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Cheap flights from Buffalo to Des Moines from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Des Moines departing on 8/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:09 pm - 12:20 am
BUF
-
DSM
7h 11m
1 stop
American Airlines Logo
5:46 am - 11:29 am
DSM
-
BUF
4h 43m
1 stop
$263American Airlines
Fri, Aug 14 - Tue, Aug 18
American Airlines Logo
6:09 pm - 12:20 am
BUF
-
DSM
7h 11m
1 stop
American Airlines Logo
6:55 am - 5:08 pm
DSM
-
BUF
9h 13m
2 stops
$268American Airlines
Fri, Aug 14 - Tue, Aug 18
United Airlines Logo
10:30 am - 2:16 pm
BUF
-
DSM
4h 46m
1 stop
United Airlines Logo
1:35 pm - 10:37 pm
DSM
-
BUF
8h 02m
1 stop
$319United Airlines
Fri, Aug 14 - Fri, Aug 21
American Airlines Logo
2:51 pm - 10:06 pm
BUF
-
DSM
8h 15m
1 stop
American Airlines Logo
5:46 am - 11:29 am
DSM
-
BUF
4h 43m
1 stop
$333American Airlines
Fri, Aug 14 - Tue, Aug 18
Delta Logo
12:02 pm - 5:19 pm
BUF
-
DSM
6h 17m
1 stop
Delta Logo
5:35 pm - 11:54 pm
DSM
-
BUF
5h 19m
1 stop
$335Delta
Wed, Sep 23 - Thu, Sep 24
American Airlines Logo
5:21 pm - 10:06 pm
BUF
-
DSM
5h 45m
1 stop
American Airlines Logo
1:55 pm - 11:36 pm
DSM
-
BUF
8h 41m
2 stops
$338American Airlines
Fri, Aug 14 - Tue, Aug 18
Multiple Airlines Logo
8:54 pm - 10:10 am
BUF
-
DSM
14h 16m
1 stop
Multiple Airlines Logo
12:45 pm - 6:01 pm
DSM
-
BUF
28h 16m
1 stop
$339Multiple Airlines
Sun, Oct 4 - Wed, Oct 7
Southwest Logo
5:50 am - 1:35 pm
BUF
-
DSM
8h 45m
2 stops
Southwest Logo
5:35 am - 10:25 am
DSM
-
BUF
3h 50m
1 stop
$341Southwest
Sun, Oct 4 - Wed, Oct 7
United Airlines Logo
6:30 am - 12:36 pm
BUF
-
DSM
7h 06m
1 stop
United Airlines Logo
11:31 am - 4:56 pm
DSM
-
BUF
4h 25m
1 stop
$343United Airlines
Sat, Oct 31 - Tue, Nov 3
Southwest Logo
4:05 pm - 10:50 pm
BUF
-
DSM
7h 45m
2 stops
Southwest Logo
5:35 am - 3:15 pm
DSM
-
BUF
8h 40m
2 stops
$346Southwest
Sun, Oct 4 - Wed, Oct 7

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Delta flights from Buffalo to Des Moines

Our best Delta deals on Buffalo to Des Moines flight tickets
Delta
Sep 23
BUF12:02 pmBuffalo
6h 17m
1 stop
DSM5:19 pmDes Moines
Sep 24
DSM5:35 pmDes Moines
5h 19m
1 stop
BUF11:54 pmBuffalo
$335
Delta
Jul 16
BUF2:27 pmBuffalo
5h 48m
1 stop
DSM7:15 pmDes Moines
Jul 18
DSM10:25 amDes Moines
10h 07m
1 stop
BUF9:32 pmBuffalo
$734
Delta
Jul 18
BUF12:03 pmBuffalo
10h 05m
2 stops
DSM9:08 pmDes Moines
Jul 19
DSM6:00 amDes Moines
10h 30m
2 stops
BUF5:30 pmBuffalo
$1,983

