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Cheap flights from Des Moines to Indianapolis from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Indianapolis departing on 1/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:36 pm - 7:53 pm
DSM
-
IND
23h 17m1 stop
Frontier Logo
8:48 pm - 6:46 pm
IND
-
DSM
22h 58m1 stop
$206Frontier
Thu, Mar 5 - Sun, Mar 8
United Airlines Logo
8:00 am - 1:09 pm
DSM
-
IND
4h 09m1 stop
United Airlines Logo
6:00 pm - 9:50 pm
IND
-
DSM
4h 50m1 stop
$240United Airlines
Thu, Jan 1 - Sat, Jan 10
Delta Logo
6:54 am - 11:47 am
DSM
-
IND
3h 53m1 stop
Delta Logo
6:13 am - 9:41 am
IND
-
DSM
4h 28m1 stop
$251Delta
Wed, Jan 21 - Wed, Jan 28
Multiple Airlines Logo
6:30 am - 11:15 pm
DSM
-
IND
15h 45m1 stop
Multiple Airlines Logo
10:38 am - 10:09 pm
IND
-
DSM
12h 31m2 stops
$264Multiple Airlines
Mon, Jan 12 - Thu, Jan 15
Multiple Airlines Logo
11:09 am - 11:15 pm
DSM
-
IND
11h 06m2 stops
Multiple Airlines Logo
10:38 am - 10:09 pm
IND
-
DSM
12h 31m2 stops
$271Multiple Airlines
Mon, Jan 12 - Thu, Jan 15
Multiple Airlines Logo
2:08 pm - 11:26 am
DSM
-
IND
20h 18m3 stops
Multiple Airlines Logo
10:38 am - 10:09 pm
IND
-
DSM
12h 31m2 stops
$283Multiple Airlines
Mon, Jan 12 - Thu, Jan 15
Multiple Airlines Logo
2:58 pm - 9:43 am
DSM
-
IND
17h 45m2 stops
Multiple Airlines Logo
6:55 am - 10:46 pm
IND
-
DSM
16h 51m2 stops
$286Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Delta Logo
4:21 pm - 10:30 pm
DSM
-
IND
5h 09m1 stop
Delta Logo
7:50 am - 11:24 am
IND
-
DSM
4h 34m1 stop
$289Delta
Mon, Jan 12 - Thu, Jan 15
Multiple Airlines Logo
6:14 pm - 1:41 pm
DSM
-
IND
18h 27m1 stop
Multiple Airlines Logo
5:10 am - 10:09 pm
IND
-
DSM
41h 59m2 stops
$293Multiple Airlines
Wed, Jan 21 - Wed, Jan 28
Multiple Airlines Logo
4:30 pm - 9:43 am
DSM
-
IND
40h 13m2 stops
Multiple Airlines Logo
5:10 am - 10:46 pm
IND
-
DSM
18h 36m1 stop
$294Multiple Airlines
Thu, Jan 22 - Thu, Jan 29

United Airlines flights from Des Moines to Indianapolis

Our best United Airlines deals on Des Moines to Indianapolis flight tickets
United Airlines
Jan 1
DSM8:00 amDes Moines
4h 09m
1 stop
IND1:09 pmIndianapolis
Jan 10
IND6:00 pmIndianapolis
4h 50m
1 stop
DSM9:50 pmDes Moines
$240
Find similar
United Airlines
Jan 21
DSM8:10 amDes Moines
6h 41m
1 stop
IND3:51 pmIndianapolis
Jan 28
IND5:50 pmIndianapolis
5h 00m
1 stop
DSM9:50 pmDes Moines
$311
Find similar
United Airlines
Dec 24
DSM3:14 pmDes Moines
3h 48m
1 stop
IND8:02 pmIndianapolis
Dec 28
IND9:00 amIndianapolis
6h 33m
1 stop
DSM2:33 pmDes Moines
$318
Find similar

