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Cheap flights from Charlotte to South America from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charlotte to South America departing on 2/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charlotte to South America

Cheap round-trip flights

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Spirit Airlines Logo
7:00 am - 2:15 pmCLT-MDE
7h 15m1 stop
Spirit Airlines Logo
3:10 pm - 12:40 amMDE-CLT
9h 30m1 stop
$267Spirit Airlines
Find Deal
Sun, Feb 8 - Sat, Feb 21
Spirit Airlines Logo
7:00 am - 1:10 pmCLT-CTG
6h 10m1 stop
Spirit Airlines Logo
2:15 pm - 11:59 pmCTG-CLT
9h 44m1 stop
$267Spirit Airlines
Find Deal
Mon, Dec 8 - Fri, Dec 12
Multiple Airlines Logo
10:13 am - 1:25 pmCLT-CTG
27h 12m1 stop
Multiple Airlines Logo
2:15 pm - 11:59 pmCTG-CLT
9h 44m1 stop
$307Multiple Airlines
Find Deal
Tue, Nov 25 - Sat, Dec 6
Multiple Airlines Logo
10:13 am - 1:25 pmCLT-CTG
27h 12m1 stop
Multiple Airlines Logo
2:15 pm - 11:59 pmCTG-CLT
9h 44m1 stop
$316Multiple Airlines
Find Deal
Tue, Nov 25 - Thu, Dec 4
LATAM Airlines Logo
2:25 pm - 9:35 pmCLT-UIO
7h 10m1 stop
LATAM Airlines Logo
7:00 pm - 1:45 pmUIO-CLT
18h 45m2 stops
$529LATAM Airlines
Find Deal
Mon, Jan 12 - Fri, Jan 23
Delta Logo
1:13 pm - 9:35 pmCLT-UIO
8h 22m1 stop
Delta Logo
11:45 pm - 4:04 pmUIO-CLT
16h 19m1 stop
$544Delta
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Mon, Jan 12 - Fri, Jan 23
Delta Logo
2:25 pm - 5:17 amCLT-UIO
14h 52m2 stops
Delta Logo
7:00 pm - 1:02 pmUIO-CLT
18h 02m2 stops
$548Delta
Find Deal
Mon, Jan 12 - Fri, Jan 23
LATAM Airlines Logo
7:40 am - 8:00 pmCLT-UIO
13h 20m1 stop
LATAM Airlines Logo
9:11 am - 11:57 pmUIO-CLT
13h 46m2 stops
$550LATAM Airlines
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Sun, Apr 12 - Tue, Apr 21
GOL Logo
5:15 am - 10:35 pmCLT-GIG
15h 20m2 stops
GOL Logo
6:00 am - 9:55 pmGIG-CLT
16h 55m2 stops
$718GOL
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Wed, Jan 21 - Sat, May 9
GOL Logo
5:15 am - 10:35 pmCLT-GIG
15h 20m2 stops
GOL Logo
6:00 am - 10:47 pmGIG-CLT
18h 47m2 stops
$735GOL
Find Deal
Sat, Jan 24 - Tue, Feb 10

Spirit Airlines flights from Charlotte to South America

Our best Spirit Airlines deals on Charlotte to South America flight tickets
Spirit Airlines
Feb 8
CLT7:00 amCharlotte Douglas
7h 15m
1 stop
MDE2:15 pmMedellín Jose Maria Cordova Intl
Feb 21
MDE3:10 pmMedellín Jose Maria Cordova Intl
9h 30m
1 stop
CLT12:40 amCharlotte Douglas
$267
Find similar
Spirit Airlines
Feb 10
CLT7:00 amCharlotte Douglas
7h 15m
1 stop
MDE2:15 pmMedellín Jose Maria Cordova Intl
Feb 18
MDE3:10 pmMedellín Jose Maria Cordova Intl
9h 30m
1 stop
CLT12:40 amCharlotte Douglas
$268
Find similar
Spirit Airlines
Feb 7
CLT7:02 pmCharlotte Douglas
19h 13m
1 stop
MDE2:15 pmMedellín Jose Maria Cordova Intl
Feb 10
MDE3:15 pmMedellín Jose Maria Cordova Intl
9h 25m
1 stop
CLT12:40 amCharlotte Douglas
$276
Find similar

Avianca flights from Charlotte to South America

Our best Avianca deals on Charlotte to South America flight tickets
Avianca
Jan 30
CLT9:55 amCharlotte Douglas
10h 10m
1 stop
BOG8:05 pmBogotá El Dorado
Feb 1
BOG4:00 amBogotá El Dorado
14h 59m
2 stops
CLT6:59 pmCharlotte Douglas
$394
Find similar
Avianca
Nov 19
CLT6:00 amCharlotte Douglas
14h 05m
1 stop
BOG8:05 pmBogotá El Dorado
Nov 21
BOG4:00 amBogotá El Dorado
14h 51m
2 stops
CLT6:51 pmCharlotte Douglas
$541
Find similar
Avianca
Nov 19
CLT6:00 amCharlotte Douglas
18h 50m
2 stops
LIM12:50 amLima J Chavez Intl
Nov 22
LIM3:00 amLima J Chavez Intl
15h 51m
2 stops
CLT6:51 pmCharlotte Douglas
$830
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Charlotte to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Charlotte to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Sun 2/8

