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Cheap flights from Des Moines to Knoxville from $140

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
1:58 pm - 7:34 pm
DSM
-
TYS
28h 36m
1 stop
Allegiant Air Logo
4:14 pm - 9:02 am
TYS
-
DSM
17h 48m
1 stop
$249Allegiant Air
Sun, Sep 27 - Wed, Sep 30
Delta Logo
5:40 am - 11:11 am
DSM
-
TYS
4h 31m
1 stop
Delta Logo
6:35 am - 10:18 am
TYS
-
DSM
4h 43m
1 stop
$279Delta
Thu, Aug 13 - Thu, Aug 20
American Airlines Logo
8:10 am - 3:57 pm
DSM
-
TYS
6h 47m
1 stop
American Airlines Logo
6:50 pm - 11:16 pm
TYS
-
DSM
5h 26m
1 stop
$279American Airlines
Sat, Aug 22 - Sat, Aug 29
Delta Logo
5:40 am - 11:11 am
DSM
-
TYS
4h 31m
1 stop
Delta Logo
7:30 am - 10:43 am
TYS
-
DSM
4h 13m
1 stop
$279Delta
Thu, Aug 13 - Sat, Aug 22
Delta Logo
5:40 am - 11:11 am
DSM
-
TYS
4h 31m
1 stop
Delta Logo
6:35 am - 10:18 am
TYS
-
DSM
4h 43m
1 stop
$279Delta
Thu, Aug 13 - Wed, Aug 19
United Airlines Logo
11:32 am - 4:58 pm
DSM
-
TYS
4h 26m
1 stop
United Airlines Logo
5:45 am - 2:16 pm
TYS
-
DSM
9h 31m
2 stops
$284United Airlines
Sat, Aug 22 - Sat, Aug 29
Multiple Airlines Logo
5:12 pm - 10:24 pm
DSM
-
TYS
28h 12m
1 stop
Multiple Airlines Logo
2:39 pm - 6:48 pm
TYS
-
DSM
29h 09m
2 stops
$284Multiple Airlines
Thu, Aug 13 - Thu, Aug 20
Allegiant Air Logo
1:55 pm - 6:35 pm
DSM
-
TYS
27h 40m
1 stop
Allegiant Air Logo
1:21 pm - 4:38 pm
TYS
-
DSM
28h 17m
1 stop
$286Allegiant Air
Sun, Aug 23 - Sun, Aug 30
American Airlines Logo
10:26 am - 6:22 pm
DSM
-
TYS
6h 56m
1 stop
American Airlines Logo
6:52 pm - 12:35 am
TYS
-
DSM
6h 43m
1 stop
$287American Airlines
Tue, Aug 25 - Sat, Aug 29
United Airlines Logo
6:15 am - 1:20 pm
DSM
-
TYS
6h 05m
1 stop
United Airlines Logo
6:02 pm - 9:23 pm
TYS
-
DSM
4h 21m
1 stop
$287United Airlines
Tue, Aug 25 - Sat, Aug 29

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United Airlines flights from Des Moines to Knoxville

Our best United Airlines deals on Des Moines to Knoxville flight tickets
United Airlines
Aug 25
DSM3:02 pmDes Moines
5h 43m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
Aug 29
TYS5:45 amKnoxville McGhee Tyson
9h 31m
2 stops
DSM2:16 pmDes Moines
$292
United Airlines
Sep 2
DSM6:00 amDes Moines
7h 37m
2 stops
TYS2:37 pmKnoxville McGhee Tyson
Sep 6
TYS7:00 amKnoxville McGhee Tyson
4h 26m
1 stop
DSM10:26 amDes Moines
$293
United Airlines
Sep 12
DSM6:24 amDes Moines
7h 13m
2 stops
TYS2:37 pmKnoxville McGhee Tyson
Sep 19
TYS5:45 amKnoxville McGhee Tyson
9h 35m
2 stops
DSM2:20 pmDes Moines
$298

