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Cheap flights from Des Moines to Knoxville from $152

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:48 pm - 11:11 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 23m1 stop Minneapolis St Paul
Delta Logo
11:43 am - 4:49 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
6h 06m1 stop Detroit Metropolitan Wayne County
$303Delta
Mon, Nov 9 - Thu, Nov 12
United Airlines Logo
3:11 pm - 8:49 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 38m1 stop Chicago O'Hare Intl
United Airlines Logo
10:42 am - 2:15 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 33m1 stop Chicago O'Hare Intl
$303United Airlines
Mon, Oct 12 - Thu, Oct 15
United Airlines Logo
3:11 pm - 8:49 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 38m1 stop Chicago O'Hare Intl
United Airlines Logo
5:45 am - 2:15 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
9h 30m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
$308United Airlines
Mon, Oct 12 - Thu, Oct 15
Delta Logo
10:24 am - 5:49 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 25m1 stop Detroit Metropolitan Wayne County
Delta Logo
7:22 pm - 10:35 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 13m1 stop Atlanta Hartsfield-Jackson
$321Delta
Fri, Nov 13 - Mon, Nov 16
Allegiant Air Logo
6:37 pm - 7:24 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
23h 47m1 stop Fort Lauderdale
Allegiant Air Logo
1:52 pm - 2:18 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
25h 26m1 stop Punta Gorda
$333Allegiant Air
Sun, Oct 25 - Sat, Oct 31
Allegiant Air Logo
8:30 am - 8:15 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
10h 45m1 stop Punta Gorda
Allegiant Air Logo
2:21 pm - 10:40 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
9h 19m1 stop Punta Gorda
$362Allegiant Air
Mon, Jan 4 - Fri, Jan 8
United Airlines Logo
5:00 am - 2:42 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
8h 42m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
5:20 pm - 10:30 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
6h 10m1 stop Houston George Bush Intcntl
$368United Airlines
Mon, Jan 4 - Fri, Jan 8
American Airlines Logo
4:12 pm - 11:18 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 06m1 stop Dallas/Fort Worth
American Airlines Logo
6:05 pm - 11:04 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 59m1 stop Washington, D.C. Reagan-National
$421American Airlines
Sat, Oct 17 - Mon, Oct 19
American Airlines Logo
4:12 pm - 11:18 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 06m1 stop Dallas/Fort Worth
American Airlines Logo
6:05 pm - 10:45 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 40m1 stop Washington, D.C. Reagan-National
$421American Airlines
Mon, Oct 19 - Mon, Oct 26
Delta Logo
5:45 am - 11:06 amDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 21m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:07 am - 10:18 amTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 11m1 stop Atlanta Hartsfield-Jackson
$463Delta
Wed, Mar 10 - Wed, Mar 17

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United Airlines flights from Des Moines to Knoxville

Our best United Airlines deals on Des Moines to Knoxville flight tickets
United Airlines
Oct 12
DSM3:11 pmDes Moines
4h 38m
1 stop
TYS8:49 pmKnoxville McGhee Tyson
Oct 15
TYS10:42 amKnoxville McGhee Tyson
4h 33m
1 stop
DSM2:15 pmDes Moines
$303
United Airlines
Oct 12
DSM3:11 pmDes Moines
4h 38m
1 stop
TYS8:49 pmKnoxville McGhee Tyson
Oct 15
TYS5:45 amKnoxville McGhee Tyson
9h 30m
2 stops
DSM2:15 pmDes Moines
$308
United Airlines
Jan 4
DSM5:00 amDes Moines
8h 42m
2 stops
TYS2:42 pmKnoxville McGhee Tyson
Jan 8
TYS5:20 pmKnoxville McGhee Tyson
6h 10m
1 stop
DSM10:30 pmDes Moines
$368

