What airlines fly to South Carolina?

Breeze Airways, American Airlines and Delta are the top three most popular airlines that fly to South Carolina from Buffalo according to our data. Breeze Airways is the first choice among our users, with 39% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Buffalo to South Carolina?

Delta, Southwest, and JetBlue are the most popular carriers operating from Buffalo to South Carolina

When did momondo last update prices for flights from Buffalo Airport to South Carolina?

Prices for flights from Buffalo Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Buffalo Airport to South Carolina?

As of November 2026, there are 4 operators available to choose from for flights from Buffalo Airport to South Carolina.

How old do you have to be to fly from Buffalo Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$131 Cheap Flights from Buffalo to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:55 pm - 8:05 pmBUF Buffalo-CHS Charleston

4h 10m1 stop Baltimore/Washington

5:15 pm - 10:00 pmCHS Charleston-BUF Buffalo

4h 45m1 stop Baltimore/Washington

$248Southwest

Tue, Dec 1 - Fri, Dec 4

6:58 pm - 11:26 pmBUF Buffalo-CHS Charleston

4h 28m1 stop Philadelphia

7:21 pm - 11:16 pmCHS Charleston-BUF Buffalo

3h 55m1 stop Charlotte Douglas

$261American Airlines

Thu, Dec 3 - Sat, Jan 9

6:00 am - 12:59 pmBUF Buffalo-CHS Charleston

6h 59m1 stop Atlanta Hartsfield-Jackson

6:47 pm - 12:01 amCHS Charleston-BUF Buffalo

5h 14m1 stop Detroit Metropolitan Wayne County

$261Delta

Fri, Dec 18 - Tue, Dec 22

7:00 am - 11:55 amBUF Buffalo-CHS Charleston

4h 55m1 stop New York John F Kennedy Intl

6:49 pm - 11:18 pmCHS Charleston-BUF Buffalo

4h 29m1 stop New York LaGuardia

$261Delta

Wed, Feb 10 - Tue, Feb 16

6:58 pm - 11:26 pmBUF Buffalo-CHS Charleston

4h 28m1 stop Philadelphia

5:27 pm - 10:43 pmCHS Charleston-BUF Buffalo

5h 16m1 stop Charlotte Douglas

$261American Airlines

Thu, Dec 10 - Sat, Dec 12

6:30 am - 1:46 pmBUF Buffalo-CHS Charleston

7h 16m1 stop Chicago O'Hare Intl

10:19 am - 10:02 pmCHS Charleston-BUF Buffalo

11h 43m2 stops Chicago O'Hare Intl Newark

$266United Airlines

Wed, Feb 10 - Tue, Feb 16

5:50 pm - 10:20 pmBUF Buffalo-CHS Charleston

4h 30m1 stop Baltimore/Washington

6:20 am - 3:30 pmCHS Charleston-BUF Buffalo

9h 10m2 stops Nashville Intl Chicago Midway

$266Southwest

Thu, Feb 4 - Mon, Feb 8

6:00 am - 3:32 pmBUF Buffalo-CHS Charleston

9h 32m2 stops Newark Washington, D.C. Dulles Intl

3:30 pm - 8:24 pmCHS Charleston-BUF Buffalo

4h 54m1 stop Newark

$274United Airlines

Tue, Dec 1 - Fri, Dec 4

7:30 am - 1:08 pmBUF Buffalo-CHS Charleston

5h 38m1 stop Boston Logan Intl

2:00 pm - 8:14 pmCHS Charleston-BUF Buffalo

6h 14m1 stop Boston Logan Intl

$380JetBlue

Fri, Jan 15 - Mon, Jan 18

9:38 pm - 8:38 amBUF Buffalo-CHS Charleston

11h 00m1 stop Orlando

7:00 am - 8:43 pmCHS Charleston-BUF Buffalo

13h 43m2 stops Richmond Byrd Intl Orlando

$457Multiple Airlines

Fri, Jan 15 - Mon, Jan 18

Cheap last minute flights

Enter your travel dates to find the best prices.

