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Cheap flights from St. Louis to South America from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to South America departing on 1/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:42 pm - 12:50 pm
STL
-
BOG
18h 08m1 stop
Multiple Airlines Logo
1:45 pm - 10:27 pm
BOG
-
STL
9h 42m1 stop
$249Multiple Airlines
Sat, Feb 7 - Wed, Feb 11
Multiple Airlines Logo
5:42 pm - 12:50 pm
STL
-
BOG
18h 08m1 stop
Multiple Airlines Logo
1:45 pm - 10:27 pm
BOG
-
STL
9h 42m1 stop
$257Multiple Airlines
Mon, Feb 9 - Wed, Feb 11
American Airlines Logo
3:37 pm - 1:30 pm
STL
-
CTG
20h 53m2 stops
American Airlines Logo
4:30 pm - 9:08 am
CTG
-
STL
17h 38m1 stop
$491American Airlines
Mon, Jan 19 - Mon, Jan 26
American Airlines Logo
6:02 pm - 3:30 pm
STL
-
CTG
20h 28m1 stop
American Airlines Logo
4:30 pm - 9:08 am
CTG
-
STL
17h 38m1 stop
$498American Airlines
Mon, Jan 19 - Mon, Jan 26
United Airlines Logo
6:00 am - 11:00 pm
STL
-
CTG
16h 00m2 stops
United Airlines Logo
6:24 am - 3:52 pm
CTG
-
STL
10h 28m2 stops
$592United Airlines
Sun, Jan 25 - Thu, Jan 29
LATAM Airlines Logo
6:00 am - 2:17 pm
STL
-
CTG
7h 17m1 stop
LATAM Airlines Logo
3:32 pm - 11:37 pm
CTG
-
STL
9h 05m1 stop
$607LATAM Airlines
Sun, Jan 25 - Thu, Jan 29
LATAM Airlines Logo
9:59 am - 11:00 pm
STL
-
UIO
12h 01m2 stops
LATAM Airlines Logo
7:00 pm - 11:54 am
UIO
-
STL
17h 54m2 stops
$608LATAM Airlines
Tue, Feb 3 - Tue, Feb 10
Delta Logo
7:10 am - 5:17 am
STL
-
UIO
21h 07m2 stops
Delta Logo
7:00 pm - 2:47 pm
UIO
-
STL
20h 47m2 stops
$629Delta
Sun, Feb 1 - Sun, Feb 22
Delta Logo
10:13 am - 5:17 am
STL
-
UIO
18h 04m2 stops
Delta Logo
11:45 pm - 11:58 pm
UIO
-
STL
24h 13m1 stop
$634Delta
Sun, Mar 1 - Sun, Mar 8
United Airlines Logo
10:07 am - 8:50 am
STL
-
SCL
19h 43m1 stop
United Airlines Logo
10:45 pm - 3:52 pm
SCL
-
STL
20h 07m1 stop
$804United Airlines
Fri, Jan 23 - Tue, Jan 27

American Airlines flights from St. Louis to South America

Our best American Airlines deals on St. Louis to South America flight tickets
American Airlines
Jan 19
STL3:37 pmLambert-St Louis
20h 53m
2 stops
CTG1:30 pmCartagena Rafael Nunez
Jan 26
CTG4:30 pmCartagena Rafael Nunez
17h 38m
1 stop
STL9:08 amLambert-St Louis
$491
Find similar
American Airlines
Jan 19
STL6:02 pmLambert-St Louis
20h 28m
1 stop
CTG3:30 pmCartagena Rafael Nunez
Jan 26
CTG4:30 pmCartagena Rafael Nunez
17h 38m
1 stop
STL9:08 amLambert-St Louis
$498
Find similar
American Airlines
Jan 17
STL5:04 pmLambert-St Louis
21h 26m
2 stops
CTG3:30 pmCartagena Rafael Nunez
Jan 24
CTG4:30 pmCartagena Rafael Nunez
19h 33m
2 stops
STL11:03 amLambert-St Louis
$511
Find similar

