Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Buffalo to Des Moines from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Des Moines departing on 5/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Buffalo to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 1:11 pm
BUF
-
DSM
8h 11m
1 stop
American Airlines Logo
11:09 am - 5:30 pm
DSM
-
BUF
5h 21m
1 stop
$401American Airlines
Thu, Apr 30 - Sun, May 3
American Airlines Logo
5:02 pm - 11:49 pm
BUF
-
DSM
7h 47m
2 stops
American Airlines Logo
6:00 am - 2:21 pm
DSM
-
BUF
7h 21m
1 stop
$406American Airlines
Thu, Apr 30 - Sun, May 3
Delta Logo
5:12 pm - 10:31 pm
BUF
-
DSM
6h 19m
1 stop
Delta Logo
5:34 pm - 12:02 am
DSM
-
BUF
5h 28m
1 stop
$407Delta
Thu, Jun 25 - Mon, Jun 29
United Airlines Logo
7:00 am - 10:44 am
BUF
-
DSM
4h 44m
1 stop
United Airlines Logo
11:25 am - 5:16 pm
DSM
-
BUF
4h 51m
1 stop
$415United Airlines
Tue, Apr 28 - Wed, Apr 29
American Airlines Logo
8:00 am - 1:18 pm
BUF
-
DSM
6h 18m
1 stop
American Airlines Logo
1:48 pm - 9:57 pm
DSM
-
BUF
7h 09m
1 stop
$417American Airlines
Thu, Jun 25 - Mon, Jun 29
United Airlines Logo
10:30 am - 9:32 pm
BUF
-
DSM
12h 02m
2 stops
United Airlines Logo
3:21 pm - 8:43 pm
DSM
-
BUF
4h 22m
1 stop
$420United Airlines
Tue, Apr 28 - Wed, Apr 29
Delta Logo
6:07 am - 9:43 am
BUF
-
DSM
4h 36m
1 stop
Delta Logo
5:34 pm - 12:02 am
DSM
-
BUF
5h 28m
1 stop
$423Delta
Fri, Jun 19 - Mon, Jun 22
United Airlines Logo
2:54 pm - 11:17 pm
BUF
-
DSM
9h 23m
2 stops
United Airlines Logo
8:04 am - 6:49 pm
DSM
-
BUF
9h 45m
2 stops
$425United Airlines
Tue, Apr 28 - Wed, Apr 29
Delta Logo
3:53 pm - 8:49 pm
BUF
-
DSM
5h 56m
1 stop
Delta Logo
7:28 am - 1:54 pm
DSM
-
BUF
5h 26m
1 stop
$431Delta
Fri, Apr 24 - Mon, Apr 27
United Airlines Logo
10:55 am - 2:25 pm
BUF
-
DSM
4h 30m
1 stop
United Airlines Logo
11:25 am - 5:16 pm
DSM
-
BUF
4h 51m
1 stop
$435United Airlines
Tue, Apr 28 - Wed, Apr 29

United Airlines flights from Buffalo to Des Moines

Our best United Airlines deals on Buffalo to Des Moines flight tickets
United Airlines
Apr 28
BUF7:00 amBuffalo
4h 44m
1 stop
DSM10:44 amDes Moines
Apr 29
DSM11:25 amDes Moines
4h 51m
1 stop
BUF5:16 pmBuffalo
$415
United Airlines
Apr 28
BUF10:30 amBuffalo
12h 02m
2 stops
DSM9:32 pmDes Moines
Apr 29
DSM3:21 pmDes Moines
4h 22m
1 stop
BUF8:43 pmBuffalo
$420
United Airlines
Apr 28
BUF2:54 pmBuffalo
9h 23m
2 stops
DSM11:17 pmDes Moines
Apr 29
DSM8:04 amDes Moines
9h 45m
2 stops
BUF6:49 pmBuffalo
$425