5:20 pm - 11:47 pmBUF Buffalo-CAE Columbia Metropolitan

6h 27m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:06 amCAE Columbia Metropolitan-BUF Buffalo

5h 06m1 stop Atlanta Hartsfield-Jackson

$383Delta

Sat, Nov 7 - Sat, Nov 14

5:20 pm - 11:47 pmBUF Buffalo-CAE Columbia Metropolitan

6h 27m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:06 amCAE Columbia Metropolitan-BUF Buffalo

5h 06m1 stop Atlanta Hartsfield-Jackson

$383Delta

Wed, Nov 4 - Sat, Nov 14

6:55 pm - 10:58 pmBUF Buffalo-CAE Columbia Metropolitan

4h 03m1 stop Charlotte Douglas

6:03 am - 11:35 amCAE Columbia Metropolitan-BUF Buffalo

5h 32m1 stop Washington, D.C. Reagan-National

$397American Airlines

Sat, Nov 7 - Tue, Nov 10

12:05 pm - 6:13 pmBUF Buffalo-CAE Columbia Metropolitan

6h 08m1 stop Washington, D.C. Reagan-National

6:00 am - 10:38 amCAE Columbia Metropolitan-BUF Buffalo

4h 38m1 stop New York LaGuardia

$397American Airlines

Wed, Nov 4 - Wed, Nov 11

12:08 pm - 7:31 pmBUF Buffalo-CHS Charleston

7h 23m1 stop New York John F Kennedy Intl

9:40 am - 4:18 pmCHS Charleston-BUF Buffalo

6h 38m1 stop New York John F Kennedy Intl

$482JetBlue

Fri, Nov 6 - Thu, Nov 12

12:05 pm - 9:00 pmBUF Buffalo-CHS Charleston

8h 55m2 stops Orlando Nashville Intl

5:15 pm - 10:00 pmCHS Charleston-BUF Buffalo

4h 45m1 stop Baltimore/Washington

$492Southwest

Mon, Nov 9 - Tue, Nov 17

12:39 pm - 8:48 amBUF Buffalo-CHS Charleston

20h 09m1 stop Orlando

3:42 pm - 4:47 pmCHS Charleston-BUF Buffalo

25h 05m1 stop Orlando

$494Multiple Airlines

Thu, Nov 5 - Wed, Nov 11

10:51 am - 7:11 pmBUF Buffalo-CHS Charleston

8h 20m2 stops Newark Washington, D.C. Dulles Intl

7:00 am - 2:10 pmCHS Charleston-BUF Buffalo

7h 10m2 stops Newark Washington, D.C. Dulles Intl

$497United Airlines

Mon, Nov 9 - Tue, Nov 17

11:00 am - 5:20 pmBUF Buffalo-MYR Myrtle Beach Intl

6h 20m1 stop Nashville Intl

8:20 am - 12:15 pmMYR Myrtle Beach Intl-BUF Buffalo

3h 55m1 stop Baltimore/Washington

$535Southwest

Sat, Nov 7 - Sat, Nov 14

6:00 am - 11:21 amBUF Buffalo-CHS Charleston

5h 21m1 stop Chicago O'Hare Intl

2:52 pm - 11:49 pmCHS Charleston-BUF Buffalo

8h 57m2 stops Washington, D.C. Dulles Intl Newark

$583United Airlines

Sat, Nov 7 - Sat, Nov 14

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United Airlines flights from Buffalo to South Carolina

