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Cheap flights from Des Moines to Indianapolis from $143

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Indianapolis departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Indianapolis

Cheap round-trip flights

American Airlines Logo
5:42 pm - 11:44 pmDSM-IND
5h 02m1 stop
American Airlines Logo
6:00 am - 8:22 amIND-DSM
3h 22m1 stop
$227American Airlines
Find Deal
Wed, Oct 29 - Thu, Oct 30
Delta Logo
6:05 am - 11:14 amDSM-IND
4h 09m1 stop
Delta Logo
11:54 am - 4:52 pmIND-DSM
5h 58m1 stop
$237Delta
Find Deal
Wed, Oct 29 - Tue, Nov 4
American Airlines Logo
5:42 pm - 11:44 pmDSM-IND
5h 02m1 stop
American Airlines Logo
7:00 pm - 11:30 pmIND-DSM
5h 30m1 stop
$238American Airlines
Find Deal
Tue, Oct 28 - Tue, Nov 4
Southwest Logo
5:25 am - 12:15 pmDSM-IND
5h 50m1 stop
Southwest Logo
7:10 am - 11:25 amIND-DSM
5h 15m2 stops
$249Southwest
Find Deal
Sat, Nov 15 - Tue, Nov 18
Southwest Logo
5:25 am - 3:40 pmDSM-IND
9h 15m2 stops
Southwest Logo
7:10 am - 11:25 amIND-DSM
5h 15m2 stops
$254Southwest
Find Deal
Sat, Nov 15 - Tue, Nov 18
Delta Logo
5:52 pm - 12:15 amDSM-IND
5h 23m1 stop
Delta Logo
4:28 pm - 9:04 pmIND-DSM
5h 36m1 stop
$278Delta
Find Deal
Fri, Nov 14 - Mon, Nov 17
Allegiant Air Logo
9:22 am - 8:11 pmDSM-IND
9h 49m1 stop
Allegiant Air Logo
12:13 pm - 8:24 pmIND-DSM
9h 11m1 stop
$302Allegiant Air
Find Deal
Sun, Oct 12 - Sun, Oct 19
Allegiant Air Logo
1:51 pm - 3:41 pmDSM-IND
24h 50m1 stop
Allegiant Air Logo
12:13 pm - 8:24 pmIND-DSM
9h 11m1 stop
$323Allegiant Air
Find Deal
Sun, Sep 28 - Thu, Oct 2
United Airlines Logo
3:15 pm - 7:59 pmDSM-IND
3h 44m1 stop
United Airlines Logo
5:05 pm - 10:30 pmIND-DSM
6h 25m1 stop
$325United Airlines
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Mon, Nov 17 - Mon, Jan 19
United Airlines Logo
1:35 pm - 10:30 pmDSM-IND
7h 55m1 stop
United Airlines Logo
6:00 am - 4:07 pmIND-DSM
11h 07m2 stops
$435United Airlines
Find Deal
Wed, Oct 29 - Tue, Nov 4

Delta flights from Des Moines to Indianapolis

Our best Delta deals on Des Moines to Indianapolis flight tickets
Delta
Oct 29
DSM6:05 amDes Moines
4h 09m
1 stop
IND11:14 amIndianapolis
Nov 4
IND11:54 amIndianapolis
5h 58m
1 stop
DSM4:52 pmDes Moines
$237
Find similar
Delta
Nov 14
DSM5:52 pmDes Moines
5h 23m
1 stop
IND12:15 amIndianapolis
Nov 17
IND4:28 pmIndianapolis
5h 36m
1 stop
DSM9:04 pmDes Moines
$278
Find similar
Delta
Oct 24
DSM5:32 pmDes Moines
4h 57m
1 stop
IND11:29 pmIndianapolis
Oct 26
IND7:05 amIndianapolis
4h 21m
1 stop
DSM10:26 amDes Moines
$309
Find similar

