What airlines fly to Des Moines?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Des Moines from Buffalo according to our data. Delta is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Buffalo to Des Moines?

American Airlines, Delta, and Southwest are the most popular carriers operating from Buffalo to Des Moines

When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?

Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?

The number of operators available for flights from Buffalo Airport to Des Moines Airport is 2 as of November 2025.

How old do you have to be to fly from Buffalo Airport to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$134 Cheap Flights from Buffalo to Des Moines in 2025/26

Q: What is the typical price of a round-trip flight between Buffalo and Des Moines?

Prices are currently low for flights on this route. Typical prices usually range from $416 to $511. The lowest price recently found on this route was $327.

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Find the cheapest flights from Buffalo to Des Moines

Round-trip

One-way

Cheap round-trip flights

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6:03 am - 9:41 amBUF-DSM

4h 38m1 stop

5:49 pm - 10:57 pmDSM-BUF

4h 08m1 stop

$327Delta

Find Deal

Tue, Jan 20 - Thu, Jan 22

11:21 am - 4:24 pmBUF-DSM

6h 03m1 stop

11:42 am - 10:40 pmDSM-BUF

9h 58m2 stops

$332American Airlines

Find Deal

Tue, Jan 20 - Thu, Jan 22

10:45 am - 8:34 pmBUF-DSM

10h 49m2 stops

9:03 am - 8:29 pmDSM-BUF

10h 26m2 stops

$337United Airlines

Find Deal

Tue, Jan 20 - Thu, Jan 22

2:56 pm - 7:34 pmBUF-DSM

5h 38m1 stop

5:16 pm - 11:28 pmDSM-BUF

5h 12m1 stop

$350Delta

Find Deal

Thu, Jan 15 - Tue, Jan 20

5:16 pm - 9:04 pmBUF-DSM

4h 48m1 stop

6:00 am - 3:17 pmDSM-BUF

8h 17m2 stops

$355American Airlines

Find Deal

Thu, Jan 15 - Tue, Jan 20

11:27 am - 9:04 pmBUF-DSM

10h 37m2 stops

6:00 am - 3:17 pmDSM-BUF

8h 17m2 stops

$360American Airlines

Find Deal

Thu, Jan 15 - Tue, Jan 20

1:50 pm - 5:24 pmBUF-DSM

4h 34m1 stop

3:14 pm - 8:54 pmDSM-BUF

4h 40m1 stop

$385United Airlines

Find Deal

Wed, Dec 17 - Wed, Dec 24

1:00 pm - 4:56 pmBUF-DSM

4h 56m1 stop

5:25 pm - 11:03 pmDSM-BUF

4h 38m1 stop

$387Delta

Find Deal

Sat, Apr 4 - Mon, Apr 13

6:00 am - 2:20 pmBUF-DSM

9h 20m2 stops

3:14 pm - 8:54 pmDSM-BUF

4h 40m1 stop

$390United Airlines

Find Deal

Wed, Dec 17 - Wed, Dec 24

1:00 pm - 4:56 pmBUF-DSM

4h 56m1 stop

10:15 am - 5:26 pmDSM-BUF

6h 11m1 stop

$407Delta

Find Deal

Sat, Apr 4 - Sat, Apr 11

Delta flights from Buffalo to Des Moines

Our best Delta deals on Buffalo to Des Moines flight tickets

Delta

Jan 20

BUF6:03 amBuffalo

4h 38m

1 stop

DSM9:41 amDes Moines

Jan 22

DSM5:49 pmDes Moines

4h 08m

1 stop

BUF10:57 pmBuffalo

$327

Find similar

Delta

Jan 15

BUF2:56 pmBuffalo

5h 38m

1 stop

DSM7:34 pmDes Moines

Jan 20

DSM5:16 pmDes Moines

5h 12m

1 stop

BUF11:28 pmBuffalo

$350

Find similar

Delta

Apr 4

BUF1:00 pmBuffalo

4h 56m

1 stop

DSM4:56 pmDes Moines

Apr 13

DSM5:25 pmDes Moines

4h 38m

1 stop

BUF11:03 pmBuffalo

$387

Find similar

American Airlines flights from Buffalo to Des Moines

Our best American Airlines deals on Buffalo to Des Moines flight tickets

American Airlines

Jan 20

BUF11:21 amBuffalo

6h 03m

1 stop

DSM4:24 pmDes Moines

Jan 22

DSM11:42 amDes Moines

9h 58m

2 stops

BUF10:40 pmBuffalo

$332

Find similar

American Airlines

Jan 15

BUF5:16 pmBuffalo

4h 48m

1 stop

DSM9:04 pmDes Moines

Jan 20

DSM6:00 amDes Moines

8h 17m

2 stops

BUF3:17 pmBuffalo

$355

Find similar

American Airlines

Jan 15

BUF11:27 amBuffalo

10h 37m

2 stops

DSM9:04 pmDes Moines

Jan 20

DSM6:00 amDes Moines

8h 17m

2 stops

BUF3:17 pmBuffalo

$360

Find similar

Fly from

Fly to

Route

Depart

Return

Price

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 1/20

