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Cheap flights from Des Moines to Knoxville from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 5/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 am - 12:30 pm
DSM
-
TYS
6h 30m
1 stop
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
$231American Airlines
Sat, May 2 - Tue, May 5
Allegiant Air Logo
10:57 am - 12:03 pm
DSM
-
TYS
24h 06m
1 stop
Allegiant Air Logo
3:38 pm - 9:27 pm
TYS
-
DSM
6h 49m
1 stop
$240Allegiant Air
Sun, Jul 19 - Thu, Jul 23
American Airlines Logo
2:16 pm - 9:21 pm
DSM
-
TYS
6h 05m
1 stop
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
$261American Airlines
Sat, May 2 - Tue, May 5
American Airlines Logo
8:56 am - 5:07 pm
DSM
-
TYS
7h 11m
2 stops
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
$269American Airlines
Sat, May 2 - Tue, May 5
American Airlines Logo
5:00 am - 12:30 pm
DSM
-
TYS
6h 30m
1 stop
American Airlines Logo
6:54 pm - 11:16 pm
TYS
-
DSM
5h 22m
1 stop
$278American Airlines
Sat, May 2 - Tue, May 5
American Airlines Logo
8:56 am - 5:07 pm
DSM
-
TYS
7h 11m
2 stops
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
$282American Airlines
Sat, May 2 - Tue, May 5
Allegiant Air Logo
6:27 pm - 6:25 pm
DSM
-
TYS
22h 58m
1 stop
Allegiant Air Logo
2:56 pm - 9:31 pm
TYS
-
DSM
7h 35m
1 stop
$291Allegiant Air
Sun, Aug 9 - Thu, Aug 13
American Airlines Logo
12:00 pm - 8:18 pm
DSM
-
TYS
7h 18m
1 stop
American Airlines Logo
7:50 am - 11:30 am
TYS
-
DSM
4h 40m
1 stop
$295American Airlines
Sat, May 2 - Tue, May 5
Multiple Airlines Logo
2:16 pm - 1:52 pm
DSM
-
TYS
22h 36m
1 stop
Multiple Airlines Logo
7:26 pm - 3:21 pm
TYS
-
DSM
20h 55m
1 stop
$300Multiple Airlines
Wed, Jun 17 - Mon, Jun 22
American Airlines Logo
12:00 pm - 8:18 pm
DSM
-
TYS
7h 18m
1 stop
American Airlines Logo
1:20 pm - 5:43 pm
TYS
-
DSM
5h 23m
1 stop
$311American Airlines
Sat, May 2 - Tue, May 5

American Airlines flights from Des Moines to Knoxville

Our best American Airlines deals on Des Moines to Knoxville flight tickets
American Airlines
May 2
DSM5:00 amDes Moines
6h 30m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
May 5
TYS5:00 amKnoxville McGhee Tyson
7h 30m
2 stops
DSM11:30 amDes Moines
$231
American Airlines
May 2
DSM2:16 pmDes Moines
6h 05m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
May 5
TYS5:00 amKnoxville McGhee Tyson
7h 30m
2 stops
DSM11:30 amDes Moines
$261
American Airlines
May 2
DSM8:56 amDes Moines
7h 11m
2 stops
TYS5:07 pmKnoxville McGhee Tyson
May 5
TYS5:00 amKnoxville McGhee Tyson
7h 30m
2 stops
DSM11:30 amDes Moines
$269

Allegiant Air flights from Des Moines to Knoxville

Our best Allegiant Air deals on Des Moines to Knoxville flight tickets
Allegiant Air
Jul 19
DSM10:57 amDes Moines
24h 06m
1 stop
TYS12:03 pmKnoxville McGhee Tyson
Jul 23
TYS3:38 pmKnoxville McGhee Tyson
6h 49m
1 stop
DSM9:27 pmDes Moines
$240
Allegiant Air
Aug 9
DSM6:27 pmDes Moines
22h 58m
1 stop
TYS6:25 pmKnoxville McGhee Tyson
Aug 13
TYS2:56 pmKnoxville McGhee Tyson
7h 35m
1 stop
DSM9:31 pmDes Moines
$291
Allegiant Air
Jun 17
DSM11:00 amDes Moines
29h 14m
2 stops
TYS5:14 pmKnoxville McGhee Tyson
Jun 22
TYS10:03 pmKnoxville McGhee Tyson
18h 18m
1 stop
DSM3:21 pmDes Moines
$327

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

5:00 am-12:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Tue 5/5

5:00 am-11:30 am

2 stops7h 30m

$231

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 7/19

10:57 am-12:03 pm

1 stop24h 06m

Knoxville McGhee Tyson

Thu 7/23

3:38 pm-9:27 pm

1 stop6h 49m

$240

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

2:16 pm-9:21 pm

1 stop6h 05m

Knoxville McGhee Tyson

Tue 5/5

5:00 am-11:30 am

2 stops7h 30m

$261

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

8:56 am-5:07 pm

2 stops7h 11m

Knoxville McGhee Tyson

Tue 5/5

5:00 am-11:30 am

2 stops7h 30m

$269
Quickest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

5:00 am-12:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Tue 5/5

6:54 pm-11:16 pm

1 stop5h 22m

$278

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

8:56 am-5:07 pm

2 stops7h 11m

Knoxville McGhee Tyson

Tue 5/5

5:00 am-11:30 am

2 stops7h 30m

$282

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 8/9

6:27 pm-6:25 pm

1 stop22h 58m

Knoxville McGhee Tyson

Thu 8/13

2:56 pm-9:31 pm

1 stop7h 35m

$291

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

12:00 pm-8:18 pm

1 stop7h 18m

Knoxville McGhee Tyson

Tue 5/5

7:50 am-11:30 am

1 stop4h 40m

$295

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 6/17

2:16 pm-1:52 pm

1 stop22h 36m

Knoxville McGhee Tyson

Mon 6/22

7:26 pm-3:21 pm

1 stop20h 55m

$300

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/2

12:00 pm-8:18 pm

1 stop7h 18m

Knoxville McGhee Tyson

Tue 5/5

1:20 pm-5:43 pm

1 stop5h 23m

$311

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Knoxville?

How have Des Moines to Knoxville flight prices changed over time?

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Des Moines to Knoxville takes 4h 15m
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
Search flight deals

  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 4h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.1
11,530 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.9
8,359 reviews
Search Delta flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
9,514 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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