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Cheap flights from Buffalo to Des Moines from $203

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Des Moines departing on 7/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Buffalo to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:06 am - 1:21 pm
BUF
-
DSM
6h 15m
1 stop
American Airlines Logo
6:55 am - 12:54 pm
DSM
-
BUF
4h 59m
1 stop
$355American Airlines
Tue, Jun 23 - Tue, Jun 30
American Airlines Logo
6:21 pm - 12:35 am
BUF
-
DSM
7h 14m
2 stops
American Airlines Logo
6:30 am - 12:19 pm
DSM
-
BUF
4h 49m
1 stop
$360American Airlines
Tue, Jun 23 - Tue, Jun 30
American Airlines Logo
6:26 am - 12:52 pm
BUF
-
DSM
7h 26m
1 stop
American Airlines Logo
1:41 pm - 10:51 pm
DSM
-
BUF
8h 10m
1 stop
$371American Airlines
Wed, Jun 24 - Sun, Jul 5
American Airlines Logo
6:02 am - 12:52 pm
BUF
-
DSM
7h 50m
2 stops
American Airlines Logo
7:04 am - 12:55 pm
DSM
-
BUF
4h 51m
1 stop
$376American Airlines
Wed, Jun 24 - Sun, Jul 5
American Airlines Logo
8:06 am - 1:21 pm
BUF
-
DSM
6h 15m
1 stop
American Airlines Logo
7:04 am - 12:55 pm
DSM
-
BUF
4h 51m
1 stop
$381American Airlines
Wed, Jun 24 - Sun, Jul 5
American Airlines Logo
8:06 am - 1:21 pm
BUF
-
DSM
6h 15m
1 stop
American Airlines Logo
6:12 am - 3:24 pm
DSM
-
BUF
8h 12m
2 stops
$386American Airlines
Wed, Jun 24 - Sun, Jul 5
American Airlines Logo
6:02 am - 12:52 pm
BUF
-
DSM
7h 50m
2 stops
American Airlines Logo
6:12 am - 3:24 pm
DSM
-
BUF
8h 12m
2 stops
$391American Airlines
Wed, Jun 24 - Sun, Jul 5
Southwest Logo
7:10 pm - 10:50 pm
BUF
-
DSM
4h 40m
1 stop
Southwest Logo
5:30 am - 4:00 pm
DSM
-
BUF
9h 30m
2 stops
$404Southwest
Wed, Jul 29 - Sat, Aug 8
American Airlines Logo
8:06 am - 1:21 pm
BUF
-
DSM
6h 15m
1 stop
American Airlines Logo
3:22 pm - 11:56 pm
DSM
-
BUF
7h 34m
1 stop
$407American Airlines
Thu, Jun 25 - Mon, Jun 29
Southwest Logo
7:55 pm - 11:35 pm
BUF
-
DSM
4h 40m
1 stop
Southwest Logo
4:40 pm - 12:15 am
DSM
-
BUF
6h 35m
2 stops
$412Southwest
Fri, Jul 17 - Mon, Jul 20

American Airlines flights from Buffalo to Des Moines

Our best American Airlines deals on Buffalo to Des Moines flight tickets
American Airlines
Jun 23
BUF8:06 amBuffalo
6h 15m
1 stop
DSM1:21 pmDes Moines
Jun 30
DSM6:55 amDes Moines
4h 59m
1 stop
BUF12:54 pmBuffalo
$355
American Airlines
Jun 23
BUF6:21 pmBuffalo
7h 14m
2 stops
DSM12:35 amDes Moines
Jun 30
DSM6:30 amDes Moines
4h 49m
1 stop
BUF12:19 pmBuffalo
$360
American Airlines
Jun 24
BUF6:26 amBuffalo
7h 26m
1 stop
DSM12:52 pmDes Moines
Jul 5
DSM1:41 pmDes Moines
8h 10m
1 stop
BUF10:51 pmBuffalo
$371

