What is the cheapest airline that flies from Buffalo to Des Moines?

American Airlines is the most popular carrier operating from Buffalo to Des Moines

When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?

Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?

The number of operators available for flights from Buffalo Airport to Des Moines Airport is 2 as of January 2026.

How old do you have to be to fly from Buffalo Airport to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$171 Cheap Flights from Buffalo to Des Moines in 2026

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Find the cheapest flights from Buffalo to Des Moines

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One-way

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Cheap round-trip flights

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11:36 am - 4:25 pm

BUF

DSM

5h 49m1 stop

7:00 am - 3:11 pm

DSM

BUF

7h 11m1 stop

$340American Airlines

Sat, Apr 25 - Mon, Apr 27

9:30 am - 8:55 pm

BUF

DSM

12h 25m2 stops

5:25 am - 10:15 am

DSM

BUF

3h 50m1 stop

$346Southwest

Sat, Apr 25 - Mon, Apr 27

8:30 am - 2:33 pm

BUF

DSM

7h 03m1 stop

8:00 am - 1:24 pm

DSM

BUF

4h 24m1 stop

$352United Airlines

Sat, Feb 7 - Sun, Feb 8

5:15 am - 12:40 pm

BUF

DSM

8h 25m1 stop

6:10 am - 3:10 pm

DSM

BUF

8h 00m2 stops

$357Southwest

Sat, Feb 7 - Sun, Feb 8

7:31 pm - 5:08 pm

BUF

DSM

22h 37m1 stop

7:17 pm - 10:52 am

DSM

BUF

14h 35m2 stops

$363Multiple Airlines

Fri, Feb 6 - Fri, Feb 13

9:30 am - 8:55 pm

BUF

DSM

12h 25m2 stops

5:25 am - 4:40 pm

DSM

BUF

10h 15m2 stops

$375Southwest

Sat, Apr 25 - Mon, Apr 27

7:31 pm - 5:08 pm

BUF

DSM

22h 37m1 stop

7:20 pm - 5:45 pm

DSM

BUF

21h 25m1 stop

$376Multiple Airlines

Fri, Feb 6 - Fri, Feb 13

6:02 pm - 11:40 pm

BUF

DSM

6h 38m1 stop

6:32 am - 11:43 am

DSM

BUF

4h 11m1 stop

$387American Airlines

Thu, Feb 12 - Sun, Feb 15

6:02 pm - 11:40 pm

BUF

DSM

6h 38m1 stop

5:00 am - 3:25 pm

DSM

BUF

9h 25m2 stops

$392American Airlines

Thu, Feb 12 - Sun, Feb 15

8:30 am - 2:33 pm

BUF

DSM

7h 03m1 stop

8:00 am - 1:24 pm

DSM

BUF

4h 24m1 stop

$397United Airlines

Fri, Feb 6 - Sun, Feb 8

American Airlines flights from Buffalo to Des Moines

Our best American Airlines deals on Buffalo to Des Moines flight tickets

American Airlines

Apr 25

BUF11:36 amBuffalo

5h 49m

1 stop

DSM4:25 pmDes Moines

Apr 27

DSM7:00 amDes Moines

7h 11m

1 stop

BUF3:11 pmBuffalo

$340

American Airlines

Feb 12

BUF6:02 pmBuffalo

6h 38m

1 stop

DSM11:40 pmDes Moines

Feb 15

DSM6:32 amDes Moines

4h 11m

1 stop

BUF11:43 amBuffalo

$387

American Airlines

Feb 12

BUF6:02 pmBuffalo

6h 38m

1 stop

DSM11:40 pmDes Moines

Feb 15

DSM5:00 amDes Moines

9h 25m

2 stops

BUF3:25 pmBuffalo

$392

Southwest flights from Buffalo to Des Moines

Our best Southwest deals on Buffalo to Des Moines flight tickets

Southwest

Apr 25

BUF9:30 amBuffalo

12h 25m

2 stops

DSM8:55 pmDes Moines

Apr 27

DSM5:25 amDes Moines

3h 50m

1 stop

BUF10:15 amBuffalo

$346

Southwest

Feb 7

BUF5:15 amBuffalo

8h 25m

1 stop

DSM12:40 pmDes Moines

Feb 8

DSM6:10 amDes Moines

8h 00m

2 stops

BUF3:10 pmBuffalo

$357

Southwest

Apr 25

BUF9:30 amBuffalo

12h 25m

2 stops

DSM8:55 pmDes Moines

Apr 27

DSM5:25 amDes Moines

10h 15m

2 stops

BUF4:40 pmBuffalo

$375

Fly from

Fly to

Route

Depart

Return

Price

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 4/25

11:36 am-4:25 pm

1 stop5h 49m

Des Moines

Mon 4/27

7:00 am-3:11 pm

1 stop7h 11m

$340

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 4/25