Our best United Airlines deals on Buffalo to South Carolina flight tickets

United Airlines

Dec 1

BUF6:00 amBuffalo

9h 32m

2 stops

CHS3:32 pmCharleston

Dec 4

CHS3:30 pmCharleston

4h 54m

1 stop

BUF8:24 pmBuffalo

$274

United Airlines

Dec 3

BUF7:00 amBuffalo

7h 20m

1 stop

CHS2:20 pmCharleston

Dec 9

CHS10:22 amCharleston

10h 02m

2 stops

BUF8:24 pmBuffalo

$304

United Airlines

Nov 24

BUF6:00 amBuffalo

4h 06m

1 stop

CHS10:06 amCharleston

Nov 27

CHS10:23 amCharleston

3h 57m

1 stop

BUF2:20 pmBuffalo

$309

Delta flights from Buffalo to South Carolina

Our best Delta deals on Buffalo to South Carolina flight tickets

Delta

Dec 18

BUF6:00 amBuffalo

6h 59m

1 stop

CHS12:59 pmCharleston

Dec 22

CHS6:47 pmCharleston

5h 14m

1 stop

BUF12:01 amBuffalo

$261

Delta

Nov 30

BUF6:00 amBuffalo

4h 13m

1 stop

CHS10:13 amCharleston

Dec 7

CHS3:20 pmCharleston

7h 36m

1 stop

BUF10:56 pmBuffalo

$271

Delta

Nov 30

BUF6:00 amBuffalo

4h 13m

1 stop

CHS10:13 amCharleston

Dec 6

CHS6:59 pmCharleston

5h 05m

1 stop

BUF12:04 amBuffalo

$281

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Tue 12/1

3:55 pm-8:05 pm

1 stop4h 10m

Charleston

Fri 12/4

5:15 pm-10:00 pm

1 stop4h 45m

$248

Quickest round-trip

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Thu 12/3

6:58 pm-11:26 pm

1 stop4h 28m

Charleston

Sat 1/9

7:21 pm-11:16 pm

1 stop3h 55m

$261

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Fri 12/18

6:00 am-12:59 pm

1 stop6h 59m

Charleston

Tue 12/22

6:47 pm-12:01 am

1 stop5h 14m

$261

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 2/10

7:00 am-11:55 am

1 stop4h 55m

Charleston

Tue 2/16

6:49 pm-11:18 pm

1 stop4h 29m

$261

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Thu 12/10

6:58 pm-11:26 pm

1 stop4h 28m

Charleston

Sat 12/12

5:27 pm-10:43 pm

1 stop5h 16m

$261

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 2/10

6:30 am-1:46 pm

1 stop7h 16m

Charleston

Tue 2/16

10:19 am-10:02 pm

2 stops11h 43m

$266

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Thu 2/4

5:50 pm-10:20 pm

1 stop4h 30m

Charleston

Mon 2/8

6:20 am-3:30 pm

2 stops9h 10m

$266

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Tue 12/1

6:00 am-3:32 pm

2 stops9h 32m

Charleston

Fri 12/4

3:30 pm-8:24 pm

1 stop4h 54m

$274

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Fri 1/15

7:30 am-1:08 pm

1 stop5h 38m

Charleston

Mon 1/18

2:00 pm-8:14 pm

1 stop6h 14m

$380

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Fri 1/15

9:38 pm-8:38 am

1 stop11h 00m

Charleston

Mon 1/18

7:00 am-8:43 pm

2 stops13h 43m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in January. Flight prices, which tend to average around $314, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Buffalo during February instead. Flights to South Carolina in February, while not as cheap as those in January, still average around $335.

How far in advance should I book a flight from Buffalo to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $335 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $221 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Best Price Found	$131
Fastest flight time	2h 00m
Direct flights	None

The best one-way flight to South Carolina from Buffalo in the past 72 hours is $131. The best round-trip flight deal from Buffalo to South Carolina found on momondo in the last 72 hours is $248.

The fastest flight from Buffalo to South Carolina takes 2h 00m

There are no direct flights from Buffalo to South Carolina. There are no popular flight routes from Buffalo to South Carolina.

Search flight deals

Frequently asked questions about flying from Buffalo to South Carolina

When did momondo last update prices for flights from Buffalo Airport to South Carolina?
Prices for flights from Buffalo Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Buffalo Airport to South Carolina?
As of November 2026, there are 4 operators available to choose from for flights from Buffalo Airport to South Carolina.
How old do you have to be to fly from Buffalo Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $188	Free Cancellation	Rating 7.3 10,460 reviews	Search United Airlines flights
Delta	PriceFrom $196	Free Cancellation	Rating 7.8 8,696 reviews	Search Delta flights
American Airlines	PriceFrom $200	Free Cancellation	Rating 7.0 12,230 reviews	Search American Airlines flights
Southwest	PriceFrom $266	Free Cancellation	Rating 8.0 4,215 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.