG
-
DTW
17h 21m
2 stops
$373Multiple Airlines
Sun, May 10 - Thu, May 14
Spirit Airlines Logo
6:00 am - 12:26 pm
DTW
-
CTG
7h 26m
1 stop
Spirit Airlines Logo
1:31 pm - 11:53 pm
CTG
-
DTW
9h 22m
1 stop
$374Spirit Airlines
Mon, May 11 - Fri, May 15
Multiple Airlines Logo
8:12 pm - 9:27 pm
DTW
-
CTG
26h 15m
2 stops
Multiple Airlines Logo
1:31 pm - 7:52 am
CTG
-
DTW
17h 21m
2 stops
$409Multiple Airlines
Mon, May 11 - Fri, May 15
GOL Logo
6:57 pm - 11:00 pm
DTW
-
GIG
27h 03m
2 stops
GOL Logo
11:05 pm - 11:56 pm
GIG
-
DTW
25h 51m
2 stops
$746GOL
Tue, Jun 16 - Wed, Jun 24
GOL Logo
6:57 pm - 12:25 pm
DTW
-
SDU
40h 28m
2 stops
GOL Logo
6:05 am - 11:56 pm
SDU
-
DTW
18h 51m
2 stops
$756GOL
Thu, Jun 4 - Thu, Jun 11
Air Canada Logo
10:05 am - 2:30 pm
DTW
-
EZE
27h 25m
2 stops
Air Canada Logo
4:35 pm - 9:29 pm
EZE
-
DTW
29h 54m
2 stops
$976Air Canada
Tue, Oct 6 - Mon, Oct 19
Air Canada Logo
10:05 am - 2:30 pm
DTW
-
EZE
51h 25m
3 stops
Air Canada Logo
4:35 pm - 9:29 pm
EZE
-
DTW
29h 54m
2 stops
$979Air Canada
Mon, Sep 14 - Wed, Sep 23
Azul Logo
2:55 pm - 2:30 pm
DTW
-
EZE
22h 35m
1 stop
Azul Logo
4:35 pm - 9:29 pm
EZE
-
DTW
29h 54m
2 stops
$1,023Azul
Tue, Sep 15 - Mon, Sep 21

Spirit Airlines flights from Detroit to South America

Our best Spirit Airlines deals on Detroit to South America flight tickets
Spirit Airlines
May 10
DTW5:42 pmDetroit Metropolitan Wayne County
19h 44m
1 stop
CTG12:26 pmCartagena Rafael Nunez
May 14
CTG1:31 pmCartagena Rafael Nunez
9h 22m
1 stop
DTW11:53 pmDetroit Metropolitan Wayne County
$367
Spirit Airlines
May 11
DTW6:00 amDetroit Metropolitan Wayne County
7h 26m
1 stop
CTG12:26 pmCartagena Rafael Nunez
May 15
CTG1:31 pmCartagena Rafael Nunez
17h 21m
2 stops
DTW7:52 amDetroit Metropolitan Wayne County
$368
Spirit Airlines
May 11
DTW6:00 amDetroit Metropolitan Wayne County
7h 26m
1 stop
CTG12:26 pmCartagena Rafael Nunez
May 15
CTG1:31 pmCartagena Rafael Nunez
9h 22m
1 stop
DTW11:53 pmDetroit Metropolitan Wayne County
$374

Air Canada flights from Detroit to South America

Our best Air Canada deals on Detroit to South America flight tickets
Air Canada
May 3
DTW6:50 pmDetroit Metropolitan Wayne County
10h 15m
1 stop
BOG4:05 amBogotá El Dorado
May 18
BOG9:00 amBogotá El Dorado
24h 08m
1 stop
DTW10:08 amDetroit Metropolitan Wayne County
$605
Air Canada
May 3
DTW10:15 amDetroit Metropolitan Wayne County
18h 50m
2 stops
BOG4:05 amBogotá El Dorado
May 18
BOG9:00 amBogotá El Dorado
28h 13m
1 stop
DTW2:13 pmDetroit Metropolitan Wayne County
$608
Air Canada
Apr 24
DTW6:15 pmDetroit Metropolitan Wayne County
10h 50m
1 stop
BOG4:05 amBogotá El Dorado
May 9
BOG9:00 amBogotá El Dorado
11h 25m
1 stop
DTW9:25 pmDetroit Metropolitan Wayne County
$622

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Detroit to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Sun 5/10

