Cheap flights from Detroit to Charleston from $110

The cheapest month to fly to Charleston from Detroit is in January. Flight prices, which tend to average around $369, are often lower during this time because this is during the off-season. The month of December is another great option to travel to Charleston, with average flight prices from Detroit averaging around $378.

The cheapest day to depart from Detroit to Charleston is on a Tuesday. Travelers who choose to depart for Charleston on a Tuesday will often find tickets for as low as $375. The most expensive day to fly to Charleston is Thursday, with ticket prices averaging around $528.

The cheapest time of day to fly to Charleston is in the evening when flights can be purchased for as low as $419. In the morning is when there is more demand to fly to Charleston, so prices are often more expensive at around $456 per ticket.

Fly from Detroit Metropolitan Wayne County to Charleston for the best Detroit - Charleston flight prices

You are more likely to see cheaper flights to Charleston from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $446 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Detroit for as low as $366 on momondo.

There are 4 cabin classes available to choose from on Detroit to Charleston flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 13% on your flight if you consider stops on a Detroit to Charleston flight.

JetBlue, Southwest, and Delta are the most popular carriers operating from Detroit to Charleston

Delta, American Airlines and Southwest are the top three most popular airlines that fly to Charleston from Detroit according to our data. Delta is the first choice among our users, with 77% of people opting to fly with this airline when traveling to Charleston. Keep in mind that there are 3 different airlines that fly to Charleston on a routine basis, so you have a few additional options to choose from.

The number of flights available between Detroit and Charleston is 3 per day as of October 2026. The most frequent departure time is 7:00PM, with 55% of daily flights leaving in the evening.

The number of flights available between Detroit and Charleston is 23 per week as of October 2026. The most frequent departure day is Thu, with 30% of weekly flights leaving on this day.