What is the cheapest airline that flies from Buffalo to Des Moines?

United Airlines, Delta, and American Airlines are the most popular carriers operating from Buffalo to Des Moines

What airlines fly to Des Moines?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Des Moines from Buffalo according to our data. Delta is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?

Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?

The number of operators available for flights from Buffalo Airport to Des Moines Airport is 3 as of August 2025.

How old do you have to be to fly from Buffalo Airport to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$154 Cheap Flights from Buffalo to Des Moines in 2025

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Find the cheapest flights from Buffalo to Des Moines

Round-trip

One-way

Cheap round-trip flights

8:00 am - 12:14 pmBUF-DSM

5h 14m1 stop

3:21 pm - 9:52 pmDSM-BUF

5h 31m1 stop

$236American Airlines

Find Deal

Wed, Aug 27 - Mon, Sep 1

12:02 pm - 4:29 pmBUF-DSM

5h 27m1 stop

3:12 pm - 11:24 pmDSM-BUF

7h 12m1 stop

$237Delta

Find Deal

Sat, Sep 6 - Mon, Sep 8

6:50 pm - 11:06 pmBUF-DSM

5h 16m1 stop

7:03 am - 5:55 pmDSM-BUF

9h 52m2 stops

$242American Airlines

Find Deal

Sat, Sep 6 - Tue, Sep 9

12:49 pm - 4:52 pmBUF-DSM

5h 03m1 stop

6:05 am - 12:09 pmDSM-BUF

5h 04m1 stop

$288Delta

Find Deal

Tue, Oct 21 - Fri, Oct 24

7:05 am - 4:13 pmBUF-DSM

10h 08m2 stops

3:25 pm - 9:16 pmDSM-BUF

4h 51m1 stop

$311United Airlines

Find Deal

Wed, Aug 27 - Mon, Sep 1

6:00 am - 2:10 pmBUF-DSM

9h 10m2 stops

3:25 pm - 9:16 pmDSM-BUF

4h 51m1 stop

$312United Airlines

Find Deal

Sat, Sep 6 - Mon, Sep 8

10:30 am - 5:14 pmBUF-DSM

7h 44m2 stops

6:00 am - 4:52 pmDSM-BUF

9h 52m2 stops

$317United Airlines

Find Deal

Sat, Sep 6 - Tue, Sep 9

6:00 am - 10:38 amBUF-DSM

5h 38m1 stop

3:12 pm - 11:24 pmDSM-BUF

7h 12m1 stop

$332Delta

Find Deal

Thu, Aug 14 - Mon, Aug 25

4:50 pm - 10:50 pmBUF-DSM

7h 00m2 stops

6:00 am - 7:35 pmDSM-BUF

12h 35m2 stops

$504Southwest

Find Deal

Fri, Aug 29 - Mon, Sep 1

1:20 pm - 9:25 pmBUF-DSM

9h 05m2 stops

6:00 am - 4:45 pmDSM-BUF

9h 45m2 stops

$544Southwest

Find Deal

Tue, Aug 12 - Fri, Aug 22

Delta flights from Buffalo to Des Moines

Our best Delta deals on Buffalo to Des Moines flight tickets

Delta

Sep 6

BUF12:02 pmBuffalo

5h 27m

1 stop

DSM4:29 pmDes Moines

Sep 8

DSM3:12 pmDes Moines

7h 12m

1 stop

BUF11:24 pmBuffalo

$237

Find similar

Delta

Oct 21

BUF12:49 pmBuffalo

5h 03m

1 stop

DSM4:52 pmDes Moines

Oct 24

DSM6:05 amDes Moines

5h 04m

1 stop

BUF12:09 pmBuffalo

$288

Find similar

Delta

Aug 14

BUF6:00 amBuffalo

5h 38m

1 stop

DSM10:38 amDes Moines

Aug 25

DSM3:12 pmDes Moines

7h 12m

1 stop

BUF11:24 pmBuffalo

$332

Find similar

United Airlines flights from Buffalo to Des Moines

Our best United Airlines deals on Buffalo to Des Moines flight tickets

United Airlines

Aug 27

BUF7:05 amBuffalo

10h 08m

2 stops

DSM4:13 pmDes Moines

Sep 1

DSM3:25 pmDes Moines

4h 51m

1 stop

BUF9:16 pmBuffalo

$311

Find similar

United Airlines

Sep 6

BUF6:00 amBuffalo

9h 10m

2 stops

DSM2:10 pmDes Moines

Sep 8

DSM3:25 pmDes Moines

4h 51m

1 stop

BUF9:16 pmBuffalo

$312

Find similar

United Airlines

Sep 6

BUF10:30 amBuffalo

7h 44m

2 stops

DSM5:14 pmDes Moines

Sep 9

DSM6:00 amDes Moines

9h 52m

2 stops

BUF4:52 pmBuffalo

$317

Find similar

Fly from

Fly to

Route

Depart

Return

Price

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 8/27

8:00 am-12:14 pm

1 stop5h 14m

Des Moines

Mon 9/1

3:21 pm-9:52 pm

1 stop5h 31m

$236

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 9/6

12:02 pm-4:29 pm

1 stop5h 27m

Des Moines

Mon 9/8

3:12 pm-11:24 pm

1 stop7h 12m

$237

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 9/6

6:50 pm-11:06 pm

1 stop5h 16m

Des Moines

Tue 9/9