United Airlines flights from Buffalo to Des Moines

Our best United Airlines deals on Buffalo to Des Moines flight tickets
United Airlines
Aug 18
BUF5:58 pmBuffalo
4h 25m
1 stop
DSM9:23 pmDes Moines
Aug 19
DSM11:32 amDes Moines
4h 24m
1 stop
BUF4:56 pmBuffalo
$415
United Airlines
Aug 18
BUF10:30 amBuffalo
4h 46m
1 stop
DSM2:16 pmDes Moines
Aug 19
DSM3:20 pmDes Moines
4h 47m
1 stop
BUF9:07 pmBuffalo
$435
United Airlines
Aug 18
BUF5:58 pmBuffalo
5h 55m
1 stop
DSM10:53 pmDes Moines
Aug 19
DSM6:00 amDes Moines
7h 18m
2 stops
BUF2:18 pmBuffalo
$488

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 6/23

8:06 am-1:21 pm

1 stop6h 15m

Des Moines

Tue 6/30

6:55 am-12:54 pm

1 stop4h 59m

$355

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 6/23

6:21 pm-12:35 am

2 stops7h 14m

Des Moines

Tue 6/30

6:30 am-12:19 pm

1 stop4h 49m

$360

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 6/24

6:26 am-12:52 pm

1 stop7h 26m

Des Moines

Sun 7/5

1:41 pm-10:51 pm

1 stop8h 10m

$371

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 6/24

6:02 am-12:52 pm

2 stops7h 50m

Des Moines

Sun 7/5

7:04 am-12:55 pm

1 stop4h 51m

$376
Quickest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 6/24

8:06 am-1:21 pm

1 stop6h 15m

Des Moines

Sun 7/5

7:04 am-12:55 pm

1 stop4h 51m

$381

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 6/24

8:06 am-1:21 pm

1 stop6h 15m

Des Moines

Sun 7/5

6:12 am-3:24 pm

2 stops8h 12m

$386

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 6/24

6:02 am-12:52 pm

2 stops7h 50m

Des Moines

Sun 7/5

6:12 am-3:24 pm

2 stops8h 12m

$391

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 7/29

7:10 pm-10:50 pm

1 stop4h 40m

Des Moines

Sat 8/8

5:30 am-4:00 pm

2 stops9h 30m

$404

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 6/25

8:06 am-1:21 pm

1 stop6h 15m

Des Moines

Mon 6/29

3:22 pm-11:56 pm

1 stop7h 34m

$407

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 7/17

7:55 pm-11:35 pm

1 stop4h 40m

Des Moines

Mon 7/20

4:40 pm-12:15 am

2 stops6h 35m

$412

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Buffalo to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then April is your next best option. Flight prices from Buffalo to Des Moines during April average around $364.

Can stopping save me money on Buffalo to Des Moines flights?

You could potentially save up to 67% on your flight if you consider stops on a Buffalo to Des Moines flight.

When to book flights from Buffalo to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Des Moines (BUF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Des Moines

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Buffalo to Des Moines takes 4h 15m
There are no direct flights from Buffalo to Des Moines. There are no popular flight routes from Buffalo to Des Moines.
Search flight deals

Frequently asked questions about flying from Buffalo to Des Moines

  • How far is Buffalo to Des Moines by plane?

    Buffalo and Des Moines are 758.3 mi apart from one another. Flights usually cover this in 4h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?

    Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?

  • How old do you have to be to fly from Buffalo Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Buffalo to Des Moines?

Best airlines flying from Buffalo to Des Moines

Compare and see reviews for airlines that fly from Buffalo to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,629 reviews
Search American Airlines flights
DeltaPriceFrom $319Free CancellationRating
7.9
8,425 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Boone
Osceola
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Des Moines for you.

Can I find flights from Buffalo to Des Moines with flexible booking policies on momondo?

Flights from Buffalo to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Des Moines?

momondo helps you find the best flight between Buffalo and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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