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Cheap flights from St. Louis to South America from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to South America departing on 10/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to South America

Cheap round-trip flights

Spirit Airlines Logo
7:15 pm - 12:25 pmSTL-CTG
17h 10m1 stop
Spirit Airlines Logo
1:32 pm - 11:02 amCTG-STL
21h 30m1 stop
$319Spirit Airlines
Find Deal
Sat, Oct 25 - Sat, Nov 1
Logo
7:15 pm - 12:25 pmSTL-CTG
17h 10m1 stop
Logo
9:56 pm - 11:02 amCTG-STL
13h 06m2 stops
$373
Find Deal
Sat, Oct 25 - Sat, Nov 1
American Airlines Logo
5:15 am - 1:26 pmSTL-CTG
7h 11m1 stop
American Airlines Logo
8:00 am - 11:59 pmCTG-STL
16h 59m1 stop
$554American Airlines
Find Deal
Tue, Dec 2 - Mon, Dec 8
American Airlines Logo
5:56 pm - 1:30 pmSTL-CTG
18h 34m2 stops
American Airlines Logo
8:00 am - 9:47 pmCTG-STL
14h 47m2 stops
$558American Airlines
Find Deal
Tue, Dec 2 - Mon, Dec 8
United Airlines Logo
8:20 am - 9:05 pmSTL-MDE
12h 45m1 stop
United Airlines Logo
10:45 am - 6:47 pmMDE-STL
9h 02m1 stop
$576United Airlines
Find Deal
Fri, Oct 31 - Tue, Nov 11
United Airlines Logo
8:20 am - 10:05 pmSTL-MDE
12h 45m1 stop
United Airlines Logo
10:45 am - 10:22 pmMDE-STL
12h 37m1 stop
$586United Airlines
Find Deal
Fri, Nov 7 - Sun, Nov 16
LATAM Airlines Logo
6:00 am - 1:15 pmSTL-CTG
7h 15m1 stop
LATAM Airlines Logo
2:30 pm - 11:40 pmCTG-STL
9h 10m1 stop
$597LATAM Airlines
Find Deal
Mon, Mar 9 - Thu, Mar 12
Delta Logo
6:00 am - 1:15 pmSTL-CTG
7h 15m1 stop
Delta Logo
10:12 am - 9:04 amCTG-STL
22h 52m2 stops
$600Delta
Find Deal
Mon, Mar 9 - Thu, Mar 12
Delta Logo
7:05 am - 6:59 pmSTL-UIO
11h 54m1 stop
Delta Logo
12:55 am - 2:43 pmUIO-STL
13h 48m1 stop
$614Delta
Find Deal
Thu, Oct 23 - Wed, Oct 29
LATAM Airlines Logo
10:00 am - 8:55 pmSTL-LIM
9h 55m1 stop
LATAM Airlines Logo
12:15 pm - 11:40 pmLIM-STL
11h 25m1 stop
$631LATAM Airlines
Find Deal
Mon, Mar 2 - Mon, Mar 9

Air Canada flights from St. Louis to South America

Our best Air Canada deals on St. Louis to South America flight tickets
Air Canada
Nov 12
STL4:05 pmLambert-St Louis
13h 55m
1 stop
GRU9:00 amSao Paulo Guarulhos Intl
Nov 19
GRU9:30 pmSao Paulo Guarulhos Intl
20h 59m
1 stop
STL3:29 pmLambert-St Louis
$763
Find similar
Air Canada
Jan 18
STL4:05 pmLambert-St Louis
15h 30m
1 stop
GRU10:35 amSao Paulo Guarulhos Intl
Feb 1
GRU9:45 pmSao Paulo Guarulhos Intl
20h 44m
2 stops
STL3:29 pmLambert-St Louis
$768
Find similar
Air Canada
Jan 20
STL4:05 pmLambert-St Louis
22h 05m
2 stops
GRU5:10 pmSao Paulo Guarulhos Intl
Feb 1
GRU9:45 pmSao Paulo Guarulhos Intl
44h 44m
2 stops
STL3:29 pmLambert-St Louis
$775
Find similar

