Cheap flights from Des Moines to Knoxville from $128
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 7/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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How to get the cheapest flight ticket from Des Moines to Knoxville
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to Knoxville?
The month of January is, on average, the cheapest month to fly to Knoxville from Des Moines, with most prices found around $253. If you aren’t able to travel during the month of January, then book flights to Knoxville from Des Moines during November instead. Flights to Knoxville in November, while not as cheap as those in January, still average around $326.
What is the cheapest day to depart on your flight to Knoxville?
The cheapest day to depart from Des Moines to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $283. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Knoxville for around $456.
What is the cheapest time of day to depart on your flight to Knoxville?
At noon is the cheapest time of day to fly from Des Moines to Knoxville when you can find flight prices for as low as $322. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $368.
How far in advance should I book a flight to Knoxville?
You are more likely to see cheaper flights to Knoxville from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $357 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Des Moines for as low as $252 on momondo.
What is the cheapest airline that flies from Des Moines to Knoxville McGhee Tyson?
Allegiant Air is the most popular carrier operating from Des Moines to Knoxville McGhee Tyson
What airlines fly to Knoxville?
American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Des Moines according to our data. American Airlines is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.
When to book flights from Des Moines to Knoxville
Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville
How far is Des Moines to Knoxville McGhee Tyson by plane?
Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 4h 19m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.
How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?
As of June 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Knoxville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Knoxville is American Airlines (65% of total bookings). The next most popular airlines are Delta (21%) and United Airlines (14%).
Best airlines flying from Des Moines to Knoxville
Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $208 | Free Cancellation | Rating 8.0 7,964 reviews | |||
| PriceFrom $248 | Free Cancellation | Rating 7.4 8,810 reviews | |||
| PriceFrom $248 | Free Cancellation | Rating 7.2 10,000 reviews |
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Des Moines to Knoxville?
To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.
Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?
Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.
How can momondo help me find flights from Des Moines to Knoxville?
Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.
I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?
If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.