American Airlines flights from Buffalo to Des Moines

Our best American Airlines deals on Buffalo to Des Moines flight tickets
American Airlines
Apr 30
BUF6:00 amBuffalo
8h 11m
1 stop
DSM1:11 pmDes Moines
May 3
DSM11:09 amDes Moines
5h 21m
1 stop
BUF5:30 pmBuffalo
$401
American Airlines
Apr 30
BUF5:02 pmBuffalo
7h 47m
2 stops
DSM11:49 pmDes Moines
May 3
DSM6:00 amDes Moines
7h 21m
1 stop
BUF2:21 pmBuffalo
$406
American Airlines
Jun 25
BUF8:00 amBuffalo
6h 18m
1 stop
DSM1:18 pmDes Moines
Jun 29
DSM1:48 pmDes Moines
7h 09m
1 stop
BUF9:57 pmBuffalo
$417

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 4/30

6:00 am-1:11 pm

1 stop8h 11m

Des Moines

Sun 5/3

11:09 am-5:30 pm

1 stop5h 21m

$401

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 4/30

5:02 pm-11:49 pm

2 stops7h 47m

Des Moines

Sun 5/3

6:00 am-2:21 pm

1 stop7h 21m

$406

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 6/25

5:12 pm-10:31 pm

1 stop6h 19m

Des Moines

Mon 6/29

5:34 pm-12:02 am

1 stop5h 28m

$407

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 4/28

7:00 am-10:44 am

1 stop4h 44m

Des Moines

Wed 4/29

11:25 am-5:16 pm

1 stop4h 51m

$415

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 6/25

8:00 am-1:18 pm

1 stop6h 18m

Des Moines

Mon 6/29

1:48 pm-9:57 pm

1 stop7h 09m

$417

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 4/28

10:30 am-9:32 pm

2 stops12h 02m

Des Moines

Wed 4/29

3:21 pm-8:43 pm

1 stop4h 22m

$420

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 6/19

6:07 am-9:43 am

1 stop4h 36m

Des Moines

Mon 6/22

5:34 pm-12:02 am

1 stop5h 28m

$423

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 4/28

2:54 pm-11:17 pm

2 stops9h 23m

Des Moines

Wed 4/29

8:04 am-6:49 pm

2 stops9h 45m

$425

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 4/24

3:53 pm-8:49 pm

1 stop5h 56m

Des Moines

Mon 4/27

7:28 am-1:54 pm

1 stop5h 26m

$431
Quickest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 4/28

10:55 am-2:25 pm

1 stop4h 30m

Des Moines

Wed 4/29

11:25 am-5:16 pm

1 stop4h 51m

$435

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from Buffalo to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Des Moines?

Can stopping save me money on Buffalo to Des Moines flights?

You could potentially save up to 31% on your flight if you consider stops on a Buffalo to Des Moines flight.

When to book flights from Buffalo to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Des Moines (BUF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Des Moines

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Buffalo to Des Moines takes 4h 05m
There are no direct flights from Buffalo to Des Moines. There are no popular flight routes from Buffalo to Des Moines.
Search flight deals

Frequently asked questions about flying from Buffalo to Des Moines

  • How far is Buffalo to Des Moines by plane?

    Buffalo and Des Moines are 758.3 mi apart from one another. Flights usually cover this in 4h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Buffalo Airport to Des Moines Airport?

    Prices for flights from Buffalo Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Buffalo Airport to Des Moines Airport?

  • How old do you have to be to fly from Buffalo Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Buffalo to Des Moines?

Best airlines flying from Buffalo to Des Moines

Compare and see reviews for airlines that fly from Buffalo to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $319Free CancellationRating
7.9
8,398 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Des Moines for you.

Can I find flights from Buffalo to Des Moines with flexible booking policies on momondo?

Flights from Buffalo to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to Des Moines?

momondo helps you find the best flight between Buffalo and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 5/10
Sun 5/17
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States