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Cheap flights from Buffalo to South Carolina from $65

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to South Carolina departing on 11/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:18 pm - 4:54 pmBUF-CLT
20h 36m1 stop
Multiple Airlines Logo
11:12 am - 7:23 pmCLT-BUF
8h 11m1 stop
$195Multiple Airlines
Find Deal
lun., ene. 26 - vie., ene. 30
American Airlines Logo
5:43 pm - 10:24 pmBUF-CHS
4h 41m1 stop
American Airlines Logo
6:23 pm - 10:49 pmCHS-BUF
4h 26m1 stop
$198American Airlines
Find Deal
lun., nov. 24 - mar., dic. 2
Delta Logo
6:00 am - 1:05 pmBUF-CHS
7h 05m1 stop
Delta Logo
5:46 pm - 12:16 amCHS-BUF
6h 30m1 stop
$200Delta
Find Deal
sáb., dic. 6 - lun., dic. 8
Delta Logo
11:19 am - 5:05 pmBUF-CHS
5h 46m1 stop
Delta Logo
6:30 am - 11:04 amCHS-BUF
4h 34m1 stop
$201Delta
Find Deal
lun., dic. 1 - mar., dic. 9
United Airlines Logo
10:37 am - 2:42 pmBUF-SAV
4h 05m1 stop
United Airlines Logo
10:00 am - 4:38 pmSAV-BUF
6h 38m1 stop
$236United Airlines
Find Deal
jue., nov. 20 - jue., nov. 27
United Airlines Logo
6:00 am - 3:11 pmBUF-SAV
9h 11m2 stops
United Airlines Logo
9:45 am - 2:20 pmSAV-BUF
4h 35m1 stop
$241United Airlines
Find Deal
jue., nov. 20 - jue., nov. 27
JetBlue Logo
9:15 am - 5:22 pmBUF-CHS
8h 07m1 stop
JetBlue Logo
2:40 pm - 11:00 pmCHS-BUF
8h 20m1 stop
$248JetBlue
Find Deal
lun., mar. 23 - vie., mar. 27
Southwest Logo
5:50 am - 10:00 amBUF-CHS
4h 10m1 stop
Southwest Logo
1:00 pm - 10:00 pmCHS-BUF
9h 00m2 stops
$255Southwest
Find Deal
sáb., dic. 6 - mar., dic. 9
Southwest Logo
5:50 am - 10:00 amBUF-CHS
4h 10m1 stop
Southwest Logo
6:00 am - 2:20 pmCHS-BUF
8h 20m2 stops
$265Southwest
Find Deal
sáb., dic. 6 - lun., dic. 8
JetBlue Logo
12:30 pm - 6:31 pmBUF-SAV
6h 01m1 stop
JetBlue Logo
12:05 pm - 6:46 pmSAV-BUF
6h 41m1 stop
$280JetBlue
Find Deal
mié., nov. 19 - sáb., nov. 22

Frontier flights from Buffalo to South Carolina

Our best Frontier deals on Buffalo to South Carolina flight tickets
Frontier
Jan 5
BUF10:43 amBuffalo
10h 15m
1 stop
CLT8:58 pmCharlotte Douglas
Jan 22
CLT8:52 amCharlotte Douglas
10h 31m
1 stop
BUF7:23 pmBuffalo
$206
Find similar
Frontier
Nov 20
BUF11:40 amBuffalo
20h 59m
1 stop
CLT8:39 amCharlotte Douglas
Nov 24
CLT8:13 amCharlotte Douglas
28h 51m
1 stop
BUF1:04 pmBuffalo
$208
Find similar
Frontier
Dec 21
BUF7:58 pmBuffalo
21h 03m
1 stop
CLT5:01 pmCharlotte Douglas
Dec 29
CLT9:43 pmCharlotte Douglas
21h 30m
2 stops
BUF7:13 pmBuffalo
$209
Find similar

Southwest flights from Buffalo to South Carolina

Our best Southwest deals on Buffalo to South Carolina flight tickets
Southwest
Dec 6
BUF5:50 amBuffalo
4h 10m
1 stop
CHS10:00 amCharleston
Dec 9
CHS1:00 pmCharleston
9h 00m
2 stops
BUF10:00 pmBuffalo
$255
Find similar
Southwest
Dec 6
BUF5:50 amBuffalo
4h 10m
1 stop
CHS10:00 amCharleston
Dec 8
CHS6:00 amCharleston
8h 20m
2 stops
BUF2:20 pmBuffalo
$265
Find similar
Southwest
Dec 9
BUF12:35 pmBuffalo
8h 35m
2 stops
CLT9:10 pmCharlotte Douglas
Dec 10
CLT6:20 pmCharlotte Douglas
3h 40m
1 stop
BUF10:00 pmBuffalo
$278
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated noviembre 5, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

lun. 1/26

8:18 pm-4:54 pm

1 stop20h 36m

Charlotte Douglas

vie. 1/30

11:12 am-7:23 pm

1 stop8h 11m

$195

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

lun. 11/24

5:43 pm-10:24 pm

1 stop4h 41m

Charleston

mar. 12/2

6:23 pm-10:49 pm

1 stop4h 26m

$198

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

sáb. 12/6

6:00 am-1:05 pm

1 stop7h 05m

Charleston

lun. 12/8

5:46 pm-12:16 am

1 stop6h 30m

$200

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

lun. 12/1

11:19 am-5:05 pm

1 stop5h 46m

Charleston

mar. 12/9

6:30 am-11:04 am

1 stop4h 34m

$201

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

jue. 11/20

10:37 am-2:42 pm

1 stop4h 05m

Savannah/Hilton Head

jue. 11/27

10:00 am-4:38 pm

1 stop6h 38m

$236

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

jue. 11/20

6:00 am-3:11 pm

2 stops9h 11m

Savannah/Hilton Head

jue. 11/27

9:45 am-2:20 pm

1 stop4h 35m

$241

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

lun. 3/23

9:15 am-5:22 pm

1 stop8h 07m

Charleston

vie. 3/27

2:40 pm-11:00 pm

1 stop8h 20m

$248

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

sáb. 12/6

5:50 am-10:00 am

1 stop4h 10m

Charleston

mar. 12/9

1:00 pm-10:00 pm

2 stops9h 00m

$255

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

sáb. 12/6

5:50 am-10:00 am

1 stop4h 10m

Charleston

lun. 12/8

6:00 am-2:20 pm

2 stops8h 20m

$265

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mié. 11/19

12:30 pm-6:31 pm

1 stop6h 01m

Savannah/Hilton Head

sáb. 11/22

12:05 pm-6:46 pm

1 stop6h 41m

$280

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in January. Flight prices, which tend to average around $226, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Buffalo during September instead. Flights to South Carolina in September, while not as cheap as those in January, still average around $236.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $307. The most expensive day to fly to South Carolina is Monday, with ticket prices averaging around $404.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Buffalo to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $346. Try not to purchase tickets in the morning because they tend to be around $360. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $306 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $226 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Fastest flight time

1h 54m

Direct flights

Every day

Airports in South Carolina

1 airport
The fastest flight from Buffalo to South Carolina takes 1h 54m
Direct flights go from Buffalo to South Carolina every day.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Buffalo Airport to South Carolina?

    Prices for flights from Buffalo Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to South Carolina?

  • How old do you have to be to fly from Buffalo Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $180Free CancellationRating
7.2
2,907 reviews
Search JetBlue flights
DeltaPriceFrom $196Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
United AirlinesPriceFrom $234Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights
SouthwestPriceFrom $251Free CancellationRating
8.0
4,240 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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