What is the cheapest airline that flies from Buffalo to South Carolina?

JetBlue, Delta, and American Airlines are the most popular carriers operating from Buffalo to South Carolina

What airlines fly to South Carolina?

Breeze Airways, American Airlines and Delta are the top three most popular airlines that fly to South Carolina from Buffalo according to our data. Breeze Airways is the first choice among our users, with 42% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 7 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from Buffalo to South Carolina on average per week?

As of June 2026, 22 flights take off from Buffalo and land in South Carolina each week. The most common flight departure day for this route is Mon, with 18% of weekly flights taking off on this day.

When did momondo last update prices for flights from Buffalo Airport to South Carolina?

Prices for flights from Buffalo Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Buffalo Airport to South Carolina?

As of June 2026, there are 6 operators available to choose from for flights from Buffalo Airport to South Carolina.

How old do you have to be to fly from Buffalo Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$90 Cheap Flights from Buffalo to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 12:15 pm

BUF

CHS

6h 15m

1 stop

11:00 am - 6:54 pm

CHS

BUF

7h 54m

1 stop

$197JetBlue

Wed, Jul 29 - Thu, Aug 6

10:25 am - 5:46 pm

BUF

CHS

7h 21m

1 stop

11:00 am - 6:54 pm

CHS

BUF

7h 54m

1 stop

$202JetBlue

Tue, Sep 1 - Wed, Sep 2

5:30 am - 10:19 am

BUF

CAE

4h 49m

1 stop

7:00 am - 11:20 am

CAE

BUF

4h 20m

1 stop

$261American Airlines

Sat, Sep 12 - Sat, Sep 19

6:00 am - 1:40 pm

BUF

CAE

7h 40m

2 stops

2:15 pm - 9:07 pm

CAE

BUF

6h 52m

1 stop

$266United Airlines

Sat, Sep 12 - Sat, Sep 19

6:00 am - 2:21 pm

BUF

CAE

8h 21m

2 stops

7:54 pm - 11:44 pm

CAE

BUF

3h 50m

1 stop

$296United Airlines

Wed, Sep 2 - Sat, Sep 5

10:21 am - 3:03 pm

BUF

GSP

4h 42m

1 stop

6:10 pm - 11:38 pm

GSP

BUF

5h 28m

1 stop

$302Delta

Wed, Jul 15 - Wed, Jul 22

6:00 am - 11:22 am

BUF

MYR

5h 22m

1 stop

6:10 pm - 10:51 pm

MYR

BUF

4h 41m

1 stop

$303American Airlines

Wed, Jul 15 - Wed, Jul 22

3:00 pm - 7:10 pm

BUF

MYR

4h 10m

1 stop

8:15 am - 3:15 pm

MYR

BUF

7h 00m

2 stops

$308Southwest

Wed, Aug 12 - Wed, Aug 19

6:05 am - 10:47 am

BUF

MYR

4h 42m

1 stop

7:02 pm - 11:59 pm

MYR

BUF

4h 57m

1 stop

$313Delta

Sat, Aug 22 - Wed, Aug 26

12:00 pm - 7:10 pm

BUF

MYR

7h 10m

1 stop

8:15 am - 3:15 pm

MYR

BUF

7h 00m

2 stops

$324Southwest

Wed, Aug 5 - Tue, Aug 11

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Frontier flights from Buffalo to South Carolina

