What is the cheapest airline that flies from Buffalo to South Carolina?

United Airlines, Delta, and American Airlines are the most popular carriers operating from Buffalo to South Carolina

What airlines fly to South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to South Carolina from Buffalo according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 8 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from Buffalo to South Carolina on average per week?

As of February 2026, 16 flights take off from Buffalo and land in South Carolina each week. The most common flight departure day for this route is Mon, with 19% of weekly flights taking off on this day.

When did momondo last update prices for flights from Buffalo Airport to South Carolina?

Prices for flights from Buffalo Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Buffalo Airport to South Carolina?

As of February 2026, there are 6 operators available to choose from for flights from Buffalo Airport to South Carolina.

How old do you have to be to fly from Buffalo Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$65 Cheap Flights from Buffalo to South Carolina in 2026

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Find the cheapest flights from Buffalo to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

9:25 pm - 8:03 am

BUF

CLT

10h 38m

1 stop

10:49 pm - 12:17 pm

CLT

BUF

13h 28m

2 stops

$178Frontier

Mon, Mar 9 - Mon, Apr 6

10:52 am - 4:30 pm

BUF

CLT

5h 38m

1 stop

10:07 am - 7:13 pm

CLT

BUF

9h 06m

1 stop

$181Frontier

Fri, Apr 17 - Sun, Apr 19

8:16 pm - 4:35 pm

BUF

CLT

20h 19m

1 stop

9:28 pm - 12:42 pm

CLT

BUF

15h 14m

2 stops

$187Multiple Airlines

Mon, Apr 13 - Mon, Apr 20

4:30 pm - 8:53 pm

BUF

SAV

4h 23m

1 stop

8:45 am - 3:30 pm

SAV

BUF

6h 45m

1 stop

$197Delta

Tue, Aug 25 - Sat, Sep 12

7:38 pm - 12:16 am

BUF

CHS

4h 38m

1 stop

5:51 pm - 12:14 am

CHS

BUF

6h 23m

1 stop

$197Delta

Mon, Mar 16 - Wed, Mar 25

5:30 am - 10:37 am

BUF

CHS

5h 07m

1 stop

4:30 pm - 11:19 pm

CHS

BUF

6h 49m

1 stop

$200American Airlines

Wed, Apr 8 - Wed, Apr 15

10:35 am - 9:08 pm

BUF

SAV

10h 33m

2 stops

11:31 am - 5:16 pm

SAV

BUF

5h 45m

1 stop

$202United Airlines

Sat, Apr 18 - Wed, Apr 22

10:35 am - 9:25 pm

BUF

CHS

10h 50m

2 stops

8:00 am - 1:13 pm

CHS

BUF

5h 13m

1 stop

$202United Airlines

Tue, Apr 14 - Tue, Apr 21

7:02 pm - 11:55 pm

BUF

CHS

4h 53m

1 stop

7:27 pm - 11:31 pm

CHS

BUF

4h 04m

1 stop

$203American Airlines

Sat, Mar 21 - Fri, Mar 27

3:10 pm - 8:55 pm

BUF

CLT

5h 45m

1 stop

12:15 pm - 8:40 pm

CLT

BUF

8h 25m

1 stop

$229Southwest

Tue, Apr 21 - Sat, Apr 25

Southwest flights from Buffalo to South Carolina

Our best Southwest deals on Buffalo to South Carolina flight tickets

Southwest

Apr 21

BUF3:10 pmBuffalo

5h 45m

1 stop

CLT8:55 pmCharlotte Douglas

Apr 25

CLT12:15 pmCharlotte Douglas

8h 25m

1 stop

BUF8:40 pmBuffalo

$229

Southwest

Apr 16

BUF4:00 pmBuffalo

5h 40m

1 stop

CLT9:40 pmCharlotte Douglas

Apr 21

CLT8:00 amCharlotte Douglas

4h 15m

1 stop

BUF12:15 pmBuffalo

$246

Southwest

Apr 14

BUF11:00 amBuffalo

6h 40m

2 stops

CHS5:40 pmCharleston

Apr 21

CHS6:40 amCharleston

7h 55m

2 stops

BUF2:35 pmBuffalo

$267

Frontier flights from Buffalo to South Carolina

Our best Frontier deals on Buffalo to South Carolina flight tickets

Frontier

Apr 17

BUF10:52 amBuffalo

5h 38m

1 stop

CLT4:30 pmCharlotte Douglas

Apr 19

CLT10:07 amCharlotte Douglas

9h 06m

1 stop

BUF7:13 pmBuffalo

$160

Frontier

May 1

BUF11:02 amBuffalo

