How many flights depart from Buffalo to South Carolina on average per week?

As of September 2026, 15 flights take off from Buffalo and land in South Carolina each week. The most common flight departure day for this route is Tue, with 20% of weekly flights taking off on this day.

What is the cheapest airline that flies from Buffalo to South Carolina?

Southwest, Delta, and Frontier are the most popular carriers operating from Buffalo to South Carolina

What airlines fly to South Carolina?

Breeze Airways, American Airlines and Delta are the top three most popular airlines that fly to South Carolina from Buffalo according to our data. Breeze Airways is the first choice among our users, with 41% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 7 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Buffalo Airport to South Carolina?

Prices for flights from Buffalo Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Buffalo Airport to South Carolina?

As of September 2026, there are 6 operators available to choose from for flights from Buffalo Airport to South Carolina.

How old do you have to be to fly from Buffalo Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$89 Cheap Flights from Buffalo to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:00 am - 2:12 pmBUF Buffalo-CHS Charleston

7h 12m1 stop Boston Logan Intl

9:35 am - 2:58 pmCHS Charleston-BUF Buffalo

5h 23m1 stop New York John F Kennedy Intl

$172JetBlue

Tue, Oct 20 - Wed, Oct 28

7:35 pm - 11:56 pmBUF Buffalo-CHS Charleston

4h 21m1 stop Philadelphia

6:00 am - 11:23 amCHS Charleston-BUF Buffalo

5h 23m1 stop Washington, D.C. Reagan-National

$177American Airlines

Sat, Oct 24 - Wed, Oct 28

12:10 pm - 5:45 pmBUF Buffalo-CHS Charleston

5h 35m1 stop Nashville Intl

8:05 am - 12:20 pmCHS Charleston-BUF Buffalo

4h 15m1 stop Baltimore/Washington

$177Southwest

Sat, Jan 23 - Sat, Jan 30

1:10 pm - 8:10 pmBUF Buffalo-CHS Charleston

7h 00m1 stop Baltimore/Washington

7:30 am - 12:05 pmCHS Charleston-BUF Buffalo

4h 35m1 stop Baltimore/Washington

$177Southwest

Sat, Nov 7 - Tue, Nov 10

11:08 am - 5:21 pmBUF Buffalo-CHS Charleston

6h 13m1 stop New York LaGuardia

6:00 am - 10:11 amCHS Charleston-BUF Buffalo

4h 11m1 stop Philadelphia

$177American Airlines

Wed, Nov 11 - Sat, Nov 14

6:00 am - 10:10 amBUF Buffalo-CHS Charleston

4h 10m1 stop Atlanta Hartsfield-Jackson

7:05 pm - 11:59 pmCHS Charleston-BUF Buffalo

4h 54m1 stop Atlanta Hartsfield-Jackson

$197Delta

Wed, Oct 21 - Mon, Oct 26

6:30 am - 1:55 pmBUF Buffalo-CHS Charleston

7h 25m1 stop Newark

7:52 pm - 11:46 pmCHS Charleston-BUF Buffalo

3h 54m1 stop Washington, D.C. Dulles Intl

$197United Airlines

Wed, Oct 21 - Mon, Oct 26

6:10 am - 11:02 amBUF Buffalo-SAV Savannah/Hilton Head

4h 52m1 stop Detroit Metropolitan Wayne County

6:30 pm - 11:59 pmSAV Savannah/Hilton Head-BUF Buffalo

5h 29m1 stop Atlanta Hartsfield-Jackson

$202Delta

Wed, Nov 11 - Wed, Nov 18

6:30 am - 1:55 pmBUF Buffalo-CHS Charleston

7h 25m1 stop Newark

2:52 pm - 10:59 pmCHS Charleston-BUF Buffalo

8h 07m2 stops Washington, D.C. Dulles Intl Newark

$202United Airlines

Wed, Oct 21 - Tue, Oct 27

6:01 am - 10:26 amBUF Buffalo-SAV Savannah/Hilton Head

4h 25m1 stop Baltimore/Washington

8:06 am - 4:36 pmSAV Savannah/Hilton Head-BUF Buffalo

8h 30m1 stop Baltimore/Washington

$261JetBlue

Wed, Nov 11 - Wed, Nov 18

Cheap last minute flights

Enter your travel dates to find the best prices.

