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Cheap flights from Des Moines to Indianapolis from $120

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Indianapolis departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Indianapolis

Cheap round-trip flights

United Airlines Logo
6:36 pm - 11:44 pmDSM-IND
4h 08m1 stop
United Airlines Logo
9:00 am - 2:23 pmIND-DSM
6h 23m1 stop
$242United Airlines
Find Deal
Mon, Oct 20 - Wed, Oct 22
Delta Logo
7:03 am - 11:33 amDSM-IND
3h 30m1 stop
Delta Logo
6:30 am - 9:20 amIND-DSM
3h 50m1 stop
$247Delta
Find Deal
Thu, Oct 9 - Thu, Oct 16
Delta Logo
5:32 pm - 11:29 pmDSM-IND
4h 57m1 stop
Delta Logo
7:05 am - 10:26 amIND-DSM
4h 21m1 stop
$254Delta
Find Deal
Tue, Oct 14 - Fri, Oct 17
American Airlines Logo
5:00 am - 10:20 amDSM-IND
4h 20m1 stop
American Airlines Logo
7:25 pm - 11:23 pmIND-DSM
4h 58m1 stop
$259American Airlines
Find Deal
Fri, Oct 3 - Mon, Oct 6
Logo
8:25 am - 8:13 pmDSM-IND
10h 48m1 stop
Logo
5:00 am - 2:50 pmIND-DSM
10h 50m1 stop
$266
Find Deal
Fri, Sep 26 - Fri, Oct 3
Logo
8:25 am - 11:11 pmDSM-IND
13h 46m2 stops
Logo
5:00 am - 2:40 pmIND-DSM
10h 40m1 stop
$270
Find Deal
Mon, Sep 8 - Fri, Sep 19
Delta Logo
5:56 pm - 11:59 pmDSM-IND
5h 03m1 stop
Delta Logo
6:30 am - 9:20 amIND-DSM
3h 50m1 stop
$271Delta
Find Deal
Fri, Oct 10 - Fri, Oct 17
Southwest Logo
7:25 am - 1:55 pmDSM-IND
5h 30m1 stop
Southwest Logo
7:10 am - 11:25 amIND-DSM
5h 15m2 stops
$310Southwest
Find Deal
Sat, Nov 1 - Mon, Nov 3
Southwest Logo
7:25 am - 9:25 pmDSM-IND
13h 00m2 stops
Southwest Logo
7:10 am - 11:25 amIND-DSM
5h 15m2 stops
$355Southwest
Find Deal
Sat, Nov 1 - Mon, Nov 3
United Airlines Logo
8:00 am - 1:17 pmDSM-IND
4h 17m1 stop
United Airlines Logo
9:05 am - 2:20 pmIND-DSM
6h 15m1 stop
$378United Airlines
Find Deal
Thu, Sep 18 - Sun, Sep 21

Delta flights from Des Moines to Indianapolis

Our best Delta deals on Des Moines to Indianapolis flight tickets
Delta
Oct 9
DSM7:03 amDes Moines
3h 30m
1 stop
IND11:33 amIndianapolis
Oct 16
IND6:30 amIndianapolis
3h 50m
1 stop
DSM9:20 amDes Moines
$247
Find similar
Delta
Oct 14
DSM5:32 pmDes Moines
4h 57m
1 stop
IND11:29 pmIndianapolis
Oct 17
IND7:05 amIndianapolis
4h 21m
1 stop
DSM10:26 amDes Moines
$254
Find similar
Delta
Oct 10
DSM5:56 pmDes Moines
5h 03m
1 stop
IND11:59 pmIndianapolis
Oct 17
IND6:30 amIndianapolis
3h 50m
1 stop
DSM9:20 amDes Moines
$271
Find similar

