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Cheap flights from Detroit Metropolitan Wayne County Airport to La Crosse from $255

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to La Crosse departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Detroit Metropolitan Wayne County Airport to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:54 pm - 11:53 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
15h 59m1 stop Chicago O'Hare Intl
American Airlines Logo
6:49 pm - 9:26 amLSE  La Crosse-DTW Detroit Metropolitan Wayne County
13h 37m1 stop Chicago O'Hare Intl
$410American Airlines
Wed, Oct 28 - Mon, Nov 2
American Airlines Logo
4:54 pm - 11:53 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
19h 59m1 stop Chicago O'Hare Intl
American Airlines Logo
6:49 pm - 9:26 amLSE  La Crosse-DTW Detroit Metropolitan Wayne County
13h 37m1 stop Chicago O'Hare Intl
$410American Airlines
Tue, Oct 27 - Mon, Nov 2
American Airlines Logo
4:27 pm - 12:21 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
8h 54m1 stop Chicago O'Hare Intl
American Airlines Logo
5:53 am - 9:33 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
14h 40m1 stop Chicago O'Hare Intl
$410American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:40 am - 12:22 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
18h 42m1 stop Chicago O'Hare Intl
American Airlines Logo
5:22 pm - 12:22 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
18h 00m1 stop Chicago O'Hare Intl
$422American Airlines
Mon, Sep 7 - Mon, Sep 14
American Airlines Logo
6:40 am - 12:22 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
18h 42m1 stop Chicago O'Hare Intl
American Airlines Logo
6:02 am - 4:55 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
9h 53m1 stop Chicago O'Hare Intl
$452American Airlines
Fri, Sep 4 - Sun, Sep 6
American Airlines Logo
9:03 pm - 11:49 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
15h 46m1 stop Chicago O'Hare Intl
American Airlines Logo
5:53 am - 9:33 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
14h 40m1 stop Chicago O'Hare Intl
$498American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
7:15 am - 2:42 pmDTW  Detroit Metropolitan Wayne County-LSE La Crosse
8h 27m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
5:53 am - 12:22 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
5h 29m1 stop Chicago O'Hare Intl
$501American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
1:49 pm - 11:59 pmDTW  Detroit Metropolitan Wayne County-LSE La Crosse
11h 10m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:49 pm - 9:26 amLSE  La Crosse-DTW Detroit Metropolitan Wayne County
13h 37m1 stop Chicago O'Hare Intl
$518American Airlines
Wed, Oct 28 - Mon, Nov 2
American Airlines Logo
11:06 am - 11:59 pmDTW  Detroit Metropolitan Wayne County-LSE La Crosse
13h 53m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:49 pm - 9:26 amLSE  La Crosse-DTW Detroit Metropolitan Wayne County
13h 37m1 stop Chicago O'Hare Intl
$518American Airlines
Tue, Oct 27 - Mon, Nov 2
American Airlines Logo
6:40 am - 11:49 amDTW  Detroit Metropolitan Wayne County-LSE La Crosse
6h 09m1 stop Chicago O'Hare Intl
American Airlines Logo
5:53 am - 12:22 pmLSE  La Crosse-DTW Detroit Metropolitan Wayne County
5h 29m1 stop Chicago O'Hare Intl
$533American Airlines
Tue, Sep 8 - Sat, Sep 12

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American Airlines flights from Detroit Metropolitan Wayne County Airport to La Crosse

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to La Crosse flight tickets
American Airlines
Sep 5
DTW4:27 pmDetroit Metropolitan Wayne County
8h 54m
1 stop
LSE12:21 amLa Crosse
Sep 12
LSE5:53 amLa Crosse
14h 40m
1 stop
DTW9:33 pmDetroit Metropolitan Wayne County
$410
American Airlines
Sep 7
DTW6:40 amDetroit Metropolitan Wayne County
18h 42m
1 stop
LSE12:22 amLa Crosse
Sep 14
LSE5:22 pmLa Crosse
18h 00m
1 stop
DTW12:22 pmDetroit Metropolitan Wayne County
$422
American Airlines
Sep 4
DTW6:40 amDetroit Metropolitan Wayne County
18h 42m
1 stop
LSE12:22 amLa Crosse
Sep 6
LSE6:02 amLa Crosse
9h 53m
1 stop
DTW4:55 pmDetroit Metropolitan Wayne County
$452

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Wed 10/28

8:54 pm-11:53 am

1 stop15h 59m

La Crosse

Mon 11/2

6:49 pm-9:26 am

1 stop13h 37m

$410

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Tue 10/27

4:54 pm-11:53 am

1 stop19h 59m

La Crosse

Mon 11/2

6:49 pm-9:26 am

1 stop13h 37m

$410

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sat 9/5

4:27 pm-12:21 am

1 stop8h 54m

La Crosse

Sat 9/12

5:53 am-9:33 pm

1 stop14h 40m

$410

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Mon 9/7

6:40 am-12:22 am

1 stop18h 42m

La Crosse

Mon 9/14

5:22 pm-12:22 pm

1 stop18h 00m

$422

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Fri 9/4

6:40 am-12:22 am

1 stop18h 42m

La Crosse

Sun 9/6

6:02 am-4:55 pm

1 stop9h 53m

$452

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sun 9/6

9:03 pm-11:49 am

1 stop15h 46m

La Crosse

Sun 9/13

5:53 am-9:33 pm

1 stop14h 40m

$498

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Sat 9/5

7:15 am-2:42 pm

2 stops8h 27m

La Crosse

Sat 9/12

5:53 am-12:22 pm

1 stop5h 29m

$501

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Wed 10/28

1:49 pm-11:59 pm

2 stops11h 10m

La Crosse

Mon 11/2

6:49 pm-9:26 am

1 stop13h 37m

$518

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Tue 10/27

11:06 am-11:59 pm

2 stops13h 53m

La Crosse

Mon 11/2

6:49 pm-9:26 am

1 stop13h 37m

$518
Quickest round-trip

DetroitLa Crosse

DTW Detroit Metropolitan Wayne County - LSE La Crosse

DTWLSE

Detroit Metropolitan Wayne County

Tue 9/8

6:40 am-11:49 am

1 stop6h 09m

La Crosse

Sat 9/12

5:53 am-12:22 pm

1 stop5h 29m

$533

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Detroit Metropolitan Wayne County to La Crosse?

American Airlines is the most popular carrier operating from Detroit Metropolitan Wayne County to La Crosse

When to book flights from Detroit Metropolitan Wayne County Airport to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to La Crosse (DTW to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to La Crosse

Fastest flight time

5h 51m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to La Crosse takes 5h 51m
There are no direct flights from Detroit Metropolitan Wayne County Airport to La Crosse. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to La Crosse.
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Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to La Crosse

  • How far is Detroit Metropolitan Wayne County to La Crosse by plane?

    Detroit Metropolitan Wayne County and La Crosse are 412.7 mi apart from one another. By plane, this route typically takes 5h 51m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to La Crosse Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to La Crosse Airport refresh daily.

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to La Crosse Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The necessary travel and health documents for your La Crosse Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to La Crosse?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to La Crosse from Detroit.

Can I find flights from Detroit to La Crosse with flexible booking policies on momondo?

Yes. All flights to La Crosse from Detroit on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Detroit to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Detroit.

I’m not ready to book a flight from Detroit to La Crosse right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to La Crosse from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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