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Cheap flights from Des Moines to Knoxville from $147

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 3/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:30 am - 4:12 pm
DSM
-
TYS
7h 42m
1 stop
Delta Logo
5:40 am - 10:48 am
TYS
-
DSM
6h 08m
1 stop
$271Delta
ג', מרץ 10 - ש', מרץ 14
American Airlines Logo
1:52 pm - 8:24 pm
DSM
-
TYS
5h 32m
1 stop
American Airlines Logo
7:02 am - 1:07 pm
TYS
-
DSM
7h 05m
1 stop
$282American Airlines
ש', מרץ 28 - ש', אפר' 4
American Airlines Logo
6:00 am - 11:18 am
DSM
-
TYS
4h 18m
1 stop
American Airlines Logo
8:48 pm - 10:26 am
TYS
-
DSM
14h 38m
1 stop
$290American Airlines
ש', אפר' 25 - ו', מאי 1
American Airlines Logo
1:52 pm - 8:05 pm
DSM
-
TYS
5h 13m
1 stop
American Airlines Logo
5:40 am - 10:34 am
TYS
-
DSM
5h 54m
1 stop
$293American Airlines
ב', מרץ 23 - ד', מרץ 25
American Airlines Logo
6:00 am - 3:30 pm
DSM
-
TYS
8h 30m
2 stops
American Airlines Logo
6:05 am - 11:54 am
TYS
-
DSM
6h 49m
1 stop
$305American Airlines
ג', מרץ 10 - ש', מרץ 14
Southwest Logo
5:20 am - 12:05 pm
DSM
-
TYS
5h 45m
2 stops
Southwest Logo
2:45 pm - 10:45 pm
TYS
-
DSM
9h 00m
2 stops
$314Southwest
ג', יוני 23 - ג', יולי 14
Delta Logo
6:30 pm - 11:46 pm
DSM
-
TYS
4h 16m
1 stop
Delta Logo
11:30 am - 4:49 pm
TYS
-
DSM
6h 19m
1 stop
$319Delta
ג', יוני 23 - ג', יולי 14
American Airlines Logo
3:58 pm - 12:28 am
DSM
-
TYS
7h 30m
1 stop
American Airlines Logo
5:02 pm - 9:51 pm
TYS
-
DSM
5h 49m
1 stop
$326American Airlines
ש', פב​​​​​​​' 28 - ב', מרץ 2
American Airlines Logo
5:00 am - 2:29 pm
DSM
-
TYS
8h 29m
2 stops
American Airlines Logo
5:02 pm - 9:51 pm
TYS
-
DSM
5h 49m
1 stop
$331American Airlines
ש', פב​​​​​​​' 28 - ב', מרץ 2
Southwest Logo
6:25 am - 6:20 pm
DSM
-
TYS
10h 55m
1 stop
Southwest Logo
2:45 pm - 10:45 pm
TYS
-
DSM
9h 00m
2 stops
$335Southwest
ג', יוני 23 - ג', יולי 14

American Airlines flights from Des Moines to Knoxville

Our best American Airlines deals on Des Moines to Knoxville flight tickets
American Airlines
Mar 28
DSM1:52 pmDes Moines
5h 32m
1 stop
TYS8:24 pmKnoxville McGhee Tyson
Apr 4
TYS7:02 amKnoxville McGhee Tyson
7h 05m
1 stop
DSM1:07 pmDes Moines
$282
American Airlines
Apr 25
DSM6:00 amDes Moines
4h 18m
1 stop
TYS11:18 amKnoxville McGhee Tyson
May 1
TYS8:48 pmKnoxville McGhee Tyson
14h 38m
1 stop
DSM10:26 amDes Moines
$290
American Airlines
Mar 23
DSM1:52 pmDes Moines
5h 13m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
Mar 25
TYS5:40 amKnoxville McGhee Tyson
5h 54m
1 stop
DSM10:34 amDes Moines
$293

Southwest flights from Des Moines to Knoxville

Our best Southwest deals on Des Moines to Knoxville flight tickets
Southwest
Jun 23
DSM5:20 amDes Moines
5h 45m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
Jul 14
TYS2:45 pmKnoxville McGhee Tyson
9h 00m
2 stops
DSM10:45 pmDes Moines
$314
Southwest
Jun 23
DSM6:25 amDes Moines
10h 55m
1 stop
TYS6:20 pmKnoxville McGhee Tyson
Jul 14
TYS2:45 pmKnoxville McGhee Tyson
9h 00m
2 stops
DSM10:45 pmDes Moines
$335
Southwest
Apr 25
DSM6:40 amDes Moines
10h 50m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
May 1
TYS8:05 amKnoxville McGhee Tyson
16h 00m
2 stops
DSM11:05 pmDes Moines
$352

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated פברואר 9, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ג' 3/10

7:30 am-4:12 pm

1 stop7h 42m

Knoxville McGhee Tyson

ש' 3/14

5:40 am-10:48 am

1 stop6h 08m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ש' 3/28

1:52 pm-8:24 pm

1 stop5h 32m

Knoxville McGhee Tyson

ש' 4/4

7:02 am-1:07 pm

1 stop7h 05m

$282

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ש' 4/25

6:00 am-11:18 am

1 stop4h 18m

Knoxville McGhee Tyson

ו' 5/1

8:48 pm-10:26 am

1 stop14h 38m

$290

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ב' 3/23

1:52 pm-8:05 pm

1 stop5h 13m

Knoxville McGhee Tyson

ד' 3/25

5:40 am-10:34 am

1 stop5h 54m

$293

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ג' 3/10

6:00 am-3:30 pm

2 stops8h 30m

Knoxville McGhee Tyson

ש' 3/14

6:05 am-11:54 am

1 stop6h 49m

$305

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ג' 6/23

5:20 am-12:05 pm

2 stops5h 45m

Knoxville McGhee Tyson

ג' 7/14

2:45 pm-10:45 pm

2 stops9h 00m

$314

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ג' 6/23

6:30 pm-11:46 pm

1 stop4h 16m

Knoxville McGhee Tyson

ג' 7/14

11:30 am-4:49 pm

1 stop6h 19m

$319

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ש' 2/28

3:58 pm-12:28 am

1 stop7h 30m

Knoxville McGhee Tyson

ב' 3/2

5:02 pm-9:51 pm

1 stop5h 49m

$326

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ש' 2/28

5:00 am-2:29 pm

2 stops8h 29m

Knoxville McGhee Tyson

ב' 3/2

5:02 pm-9:51 pm

1 stop5h 49m

$331

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

ג' 6/23

6:25 am-6:20 pm

1 stop10h 55m

Knoxville McGhee Tyson

ג' 7/14

2:45 pm-10:45 pm

2 stops9h 00m

$335

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Des Moines to Knoxville flight prices changed over time?

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Fastest flight time

3h 35m

Direct flights

None
The fastest flight from Des Moines to Knoxville takes 3h 35m
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
Search flight deals

  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 3h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.9
8,176 reviews
Search Delta flights
United AirlinesPriceFrom $300Free CancellationRating
7.4
9,262 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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ד' 3/11
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