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Cheap flights from Des Moines to Knoxville from $198

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 11/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
2:43 pm - 10:26 pmDSM-TYS
6h 43m1 stop
Allegiant Air Logo
1:20 pm - 9:14 pmTYS-DSM
8h 54m1 stop
$232Allegiant Air
Find Deal
Thu, Nov 20 - Sun, Nov 23
Delta Logo
6:29 am - 12:13 pmDSM-TYS
4h 44m1 stop
Delta Logo
5:30 am - 10:41 amTYS-DSM
6h 11m1 stop
$271Delta
Find Deal
Sat, Jan 24 - Wed, Jan 28
United Airlines Logo
7:50 am - 1:24 pmDSM-TYS
4h 34m1 stop
United Airlines Logo
2:25 pm - 9:50 pmTYS-DSM
8h 25m2 stops
$276United Airlines
Find Deal
Sat, Jan 24 - Wed, Jan 28
Allegiant Air Logo
4:21 pm - 9:47 pmDSM-TYS
28h 26m1 stop
Allegiant Air Logo
12:21 pm - 9:58 pmTYS-DSM
10h 37m1 stop
$280Allegiant Air
Find Deal
Thu, Dec 18 - Sun, Dec 21
United Airlines Logo
7:50 am - 7:27 pmDSM-TYS
10h 37m2 stops
United Airlines Logo
2:25 pm - 9:50 pmTYS-DSM
8h 25m2 stops
$281United Airlines
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Sat, Jan 24 - Wed, Jan 28
American Airlines Logo
11:32 am - 5:30 pmDSM-TYS
4h 58m1 stop
American Airlines Logo
3:01 pm - 6:22 pmTYS-DSM
4h 21m1 stop
$300American Airlines
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Thu, Jan 1 - Mon, Jan 5
American Airlines Logo
1:40 pm - 9:38 pmDSM-TYS
6h 58m1 stop
American Airlines Logo
6:25 pm - 11:42 pmTYS-DSM
6h 17m1 stop
$329American Airlines
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Fri, Feb 27 - Mon, Mar 2
Multiple Airlines Logo
9:19 am - 11:55 amDSM-TYS
25h 36m3 stops
Multiple Airlines Logo
1:20 pm - 9:14 pmTYS-DSM
8h 54m1 stop
$366Multiple Airlines
Find Deal
Thu, Nov 20 - Sun, Nov 23
Southwest Logo
5:25 am - 8:20 pmDSM-TYS
13h 55m2 stops
Southwest Logo
6:35 am - 1:15 pmTYS-DSM
7h 40m2 stops
$374Southwest
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Fri, Apr 17 - Mon, Apr 20
Multiple Airlines Logo
4:21 pm - 4:48 pmDSM-TYS
23h 27m3 stops
Multiple Airlines Logo
8:30 am - 10:26 pmTYS-DSM
14h 56m1 stop
$439Multiple Airlines
Find Deal
Thu, Dec 18 - Sun, Dec 21

Allegiant Air flights from Des Moines to Knoxville

Our best Allegiant Air deals on Des Moines to Knoxville flight tickets
Allegiant Air
Nov 20
DSM2:43 pmDes Moines
6h 43m
1 stop
TYS10:26 pmKnoxville McGhee Tyson
Nov 23
TYS1:20 pmKnoxville McGhee Tyson
8h 54m
1 stop
DSM9:14 pmDes Moines
$232
Find similar
Allegiant Air
Dec 18
DSM4:21 pmDes Moines
28h 26m
1 stop
TYS9:47 pmKnoxville McGhee Tyson
Dec 21
TYS12:21 pmKnoxville McGhee Tyson
10h 37m
1 stop
DSM9:58 pmDes Moines
$280
Find similar
Allegiant Air
Nov 10
DSM8:00 amDes Moines
28h 01m
1 stop
TYS1:01 pmKnoxville McGhee Tyson
Nov 13
TYS9:00 amKnoxville McGhee Tyson
6h 01m
1 stop
DSM2:01 pmDes Moines
$283
Find similar

Delta flights from Des Moines to Knoxville

Our best Delta deals on Des Moines to Knoxville flight tickets
Delta
Jan 24
DSM6:29 amDes Moines
4h 44m
1 stop
TYS12:13 pmKnoxville McGhee Tyson
Jan 28
TYS5:30 amKnoxville McGhee Tyson
6h 11m
1 stop
DSM10:41 amDes Moines
$271
Find similar
Delta
Nov 17
DSM2:17 pmDes Moines
6h 33m
1 stop
TYS9:50 pmKnoxville McGhee Tyson
Nov 21
TYS2:41 pmKnoxville McGhee Tyson
4h 05m
1 stop
DSM5:46 pmDes Moines
$417
Find similar
Delta
Nov 24
DSM6:17 amDes Moines
4h 28m
1 stop
TYS11:45 amKnoxville McGhee Tyson
Nov 28
TYS6:35 amKnoxville McGhee Tyson
4h 45m
1 stop
DSM10:20 amDes Moines
$480
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 11/20

2:43 pm-10:26 pm

1 stop6h 43m

Knoxville McGhee Tyson

Sun 11/23

1:20 pm-9:14 pm

1 stop8h 54m

$232

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 1/24

6:29 am-12:13 pm

1 stop4h 44m

Knoxville McGhee Tyson

Wed 1/28

5:30 am-10:41 am

1 stop6h 11m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 1/24

7:50 am-1:24 pm

1 stop4h 34m

Knoxville McGhee Tyson

Wed 1/28

2:25 pm-9:50 pm

2 stops8h 25m

$276

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 12/18

4:21 pm-9:47 pm

1 stop28h 26m

Knoxville McGhee Tyson

Sun 12/21

12:21 pm-9:58 pm

1 stop10h 37m

$280

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 1/24

7:50 am-7:27 pm

2 stops10h 37m

Knoxville McGhee Tyson

Wed 1/28

2:25 pm-9:50 pm

2 stops8h 25m

$281

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 1/1

11:32 am-5:30 pm

1 stop4h 58m

Knoxville McGhee Tyson

Mon 1/5

3:01 pm-6:22 pm

1 stop4h 21m

$300

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 2/27

1:40 pm-9:38 pm

1 stop6h 58m

Knoxville McGhee Tyson

Mon 3/2

6:25 pm-11:42 pm

1 stop6h 17m

$329

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 11/20

9:19 am-11:55 am

3 stops25h 36m

Knoxville McGhee Tyson

Sun 11/23

1:20 pm-9:14 pm

1 stop8h 54m

$366

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 4/17

5:25 am-8:20 pm

2 stops13h 55m

Knoxville McGhee Tyson

Mon 4/20

6:35 am-1:15 pm

2 stops7h 40m

$374

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 12/18

4:21 pm-4:48 pm

3 stops23h 27m

Knoxville McGhee Tyson

Sun 12/21

8:30 am-10:26 pm

1 stop14h 56m

$439

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Des Moines, with most prices found around $253. If you aren’t able to travel during the month of January, then book flights to Knoxville from Des Moines during November instead. Flights to Knoxville in November, while not as cheap as those in January, still average around $283.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Des Moines to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $283. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Knoxville for around $456.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Des Moines to Knoxville when you can find flight prices for as low as $322. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $368.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $366 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Des Moines for as low as $228 on momondo.

How have Des Moines to Knoxville flight prices changed over time?

As of November 2025, prices for Des Moines to Knoxville flights are approximately 47% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Direct flights

None
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
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  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 3h 45m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $203Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
United AirlinesPriceFrom $354Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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