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Cheap flights from Des Moines to Knoxville from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 12/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Allegiant Air Logo
6:30 am - 4:44 pmDSM-TYS
9h 14m1 stop
Allegiant Air Logo
2:20 pm - 8:02 amTYS-DSM
18h 42m1 stop
$236Allegiant Air
Find Deal
jue., oct. 16 - sáb., oct. 25
Logo
6:30 am - 6:45 pmDSM-TYS
11h 15m1 stop
Logo
7:00 am - 1:40 pmTYS-DSM
7h 40m1 stop
$247
Find Deal
dom., sep. 28 - jue., oct. 2
Allegiant Air Logo
6:30 am - 6:45 pmDSM-TYS
11h 15m1 stop
Allegiant Air Logo
5:44 pm - 8:05 amTYS-DSM
15h 21m2 stops
$268Allegiant Air
Find Deal
dom., sep. 28 - jue., oct. 2
Allegiant Air Logo
10:50 am - 10:33 pmDSM-TYS
10h 43m1 stop
Allegiant Air Logo
9:00 am - 2:01 pmTYS-DSM
6h 01m1 stop
$276Allegiant Air
Find Deal
jue., nov. 6 - dom., nov. 9
Delta Logo
6:05 am - 11:04 amDSM-TYS
3h 59m1 stop
Delta Logo
7:11 am - 10:05 amTYS-DSM
3h 54m1 stop
$304Delta
Find Deal
mié., oct. 22 - dom., oct. 26
American Airlines Logo
5:40 am - 12:44 pmDSM-TYS
6h 04m1 stop
American Airlines Logo
5:45 pm - 11:45 pmTYS-DSM
7h 00m1 stop
$306American Airlines
Find Deal
dom., dic. 7 - sáb., dic. 13
American Airlines Logo
5:40 am - 2:29 pmDSM-TYS
7h 49m2 stops
American Airlines Logo
8:06 am - 11:42 amTYS-DSM
4h 36m1 stop
$311American Airlines
Find Deal
dom., dic. 7 - sáb., dic. 13
Delta Logo
2:45 pm - 11:09 pmDSM-TYS
7h 24m1 stop
Delta Logo
6:29 am - 10:20 amTYS-DSM
4h 51m1 stop
$337Delta
Find Deal
lun., nov. 17 - vie., nov. 21
United Airlines Logo
3:15 pm - 11:59 pmDSM-TYS
7h 44m2 stops
United Airlines Logo
5:45 am - 2:19 pmTYS-DSM
9h 34m2 stops
$391United Airlines
Find Deal
lun., oct. 27 - jue., oct. 30
United Airlines Logo
8:02 am - 1:17 pmDSM-TYS
4h 15m1 stop
United Airlines Logo
10:50 am - 2:19 pmTYS-DSM
4h 29m1 stop
$399United Airlines
Find Deal
mié., nov. 19 - sáb., nov. 22

American Airlines flights from Des Moines to Knoxville

Our best American Airlines deals on Des Moines to Knoxville flight tickets
American Airlines
Dec 7
DSM5:40 amDes Moines
6h 04m
1 stop
TYS12:44 pmKnoxville McGhee Tyson
Dec 13
TYS5:45 pmKnoxville McGhee Tyson
7h 00m
1 stop
DSM11:45 pmDes Moines
$306
Find similar
American Airlines
Dec 7
DSM5:40 amDes Moines
7h 49m
2 stops
TYS2:29 pmKnoxville McGhee Tyson
Dec 13
TYS8:06 amKnoxville McGhee Tyson
4h 36m
1 stop
DSM11:42 amDes Moines
$311
Find similar
American Airlines
Nov 21
DSM8:51 amDes Moines
7h 29m
1 stop
TYS5:20 pmKnoxville McGhee Tyson
Nov 23
TYS6:30 amKnoxville McGhee Tyson
7h 59m
1 stop
DSM1:29 pmDes Moines
$329
Find similar

Allegiant Air flights from Des Moines to Knoxville

Our best Allegiant Air deals on Des Moines to Knoxville flight tickets
Allegiant Air
Oct 16
DSM6:30 amDes Moines
9h 14m
1 stop
TYS4:44 pmKnoxville McGhee Tyson
Oct 25
TYS2:20 pmKnoxville McGhee Tyson
18h 42m
1 stop
DSM8:02 amDes Moines
$236
Find similar
Allegiant Air
Sep 28
DSM6:30 amDes Moines
11h 15m
1 stop
TYS6:45 pmKnoxville McGhee Tyson
Oct 2
TYS5:44 pmKnoxville McGhee Tyson
15h 21m
2 stops
DSM8:05 amDes Moines
$268
Find similar
Allegiant Air
Nov 6
DSM10:50 amDes Moines
10h 43m
1 stop
TYS10:33 pmKnoxville McGhee Tyson
Nov 9
TYS9:00 amKnoxville McGhee Tyson
6h 01m
1 stop
DSM2:01 pmDes Moines
$276
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

jue. 10/16

6:30 am-4:44 pm

1 stop9h 14m

Knoxville McGhee Tyson

sáb. 10/25

2:20 pm-8:02 am

1 stop18h 42m

$236

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

dom. 9/28

6:30 am-6:45 pm

1 stop11h 15m

Knoxville McGhee Tyson

jue. 10/2

7:00 am-1:40 pm

1 stop7h 40m

$247

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

dom. 9/28

6:30 am-6:45 pm

1 stop11h 15m

Knoxville McGhee Tyson

jue. 10/2

5:44 pm-8:05 am

2 stops15h 21m

$268

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

jue. 11/6

10:50 am-10:33 pm

1 stop10h 43m

Knoxville McGhee Tyson

dom. 11/9

9:00 am-2:01 pm

1 stop6h 01m

$276

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

mié. 10/22

6:05 am-11:04 am

1 stop3h 59m

Knoxville McGhee Tyson

dom. 10/26

7:11 am-10:05 am

1 stop3h 54m

$304

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

dom. 12/7

5:40 am-12:44 pm

1 stop6h 04m

Knoxville McGhee Tyson

sáb. 12/13

5:45 pm-11:45 pm

1 stop7h 00m

$306

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

dom. 12/7

5:40 am-2:29 pm

2 stops7h 49m

Knoxville McGhee Tyson

sáb. 12/13

8:06 am-11:42 am

1 stop4h 36m

$311

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

lun. 11/17

2:45 pm-11:09 pm

1 stop7h 24m

Knoxville McGhee Tyson

vie. 11/21

6:29 am-10:20 am

1 stop4h 51m

$337

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

lun. 10/27

3:15 pm-11:59 pm

2 stops7h 44m

Knoxville McGhee Tyson

jue. 10/30

5:45 am-2:19 pm

2 stops9h 34m

$391

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

mié. 11/19

8:02 am-1:17 pm

1 stop4h 15m

Knoxville McGhee Tyson

sáb. 11/22

10:50 am-2:19 pm

1 stop4h 29m

$399

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Des Moines, with most prices found around $253. If you aren’t able to travel during the month of January, then book flights to Knoxville from Des Moines during July instead. Flights to Knoxville in July, while not as cheap as those in January, still average around $308.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Des Moines to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $283. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Knoxville for around $456.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Des Moines to Knoxville when you can find flight prices for as low as $322. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $368.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $369 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Des Moines for as low as $308 on momondo.

How have Des Moines to Knoxville flight prices changed over time?

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Direct flights

None
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
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  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 3h 59m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
7,954 reviews
Search Delta flights
United AirlinesPriceFrom $331Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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