12:49 pm - 3:16 pmBUF Buffalo-CLT Charlotte Douglas

26h 27m1 stop Orlando

9:32 am - 5:45 pmCLT Charlotte Douglas-BUF Buffalo

8h 13m1 stop Orlando

$340Frontier

Sun, Sep 20 - Sun, Sep 27

6:51 pm - 8:35 amBUF Buffalo-CLT Charlotte Douglas

13h 44m1 stop Orlando

9:32 am - 5:45 pmCLT Charlotte Douglas-BUF Buffalo

8h 13m1 stop Orlando

$350Frontier

Tue, Sep 22 - Thu, Sep 24

10:00 am - 2:52 pmBUF Buffalo-CAE Columbia Metropolitan

4h 52m1 stop New York LaGuardia

4:10 pm - 10:57 pmCAE Columbia Metropolitan-BUF Buffalo

6h 47m1 stop New York LaGuardia

$373Delta

Wed, Sep 23 - Tue, Sep 29

10:33 am - 9:13 pmBUF Buffalo-CAE Columbia Metropolitan

10h 40m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

10:23 am - 2:23 pmCAE Columbia Metropolitan-BUF Buffalo

4h 00m1 stop Washington, D.C. Dulles Intl

$378United Airlines

Wed, Sep 23 - Tue, Sep 29

9:40 am - 2:10 pmBUF Buffalo-MYR Myrtle Beach Intl

4h 30m1 stop Baltimore/Washington

6:40 pm - 10:25 pmMYR Myrtle Beach Intl-BUF Buffalo

3h 45m1 stop Baltimore/Washington

$416Southwest

Sun, Sep 20 - Tue, Oct 20

12:35 pm - 9:15 pmBUF Buffalo-CLT Charlotte Douglas

8h 40m1 stop Chicago Midway

8:30 am - 12:30 pmCLT Charlotte Douglas-BUF Buffalo

4h 00m1 stop Baltimore/Washington

$432Southwest

Wed, Sep 23 - Tue, Sep 29

6:30 am - 8:28 amBUF Buffalo-CLT Charlotte Douglas

1h 58mnonstop

8:00 pm - 9:47 pmCLT Charlotte Douglas-BUF Buffalo

1h 47mnonstop

$435American Airlines

Tue, Sep 22 - Tue, Sep 29

4:31 pm - 6:30 pmBUF Buffalo-CLT Charlotte Douglas

1h 59mnonstop

8:00 pm - 9:47 pmCLT Charlotte Douglas-BUF Buffalo

1h 47mnonstop

$435American Airlines

Sat, Sep 19 - Sat, Sep 26

3:58 pm - 10:35 pmBUF Buffalo-SAV Savannah/Hilton Head

6h 37m1 stop Atlanta Hartsfield-Jackson

6:35 pm - 11:59 pmSAV Savannah/Hilton Head-BUF Buffalo

5h 24m1 stop Detroit Metropolitan Wayne County

$445Delta

Thu, Sep 24 - Fri, Oct 30

6:00 am - 11:11 amBUF Buffalo-CAE Columbia Metropolitan

5h 11m1 stop Newark

10:23 am - 2:23 pmCAE Columbia Metropolitan-BUF Buffalo

4h 00m1 stop Washington, D.C. Dulles Intl

$457United Airlines

Wed, Sep 23 - Tue, Sep 29

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Frontier flights from Buffalo to South Carolina

