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Cheap flights from Des Moines to Indianapolis from $133

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Indianapolis departing on 11/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:17 am - 11:28 amDSM-IND
4h 11m1 stop
Delta Logo
4:46 pm - 8:46 pmIND-DSM
5h 00m1 stop
$232Delta
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Mon, Nov 24 - Tue, Dec 2
Delta Logo
6:17 am - 11:28 amDSM-IND
4h 11m1 stop
Delta Logo
12:09 pm - 4:16 pmIND-DSM
5h 07m1 stop
$239Delta
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Mon, Nov 24 - Thu, Dec 4
Multiple Airlines Logo
9:19 am - 7:51 pmDSM-IND
9h 32m1 stop
Multiple Airlines Logo
8:48 am - 12:55 pmIND-DSM
29h 07m1 stop
$260Multiple Airlines
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Thu, Nov 20 - Thu, Dec 4
Multiple Airlines Logo
10:55 am - 8:44 amDSM-IND
20h 49m1 stop
Multiple Airlines Logo
5:05 am - 2:55 pmIND-DSM
10h 50m1 stop
$264Multiple Airlines
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Wed, Nov 12 - Fri, Nov 14
Southwest Logo
6:15 am - 4:40 pmDSM-IND
9h 25m2 stops
Southwest Logo
6:10 pm - 11:35 pmIND-DSM
6h 25m2 stops
$290Southwest
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Wed, Nov 12 - Fri, Nov 14
Southwest Logo
6:15 am - 4:40 pmDSM-IND
9h 25m2 stops
Southwest Logo
7:10 am - 9:35 pmIND-DSM
15h 25m2 stops
$294Southwest
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Wed, Nov 12 - Wed, Nov 19
American Airlines Logo
7:00 am - 1:53 pmDSM-IND
5h 53m1 stop
American Airlines Logo
8:32 am - 12:34 pmIND-DSM
5h 02m1 stop
$300American Airlines
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Fri, Oct 31 - Tue, Nov 4
American Airlines Logo
7:00 am - 3:31 pmDSM-IND
7h 31m1 stop
American Airlines Logo
6:25 pm - 11:50 pmIND-DSM
6h 25m1 stop
$387American Airlines
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Wed, Oct 29 - Sun, Nov 2
United Airlines Logo
6:50 pm - 11:18 pmDSM-IND
3h 28m1 stop
United Airlines Logo
11:25 am - 1:42 amIND-DSM
15h 17m1 stop
$434United Airlines
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Mon, Nov 24 - Sun, Nov 30
United Airlines Logo
8:02 am - 3:43 pmDSM-IND
6h 41m1 stop
United Airlines Logo
11:25 am - 2:19 pmIND-DSM
3h 54m1 stop
$447United Airlines
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Thu, Oct 30 - Mon, Nov 3

Southwest flights from Des Moines to Indianapolis

Our best Southwest deals on Des Moines to Indianapolis flight tickets
Southwest
Nov 12
DSM6:15 amDes Moines
9h 25m
2 stops
IND4:40 pmIndianapolis
Nov 14
IND6:10 pmIndianapolis
6h 25m
2 stops
DSM11:35 pmDes Moines
$290
Find similar
Southwest
Nov 12
DSM6:15 amDes Moines
9h 25m
2 stops
IND4:40 pmIndianapolis
Nov 19
IND7:10 amIndianapolis
15h 25m
2 stops
DSM9:35 pmDes Moines
$294
Find similar
Southwest
Nov 15
DSM6:25 amDes Moines
7h 50m
2 stops
IND3:15 pmIndianapolis
Nov 17
IND7:10 amIndianapolis
15h 25m
2 stops
DSM9:35 pmDes Moines
$296
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American Airlines flights from Des Moines to Indianapolis