5h 28m

1 stop

CLT4:30 pmCharlotte Douglas

May 7

CLT5:41 pmCharlotte Douglas

15h 06m

1 stop

BUF8:47 amBuffalo

$171

Frontier

Mar 9

BUF9:25 pmBuffalo

10h 38m

1 stop

CLT8:03 amCharlotte Douglas

Apr 6

CLT10:49 pmCharlotte Douglas

13h 28m

2 stops

BUF12:17 pmBuffalo

$178

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Mon 3/9

9:25 pm-8:03 am

1 stop10h 38m

Charlotte Douglas

Mon 4/6

10:49 pm-12:17 pm

2 stops13h 28m

$178

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Fri 4/17

10:52 am-4:30 pm

1 stop5h 38m

Charlotte Douglas

Sun 4/19

10:07 am-7:13 pm

1 stop9h 06m

$181

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Mon 4/13

8:16 pm-4:35 pm

1 stop20h 19m

Charlotte Douglas

Mon 4/20

9:28 pm-12:42 pm

2 stops15h 14m

$187

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 8/25

4:30 pm-8:53 pm

1 stop4h 23m

Savannah/Hilton Head

Sat 9/12

8:45 am-3:30 pm

1 stop6h 45m

$197

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 3/16

7:38 pm-12:16 am

1 stop4h 38m

Charleston

Wed 3/25

5:51 pm-12:14 am

1 stop6h 23m

$197

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 4/8

5:30 am-10:37 am

1 stop5h 07m

Charleston

Wed 4/15

4:30 pm-11:19 pm

1 stop6h 49m

$200

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 4/18

10:35 am-9:08 pm

2 stops10h 33m

Savannah/Hilton Head

Wed 4/22

11:31 am-5:16 pm

1 stop5h 45m

$202

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 4/14

10:35 am-9:25 pm

2 stops10h 50m

Charleston

Tue 4/21

8:00 am-1:13 pm

1 stop5h 13m

$202

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 3/21

7:02 pm-11:55 pm

1 stop4h 53m

Charleston

Fri 3/27

7:27 pm-11:31 pm

1 stop4h 04m

$203

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Tue 4/21

3:10 pm-8:55 pm

1 stop5h 45m

Charlotte Douglas

Sat 4/25

12:15 pm-8:40 pm

1 stop8h 25m

$229

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in February. Flight prices, which tend to average around $201, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from Buffalo during September instead. Flights to South Carolina in September, while not as cheap as those in February, still average around $236.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $280 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $221 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Fastest flight time	1h 59m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Buffalo to South Carolina takes 1h 59m

Direct flights go from Buffalo to South Carolina every day.

There are 57 airports in South Carolina. From Buffalo there are direct flights to Charlotte Douglas (CLT).

Search flight deals

When did momondo last update prices for flights from Buffalo Airport to South Carolina?
Prices for flights from Buffalo Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Buffalo Airport to South Carolina?
As of February 2026, there are 6 operators available to choose from for flights from Buffalo Airport to South Carolina.
How old do you have to be to fly from Buffalo Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
JetBlue	PriceFrom $80	Free Cancellation	Rating 7.2 2,896 reviews	Search JetBlue flights
Delta	PriceFrom $118	Free Cancellation	Rating 7.9 8,243 reviews	Search Delta flights
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.2 11,357 reviews	Search American Airlines flights
United Airlines	PriceFrom $200	Free Cancellation	Rating 7.4 9,349 reviews	Search United Airlines flights
Southwest	PriceFrom $248	Free Cancellation	Rating 8.0 4,301 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.