Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Buffalo to South Carolina from $68

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to South Carolina departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Buffalo to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:31 pm - 9:55 am
BUF
-
CLT
14h 24m1 stop
Multiple Airlines Logo
11:12 am - 6:36 pm
CLT
-
BUF
7h 24m1 stop
$195Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
JetBlue Logo
10:25 am - 4:22 pm
BUF
-
SAV
5h 57m1 stop
JetBlue Logo
5:21 pm - 11:32 pm
SAV
-
BUF
6h 11m1 stop
$197JetBlue
Sat, Feb 28 - Thu, Mar 5
Delta Logo
6:00 am - 10:45 am
BUF
-
CHS
4h 45m1 stop
Delta Logo
6:00 am - 11:11 am
CHS
-
BUF
5h 11m1 stop
$201Delta
Thu, Jan 15 - Fri, Jan 23
American Airlines Logo
5:12 am - 10:39 am
BUF
-
SAV
5h 27m1 stop
American Airlines Logo
6:00 am - 11:21 am
SAV
-
BUF
5h 21m1 stop
$203American Airlines
Thu, Jan 29 - Sun, Feb 1
American Airlines Logo
7:00 am - 2:24 pm
BUF
-
SAV
7h 24m1 stop
American Airlines Logo
6:15 am - 12:08 pm
SAV
-
BUF
5h 53m1 stop
$204American Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
11:24 am - 7:11 pm
BUF
-
CHS
7h 47m2 stops
United Airlines Logo
1:13 pm - 10:31 pm
CHS
-
BUF
9h 18m2 stops
$211United Airlines
Sat, Jan 24 - Sat, Jan 31
Delta Logo
4:47 pm - 11:53 pm
BUF
-
SAV
7h 06m1 stop
Delta Logo
9:01 am - 3:51 pm
SAV
-
BUF
6h 50m1 stop
$219Delta
Sat, Mar 28 - Wed, Apr 1
United Airlines Logo
9:55 am - 8:02 pm
BUF
-
CHS
10h 07m2 stops
United Airlines Logo
2:58 pm - 7:25 pm
CHS
-
BUF
4h 27m1 stop
$268United Airlines
Thu, Jan 8 - Mon, Jan 12
Southwest Logo
3:45 pm - 7:45 pm
BUF
-
MYR
4h 00m1 stop
Southwest Logo
8:20 am - 11:55 am
MYR
-
BUF
3h 35m1 stop
$309Southwest
Wed, Jan 28 - Thu, Feb 5
Southwest Logo
3:45 pm - 7:45 pm
BUF
-
MYR
4h 00m1 stop
Southwest Logo
10:35 am - 6:40 pm
MYR
-
BUF
8h 05m2 stops
$314Southwest
Wed, Jan 28 - Thu, Feb 5

Delta flights from Buffalo to South Carolina

Our best Delta deals on Buffalo to South Carolina flight tickets
Delta
Jan 15
BUF6:00 amBuffalo
4h 45m
1 stop
CHS10:45 amCharleston
Jan 23
CHS6:00 amCharleston
5h 11m
1 stop
BUF11:11 amBuffalo
$201
Find similar
Delta
Mar 12
BUF4:47 pmBuffalo
5h 24m
1 stop
SAV10:11 pmSavannah/Hilton Head
Mar 15
SAV5:33 amSavannah/Hilton Head
5h 28m
1 stop
BUF11:01 amBuffalo
$219
Find similar
Delta
Feb 22
BUF12:05 pmBuffalo
6h 40m
1 stop
SAV6:45 pmSavannah/Hilton Head
Mar 22
SAV9:01 amSavannah/Hilton Head
6h 50m
1 stop
BUF3:51 pmBuffalo
$239
Find similar

