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Cheap flights from Buffalo to South Carolina from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to South Carolina departing on 9/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Buffalo to South Carolina

Cheap round-trip flights

JetBlue Logo
7:00 am - 1:19 pmBUF-CHS
6h 19m1 stop
JetBlue Logo
2:15 pm - 8:34 pmCHS-BUF
6h 19m1 stop
$180JetBlue
Find Deal
Wed, Nov 12 - Sat, Nov 15
JetBlue Logo
6:00 am - 10:25 amBUF-CHS
4h 25m1 stop
JetBlue Logo
11:10 am - 7:04 pmCHS-BUF
7h 54m1 stop
$181JetBlue
Find Deal
Wed, Oct 8 - Sat, Oct 11
American Airlines Logo
4:25 pm - 8:47 pmBUF-MYR
4h 22m1 stop
American Airlines Logo
2:55 pm - 6:48 pmMYR-BUF
3h 53m1 stop
$224American Airlines
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Fri, Oct 31 - Sat, Nov 1
American Airlines Logo
7:40 am - 1:39 pmBUF-CHS
5h 59m1 stop
American Airlines Logo
8:12 am - 12:10 pmCHS-BUF
3h 58m1 stop
$226American Airlines
Find Deal
Mon, Sep 22 - Tue, Sep 30
Delta Logo
7:30 pm - 11:58 pmBUF-SAV
4h 28m1 stop
Delta Logo
6:35 pm - 10:52 pmSAV-BUF
4h 17m1 stop
$235Delta
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Thu, Oct 16 - Tue, Oct 21
Delta Logo
6:15 am - 10:39 amBUF-MYR
4h 24m1 stop
Delta Logo
11:34 am - 3:11 pmMYR-BUF
3h 37m1 stop
$237Delta
Find Deal
Wed, Sep 24 - Wed, Oct 1
Southwest Logo
1:20 pm - 9:15 pmBUF-MYR
7h 55m2 stops
Southwest Logo
8:25 am - 12:30 pmMYR-BUF
4h 05m1 stop
$262Southwest
Find Deal
Tue, Sep 30 - Tue, Oct 7
Southwest Logo
6:50 am - 4:00 pmBUF-MYR
9h 10m2 stops
Southwest Logo
4:35 pm - 10:10 pmMYR-BUF
5h 35m1 stop
$275Southwest
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Wed, Sep 24 - Wed, Oct 1
United Airlines Logo
6:30 am - 12:39 pmBUF-CLT
6h 09m1 stop
United Airlines Logo
6:30 am - 2:12 pmCLT-BUF
7h 42m2 stops
$278United Airlines
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Wed, Oct 1 - Tue, Oct 7
United Airlines Logo
2:49 pm - 10:46 pmBUF-SAV
7h 57m2 stops
United Airlines Logo
9:45 am - 2:14 pmSAV-BUF
4h 29m1 stop
$311United Airlines
Find Deal
Tue, Feb 3 - Sat, Feb 7

Frontier flights from Buffalo to South Carolina

Our best Frontier deals on Buffalo to South Carolina flight tickets
Frontier
Oct 26
BUF6:51 pmBuffalo
14h 24m
1 stop
CLT9:15 amCharlotte Douglas
Oct 27
CLT12:04 pmCharlotte Douglas
8h 14m
1 stop
BUF8:18 pmBuffalo
$243
Find similar
Frontier
Sep 4
BUF6:22 pmBuffalo
13h 48m
2 stops
CLT8:10 amCharlotte Douglas
Sep 21
CLT8:51 pmCharlotte Douglas
21h 23m
1 stop
BUF6:14 pmBuffalo
$244
Find similar
Frontier
Sep 4
BUF7:41 pmBuffalo
12h 29m
1 stop
CLT8:10 amCharlotte Douglas
Sep 21
CLT8:51 pmCharlotte Douglas
21h 23m
1 stop
BUF6:14 pmBuffalo
$252
Find similar

United Airlines flights from Buffalo to South Carolina

Our best United Airlines deals on Buffalo to South Carolina flight tickets
United Airlines
Oct 1
BUF6:30 amBuffalo
6h 09m
1 stop
CLT12:39 pmCharlotte Douglas
Oct 7
CLT6:30 amCharlotte Douglas
7h 42m
2 stops
BUF2:12 pmBuffalo
$278
Find similar
United Airlines
Feb 3
BUF2:49 pmBuffalo
7h 57m
2 stops
SAV10:46 pmSavannah/Hilton Head
Feb 7
SAV9:45 amSavannah/Hilton Head
4h 29m
1 stop
BUF2:14 pmBuffalo
$311
Find similar
United Airlines
Oct 18
BUF1:14 pmBuffalo
6h 54m
1 stop
CHS8:08 pmCharleston
Oct 23
CHS6:02 amCharleston
8h 10m
2 stops
BUF2:12 pmBuffalo
$312
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 11/12

7:00 am-1:19 pm

1 stop6h 19m

Charleston

Sat 11/15

2:15 pm-8:34 pm

1 stop6h 19m

$180

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 10/8

6:00 am-10:25 am

1 stop4h 25m

Charleston

Sat 10/11

11:10 am-7:04 pm

1 stop7h 54m

$181

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Fri 10/31

4:25 pm-8:47 pm

1 stop4h 22m

Myrtle Beach Intl

Sat 11/1

2:55 pm-6:48 pm

1 stop3h 53m

$224

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 9/22

7:40 am-1:39 pm

1 stop5h 59m

Charleston

Tue 9/30

8:12 am-12:10 pm

1 stop3h 58m

$226

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Thu 10/16

7:30 pm-11:58 pm

1 stop4h 28m

Savannah/Hilton Head

Tue 10/21

6:35 pm-10:52 pm

1 stop4h 17m

$235

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 9/24

6:15 am-10:39 am

1 stop4h 24m

Myrtle Beach Intl

Wed 10/1

11:34 am-3:11 pm

1 stop3h 37m

$237

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Tue 9/30

1:20 pm-9:15 pm

2 stops7h 55m

Myrtle Beach Intl

Tue 10/7

8:25 am-12:30 pm

1 stop4h 05m

$262

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 9/24

6:50 am-4:00 pm

2 stops9h 10m

Myrtle Beach Intl

Wed 10/1

4:35 pm-10:10 pm

1 stop5h 35m

$275

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Wed 10/1

6:30 am-12:39 pm

1 stop6h 09m

Charlotte Douglas

Tue 10/7

6:30 am-2:12 pm

2 stops7h 42m

$278

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 2/3

2:49 pm-10:46 pm

2 stops7h 57m

Savannah/Hilton Head

Sat 2/7

9:45 am-2:14 pm

1 stop4h 29m

$311

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in January. Flight prices, which tend to average around $217, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Buffalo during September instead. Flights to South Carolina in September, while not as cheap as those in January, still average around $237.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $307. The most expensive day to fly to South Carolina is Monday, with ticket prices averaging around $404.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Buffalo to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $346. Try not to purchase tickets in the morning because they tend to be around $360. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $314 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $223 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Fastest flight time

1h 55m

Direct flights

Every day

Airports in South Carolina

1 airport
The fastest flight from Buffalo to South Carolina takes 1h 55m
Direct flights go from Buffalo to South Carolina every day.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Buffalo Airport to South Carolina?

    Prices for flights from Buffalo Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to South Carolina?

  • How old do you have to be to fly from Buffalo Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $80Free CancellationRating
7.2
2,920 reviews
Search JetBlue flights
DeltaPriceFrom $196Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $218Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $234Free CancellationRating
7.4
8,944 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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