9:30 am-8:55 pm

2 stops12h 25m

Des Moines

Mon 4/27

5:25 am-10:15 am

1 stop3h 50m

$346

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 2/7

8:30 am-2:33 pm

1 stop7h 03m

Des Moines

Sun 2/8

8:00 am-1:24 pm

1 stop4h 24m

$352

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 2/7

5:15 am-12:40 pm

1 stop8h 25m

Des Moines

Sun 2/8

6:10 am-3:10 pm

2 stops8h 00m

$357

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 2/6

7:31 pm-5:08 pm

1 stop22h 37m

Des Moines

Fri 2/13

7:17 pm-10:52 am

2 stops14h 35m

$363

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 4/25

9:30 am-8:55 pm

2 stops12h 25m

Des Moines

Mon 4/27

5:25 am-4:40 pm

2 stops10h 15m

$375

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 2/6

7:31 pm-5:08 pm

1 stop22h 37m

Des Moines

Fri 2/13

7:20 pm-5:45 pm

1 stop21h 25m

$376

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 2/12

6:02 pm-11:40 pm

1 stop6h 38m

Des Moines

Sun 2/15

6:32 am-11:43 am

1 stop4h 11m

$387

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 2/12

6:02 pm-11:40 pm

1 stop6h 38m

Des Moines

Sun 2/15

5:00 am-3:25 pm

2 stops9h 25m

$392

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 2/6

8:30 am-2:33 pm

1 stop7h 03m

Des Moines

Sun 2/8

8:00 am-1:24 pm

1 stop4h 24m

$397

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Can stopping save me money on Buffalo to Des Moines flights?

You could potentially save up to 47% on your flight if you consider stops on a Buffalo to Des Moines flight.

When to book flights from Buffalo to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Buffalo to Des Moines (BUF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Des Moines

Fastest flight time	4h 30m
Direct flights	None

The fastest flight from Buffalo to Des Moines takes 4h 30m

There are no direct flights from Buffalo to Des Moines. There are no popular flight routes from Buffalo to Des Moines.

Search flight deals

How far is Buffalo to Des Moines by plane?
Buffalo and Des Moines are 758.3 mi apart from one another. Flights usually cover this in 4h 30m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?
Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?
The number of operators available for flights from Buffalo Airport to Des Moines Airport is 2 as of January 2026.
How old do you have to be to fly from Buffalo Airport to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Buffalo to Des Moines?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Buffalo to Des Moines is Delta (62% of total bookings). The next most popular airline is American Airlines (38%).

Best airlines flying from Buffalo to Des Moines

Compare and see reviews for airlines that fly from Buffalo to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $258	Free Cancellation	Rating 7.2 11,102 reviews		Search American Airlines flights
Delta	PriceFrom $279	Free Cancellation	Rating 7.9 8,038 reviews		Search Delta flights

West Des Moines

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Clive

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

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Why should I use momondo to find a flight deal from Buffalo to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Des Moines for you.

Can I find flights from Buffalo to Des Moines with flexible booking policies on momondo?

Flights from Buffalo to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Des Moines?

momondo helps you find the best flight between Buffalo and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.