Our best Frontier deals on Buffalo to South Carolina flight tickets

Frontier

Oct 20

BUF6:51 pmBuffalo

13h 46m

1 stop

CLT8:37 amCharlotte Douglas

Oct 22

CLT9:32 amCharlotte Douglas

8h 20m

1 stop

BUF5:52 pmBuffalo

$239

Frontier

Oct 6

BUF6:51 pmBuffalo

13h 44m

1 stop

CLT8:35 amCharlotte Douglas

Oct 10

CLT9:42 pmCharlotte Douglas

20h 10m

1 stop

BUF5:52 pmBuffalo

$240

Frontier

Oct 23

BUF1:44 pmBuffalo

18h 13m

2 stops

CLT7:57 amCharlotte Douglas

Oct 27

CLT11:52 amCharlotte Douglas

25h 23m

2 stops

BUF1:15 pmBuffalo

$267

Southwest flights from Buffalo to South Carolina

Our best Southwest deals on Buffalo to South Carolina flight tickets

Southwest

Oct 17

BUF7:15 amBuffalo

6h 10m

1 stop

CHS1:25 pmCharleston

Oct 24

CHS6:15 amCharleston

8h 20m

2 stops

BUF2:35 pmBuffalo

$182

Southwest

Oct 20

BUF8:00 amBuffalo

9h 35m

2 stops

CHS5:35 pmCharleston

Oct 27

CHS6:40 amCharleston

8h 40m

2 stops

BUF3:20 pmBuffalo

$187

Southwest

Oct 24

BUF12:30 pmBuffalo

7h 15m

1 stop

CHS7:45 pmCharleston

Oct 28

CHS6:40 amCharleston

8h 40m

2 stops

BUF3:20 pmBuffalo

$188

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Tue 10/20

7:00 am-2:12 pm

1 stop7h 12m

Charleston

Wed 10/28

9:35 am-2:58 pm

1 stop5h 23m

$172

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Sat 10/24

7:35 pm-11:56 pm

1 stop4h 21m

Charleston

Wed 10/28

6:00 am-11:23 am

1 stop5h 23m

$177

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Sat 1/23

12:10 pm-5:45 pm

1 stop5h 35m

Charleston

Sat 1/30

8:05 am-12:20 pm

1 stop4h 15m

$177

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Sat 11/7

1:10 pm-8:10 pm

1 stop7h 00m

Charleston

Tue 11/10

7:30 am-12:05 pm

1 stop4h 35m

$177

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 11/11

11:08 am-5:21 pm

1 stop6h 13m

Charleston

Sat 11/14

6:00 am-10:11 am

1 stop4h 11m

$177

Quickest round-trip

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 10/21

6:00 am-10:10 am

1 stop4h 10m

Charleston

Mon 10/26

7:05 pm-11:59 pm

1 stop4h 54m

$197

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 10/21

6:30 am-1:55 pm

1 stop7h 25m

Charleston

Mon 10/26

7:52 pm-11:46 pm

1 stop3h 54m

$197

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Wed 11/11

6:10 am-11:02 am

1 stop4h 52m

Savannah/Hilton Head

Wed 11/18

6:30 pm-11:59 pm

1 stop5h 29m

$202

BuffaloCharleston

BUF Buffalo - CHS Charleston

BUFCHS

Buffalo

Wed 10/21

6:30 am-1:55 pm

1 stop7h 25m

Charleston

Tue 10/27

2:52 pm-10:59 pm

2 stops8h 07m

$202

BuffaloSavannah

BUF Buffalo - SAV Savannah/Hilton Head

BUFSAV

Buffalo

Wed 11/11

6:01 am-10:26 am

1 stop4h 25m

Savannah/Hilton Head

Wed 11/18

8:06 am-4:36 pm

1 stop8h 30m

$261

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Buffalo is in February. Flight prices, which tend to average around $303, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from Buffalo during January instead. Flights to South Carolina in January, while not as cheap as those in February, still average around $313.

How far in advance should I book a flight from Buffalo to South Carolina?

You are more likely to see cheaper flights to South Carolina from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $324 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Buffalo for as low as $221 on momondo.

Cheap Buffalo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South Carolina

Best Price Found	$89
Fastest flight time	1h 58m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Buffalo in the past 72 hours is $89. The best round-trip flight deal from Buffalo to South Carolina found on momondo in the last 72 hours is $172.

The fastest flight from Buffalo to South Carolina takes 1h 58m

Direct flights go from Buffalo to South Carolina every day.

There are 57 airports in South Carolina. From Buffalo there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Buffalo to South Carolina

When did momondo last update prices for flights from Buffalo Airport to South Carolina?
Prices for flights from Buffalo Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Buffalo Airport to South Carolina?
As of September 2026, there are 6 operators available to choose from for flights from Buffalo Airport to South Carolina.
How old do you have to be to fly from Buffalo Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Buffalo to South Carolina

Compare and see reviews for airlines that fly from Buffalo to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
JetBlue	PriceFrom $191	Free Cancellation	Rating 7.1 3,034 reviews	Search JetBlue flights
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.1 12,077 reviews	Search American Airlines flights
Delta	PriceFrom $199	Free Cancellation	Rating 7.8 8,588 reviews	Search Delta flights
United Airlines	PriceFrom $200	Free Cancellation	Rating 7.4 10,224 reviews	Search United Airlines flights
Southwest	PriceFrom $266	Free Cancellation	Rating 8.0 4,189 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South Carolina?

It is quick and easy to find Buffalo to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Buffalo to South Carolina with flexible booking policies on momondo?

All flight searches from Buffalo to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to South Carolina?

Once all potential Buffalo to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Buffalo and alert you when they change.