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Cheap flights from Tyler to Des Moines from $599

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Tyler to Des Moines departing on 5/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Tyler to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:14 am - 4:03 pm
TYR
-
DSM
5h 49m
1 stop
American Airlines Logo
7:09 pm - 11:40 pm
DSM
-
TYR
4h 31m
1 stop
$599American Airlines
Thu, May 21 - Tue, May 26
American Airlines Logo
5:00 am - 1:18 pm
TYR
-
DSM
8h 18m
2 stops
American Airlines Logo
4:48 pm - 11:40 pm
DSM
-
TYR
6h 52m
1 stop
$605American Airlines
Thu, May 21 - Tue, May 26
American Airlines Logo
5:00 am - 1:18 pm
TYR
-
DSM
8h 18m
2 stops
American Airlines Logo
1:48 pm - 11:40 pm
DSM
-
TYR
9h 52m
2 stops
$610American Airlines
Thu, May 21 - Tue, May 26

American Airlines flights from Tyler to Des Moines

Our best American Airlines deals on Tyler to Des Moines flight tickets
American Airlines
May 21
TYR10:14 amTyler Pounds Field
5h 49m
1 stop
DSM4:03 pmDes Moines
May 26
DSM7:09 pmDes Moines
4h 31m
1 stop
TYR11:40 pmTyler Pounds Field
$599
American Airlines
May 21
TYR5:00 amTyler Pounds Field
8h 18m
2 stops
DSM1:18 pmDes Moines
May 26
DSM4:48 pmDes Moines
6h 52m
1 stop
TYR11:40 pmTyler Pounds Field
$605
American Airlines
May 21
TYR5:00 amTyler Pounds Field
8h 18m
2 stops
DSM1:18 pmDes Moines
May 26
DSM1:48 pmDes Moines
9h 52m
2 stops
TYR11:40 pmTyler Pounds Field
$610

momondo Fare Finder

 
Customize your flight search to find flights from Tyler to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Tyler to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

TylerDes Moines

TYR - DSM

TYRDSM

Tyler Pounds Field

Thu 5/21

10:14 am-4:03 pm

1 stop5h 49m

Des Moines

Tue 5/26

7:09 pm-11:40 pm

1 stop4h 31m

$599

TylerDes Moines

TYR - DSM

TYRDSM

Tyler Pounds Field

Thu 5/21

5:00 am-1:18 pm

2 stops8h 18m

Des Moines

Tue 5/26

4:48 pm-11:40 pm

1 stop6h 52m

$605

TylerDes Moines

TYR - DSM

TYRDSM

Tyler Pounds Field

Thu 5/21

5:00 am-1:18 pm

2 stops8h 18m

Des Moines

Tue 5/26

1:48 pm-11:40 pm

2 stops9h 52m

$610

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Tyler to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Tyler to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tyler to Des Moines (TYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tyler to Des Moines

Fastest flight time

6h 04m

Direct flights

None
The fastest flight from Tyler to Des Moines takes 6h 04m
There are no direct flights from Tyler to Des Moines. There are no popular flight routes from Tyler to Des Moines.
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Frequently asked questions about flying from Tyler to Des Moines

  • How far is Tyler Pounds Field to Des Moines by plane?

    Des Moines is 644.2 mi away from Tyler Pounds Field. A reasonable flight in good conditions will take 6h 04m.

  • When did momondo last update prices for flights from Tyler Pounds Field Airport to Des Moines Airport?

    Prices for flights from Tyler Pounds Field Airport to Des Moines Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Tyler Pounds Field Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Tyler Pounds Field Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Frequently asked questions about flying from Tyler to Des Moines

  • How do I get Price Alerts for flights from Tyler to Des Moines?

    Confirm your travel details to search for the latest offers for flights from Tyler to Des Moines. While browsing offers there will be the option to toggle “Price Alerts”. You’ll then receive updates when prices for the flight route increase or decrease.

  • How can I save money on flights from Tyler to Des Moines with momondo?

    Plan your trips smart with the “Price Forecast” feature, which uses flight data to help you pick the best days to fly for the lowest fares. Our “Price Calendar” helps you get the most for your money by showing you when it’s most advantageous to fly. Curate your own travel experiences for less with “Explore”. Expert travel hacks to fuel your next adventure are a click away with “Discover” by momondo. Set up our “Price Alerts” to track fare changes and book when prices are at their lowest point.

  • How does momondo find its flight prices?

    We aggregate our prices from over 700+ competitors from airlines to OTAs. We operate in over 30 markets worldwide to show you a wide range of travel options.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Tyler to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Tyler to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Tyler to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Tyler to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Tyler to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Tyler to Des Moines.

I’m not ready to book a flight from Tyler to Des Moines right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Des Moines from Tyler. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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