Allegiant Air flights from Des Moines to Knoxville

Our best Allegiant Air deals on Des Moines to Knoxville flight tickets
Allegiant Air
Oct 25
DSM6:37 pmDes Moines
23h 47m
1 stop
TYS7:24 pmKnoxville McGhee Tyson
Oct 31
TYS1:52 pmKnoxville McGhee Tyson
25h 26m
1 stop
DSM2:18 pmDes Moines
$333
Allegiant Air
Jan 4
DSM8:30 amDes Moines
10h 45m
1 stop
TYS8:15 pmKnoxville McGhee Tyson
Jan 8
TYS2:21 pmKnoxville McGhee Tyson
9h 19m
1 stop
DSM10:40 pmDes Moines
$362
Allegiant Air
Oct 5
DSM11:00 amDes Moines
8h 38m
1 stop
TYS8:38 pmKnoxville McGhee Tyson
Oct 9
TYS10:07 pmKnoxville McGhee Tyson
18h 19m
1 stop
DSM3:26 pmDes Moines
$543

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

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Price

Cheapest round-trip

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Mon 11/9

2:48 pm-11:11 pm

1 stop7h 23m

Knoxville McGhee Tyson

Thu 11/12

11:43 am-4:49 pm

1 stop6h 06m

$303

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Mon 10/12

3:11 pm-8:49 pm

1 stop4h 38m

Knoxville McGhee Tyson

Thu 10/15

10:42 am-2:15 pm

1 stop4h 33m

$303

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Mon 10/12

3:11 pm-8:49 pm

1 stop4h 38m

Knoxville McGhee Tyson

Thu 10/15

5:45 am-2:15 pm

2 stops9h 30m

$308

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Fri 11/13

10:24 am-5:49 pm

1 stop6h 25m

Knoxville McGhee Tyson

Mon 11/16

7:22 pm-10:35 pm

1 stop4h 13m

$321

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Sun 10/25

6:37 pm-7:24 pm

1 stop23h 47m

Knoxville McGhee Tyson

Sat 10/31

1:52 pm-2:18 pm

1 stop25h 26m

$333

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Mon 1/4

8:30 am-8:15 pm

1 stop10h 45m

Knoxville McGhee Tyson

Fri 1/8

2:21 pm-10:40 pm

1 stop9h 19m

$362

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Mon 1/4

5:00 am-2:42 pm

2 stops8h 42m

Knoxville McGhee Tyson

Fri 1/8

5:20 pm-10:30 pm

1 stop6h 10m

$368

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Sat 10/17

4:12 pm-11:18 pm

1 stop6h 06m

Knoxville McGhee Tyson

Mon 10/19

6:05 pm-11:04 pm

1 stop5h 59m

$421

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Mon 10/19

4:12 pm-11:18 pm

1 stop6h 06m

Knoxville McGhee Tyson

Mon 10/26

6:05 pm-10:45 pm

1 stop5h 40m

$421
Quickest round-trip

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Wed 3/10

5:45 am-11:06 am

1 stop4h 21m

Knoxville McGhee Tyson

Wed 3/17

7:07 am-10:18 am

1 stop4h 11m

$463

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $363 to $614.
The lowest price recently found on this route was $303.

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Des Moines, with most prices found around $0. If you aren’t able to travel during the month of January, then book flights to Knoxville from Des Moines during November instead. Flights to Knoxville in November, while not as cheap as those in January, still average around $203.

How have Des Moines to Knoxville flight prices changed over time?

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Best Price Found

$152

Fastest flight time

4h 41m

Direct flights

None
The best one-way flight to Knoxville from Des Moines in the past 72 hours is $152. The best round-trip flight deal from Des Moines to Knoxville found on momondo in the last 72 hours is $303.
The fastest flight from Des Moines to Knoxville takes 4h 41m
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
Search flight deals

Frequently asked questions about flying from Des Moines to Knoxville

  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 4h 41m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.0
12,082 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.8
8,595 reviews
Search Delta flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
10,225 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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