Southwest flights from Des Moines to Indianapolis

Our best Southwest deals on Des Moines to Indianapolis flight tickets
Southwest
Nov 15
DSM5:25 amDes Moines
5h 50m
1 stop
IND12:15 pmIndianapolis
Nov 18
IND7:10 amIndianapolis
5h 15m
2 stops
DSM11:25 amDes Moines
$249
Find similar
Southwest
Nov 15
DSM5:25 amDes Moines
9h 15m
2 stops
IND3:40 pmIndianapolis
Nov 18
IND7:10 amIndianapolis
5h 15m
2 stops
DSM11:25 amDes Moines
$254
Find similar
Southwest
Nov 14
DSM8:00 amDes Moines
14h 35m
2 stops
IND11:35 pmIndianapolis
Nov 17
IND7:10 amIndianapolis
5h 15m
2 stops
DSM11:25 amDes Moines
$307
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 10/29

5:42 pm-11:44 pm

1 stop5h 02m

Indianapolis

Thu 10/30

6:00 am-8:22 am

1 stop3h 22m

$227

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 10/29

6:05 am-11:14 am

1 stop4h 09m

Indianapolis

Tue 11/4

11:54 am-4:52 pm

1 stop5h 58m

$237

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 10/28

5:42 pm-11:44 pm

1 stop5h 02m

Indianapolis

Tue 11/4

7:00 pm-11:30 pm

1 stop5h 30m

$238

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sat 11/15

5:25 am-12:15 pm

1 stop5h 50m

Indianapolis

Tue 11/18

7:10 am-11:25 am

2 stops5h 15m

$249

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sat 11/15

5:25 am-3:40 pm

2 stops9h 15m

Indianapolis

Tue 11/18

7:10 am-11:25 am

2 stops5h 15m

$254

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Fri 11/14

5:52 pm-12:15 am

1 stop5h 23m

Indianapolis

Mon 11/17

4:28 pm-9:04 pm

1 stop5h 36m

$278

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sun 10/12

9:22 am-8:11 pm

1 stop9h 49m

Indianapolis

Sun 10/19

12:13 pm-8:24 pm

1 stop9h 11m

$302

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sun 9/28

1:51 pm-3:41 pm

1 stop24h 50m

Indianapolis

Thu 10/2

12:13 pm-8:24 pm

1 stop9h 11m

$323

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 11/17

3:15 pm-7:59 pm

1 stop3h 44m

Indianapolis

Mon 1/19

5:05 pm-10:30 pm

1 stop6h 25m

$325

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 10/29

1:35 pm-10:30 pm

1 stop7h 55m

Indianapolis

Tue 11/4

6:00 am-4:07 pm

2 stops11h 07m

$435

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Des Moines to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, July is the cheapest month to fly from Des Moines to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $259. If you are unable to visit Indianapolis during the month of July, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $272.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Monday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $479. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Wednesday is $1,408.

How have Des Moines to Indianapolis flight prices changed over time?

As of September 2025, prices for Des Moines to Indianapolis flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Indianapolis (DSM to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Indianapolis

Direct flights

None
There are no direct flights from Des Moines to Indianapolis. There are no popular flight routes from Des Moines to Indianapolis.
Search flight deals

  • How far is Des Moines to Indianapolis by plane?

    There are 410.6 mi between Des Moines and Indianapolis. 3h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Indianapolis Airport?

    Prices for flights from Des Moines Airport to Indianapolis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Indianapolis Airport?

  • How old do you have to be to fly from Des Moines Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents required for your trip to Indianapolis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indianapolis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Indianapolis?

Best airlines flying from Des Moines to Indianapolis

Compare and see reviews for airlines that fly from Des Moines to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
7,954 reviews
Search Delta flights
American AirlinesPriceFrom $196Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $210Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Brownsburg
Crawfordsville
Speedway
Greenfield
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Indianapolis?

Finding the right flight to Indianapolis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Indianapolis quick and easy, saving you time and money.

Can I find flights from Des Moines to Indianapolis with flexible booking policies on momondo?

All flight searches from Des Moines to Indianapolis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Indianapolis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Indianapolis from Des Moines.

I’m not ready to book a flight from Des Moines to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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