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Cheap flights from Des Moines to Knoxville from $123

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 6/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
$219Allegiant Air
Thu, Jul 16 - Sun, Jul 19
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
10:05 pm - 3:24 pm
TYS
-
DSM
18h 19m
1 stop
$229Allegiant Air
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Multiple Airlines Logo
12:56 pm - 11:19 pm
TYS
-
DSM
35h 23m
2 stops
$245Multiple Airlines
Thu, Jul 30 - Wed, Aug 5
Allegiant Air Logo
1:58 pm - 6:34 pm
DSM
-
TYS
27h 36m
1 stop
Allegiant Air Logo
11:34 am - 3:35 pm
TYS
-
DSM
29h 01m
1 stop
$248Allegiant Air
Thu, Sep 10 - Thu, Sep 17
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
$263Allegiant Air
Thu, Jul 2 - Sun, Jul 5
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
2:23 pm - 8:33 am
TYS
-
DSM
19h 10m
1 stop
$270Allegiant Air
Thu, Jul 9 - Wed, Jul 15
Allegiant Air Logo
4:40 pm - 8:32 am
DSM
-
TYS
14h 52m
1 stop
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
$271Allegiant Air
Fri, Jul 17 - Sun, Jul 19
Allegiant Air Logo
5:45 pm - 8:35 am
DSM
-
TYS
13h 50m
1 stop
Allegiant Air Logo
3:06 pm - 2:30 pm
TYS
-
DSM
24h 24m
1 stop
$279Allegiant Air
Fri, Jun 26 - Fri, Jul 3
Allegiant Air Logo
1:37 pm - 10:48 pm
DSM
-
TYS
8h 11m
1 stop
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
$280Allegiant Air
Fri, Jul 17 - Sun, Jul 19
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
2:23 pm - 8:33 am
TYS
-
DSM
19h 10m
1 stop
$281Allegiant Air
Thu, Jul 9 - Wed, Jul 15

American Airlines flights from Des Moines to Knoxville

Our best American Airlines deals on Des Moines to Knoxville flight tickets
American Airlines
Aug 4
DSM5:00 amDes Moines
5h 05m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Aug 11
TYS6:52 pmKnoxville McGhee Tyson
6h 28m
1 stop
DSM12:20 amDes Moines
$295
American Airlines
Jul 15
DSM4:48 pmDes Moines
6h 03m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Jul 18
TYS8:05 pmKnoxville McGhee Tyson
5h 04m
1 stop
DSM12:09 amDes Moines
$303
American Airlines
Aug 20
DSM4:13 pmDes Moines
6h 05m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Aug 24
TYS6:52 pmKnoxville McGhee Tyson
6h 28m
1 stop
DSM12:20 amDes Moines
$319

Allegiant Air flights from Des Moines to Knoxville

Our best Allegiant Air deals on Des Moines to Knoxville flight tickets
Allegiant Air
Jul 16
DSM5:08 pmDes Moines
27h 52m
1 stop
TYS10:00 pmKnoxville McGhee Tyson
Jul 19
TYS3:38 pmKnoxville McGhee Tyson
8h 09m
1 stop
DSM10:47 pmDes Moines
$219
Allegiant Air
Jul 16
DSM5:08 pmDes Moines
27h 52m
1 stop
TYS10:00 pmKnoxville McGhee Tyson
Jul 20
TYS10:05 pmKnoxville McGhee Tyson
18h 19m
1 stop
DSM3:24 pmDes Moines
$229
Allegiant Air
Sep 10
DSM1:58 pmDes Moines
27h 36m
1 stop
TYS6:34 pmKnoxville McGhee Tyson
Sep 17
TYS11:34 amKnoxville McGhee Tyson
29h 01m
1 stop
DSM3:35 pmDes Moines
$248

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/16

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Sun 7/19

3:38 pm-10:47 pm

1 stop8h 09m

$219

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/16

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Mon 7/20

10:05 pm-3:24 pm

1 stop18h 19m

$229

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/30

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Wed 8/5

12:56 pm-11:19 pm

2 stops35h 23m

$245

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 9/10

1:58 pm-6:34 pm

1 stop27h 36m

Knoxville McGhee Tyson

Thu 9/17

11:34 am-3:35 pm

1 stop29h 01m

$248

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/2

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Sun 7/5

3:38 pm-10:47 pm

1 stop8h 09m

$263

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/9

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Wed 7/15

2:23 pm-8:33 am

1 stop19h 10m

$270

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 7/17

4:40 pm-8:32 am

1 stop14h 52m

Knoxville McGhee Tyson

Sun 7/19

3:38 pm-10:47 pm

1 stop8h 09m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 6/26

5:45 pm-8:35 am

1 stop13h 50m

Knoxville McGhee Tyson

Fri 7/3

3:06 pm-2:30 pm

1 stop24h 24m

$279
Quickest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 7/17

1:37 pm-10:48 pm

1 stop8h 11m

Knoxville McGhee Tyson

Sun 7/19

3:38 pm-10:47 pm

1 stop8h 09m

$280

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/9

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Wed 7/15

2:23 pm-8:33 am

1 stop19h 10m

$281

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Des Moines, with most prices found around $0. If you aren’t able to travel during the month of January, then book flights to Knoxville from Des Moines during November instead. Flights to Knoxville in November, while not as cheap as those in January, still average around $203.

How have Des Moines to Knoxville flight prices changed over time?

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Des Moines to Knoxville takes 4h 05m
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
Search flight deals

Frequently asked questions about flying from Des Moines to Knoxville

  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 4h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.1
11,643 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.9
8,419 reviews
Search Delta flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
9,763 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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