6:03 am-9:41 am

1 stop4h 38m

Des Moines

Thu 1/22

5:49 pm-10:57 pm

1 stop4h 08m

$327

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 1/20

11:21 am-4:24 pm

1 stop6h 03m

Des Moines

Thu 1/22

11:42 am-10:40 pm

2 stops9h 58m

$332

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 1/20

10:45 am-8:34 pm

2 stops10h 49m

Des Moines

Thu 1/22

9:03 am-8:29 pm

2 stops10h 26m

$337

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 1/15

2:56 pm-7:34 pm

1 stop5h 38m

Des Moines

Tue 1/20

5:16 pm-11:28 pm

1 stop5h 12m

$350

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 1/15

5:16 pm-9:04 pm

1 stop4h 48m

Des Moines

Tue 1/20

6:00 am-3:17 pm

2 stops8h 17m

$355

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 1/15

11:27 am-9:04 pm

2 stops10h 37m

Des Moines

Tue 1/20

6:00 am-3:17 pm

2 stops8h 17m

$360

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 12/17

1:50 pm-5:24 pm

1 stop4h 34m

Des Moines

Wed 12/24

3:14 pm-8:54 pm

1 stop4h 40m

$385

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 4/4

1:00 pm-4:56 pm

1 stop4h 56m

Des Moines

Mon 4/13

5:25 pm-11:03 pm

1 stop4h 38m

$387

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 12/17

6:00 am-2:20 pm

2 stops9h 20m

Des Moines

Wed 12/24

3:14 pm-8:54 pm

1 stop4h 40m

$390

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 4/4

1:00 pm-4:56 pm

1 stop4h 56m

Des Moines

Sat 4/11

10:15 am-5:26 pm

1 stop6h 11m

$407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Buffalo and Des Moines?

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Buffalo to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $359. Flights from Buffalo to Des Moines on a Tuesday will generally be more expensive and average around $534. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Buffalo to Des Moines at noon for as low as $346. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $451. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Buffalo to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Buffalo to Des Moines (BUF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Des Moines

Direct flights	None

There are no direct flights from Buffalo to Des Moines. There are no popular flight routes from Buffalo to Des Moines.

Search flight deals

How far is Buffalo to Des Moines by plane?
Buffalo and Des Moines are 758.3 mi apart from one another. Flights usually cover this in 3h 56m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?
Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?
The number of operators available for flights from Buffalo Airport to Des Moines Airport is 2 as of November 2025.
How old do you have to be to fly from Buffalo Airport to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Buffalo to Des Moines?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Buffalo to Des Moines is Delta (55% of total bookings). The next most popular airline is American Airlines (45%).

Best airlines flying from Buffalo to Des Moines

Compare and see reviews for airlines that fly from Buffalo to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $258	Free Cancellation	Rating 7.2 11,047 reviews		Search American Airlines flights
Delta	PriceFrom $316	Free Cancellation	Rating 7.9 8,002 reviews		Search Delta flights

West Des Moines

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Osceola

Boone

Norwalk

Grinnell

Oskaloosa

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Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Des Moines for you.

Can I find flights from Buffalo to Des Moines with flexible booking policies on momondo?

Flights from Buffalo to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Des Moines?

momondo helps you find the best flight between Buffalo and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.