7:00 am-2:15 pm

1 stop7h 15m

Medellín Jose Maria Cordova Intl

Sat 2/21

3:10 pm-12:40 am

1 stop9h 30m

$267

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Mon 12/8

7:00 am-1:10 pm

1 stop6h 10m

Cartagena Rafael Nunez

Fri 12/12

2:15 pm-11:59 pm

1 stop9h 44m

$267

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Tue 11/25

10:13 am-1:25 pm

1 stop27h 12m

Cartagena Rafael Nunez

Sat 12/6

2:15 pm-11:59 pm

1 stop9h 44m

$307

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Tue 11/25

10:13 am-1:25 pm

1 stop27h 12m

Cartagena Rafael Nunez

Thu 12/4

2:15 pm-11:59 pm

1 stop9h 44m

$316

CharlotteQuito

CLT - UIO

CLTUIO

Charlotte Douglas

Mon 1/12

2:25 pm-9:35 pm

1 stop7h 10m

Quito Mariscal Sucr

Fri 1/23

7:00 pm-1:45 pm

2 stops18h 45m

$529

CharlotteQuito

CLT - UIO

CLTUIO

Charlotte Douglas

Mon 1/12

1:13 pm-9:35 pm

1 stop8h 22m

Quito Mariscal Sucr

Fri 1/23

11:45 pm-4:04 pm

1 stop16h 19m

$544

CharlotteQuito

CLT - UIO

CLTUIO

Charlotte Douglas

Mon 1/12

2:25 pm-5:17 am

2 stops14h 52m

Quito Mariscal Sucr

Fri 1/23

7:00 pm-1:02 pm

2 stops18h 02m

$548

CharlotteQuito

CLT - UIO

CLTUIO

Charlotte Douglas

Sun 4/12

7:40 am-8:00 pm

1 stop13h 20m

Quito Mariscal Sucr

Tue 4/21

9:11 am-11:57 pm

2 stops13h 46m

$550

CharlotteRio de Janeiro

CLT - GIG

CLTGIG

Charlotte Douglas

Wed 1/21

5:15 am-10:35 pm

2 stops15h 20m

Rio de Janeiro–Galeão Intl

Sat 5/9

6:00 am-9:55 pm

2 stops16h 55m

$718

CharlotteRio de Janeiro

CLT - GIG

CLTGIG

Charlotte Douglas

Sat 1/24

5:15 am-10:35 pm

2 stops15h 20m

Rio de Janeiro–Galeão Intl

Tue 2/10

6:00 am-10:47 pm

2 stops18h 47m

$735

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Charlotte to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, November is the cheapest month to fly from Charlotte to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $678. If you aren’t able to travel during the month of November, then book flights to South America from Charlotte during October instead. Flights to South America in October, while not as cheap as those in November, still average around $720.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Charlotte to South America is on a Tuesday when prices can be found for as low as $616. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Charlotte to South America for around $888.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Charlotte to South America flights are usually those with departure times in the evening. Our users have found flights to South America in the evening for as low as $685. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $874 on average. Flights to South America from Charlotte in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Charlotte when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $764 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Charlotte for as low as $702 on momondo.

Can stopping save me money on Charlotte to South America flights?

You could potentially save up to 9% on your flight if you consider stops on a Charlotte to South America flight.

Cheap Charlotte to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charlotte to South America

Direct flights

None
There are no direct flights from Charlotte to South America. There are no popular flight routes from Charlotte to South America.
Search flight deals

  • When did momondo last update prices for flights from Charlotte Douglas Airport to South America?

    Prices for flights from Charlotte Douglas Airport to South America are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charlotte Douglas Airport to South America?

  • How old do you have to be to fly from Charlotte Douglas Airport to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charlotte Douglas Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Charlotte to South America

Compare and see reviews for airlines that fly from Charlotte to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $251Free CancellationRating
6.3
8,139 reviews
Search Spirit Airlines flights
United AirlinesPriceFrom $394Free CancellationRating
7.4
9,016 reviews
Search United Airlines flights
American AirlinesPriceFrom $441Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
DeltaPriceFrom $449Free CancellationRating
7.9
8,009 reviews
Search Delta flights
LATAM AirlinesPriceFrom $482Free CancellationRating
7.5
1,874 reviews
Search LATAM Airlines flights
GOLPriceFrom $667Free CancellationRating
7.3
1,127 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from Charlotte to South America?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Charlotte to South America for you.

Can I find flights from Charlotte to South America with flexible booking policies on momondo?

Flights from Charlotte to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charlotte to South America?

momondo provides multiple filters to help you find the best flight to South America from Charlotte. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charlotte to South America right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Charlotte to South America flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your South America trip

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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
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Flights to Bogotáfrom $203
Flights to Sao Paulofrom $393
Flights to Rio de Janeirofrom $424
Flights to Medellínfrom $165
Flights to Santiagofrom $356
Flights to Cartagenafrom $182
Flights to Quitofrom $324
Flights to Cuscofrom $367
Flights to Guayaquilfrom $212
Flights to Califrom $187