Spirit Airlines flights from St. Louis to South America

Our best Spirit Airlines deals on St. Louis to South America flight tickets
Spirit Airlines
Oct 25
STL7:15 pmLambert-St Louis
17h 10m
1 stop
CTG12:25 pmCartagena Rafael Nunez
Nov 1
CTG1:32 pmCartagena Rafael Nunez
21h 30m
1 stop
STL11:02 amLambert-St Louis
$319
Find similar
Spirit Airlines
Sep 14
STL10:35 amLambert-St Louis
13h 53m
1 stop
MDE12:28 amMedellín Jose Maria Cordova Intl
Oct 17
MDE2:22 pmMedellín Jose Maria Cordova Intl
27h 48m
1 stop
STL6:10 pmLambert-St Louis
$397
Find similar
Spirit Airlines
Sep 14
STL10:35 amLambert-St Louis
13h 53m
1 stop
MDE12:28 amMedellín Jose Maria Cordova Intl
Oct 10
MDE1:16 amMedellín Jose Maria Cordova Intl
16h 54m
1 stop
STL6:10 pmLambert-St Louis
$419
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sat 10/25

7:15 pm-12:25 pm

1 stop17h 10m

Cartagena Rafael Nunez

Sat 11/1

1:32 pm-11:02 am

1 stop21h 30m

$319

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sat 10/25

7:15 pm-12:25 pm

1 stop17h 10m

Cartagena Rafael Nunez

Sat 11/1

9:56 pm-11:02 am

2 stops13h 06m

$373

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 12/2

5:15 am-1:26 pm

1 stop7h 11m

Cartagena Rafael Nunez

Mon 12/8

8:00 am-11:59 pm

1 stop16h 59m

$554

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 12/2

5:56 pm-1:30 pm

2 stops18h 34m

Cartagena Rafael Nunez

Mon 12/8

8:00 am-9:47 pm

2 stops14h 47m

$558

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 10/31

8:20 am-9:05 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

Tue 11/11

10:45 am-6:47 pm

1 stop9h 02m

$576

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 11/7

8:20 am-10:05 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

Sun 11/16

10:45 am-10:22 pm

1 stop12h 37m

$586

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Mon 3/9

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

Thu 3/12

2:30 pm-11:40 pm

1 stop9h 10m

$597

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Mon 3/9

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

Thu 3/12

10:12 am-9:04 am

2 stops22h 52m

$600

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

Thu 10/23

7:05 am-6:59 pm

1 stop11h 54m

Quito Mariscal Sucr

Wed 10/29

12:55 am-2:43 pm

1 stop13h 48m

$614

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Mon 3/2

10:00 am-8:55 pm

1 stop9h 55m

Lima J Chavez Intl

Mon 3/9

12:15 pm-11:40 pm

1 stop11h 25m

$631

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from St. Louis to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from St. Louis to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $665. If you aren’t able to travel during the month of February, then book flights to South America from St. Louis during January instead. Flights to South America in January, while not as cheap as those in February, still average around $733.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from St. Louis to South America is on a Wednesday when prices can be found for as low as $741. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to South America for around $967.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest St. Louis to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $785. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $831 on average. Flights to South America from St. Louis at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $785 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from St. Louis for as low as $698 on momondo.

Can stopping save me money on St. Louis to South America flights?

You could potentially save up to 26% on your flight if you consider stops on a St. Louis to South America flight.

Cheap St. Louis to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South America

Direct flights

None
There are no direct flights from St. Louis to South America. There are no popular flight routes from St. Louis to South America.
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  • When did momondo last update prices for flights from Lambert-St Louis Airport to South America?

    Prices for flights from Lambert-St Louis Airport to South America were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to South America?

  • How old do you have to be to fly from Lambert-St Louis Airport to South America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from St. Louis to South America

Compare and see reviews for airlines that fly from St. Louis to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $307Free CancellationRating
6.3
8,023 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $474Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $484Free CancellationRating
7.9
7,960 reviews
Search Delta flights
LATAM AirlinesPriceFrom $535Free CancellationRating
7.5
1,847 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $554Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights
Air CanadaPriceFrom $758Free CancellationRating
7.1
10,000 reviews
Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to South America. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to South America with flexible booking policies on momondo?

momondo does allow users to show only those flights to South America from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to South America?

Once all potential St. Louis to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from St. Louis to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $276
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Flights to Bogotáfrom $180
Flights to Sao Paulofrom $331
Flights to Medellínfrom $173
Flights to Rio de Janeirofrom $387
Flights to Santiagofrom $362
Flights to Cartagenafrom $181
Flights to Quitofrom $303
Flights to Cuscofrom $378
Flights to Califrom $195
Flights to Guayaquilfrom $231