Delta flights from Des Moines to Indianapolis

Our best Delta deals on Des Moines to Indianapolis flight tickets
Delta
Jan 21
DSM6:54 amDes Moines
3h 53m
1 stop
IND11:47 amIndianapolis
Jan 28
IND6:13 amIndianapolis
4h 28m
1 stop
DSM9:41 amDes Moines
$251
Find similar
Delta
Jan 12
DSM4:21 pmDes Moines
5h 09m
1 stop
IND10:30 pmIndianapolis
Jan 15
IND7:50 amIndianapolis
4h 34m
1 stop
DSM11:24 amDes Moines
$289
Find similar
Delta
May 8
DSM5:35 pmDes Moines
4h 28m
1 stop
IND11:03 pmIndianapolis
May 10
IND7:05 amIndianapolis
4h 10m
1 stop
DSM10:15 amDes Moines
$327
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 3/5

7:36 pm-7:53 pm

1 stop23h 17m

Indianapolis

Sun 3/8

8:48 pm-6:46 pm

1 stop22h 58m

$206

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 1/1

8:00 am-1:09 pm

1 stop4h 09m

Indianapolis

Sat 1/10

6:00 pm-9:50 pm

1 stop4h 50m

$240

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 1/21

6:54 am-11:47 am

1 stop3h 53m

Indianapolis

Wed 1/28

6:13 am-9:41 am

1 stop4h 28m

$251

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 1/12

6:30 am-11:15 pm

1 stop15h 45m

Indianapolis

Thu 1/15

10:38 am-10:09 pm

2 stops12h 31m

$264

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 1/12

11:09 am-11:15 pm

2 stops11h 06m

Indianapolis

Thu 1/15

10:38 am-10:09 pm

2 stops12h 31m

$271

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 1/12

2:08 pm-11:26 am

3 stops20h 18m

Indianapolis

Thu 1/15

10:38 am-10:09 pm

2 stops12h 31m

$283

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 1/22

2:58 pm-9:43 am

2 stops17h 45m

Indianapolis

Thu 1/29

6:55 am-10:46 pm

2 stops16h 51m

$286

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 1/12

4:21 pm-10:30 pm

1 stop5h 09m

Indianapolis

Thu 1/15

7:50 am-11:24 am

1 stop4h 34m

$289

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Wed 1/21

6:14 pm-1:41 pm

1 stop18h 27m

Indianapolis

Wed 1/28

5:10 am-10:09 pm

2 stops41h 59m

$293

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 1/22

4:30 pm-9:43 am

2 stops40h 13m

Indianapolis

Thu 1/29

5:10 am-10:46 pm

1 stop18h 36m

$294

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Des Moines to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, September is the cheapest month to fly from Des Moines to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $251. If you are unable to visit Indianapolis during the month of September, then departing from Des Moines during the month July is also very affordable. Most momondo users find prices during this month for around $259.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Monday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $479. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Wednesday is $1,408.

How have Des Moines to Indianapolis flight prices changed over time?

As of December 2025, prices for Des Moines to Indianapolis flights are approximately 158% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Indianapolis (DSM to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Indianapolis

Fastest flight time

3h 58m

Direct flights

None
The fastest flight from Des Moines to Indianapolis takes 3h 58m
There are no direct flights from Des Moines to Indianapolis. There are no popular flight routes from Des Moines to Indianapolis.
Search flight deals

  • How far is Des Moines to Indianapolis by plane?

    There are 410.6 mi between Des Moines and Indianapolis. 3h 27m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Indianapolis Airport?

    Prices for flights from Des Moines Airport to Indianapolis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Indianapolis Airport?

  • How old do you have to be to fly from Des Moines Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents required for your trip to Indianapolis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indianapolis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Indianapolis?

Best airlines flying from Des Moines to Indianapolis

Compare and see reviews for airlines that fly from Des Moines to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
8,011 reviews
Search Delta flights
American AirlinesPriceFrom $196Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
United AirlinesPriceFrom $210Free CancellationRating
7.4
9,089 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Speedway
Brownsburg
Crawfordsville
Greenfield
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Indianapolis?

Finding the right flight to Indianapolis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Indianapolis quick and easy, saving you time and money.

Can I find flights from Des Moines to Indianapolis with flexible booking policies on momondo?

All flight searches from Des Moines to Indianapolis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Indianapolis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Indianapolis from Des Moines.

I’m not ready to book a flight from Des Moines to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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