Southwest flights from Des Moines to Knoxville

Our best Southwest deals on Des Moines to Knoxville flight tickets
Southwest
Aug 25
DSM6:10 amDes Moines
7h 10m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
Aug 29
TYS6:50 amKnoxville McGhee Tyson
8h 20m
2 stops
DSM2:10 pmDes Moines
$297
Southwest
Nov 5
DSM6:40 amDes Moines
11h 05m
1 stop
TYS6:45 pmKnoxville McGhee Tyson
Nov 9
TYS12:50 pmKnoxville McGhee Tyson
11h 10m
2 stops
DSM11:00 pmDes Moines
$320
Southwest
Nov 5
DSM5:25 amDes Moines
14h 05m
2 stops
TYS8:30 pmKnoxville McGhee Tyson
Nov 9
TYS12:50 pmKnoxville McGhee Tyson
11h 10m
2 stops
DSM11:00 pmDes Moines
$325

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 9/27

1:58 pm-7:34 pm

1 stop28h 36m

Knoxville McGhee Tyson

Wed 9/30

4:14 pm-9:02 am

1 stop17h 48m

$249

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:40 am-11:11 am

1 stop4h 31m

Knoxville McGhee Tyson

Thu 8/20

6:35 am-10:18 am

1 stop4h 43m

$279

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 8/22

8:10 am-3:57 pm

1 stop6h 47m

Knoxville McGhee Tyson

Sat 8/29

6:50 pm-11:16 pm

1 stop5h 26m

$279
Quickest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:40 am-11:11 am

1 stop4h 31m

Knoxville McGhee Tyson

Sat 8/22

7:30 am-10:43 am

1 stop4h 13m

$279

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:40 am-11:11 am

1 stop4h 31m

Knoxville McGhee Tyson

Wed 8/19

6:35 am-10:18 am

1 stop4h 43m

$279

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 8/22

11:32 am-4:58 pm

1 stop4h 26m

Knoxville McGhee Tyson

Sat 8/29

5:45 am-2:16 pm

2 stops9h 31m

$284

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:12 pm-10:24 pm

1 stop28h 12m

Knoxville McGhee Tyson

Thu 8/20

2:39 pm-6:48 pm

2 stops29h 09m

$284

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 8/23

1:55 pm-6:35 pm

1 stop27h 40m

Knoxville McGhee Tyson

Sun 8/30

1:21 pm-4:38 pm

1 stop28h 17m

$286

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

10:26 am-6:22 pm

1 stop6h 56m

Knoxville McGhee Tyson

Sat 8/29

6:52 pm-12:35 am

1 stop6h 43m

$287

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

6:15 am-1:20 pm

1 stop6h 05m

Knoxville McGhee Tyson

Sat 8/29

6:02 pm-9:23 pm

1 stop4h 21m

$287

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Des Moines to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $283 to $434.
The lowest price recently found on this route was $279.

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Des Moines, with most prices found around $0. If you aren’t able to travel during the month of January, then book flights to Knoxville from Des Moines during November instead. Flights to Knoxville in November, while not as cheap as those in January, still average around $203.

How have Des Moines to Knoxville flight prices changed over time?

When to book flights from Des Moines to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Knoxville (DSM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Knoxville

Fastest flight time

5h 55m

Direct flights

None
The fastest flight from Des Moines to Knoxville takes 5h 55m
There are no direct flights from Des Moines to Knoxville. There are no popular flight routes from Des Moines to Knoxville.
Search flight deals

Frequently asked questions about flying from Des Moines to Knoxville

  • How far is Des Moines to Knoxville McGhee Tyson by plane?

    Des Moines and Knoxville McGhee Tyson are 650.4 mi apart from one another. Flights usually cover this in 5h 55m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Des Moines Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Des Moines Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Knoxville?

Best airlines flying from Des Moines to Knoxville

Compare and see reviews for airlines that fly from Des Moines to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.1
11,836 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.8
8,482 reviews
Search Delta flights
United AirlinesPriceFrom $299Free CancellationRating
7.4
10,041 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Des Moines.

Can I find flights from Des Moines to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Knoxville?

Once you have performed a search for Des Moines to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Des Moines and alert you when they change.

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