7:03 am-5:55 pm

2 stops9h 52m

$242

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 10/21

12:49 pm-4:52 pm

1 stop5h 03m

Des Moines

Fri 10/24

6:05 am-12:09 pm

1 stop5h 04m

$288

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 8/27

7:05 am-4:13 pm

2 stops10h 08m

Des Moines

Mon 9/1

3:25 pm-9:16 pm

1 stop4h 51m

$311

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 9/6

6:00 am-2:10 pm

2 stops9h 10m

Des Moines

Mon 9/8

3:25 pm-9:16 pm

1 stop4h 51m

$312

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 9/6

10:30 am-5:14 pm

2 stops7h 44m

Des Moines

Tue 9/9

6:00 am-4:52 pm

2 stops9h 52m

$317

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 8/14

6:00 am-10:38 am

1 stop5h 38m

Des Moines

Mon 8/25

3:12 pm-11:24 pm

1 stop7h 12m

$332

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 8/29

4:50 pm-10:50 pm

2 stops7h 00m

Des Moines

Mon 9/1

6:00 am-7:35 pm

2 stops12h 35m

$504

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 8/12

1:20 pm-9:25 pm

2 stops9h 05m

Des Moines

Fri 8/22

6:00 am-4:45 pm

2 stops9h 45m

$544

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Buffalo to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $359. Flights from Buffalo to Des Moines on a Tuesday will generally be more expensive and average around $534. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Buffalo to Des Moines at noon for as low as $346. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $451. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Buffalo to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Buffalo to Des Moines (BUF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Des Moines

Best Price Found	$154
Fastest flight time	4h 29m
Direct flights	None
Airports in Des Moines	1 airport

The best one-way flight to Des Moines from Buffalo in the past 72 hours is $154. The best round-trip flight deal from Buffalo to Des Moines found on momondo in the last 72 hours is $236.

The fastest flight from Buffalo to Des Moines takes 4h 29m

There are no direct flights from Buffalo to Des Moines. Popular non-direct route for this connection is Buffalo Airport - Des Moines Airport.

There is 1 airport near Des Moines: Des Moines (DSM)

Search flight deals

How far is Buffalo to Des Moines by plane?
Buffalo and Des Moines are 758.3 mi apart from one another. Flights usually cover this in 4h 29m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?
Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?
The number of operators available for flights from Buffalo Airport to Des Moines Airport is 3 as of August 2025.
How old do you have to be to fly from Buffalo Airport to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Buffalo to Des Moines?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Buffalo to Des Moines is Delta (41% of total bookings). The next most popular airlines are American Airlines (37%) and United Airlines (22%).

Best airlines flying from Buffalo to Des Moines

Compare and see reviews for airlines that fly from Buffalo to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $281	Free Cancellation	Rating 8.0 7,983 reviews	Search Delta flights
United Airlines	PriceFrom $299	Free Cancellation	Rating 7.4 8,904 reviews	Search United Airlines flights
American Airlines	PriceFrom $341	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights

West Des Moines

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Osceola

Norwalk

Grinnell

Oskaloosa

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Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Des Moines for you.

Can I find flights from Buffalo to Des Moines with flexible booking policies on momondo?

Flights from Buffalo to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Des Moines?

momondo helps you find the best flight between Buffalo and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.