United Airlines flights from Buffalo to Des Moines

Our best United Airlines deals on Buffalo to Des Moines flight tickets
United Airlines
Aug 14
BUF10:30 amBuffalo
4h 46m
1 stop
DSM2:16 pmDes Moines
Aug 21
DSM1:35 pmDes Moines
8h 02m
1 stop
BUF10:37 pmBuffalo
$319
United Airlines
Aug 14
BUF6:12 amBuffalo
9h 04m
2 stops
DSM2:16 pmDes Moines
Aug 21
DSM3:20 pmDes Moines
4h 47m
1 stop
BUF9:07 pmBuffalo
$406
United Airlines
Aug 14
BUF6:55 amBuffalo
6h 25m
1 stop
DSM12:20 pmDes Moines
Aug 18
DSM6:00 amDes Moines
16h 12m
3 stops
BUF11:12 pmBuffalo
$425

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 10, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 8/14

6:09 pm-12:20 am

1 stop7h 11m

Des Moines

Tue 8/18

5:46 am-11:29 am

1 stop4h 43m

$263

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 8/14

6:09 pm-12:20 am

1 stop7h 11m

Des Moines

Tue 8/18

6:55 am-5:08 pm

2 stops9h 13m

$268

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 8/14

10:30 am-2:16 pm

1 stop4h 46m

Des Moines

Fri 8/21

1:35 pm-10:37 pm

1 stop8h 02m

$319

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 8/14

2:51 pm-10:06 pm

1 stop8h 15m

Des Moines

Tue 8/18

5:46 am-11:29 am

1 stop4h 43m

$333

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 9/23

12:02 pm-5:19 pm

1 stop6h 17m

Des Moines

Thu 9/24

5:35 pm-11:54 pm

1 stop5h 19m

$335

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 8/14

5:21 pm-10:06 pm

1 stop5h 45m

Des Moines

Tue 8/18

1:55 pm-11:36 pm

2 stops8h 41m

$338

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sun 10/4

8:54 pm-10:10 am

1 stop14h 16m

Des Moines

Wed 10/7

12:45 pm-6:01 pm

1 stop28h 16m

$339

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sun 10/4

5:50 am-1:35 pm

2 stops8h 45m

Des Moines

Wed 10/7

5:35 am-10:25 am

1 stop3h 50m

$341
Quickest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 10/31

6:30 am-12:36 pm

1 stop7h 06m

Des Moines

Tue 11/3

11:31 am-4:56 pm

1 stop4h 25m

$343

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sun 10/4

4:05 pm-10:50 pm

2 stops7h 45m

Des Moines

Wed 10/7

5:35 am-3:15 pm

2 stops8h 40m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from Buffalo to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then April is your next best option. Flight prices from Buffalo to Des Moines during April average around $364.

Can stopping save me money on Buffalo to Des Moines flights?

You could potentially save up to 43% on your flight if you consider stops on a Buffalo to Des Moines flight.

When to book flights from Buffalo to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Des Moines (BUF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Des Moines

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Buffalo to Des Moines takes 4h 31m
There are no direct flights from Buffalo to Des Moines. There are no popular flight routes from Buffalo to Des Moines.
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Frequently asked questions about flying from Buffalo to Des Moines

  • How far is Buffalo to Des Moines by plane?

    Buffalo and Des Moines are 758.3 mi apart from one another. Flights usually cover this in 4h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?

    Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?

  • How old do you have to be to fly from Buffalo Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Buffalo to Des Moines?

Best airlines flying from Buffalo to Des Moines

Compare and see reviews for airlines that fly from Buffalo to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,799 reviews
Search American Airlines flights
DeltaPriceFrom $319Free CancellationRating
7.8
8,456 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Johnston
Newton
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Des Moines for you.

Can I find flights from Buffalo to Des Moines with flexible booking policies on momondo?

Flights from Buffalo to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Des Moines?

momondo helps you find the best flight between Buffalo and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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