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Cheap flights from St. Louis to South America from $107

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to South America departing on 9/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to South America

Cheap round-trip flights

Spirit Airlines Logo
10:57 am - 1:17 amSTL-MDE
13h 20m1 stop
Spirit Airlines Logo
6:59 pm - 11:01 amMDE-STL
17h 02m1 stop
$274Spirit Airlines
Find Deal
dom., nov. 2 - sáb., nov. 8
Spirit Airlines Logo
7:00 pm - 2:11 pmSTL-MDE
19h 11m1 stop
Spirit Airlines Logo
6:59 pm - 11:01 amMDE-STL
17h 02m1 stop
$296Spirit Airlines
Find Deal
sáb., nov. 1 - sáb., nov. 8
LATAM Airlines Logo
11:21 am - 7:15 pmSTL-BOG
7h 54m1 stop
LATAM Airlines Logo
9:00 am - 4:10 pmBOG-STL
8h 10m1 stop
$561LATAM Airlines
Find Deal
mar., oct. 7 - mar., nov. 4
United Airlines Logo
6:15 am - 10:35 pmSTL-BOG
15h 20m1 stop
United Airlines Logo
1:30 am - 4:35 pmBOG-STL
16h 05m1 stop
$564United Airlines
Find Deal
lun., feb. 9 - dom., feb. 22
Delta Logo
7:30 am - 7:30 pmSTL-BOG
11h 00m1 stop
Delta Logo
9:00 am - 11:40 pmBOG-STL
15h 40m1 stop
$566Delta
Find Deal
vie., feb. 6 - mié., feb. 25
United Airlines Logo
11:20 am - 10:35 pmSTL-BOG
10h 15m1 stop
United Airlines Logo
1:30 am - 9:42 amBOG-STL
9h 12m1 stop
$568United Airlines
Find Deal
dom., feb. 8 - jue., feb. 19
LATAM Airlines Logo
10:00 am - 7:30 pmSTL-BOG
8h 30m1 stop
LATAM Airlines Logo
10:55 am - 11:40 pmBOG-STL
13h 45m2 stops
$570LATAM Airlines
Find Deal
sáb., feb. 7 - jue., feb. 26
Delta Logo
7:30 am - 7:30 pmSTL-BOG
11h 00m1 stop
Delta Logo
10:55 am - 8:39 pmBOG-STL
10h 44m2 stops
$572Delta
Find Deal
vie., feb. 6 - sáb., feb. 21
American Airlines Logo
5:28 am - 12:25 pmSTL-CTG
6h 57m1 stop
American Airlines Logo
1:25 pm - 11:59 pmCTG-STL
10h 34m1 stop
$572American Airlines
Find Deal
sáb., sep. 27 - sáb., oct. 4
American Airlines Logo
3:59 pm - 12:25 pmSTL-CTG
20h 26m2 stops
American Airlines Logo
1:25 pm - 9:12 amCTG-STL
19h 47m2 stops
$576American Airlines
Find Deal
sáb., sep. 27 - sáb., oct. 4

Delta flights from St. Louis to South America

Our best Delta deals on St. Louis to South America flight tickets
Delta
Feb 9
STL6:00 amLambert-St Louis
12h 30m
1 stop
BOG7:30 pmBogotá El Dorado
Feb 24
BOG9:00 amBogotá El Dorado
10h 04m
1 stop
STL6:04 pmLambert-St Louis
$564
Find similar
Delta
Feb 6
STL7:30 amLambert-St Louis
11h 00m
1 stop
BOG7:30 pmBogotá El Dorado
Feb 25
BOG9:00 amBogotá El Dorado
15h 40m
1 stop
STL11:40 pmLambert-St Louis
$566
Find similar
Delta
Feb 6
STL7:30 amLambert-St Louis
11h 00m
1 stop
BOG7:30 pmBogotá El Dorado
Feb 21
BOG10:55 amBogotá El Dorado
10h 44m
2 stops
STL8:39 pmLambert-St Louis
$572
Find similar

United Airlines flights from St. Louis to South America

Our best United Airlines deals on St. Louis to South America flight tickets
United Airlines
Feb 8
STL11:20 amLambert-St Louis
10h 15m
1 stop
BOG10:35 pmBogotá El Dorado
Feb 19
BOG1:30 amBogotá El Dorado
9h 12m
1 stop
STL9:42 amLambert-St Louis
$568
Find similar
United Airlines
Nov 2
STL5:15 amLambert-St Louis
15h 20m
1 stop
BOG9:35 pmBogotá El Dorado
Nov 4
BOG1:30 amBogotá El Dorado
10h 09m
1 stop
STL10:39 amLambert-St Louis
$586
Find similar
United Airlines
Oct 17
STL6:15 amLambert-St Louis
13h 05m
1 stop
BOG7:20 pmBogotá El Dorado
Oct 19
BOG12:14 amBogotá El Dorado
15h 30m
2 stops
STL3:44 pmLambert-St Louis
$590
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