United Airlines flights from Buffalo to South Carolina

Our best United Airlines deals on Buffalo to South Carolina flight tickets
United Airlines
Jan 24
BUF11:24 amBuffalo
7h 47m
2 stops
CHS7:11 pmCharleston
Jan 31
CHS1:13 pmCharleston
9h 18m
2 stops
BUF10:31 pmBuffalo
$211
Find similar
United Airlines
Jan 10
BUF9:55 amBuffalo
4h 52m
1 stop
SAV2:47 pmSavannah/Hilton Head
Jan 14
SAV10:10 amSavannah/Hilton Head
6h 34m
1 stop
BUF4:44 pmBuffalo
$231
Find similar
United Airlines
Jan 10
BUF9:55 amBuffalo
11h 41m
2 stops
SAV9:36 pmSavannah/Hilton Head
Jan 14
SAV10:10 amSavannah/Hilton Head
6h 34m
1 stop
BUF4:44 pmBuffalo
$236
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Fri 1/23

7:31 pm-9:55 am

1 stop14h 24m

Charlotte Douglas

Fri 1/30

11:12 am-6:36 pm

1 stop7h 24m

$195

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 2/28

10:25 am-4:22 pm

1 stop5h 57m

Savannah/Hilton Head

Thu 3/5

5:21 pm-11:32 pm

1 stop6h 11m

$197

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 1/15

6:00 am-10:45 am

1 stop4h 45m

Charleston

Fri 1/23

6:00 am-11:11 am

1 stop5h 11m

$201

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Thu 1/29

5:12 am-10:39 am

1 stop5h 27m

Savannah/Hilton Head

Sun 2/1

6:00 am-11:21 am

1 stop5h 21m

$203

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 2/3

7:00 am-2:24 pm

1 stop7h 24m

Savannah/Hilton Head

Sat 2/7

6:15 am-12:08 pm

1 stop5h 53m

$204

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 1/24

11:24 am-7:11 pm

2 stops7h 47m

Charleston

Sat 1/31

1:13 pm-10:31 pm

2 stops9h 18m

$211

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 3/28

4:47 pm-11:53 pm

1 stop7h 06m

Savannah/Hilton Head

Wed 4/1

9:01 am-3:51 pm

1 stop6h 50m

$219

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 1/8

9:55 am-8:02 pm

2 stops10h 07m

Charleston

Mon 1/12

2:58 pm-7:25 pm

1 stop4h 27m

$268

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 1/28

3:45 pm-7:45 pm

1 stop4h 00m

Myrtle Beach Intl

Thu 2/5

8:20 am-11:55 am

1 stop3h 35m

$309

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 1/28

3:45 pm-7:45 pm

1 stop4h 00m

Myrtle Beach Intl

Thu 2/5

10:35 am-6:40 pm

2 stops8h 05m

$314

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to South Carolina from

How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in January. Flight prices, which tend to average around $217, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Buffalo during September instead. Flights to South Carolina in September, while not as cheap as those in January, still average around $236.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $307. The most expensive day to fly to South Carolina is Monday, with ticket prices averaging around $404.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Buffalo to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $346. Try not to purchase tickets in the morning because they tend to be around $360. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $291 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $221 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Fastest flight time

2h 02m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in South Carolina

57 airports
The fastest flight from Buffalo to South Carolina takes 2h 02m
Direct flights go from Buffalo to South Carolina on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There are 57 airports in South Carolina. From Buffalo there are direct flights to Charlotte Douglas (CLT).
Search flight deals

  • When did momondo last update prices for flights from Buffalo Airport to South Carolina?

    Prices for flights from Buffalo Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to South Carolina?

  • How old do you have to be to fly from Buffalo Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $80Free CancellationRating
7.2
2,900 reviews
Search JetBlue flights
DeltaPriceFrom $196Free CancellationRating
7.9
8,013 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,064 reviews
Search American Airlines flights
United AirlinesPriceFrom $200Free CancellationRating
7.4
9,115 reviews
Search United Airlines flights
SouthwestPriceFrom $251Free CancellationRating
8.0
4,258 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 1/25
Sun 2/1
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo
Flights to New Yorkfrom $50
Flights to Los Angelesfrom $47
Flights to Miamifrom $50
Flights to Chicagofrom $51
Flights to Orlandofrom $49
Flights to San Franciscofrom $59
Flights to Las Vegasfrom $49
Flights to Washington, D.C.from $58
Flights to Bostonfrom $51
Flights to Atlantafrom $44
Flights to Dallasfrom $51
Flights to Seattlefrom $57