United Airlines flights from St. Louis to South America

Our best United Airlines deals on St. Louis to South America flight tickets
United Airlines
Jan 25
STL6:00 amLambert-St Louis
16h 00m
2 stops
CTG11:00 pmCartagena Rafael Nunez
Jan 29
CTG6:24 amCartagena Rafael Nunez
10h 28m
2 stops
STL3:52 pmLambert-St Louis
$592
Find similar
United Airlines
Feb 4
STL6:40 pmLambert-St Louis
26h 25m
2 stops
MDE10:05 pmMedellín Jose Maria Cordova Intl
Feb 11
MDE10:45 amMedellín Jose Maria Cordova Intl
13h 13m
2 stops
STL10:58 pmLambert-St Louis
$595
Find similar
United Airlines
Jan 31
STL6:00 amLambert-St Louis
15h 05m
1 stop
MDE10:05 pmMedellín Jose Maria Cordova Intl
Feb 4
MDE10:45 amMedellín Jose Maria Cordova Intl
12h 15m
1 stop
STL10:00 pmLambert-St Louis
$625
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Sat 2/7

5:42 pm-12:50 pm

1 stop18h 08m

Bogotá El Dorado

Wed 2/11

1:45 pm-10:27 pm

1 stop9h 42m

$249

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Mon 2/9

5:42 pm-12:50 pm

1 stop18h 08m

Bogotá El Dorado

Wed 2/11

1:45 pm-10:27 pm

1 stop9h 42m

$257

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Mon 1/19

3:37 pm-1:30 pm

2 stops20h 53m

Cartagena Rafael Nunez

Mon 1/26

4:30 pm-9:08 am

1 stop17h 38m

$491

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Mon 1/19

6:02 pm-3:30 pm

1 stop20h 28m

Cartagena Rafael Nunez

Mon 1/26

4:30 pm-9:08 am

1 stop17h 38m

$498

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sun 1/25

6:00 am-11:00 pm

2 stops16h 00m

Cartagena Rafael Nunez

Thu 1/29

6:24 am-3:52 pm

2 stops10h 28m

$592

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sun 1/25

6:00 am-2:17 pm

1 stop7h 17m

Cartagena Rafael Nunez

Thu 1/29

3:32 pm-11:37 pm

1 stop9h 05m

$607

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

Tue 2/3

9:59 am-11:00 pm

2 stops12h 01m

Quito Mariscal Sucr

Tue 2/10

7:00 pm-11:54 am

2 stops17h 54m

$608

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

Sun 2/1

7:10 am-5:17 am

2 stops21h 07m

Quito Mariscal Sucr

Sun 2/22

7:00 pm-2:47 pm

2 stops20h 47m

$629

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

Sun 3/1

10:13 am-5:17 am

2 stops18h 04m

Quito Mariscal Sucr

Sun 3/8

11:45 pm-11:58 pm

1 stop24h 13m

$634

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 1/23

10:07 am-8:50 am

1 stop19h 43m

Santiago Arturo Merino Benitez

Tue 1/27

10:45 pm-3:52 pm

1 stop20h 07m

$804

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from St. Louis to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from St. Louis to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $663. If you aren’t able to travel during the month of February, then book flights to South America from St. Louis during August instead. Flights to South America in August, while not as cheap as those in February, still average around $724.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from St. Louis to South America is on a Wednesday when prices can be found for as low as $741. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to South America for around $967.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest St. Louis to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $785. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $831 on average. Flights to South America from St. Louis at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $801 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from St. Louis for as low as $671 on momondo.

Can stopping save me money on St. Louis to South America flights?

You could potentially save up to 25% on your flight if you consider stops on a St. Louis to South America flight.

Cheap St. Louis to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South America

Fastest flight time

7h 25m

Direct flights

None
The fastest flight from St. Louis to South America takes 7h 25m
There are no direct flights from St. Louis to South America. There are no popular flight routes from St. Louis to South America.
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to South America?

    Prices for flights from Lambert-St Louis Airport to South America were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to South America?

  • How old do you have to be to fly from Lambert-St Louis Airport to South America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from St. Louis to South America

Compare and see reviews for airlines that fly from St. Louis to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $307Free CancellationRating
6.3
8,193 reviews
Search Spirit Airlines flights
United AirlinesPriceFrom $474Free CancellationRating
7.4
9,102 reviews
Search United Airlines flights
American AirlinesPriceFrom $474Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
DeltaPriceFrom $484Free CancellationRating
7.9
8,014 reviews
Search Delta flights
LATAM AirlinesPriceFrom $536Free CancellationRating
7.5
1,894 reviews
Search LATAM Airlines flights
Air CanadaPriceFrom $758Free CancellationRating
7.1
10,551 reviews
Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to South America. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to South America with flexible booking policies on momondo?

momondo does allow users to show only those flights to South America from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to South America?

Once all potential St. Louis to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from St. Louis to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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