United Airlines flights from Des Moines to Indianapolis

Our best United Airlines deals on Des Moines to Indianapolis flight tickets
United Airlines
Oct 20
DSM6:36 pmDes Moines
4h 08m
1 stop
IND11:44 pmIndianapolis
Oct 22
IND9:00 amIndianapolis
6h 23m
1 stop
DSM2:23 pmDes Moines
$242
Find similar
United Airlines
Sep 18
DSM8:00 amDes Moines
4h 17m
1 stop
IND1:17 pmIndianapolis
Sep 21
IND9:05 amIndianapolis
6h 15m
1 stop
DSM2:20 pmDes Moines
$378
Find similar
United Airlines
Oct 14
DSM11:30 amDes Moines
11h 14m
2 stops
IND11:44 pmIndianapolis
Oct 17
IND6:51 pmIndianapolis
6h 05m
1 stop
DSM11:56 pmDes Moines
$545
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 10/20

6:36 pm-11:44 pm

1 stop4h 08m

Indianapolis

Wed 10/22

9:00 am-2:23 pm

1 stop6h 23m

$242

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 10/9

7:03 am-11:33 am

1 stop3h 30m

Indianapolis

Thu 10/16

6:30 am-9:20 am

1 stop3h 50m

$247

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 10/14

5:32 pm-11:29 pm

1 stop4h 57m

Indianapolis

Fri 10/17

7:05 am-10:26 am

1 stop4h 21m

$254

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Fri 10/3

5:00 am-10:20 am

1 stop4h 20m

Indianapolis

Mon 10/6

7:25 pm-11:23 pm

1 stop4h 58m

$259

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Fri 9/26

8:25 am-8:13 pm

1 stop10h 48m

Indianapolis

Fri 10/3

5:00 am-2:50 pm

1 stop10h 50m

$266

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 9/8

8:25 am-11:11 pm

2 stops13h 46m

Indianapolis

Fri 9/19

5:00 am-2:40 pm

1 stop10h 40m

$270

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Fri 10/10

5:56 pm-11:59 pm

1 stop5h 03m

Indianapolis

Fri 10/17

6:30 am-9:20 am

1 stop3h 50m

$271

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sat 11/1

7:25 am-1:55 pm

1 stop5h 30m

Indianapolis

Mon 11/3

7:10 am-11:25 am

2 stops5h 15m

$310

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sat 11/1

7:25 am-9:25 pm

2 stops13h 00m

Indianapolis

Mon 11/3

7:10 am-11:25 am

2 stops5h 15m

$355

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Thu 9/18

8:00 am-1:17 pm

1 stop4h 17m

Indianapolis

Sun 9/21

9:05 am-2:20 pm

1 stop6h 15m

$378

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, July is the cheapest month to fly from Des Moines to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $259. If you are unable to visit Indianapolis during the month of July, then departing from Des Moines during the month October is also very affordable. Most momondo users find prices during this month for around $287.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Monday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $479. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Wednesday is $1,408.

How have Des Moines to Indianapolis flight prices changed over time?

As of August 2025, prices for Des Moines to Indianapolis flights are approximately 29% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Indianapolis (DSM to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Indianapolis

Direct flights

None
There are no direct flights from Des Moines to Indianapolis. There are no popular flight routes from Des Moines to Indianapolis.
Search flight deals

  • How far is Des Moines to Indianapolis by plane?

    There are 410.6 mi between Des Moines and Indianapolis. 3h 30m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Indianapolis Airport?

    Prices for flights from Des Moines Airport to Indianapolis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Indianapolis Airport?

  • How old do you have to be to fly from Des Moines Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents required for your trip to Indianapolis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Indianapolis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Indianapolis?

Best airlines flying from Des Moines to Indianapolis

Compare and see reviews for airlines that fly from Des Moines to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $196Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $210Free CancellationRating
7.4
8,945 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Brownsburg
Crawfordsville
Greenfield
Speedway
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Indianapolis?

Finding the right flight to Indianapolis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Indianapolis quick and easy, saving you time and money.

Can I find flights from Des Moines to Indianapolis with flexible booking policies on momondo?

All flight searches from Des Moines to Indianapolis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Indianapolis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Indianapolis from Des Moines.

I’m not ready to book a flight from Des Moines to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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