5:42 pm-12:26 pm

1 stop19h 44m

Cartagena Rafael Nunez

Thu 5/14

1:31 pm-11:53 pm

1 stop9h 22m

$367

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Mon 5/11

6:00 am-12:26 pm

1 stop7h 26m

Cartagena Rafael Nunez

Fri 5/15

1:31 pm-7:52 am

2 stops17h 21m

$368

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Sun 5/10

5:42 pm-12:26 pm

1 stop19h 44m

Cartagena Rafael Nunez

Thu 5/14

1:31 pm-7:52 am

2 stops17h 21m

$373
Quickest round-trip

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Mon 5/11

6:00 am-12:26 pm

1 stop7h 26m

Cartagena Rafael Nunez

Fri 5/15

1:31 pm-11:53 pm

1 stop9h 22m

$374

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Mon 5/11

8:12 pm-9:27 pm

2 stops26h 15m

Cartagena Rafael Nunez

Fri 5/15

1:31 pm-7:52 am

2 stops17h 21m

$409

DetroitRio de Janeiro

DTW - GIG

DTWGIG

Detroit Metropolitan Wayne County

Tue 6/16

6:57 pm-11:00 pm

2 stops27h 03m

Rio de Janeiro–Galeão Intl

Wed 6/24

11:05 pm-11:56 pm

2 stops25h 51m

$746

DetroitRio de Janeiro

DTW - SDU

DTWSDU

Detroit Metropolitan Wayne County

Thu 6/4

6:57 pm-12:25 pm

2 stops40h 28m

Rio de Janeiro Santos Dumont

Thu 6/11

6:05 am-11:56 pm

2 stops18h 51m

$756

DetroitBuenos Aires

DTW - EZE

DTWEZE

Detroit Metropolitan Wayne County

Tue 10/6

10:05 am-2:30 pm

2 stops27h 25m

Buenos Aires Ministro Pistarini

Mon 10/19

4:35 pm-9:29 pm

2 stops29h 54m

$976

DetroitBuenos Aires

DTW - EZE

DTWEZE

Detroit Metropolitan Wayne County

Mon 9/14

10:05 am-2:30 pm

3 stops51h 25m

Buenos Aires Ministro Pistarini

Wed 9/23

4:35 pm-9:29 pm

2 stops29h 54m

$979

DetroitBuenos Aires

DTW - EZE

DTWEZE

Detroit Metropolitan Wayne County

Tue 9/15

2:55 pm-2:30 pm

1 stop22h 35m

Buenos Aires Ministro Pistarini

Mon 9/21

4:35 pm-9:29 pm

2 stops29h 54m

$1,023

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, March is the cheapest month to fly from Detroit to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $436. If you aren’t able to travel during the month of March, then book flights to South America from Detroit during September instead. Flights to South America in September, while not as cheap as those in March, still average around $524.

How far in advance should I book a flight from Detroit to South America?

You are more likely to see cheaper flights to South America from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $840 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Detroit for as low as $454 on momondo.

Can stopping save me money on Detroit to South America flights?

You could potentially save up to 33% on your flight if you consider stops on a Detroit to South America flight.

Cheap Detroit to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to South America

Fastest flight time

7h 26m

Direct flights

None
The fastest flight from Detroit to South America takes 7h 26m
There are no direct flights from Detroit to South America. There are no popular flight routes from Detroit to South America.

Frequently asked questions about flying from Detroit to South America

  • When did momondo last update prices for flights from Detroit to South America?

    Prices for flights from Detroit to South America refresh daily.

  • How many operators does momondo search for flights from Detroit to South America?

  • How old do you have to be to fly from Detroit to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to South America

Compare and see reviews for airlines that fly from Detroit to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $271Free CancellationRating
6.3
8,633 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $417Free CancellationRating
7.1
11,659 reviews
Search American Airlines flights
DeltaPriceFrom $563Free CancellationRating
7.9
8,438 reviews
Search Delta flights
Copa AirlinesPriceFrom $650Free CancellationRating
7.5
1,580 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $730Free CancellationRating
7.4
1,911 reviews
Search LATAM Airlines flights
Air CanadaPriceFrom $773Free CancellationRating
7.1
10,957 reviews
Search Air Canada flights
United AirlinesPriceFrom $1,078Free CancellationRating
7.4
9,635 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South America?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South America from Detroit.

Can I find flights from Detroit to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to South America?

momondo helps you find the best flight between Detroit and South America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Detroit are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South America trip

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1 adult
Fri 5/22
Fri 5/29

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