Our best American Airlines deals on Des Moines to Indianapolis flight tickets
American Airlines
Oct 31
DSM7:00 amDes Moines
5h 53m
1 stop
IND1:53 pmIndianapolis
Nov 4
IND8:32 amIndianapolis
5h 02m
1 stop
DSM12:34 pmDes Moines
$300
Find similar
American Airlines
Oct 29
DSM7:00 amDes Moines
7h 31m
1 stop
IND3:31 pmIndianapolis
Nov 2
IND6:25 pmIndianapolis
6h 25m
1 stop
DSM11:50 pmDes Moines
$387
Find similar
American Airlines
Nov 18
DSM2:19 pmDes Moines
3h 50m
1 stop
IND7:09 pmIndianapolis
Nov 30
IND10:00 pmIndianapolis
4h 23m
1 stop
DSM1:23 amDes Moines
$469
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 11/24

6:17 am-11:28 am

1 stop4h 11m

Indianapolis

Tue 12/2

4:46 pm-8:46 pm

1 stop5h 00m

$232

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 11/24

6:17 am-11:28 am

1 stop4h 11m

Indianapolis

Thu 12/4

12:09 pm-4:16 pm

1 stop5h 07m

$239

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 11/20

9:19 am-7:51 pm

1 stop9h 32m

Indianapolis

Thu 12/4

8:48 am-12:55 pm

1 stop29h 07m

$260

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 11/12

10:55 am-8:44 am

1 stop20h 49m

Indianapolis

Fri 11/14

5:05 am-2:55 pm

1 stop10h 50m

$264

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 11/12

6:15 am-4:40 pm

2 stops9h 25m

Indianapolis

Fri 11/14

6:10 pm-11:35 pm

2 stops6h 25m

$290

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 11/12

6:15 am-4:40 pm

2 stops9h 25m

Indianapolis

Wed 11/19

7:10 am-9:35 pm

2 stops15h 25m

$294

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Fri 10/31

7:00 am-1:53 pm

1 stop5h 53m

Indianapolis

Tue 11/4

8:32 am-12:34 pm

1 stop5h 02m

$300

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 10/29

7:00 am-3:31 pm

1 stop7h 31m

Indianapolis

Sun 11/2

6:25 pm-11:50 pm

1 stop6h 25m

$387

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 11/24

6:50 pm-11:18 pm

1 stop3h 28m

Indianapolis

Sun 11/30

11:25 am-1:42 am

1 stop15h 17m

$434

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 10/30

8:02 am-3:43 pm

1 stop6h 41m

Indianapolis

Mon 11/3

11:25 am-2:19 pm

1 stop3h 54m

$447

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Des Moines to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, September is the cheapest month to fly from Des Moines to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $251. If you are unable to visit Indianapolis during the month of September, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $259.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Monday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $479. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Wednesday is $1,408.

How have Des Moines to Indianapolis flight prices changed over time?

As of October 2025, prices for Des Moines to Indianapolis flights are approximately 26% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Indianapolis (DSM to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Indianapolis

Direct flights

None
There are no direct flights from Des Moines to Indianapolis. There are no popular flight routes from Des Moines to Indianapolis.
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  • How far is Des Moines to Indianapolis by plane?

    There are 410.6 mi between Des Moines and Indianapolis. 3h 27m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Indianapolis Airport?

    Prices for flights from Des Moines Airport to Indianapolis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Indianapolis Airport?

  • How old do you have to be to fly from Des Moines Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents required for your trip to Indianapolis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indianapolis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Indianapolis?

Best airlines flying from Des Moines to Indianapolis

Compare and see reviews for airlines that fly from Des Moines to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
7,984 reviews
Search Delta flights
American AirlinesPriceFrom $196Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
United AirlinesPriceFrom $210Free CancellationRating
7.4
8,982 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Crawfordsville
Brownsburg
Speedway
Greenfield
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Indianapolis?

Finding the right flight to Indianapolis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Indianapolis quick and easy, saving you time and money.

Can I find flights from Des Moines to Indianapolis with flexible booking policies on momondo?

All flight searches from Des Moines to Indianapolis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Indianapolis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Indianapolis from Des Moines.

I’m not ready to book a flight from Des Moines to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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