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Cheap flights from Des Moines to Indianapolis from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Indianapolis departing on 9/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
11:29 am - 8:01 pmDSM  Des Moines-IND Indianapolis
7h 32m1 stop Denver Intl
Frontier Logo
3:02 pm - 7:33 pmIND  Indianapolis-DSM Des Moines
5h 31m1 stop Denver Intl
$215Frontier
Thu, Sep 10 - Fri, Sep 11
Multiple Airlines Logo
11:29 am - 3:17 pmDSM  Des Moines-IND Indianapolis
26h 48m1 stop Denver Intl
Multiple Airlines Logo
11:21 am - 8:49 amIND  Indianapolis-DSM Des Moines
22h 28m2 stops Orlando Nashville Intl
$269Multiple Airlines
Sun, Sep 13 - Wed, Sep 16
Delta Logo
6:00 am - 11:32 amDSM  Des Moines-IND Indianapolis
4h 32m1 stop Detroit Metropolitan Wayne County
Delta Logo
4:16 pm - 8:59 pmIND  Indianapolis-DSM Des Moines
5h 43m1 stop Minneapolis St Paul
$279Delta
Sat, Sep 5 - Sun, Sep 6
American Airlines Logo
7:05 am - 2:01 pmDSM  Des Moines-IND Indianapolis
5h 56m1 stop Chicago O'Hare Intl
American Airlines Logo
2:31 pm - 5:26 pmIND  Indianapolis-DSM Des Moines
3h 55m1 stop Chicago O'Hare Intl
$283American Airlines
Tue, Sep 15 - Tue, Sep 22
Multiple Airlines Logo
11:29 am - 2:05 pmDSM  Des Moines-IND Indianapolis
25h 36m1 stop Denver Intl
Multiple Airlines Logo
11:21 am - 8:49 amIND  Indianapolis-DSM Des Moines
46h 28m2 stops Orlando Nashville Intl
$291Multiple Airlines
Thu, Sep 10 - Tue, Sep 15
United Airlines Logo
6:00 am - 12:42 pmDSM  Des Moines-IND Indianapolis
5h 42m1 stop Chicago O'Hare Intl
United Airlines Logo
11:37 am - 2:15 pmIND  Indianapolis-DSM Des Moines
3h 38m1 stop Chicago O'Hare Intl
$299United Airlines
Sat, Oct 17 - Tue, Oct 20
United Airlines Logo
8:00 am - 12:42 pmDSM  Des Moines-IND Indianapolis
3h 42m1 stop Chicago O'Hare Intl
United Airlines Logo
7:05 am - 10:31 amIND  Indianapolis-DSM Des Moines
4h 26m1 stop Chicago O'Hare Intl
$299United Airlines
Sat, Oct 17 - Wed, Oct 21
Delta Logo
6:00 am - 11:31 amDSM  Des Moines-IND Indianapolis
4h 31m1 stop Detroit Metropolitan Wayne County
Delta Logo
12:26 pm - 4:48 pmIND  Indianapolis-DSM Des Moines
5h 22m1 stop Minneapolis St Paul
$299Delta
Thu, Sep 17 - Wed, Sep 23
American Airlines Logo
7:05 am - 2:01 pmDSM  Des Moines-IND Indianapolis
5h 56m1 stop Chicago O'Hare Intl
American Airlines Logo
1:06 pm - 5:26 pmIND  Indianapolis-DSM Des Moines
5h 20m1 stop Chicago O'Hare Intl
$299American Airlines
Tue, Sep 15 - Tue, Sep 22
Delta Logo
6:00 am - 1:30 pmDSM  Des Moines-IND Indianapolis
6h 30m1 stop Detroit Metropolitan Wayne County
Delta Logo
7:00 am - 10:17 amIND  Indianapolis-DSM Des Moines
4h 17m1 stop Minneapolis St Paul
$299Delta
Thu, Sep 17 - Thu, Sep 24

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United Airlines flights from Des Moines to Indianapolis

Our best United Airlines deals on Des Moines to Indianapolis flight tickets
United Airlines
Sep 29
DSM6:00 amDes Moines
5h 42m
1 stop
IND12:42 pmIndianapolis
Sep 30
IND5:40 amIndianapolis
5h 51m
1 stop
DSM10:31 amDes Moines
$233
United Airlines
Aug 20
DSM6:00 amDes Moines
12h 02m
2 stops
IND7:02 pmIndianapolis
Aug 27
IND12:34 pmIndianapolis
5h 54m
1 stop
DSM5:28 pmDes Moines
$569
United Airlines
Aug 16
DSM3:20 pmDes Moines
5h 40m
1 stop
IND10:00 pmIndianapolis
Aug 21
IND8:00 amIndianapolis
5h 20m
1 stop
DSM12:20 pmDes Moines
$593