Our best Frontier deals on Buffalo to South Carolina flight tickets

Frontier

Aug 5

BUF7:57 pmBuffalo

16h 25m

1 stop

CLT12:22 pmCharlotte Douglas

Aug 12

CLT12:24 pmCharlotte Douglas

28h 08m

1 stop

BUF4:32 pmBuffalo

$220

Frontier

Jul 14

BUF9:09 pmBuffalo

14h 20m

1 stop

CLT11:29 amCharlotte Douglas

Jul 21

CLT8:02 pmCharlotte Douglas

23h 04m

1 stop

BUF7:06 pmBuffalo

$240

Frontier

Aug 1

BUF10:02 pmBuffalo

24h 02m

1 stop

CLT10:04 pmCharlotte Douglas

Aug 5

CLT9:43 pmCharlotte Douglas

18h 49m

1 stop

BUF4:32 pmBuffalo

$244

American Airlines flights from Buffalo to South Carolina

Our best American Airlines deals on Buffalo to South Carolina flight tickets

American Airlines

Sep 12

BUF5:30 amBuffalo

4h 49m

1 stop

CAE10:19 amColumbia Metropolitan

Sep 19

CAE7:00 amColumbia Metropolitan

4h 20m

1 stop

BUF11:20 amBuffalo

$261

American Airlines

Jul 3

BUF1:47 pmBuffalo

2h 02m

CLT3:49 pmCharlotte Douglas

Jul 3

CLT6:22 pmCharlotte Douglas

5h 30m

1 stop

BUF11:52 pmBuffalo

$274

American Airlines

Jul 15

BUF6:00 amBuffalo

5h 22m

1 stop

MYR11:22 amMyrtle Beach Intl

Jul 22

MYR6:10 pmMyrtle Beach Intl

4h 41m

1 stop

BUF10:51 pmBuffalo

$303

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 7/29

6:00 am-12:15 pm

1 stop6h 15m

Charleston

Thu 8/6

11:00 am-6:54 pm

1 stop7h 54m

$197

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 9/1

10:25 am-5:46 pm

1 stop7h 21m

Charleston

Wed 9/2

11:00 am-6:54 pm

1 stop7h 54m

$202

Quickest round-trip

BuffaloColumbia

BUF - CAE

BUFCAE

Buffalo

Sat 9/12

5:30 am-10:19 am

1 stop4h 49m

Columbia Metropolitan

Sat 9/19

7:00 am-11:20 am

1 stop4h 20m

$261

BuffaloColumbia

BUF - CAE

BUFCAE

Buffalo

Sat 9/12

6:00 am-1:40 pm

2 stops7h 40m

Columbia Metropolitan

Sat 9/19

2:15 pm-9:07 pm

1 stop6h 52m

$266

BuffaloColumbia

BUF - CAE

BUFCAE

Buffalo

Wed 9/2

6:00 am-2:21 pm

2 stops8h 21m

Columbia Metropolitan

Sat 9/5

7:54 pm-11:44 pm

1 stop3h 50m

$296

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 7/15

10:21 am-3:03 pm

1 stop4h 42m

Greenville

Wed 7/22

6:10 pm-11:38 pm

1 stop5h 28m

$302

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 7/15

6:00 am-11:22 am

1 stop5h 22m

Myrtle Beach Intl

Wed 7/22

6:10 pm-10:51 pm

1 stop4h 41m

$303

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 8/12

3:00 pm-7:10 pm

1 stop4h 10m

Myrtle Beach Intl

Wed 8/19

8:15 am-3:15 pm

2 stops7h 00m

$308

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Sat 8/22

6:05 am-10:47 am

1 stop4h 42m

Myrtle Beach Intl

Wed 8/26

7:02 pm-11:59 pm

1 stop4h 57m

$313

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 8/5

12:00 pm-7:10 pm

1 stop7h 10m

Myrtle Beach Intl

Tue 8/11

8:15 am-3:15 pm

2 stops7h 00m

$324

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How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in March. Flight prices, which tend to average around $98, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of March, then book flights to South Carolina from Buffalo during February instead. Flights to South Carolina in February, while not as cheap as those in March, still average around $125.

How far in advance should I book a flight from Buffalo to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $300 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $221 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Fastest flight time	1h 58m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Buffalo to South Carolina takes 1h 58m

Direct flights go from Buffalo to South Carolina every day.

There are 57 airports in South Carolina. From Buffalo there are direct flights to Charlotte Douglas (CLT).

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Frequently asked questions about flying from Buffalo to South Carolina

When did momondo last update prices for flights from Buffalo Airport to South Carolina?
Prices for flights from Buffalo Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Buffalo Airport to South Carolina?
As of June 2026, there are 6 operators available to choose from for flights from Buffalo Airport to South Carolina.
How old do you have to be to fly from Buffalo Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
JetBlue	PriceFrom $180	Free Cancellation	Rating 7.1 2,987 reviews	Search JetBlue flights
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.1 11,705 reviews	Search American Airlines flights
Delta	PriceFrom $199	Free Cancellation	Rating 7.8 8,419 reviews	Search Delta flights
United Airlines	PriceFrom $200	Free Cancellation	Rating 7.4 9,862 reviews	Search United Airlines flights
Southwest	PriceFrom $236	Free Cancellation	Rating 7.9 4,239 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.