dom. 11/2

10:57 am-1:17 am

1 stop13h 20m

Medellín Jose Maria Cordova Intl

sáb. 11/8

6:59 pm-11:01 am

1 stop17h 02m

$274

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

sáb. 11/1

7:00 pm-2:11 pm

1 stop19h 11m

Medellín Jose Maria Cordova Intl

sáb. 11/8

6:59 pm-11:01 am

1 stop17h 02m

$296

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

mar. 10/7

11:21 am-7:15 pm

1 stop7h 54m

Bogotá El Dorado

mar. 11/4

9:00 am-4:10 pm

1 stop8h 10m

$561

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

lun. 2/9

6:15 am-10:35 pm

1 stop15h 20m

Bogotá El Dorado

dom. 2/22

1:30 am-4:35 pm

1 stop16h 05m

$564

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

vie. 2/6

7:30 am-7:30 pm

1 stop11h 00m

Bogotá El Dorado

mié. 2/25

9:00 am-11:40 pm

1 stop15h 40m

$566

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

dom. 2/8

11:20 am-10:35 pm

1 stop10h 15m

Bogotá El Dorado

jue. 2/19

1:30 am-9:42 am

1 stop9h 12m

$568

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

sáb. 2/7

10:00 am-7:30 pm

1 stop8h 30m

Bogotá El Dorado

jue. 2/26

10:55 am-11:40 pm

2 stops13h 45m

$570

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

vie. 2/6

7:30 am-7:30 pm

1 stop11h 00m

Bogotá El Dorado

sáb. 2/21

10:55 am-8:39 pm

2 stops10h 44m

$572

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

sáb. 9/27

5:28 am-12:25 pm

1 stop6h 57m

Cartagena Rafael Nunez

sáb. 10/4

1:25 pm-11:59 pm

1 stop10h 34m

$572

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

sáb. 9/27

3:59 pm-12:25 pm

2 stops20h 26m

Cartagena Rafael Nunez

sáb. 10/4

1:25 pm-9:12 am

2 stops19h 47m

$576

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from St. Louis to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from St. Louis to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $665. If you aren’t able to travel during the month of February, then book flights to South America from St. Louis during September instead. Flights to South America in September, while not as cheap as those in February, still average around $693.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from St. Louis to South America is on a Wednesday when prices can be found for as low as $741. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to South America for around $967.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest St. Louis to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $785. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $831 on average. Flights to South America from St. Louis at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $780 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from St. Louis for as low as $698 on momondo.

Can stopping save me money on St. Louis to South America flights?

You could potentially save up to 22% on your flight if you consider stops on a St. Louis to South America flight.

Cheap St. Louis to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South America

Best Price Found

$107

Fastest flight time

6h 18m

Direct flights

None

Airports in South America

6 airports
The best one-way flight to South America from St. Louis in the past 72 hours is $107. The best round-trip flight deal from St. Louis to South America found on momondo in the last 72 hours is $274.
The fastest flight from St. Louis to South America takes 6h 18m
There are no direct flights from St. Louis to South America. Popular non-direct routes for this connection are Lambert-St Louis Airport - Medellín Jose Maria Cordova Intl Airport, Lambert-St Louis Airport - Cartagena Rafael Nunez Airport and Lambert-St Louis Airport - Bogotá El Dorado Airport.
There are 6 airports near South America: Lima J Chavez Intl (LIM), Rio de Janeiro–Galeão Intl (GIG), Cartagena Rafael Nunez (CTG), Bogotá El Dorado (BOG), Sao Paulo Guarulhos Intl (GRU), Medellín Jose Maria Cordova Intl (MDE)
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  • When did momondo last update prices for flights from Lambert-St Louis Airport to South America?

    Prices for flights from Lambert-St Louis Airport to South America were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to South America?

  • How old do you have to be to fly from Lambert-St Louis Airport to South America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from St. Louis to South America

Compare and see reviews for airlines that fly from St. Louis to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $336Free CancellationRating
6.3
8,045 reviews
Search Spirit Airlines flights
LATAM AirlinesPriceFrom $403Free CancellationRating
7.5
1,840 reviews
Search LATAM Airlines flights
DeltaPriceFrom $448Free CancellationRating
8.0
7,980 reviews
Search Delta flights
American AirlinesPriceFrom $474Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $554Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights
Air CanadaPriceFrom $758Free CancellationRating
7.1
9,949 reviews
Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from St. Louis to South America. momondo saves you time and could save you money on your trip.

Can I find flights from St. Louis to South America with flexible booking policies on momondo?

momondo does allow users to show only those flights to South America from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to South America?

Once all potential St. Louis to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from St. Louis to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from St. Louis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $256
Flights to Buenos Airesfrom $536
Flights to Bogotáfrom $180
Flights to Sao Paulofrom $378
Flights to Medellínfrom $171
Flights to Rio de Janeirofrom $451
Flights to Santiagofrom $352
Flights to Cartagenafrom $180
Flights to Quitofrom $309
Flights to Cuscofrom $349
Flights to Califrom $182
Flights to Guayaquilfrom $231