Southwest flights from Des Moines to Indianapolis

Our best Southwest deals on Des Moines to Indianapolis flight tickets
Southwest
Sep 17
DSM5:40 amDes Moines
5h 30m
1 stop
IND12:10 pmIndianapolis
Sep 23
IND1:30 pmIndianapolis
9h 30m
2 stops
DSM10:00 pmDes Moines
$238
Southwest
Sep 29
DSM6:10 amDes Moines
9h 45m
2 stops
IND4:55 pmIndianapolis
Sep 30
IND12:15 pmIndianapolis
10h 45m
2 stops
DSM10:00 pmDes Moines
$243
Southwest
Sep 10
DSM5:40 amDes Moines
5h 30m
1 stop
IND12:10 pmIndianapolis
Sep 11
IND5:20 pmIndianapolis
5h 55m
2 stops
DSM10:15 pmDes Moines
$294

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Thu 9/10

11:29 am-8:01 pm

1 stop7h 32m

Indianapolis

Fri 9/11

3:02 pm-7:33 pm

1 stop5h 31m

$215

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Sun 9/13

11:29 am-3:17 pm

1 stop26h 48m

Indianapolis

Wed 9/16

11:21 am-8:49 am

2 stops22h 28m

$269

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Sat 9/5

6:00 am-11:32 am

1 stop4h 32m

Indianapolis

Sun 9/6

4:16 pm-8:59 pm

1 stop5h 43m

$279

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Tue 9/15

7:05 am-2:01 pm

1 stop5h 56m

Indianapolis

Tue 9/22

2:31 pm-5:26 pm

1 stop3h 55m

$283

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Thu 9/10

11:29 am-2:05 pm

1 stop25h 36m

Indianapolis

Tue 9/15

11:21 am-8:49 am

2 stops46h 28m

$291

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Sat 10/17

6:00 am-12:42 pm

1 stop5h 42m

Indianapolis

Tue 10/20

11:37 am-2:15 pm

1 stop3h 38m

$299
Quickest round-trip

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Sat 10/17

8:00 am-12:42 pm

1 stop3h 42m

Indianapolis

Wed 10/21

7:05 am-10:31 am

1 stop4h 26m

$299

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Thu 9/17

6:00 am-11:31 am

1 stop4h 31m

Indianapolis

Wed 9/23

12:26 pm-4:48 pm

1 stop5h 22m

$299

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Tue 9/15

7:05 am-2:01 pm

1 stop5h 56m

Indianapolis

Tue 9/22

1:06 pm-5:26 pm

1 stop5h 20m

$299

Des MoinesIndianapolis

DSM Des Moines - IND Indianapolis

DSMIND

Des Moines

Thu 9/17

6:00 am-1:30 pm

1 stop6h 30m

Indianapolis

Thu 9/24

7:00 am-10:17 am

1 stop4h 17m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Indianapolis?

Prices are currently low for flights on this route.

Typical prices usually range from $366 to $453.
The lowest price recently found on this route was $215.

What is the cheapest month to fly to Indianapolis?

In general, December is the cheapest month to fly from Des Moines to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $308. If you are unable to visit Indianapolis during the month of December, then departing from Des Moines during the month February is also very affordable. Most momondo users find prices during this month for around $308.

Can stopping save me money on Des Moines to Indianapolis flights?

You could potentially save up to 2% on your flight if you consider stops on a Des Moines to Indianapolis flight.

How have Des Moines to Indianapolis flight prices changed over time?

When to book flights from Des Moines to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Indianapolis (DSM to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Indianapolis

Fastest flight time

4h 27m

Direct flights

None
The fastest flight from Des Moines to Indianapolis takes 4h 27m
There are no direct flights from Des Moines to Indianapolis. There are no popular flight routes from Des Moines to Indianapolis.
Search flight deals

Frequently asked questions about flying from Des Moines to Indianapolis

  • How far is Des Moines to Indianapolis by plane?

    There are 410.6 mi between Des Moines and Indianapolis. 4h 27m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Indianapolis Airport?

    Prices for flights from Des Moines Airport to Indianapolis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Indianapolis Airport?

  • How old do you have to be to fly from Des Moines Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents required for your trip to Indianapolis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indianapolis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Indianapolis?

Best airlines flying from Des Moines to Indianapolis

Compare and see reviews for airlines that fly from Des Moines to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.8
8,497 reviews
Search Delta flights
American AirlinesPriceFrom $254Free CancellationRating
7.1
11,897 reviews
Search American Airlines flights
United AirlinesPriceFrom $272Free CancellationRating
7.4
10,095 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Greenwood
Anderson
Plainfield
Noblesville
Carmel
West Lafayette
Speedway
Fishers
Franklin
Westfield
Seymour
Shelbyville
Brownsburg
Crawfordsville
Greenfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Indianapolis?

Finding the right flight to Indianapolis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Indianapolis quick and easy, saving you time and money.

Can I find flights from Des Moines to Indianapolis with flexible booking policies on momondo?

All flight searches from Des Moines to Indianapolis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Indianapolis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Indianapolis from Des Moines.

I’m not ready to book a flight from Des Moines to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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