What airlines fly to Knoxville?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Knoxville from South Dakota according to our data. American Airlines is the first choice among our users, with 54% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

How long does it take to fly to Knoxville?

Average flight duration from South Dakota to Knoxville depends on which airport you fly into and out of. Flying from Sioux Falls to Knoxville is 4h 48m on average, while flying from Rapid City to Knoxville is 5h 22m on average. Knoxville is the most popular airport in Knoxville.

What is the cheapest airline that flies from South Dakota to Knoxville McGhee Tyson?

United Airlines is the most popular carrier operating from South Dakota to Knoxville McGhee Tyson

When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?

Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?

There are 3 operators available for flights from South Dakota to Knoxville McGhee Tyson Airport as of July 2026.

How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$214 Cheap Flights from South Dakota to Knoxville in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Dakota to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:31 pm - 8:53 pm

RAP

TYS

5h 22m

1 stop

4:50 pm - 10:28 pm

TYS

RAP

7h 38m

1 stop

$246United Airlines

Tue, Aug 18 - Tue, Aug 25

1:31 pm - 8:53 pm

RAP

TYS

5h 22m

1 stop

2:21 pm - 10:28 pm

TYS

RAP

10h 07m

2 stops

$252United Airlines

Tue, Aug 18 - Tue, Aug 25

1:31 pm - 8:53 pm

RAP

TYS

5h 22m

1 stop

7:00 am - 10:26 am

TYS

RAP

5h 26m

1 stop

$268United Airlines

Tue, Aug 18 - Tue, Aug 25

1:31 pm - 8:53 pm

RAP

TYS

5h 22m

1 stop

4:50 pm - 10:28 pm

TYS

RAP

7h 38m

1 stop

$269United Airlines

Tue, Aug 18 - Tue, Aug 25

1:31 pm - 8:53 pm

RAP

TYS

5h 22m

1 stop

4:50 pm - 10:28 pm

TYS

RAP

7h 38m

1 stop

$270United Airlines

Tue, Aug 18 - Tue, Aug 25

1:31 pm - 8:53 pm

RAP

TYS

5h 22m

1 stop

3:40 pm - 10:28 pm

TYS

RAP

8h 48m

2 stops

$273United Airlines

Tue, Aug 18 - Tue, Aug 25

5:34 pm - 11:51 pm

FSD

TYS

5h 17m

1 stop

7:59 am - 11:36 am

TYS

FSD

4h 37m

1 stop

$305American Airlines

Sat, Aug 1 - Sat, Aug 8

7:30 am - 4:43 pm

FSD

TYS

8h 13m

1 stop

6:03 am - 12:17 pm

TYS

FSD

7h 14m

1 stop

$309American Airlines

Fri, Aug 21 - Sun, Aug 23

7:30 am - 4:43 pm

FSD

TYS

8h 13m

1 stop

5:00 am - 11:42 am

TYS

FSD

7h 42m

2 stops

$314American Airlines

Fri, Aug 21 - Sun, Aug 23

5:20 am - 11:10 am

FSD

TYS

4h 50m

1 stop

6:40 am - 12:49 pm

TYS

FSD

7h 09m

1 stop

$369Delta

Wed, Jul 15 - Sun, Jul 19

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American Airlines flights from South Dakota to Knoxville

Our best American Airlines deals on South Dakota to Knoxville flight tickets

American Airlines

Aug 1

FSD5:34 pmSioux Falls Joe Foss Field

5h 17m

1 stop

TYS11:51 pmKnoxville McGhee Tyson

Aug 8

TYS7:59 amKnoxville McGhee Tyson

4h 37m

1 stop

FSD11:36 amSioux Falls Joe Foss Field

$305

American Airlines

Jul 27

FSD5:34 pmSioux Falls Joe Foss Field

5h 17m

1 stop

TYS11:51 pmKnoxville McGhee Tyson

Aug 5

TYS6:52 pmKnoxville McGhee Tyson

6h 38m

1 stop

FSD12:30 amSioux Falls Joe Foss Field

$307

American Airlines

Aug 21

FSD7:30 amSioux Falls Joe Foss Field

8h 13m

1 stop

TYS4:43 pmKnoxville McGhee Tyson

Aug 23

TYS6:03 amKnoxville McGhee Tyson

7h 14m

1 stop

FSD12:17 pmSioux Falls Joe Foss Field

$309

Delta flights from South Dakota to Knoxville

Our best Delta deals on South Dakota to Knoxville flight tickets

Delta

Jul 15

FSD5:20 amSioux Falls Joe Foss Field

4h 50m

1 stop

TYS11:10 amKnoxville McGhee Tyson

Jul 19

TYS6:40 amKnoxville McGhee Tyson

7h 09m

1 stop

FSD12:49 pmSioux Falls Joe Foss Field

$369

Delta

Oct 19

RAP2:32 pmRapid City

7h 27m

2 stops

TYS11:59 pmKnoxville McGhee Tyson

Oct 23

TYS5:45 amKnoxville McGhee Tyson

10h 06m

2 stops

RAP1:51 pmRapid City

$617

Delta

Oct 1

FSD5:30 amSioux Falls Joe Foss Field

4h 48m

1 stop

TYS11:18 amKnoxville McGhee Tyson

Oct 4

TYS5:35 amKnoxville McGhee Tyson

7h 44m

2 stops

FSD12:19 pmSioux Falls Joe Foss Field

$648

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/18

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

4:50 pm-10:28 pm

1 stop7h 38m

$246

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/18

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

2:21 pm-10:28 pm

2 stops10h 07m

$252

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/18

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-10:26 am

1 stop5h 26m

$268

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/18

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

4:50 pm-10:28 pm

1 stop7h 38m

$269

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/18

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

4:50 pm-10:28 pm

1 stop7h 38m

$270

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/18

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

3:40 pm-10:28 pm

2 stops8h 48m

$273

Quickest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/1

5:34 pm-11:51 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 8/8

7:59 am-11:36 am

1 stop4h 37m

$305

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 8/21

7:30 am-4:43 pm

1 stop8h 13m

Knoxville McGhee Tyson

Sun 8/23

6:03 am-12:17 pm

1 stop7h 14m

$309

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 8/21

7:30 am-4:43 pm

1 stop8h 13m

Knoxville McGhee Tyson

Sun 8/23

5:00 am-11:42 am

2 stops7h 42m

$314

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 7/15

5:20 am-11:10 am

1 stop4h 50m

Knoxville McGhee Tyson

Sun 7/19

6:40 am-12:49 pm

1 stop7h 09m

$369

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Dakota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from South Dakota, with most prices found around $248. If you aren’t able to travel during the month of December, then book flights to Knoxville from South Dakota during November instead. Flights to Knoxville in November, while not as cheap as those in December, still average around $248.

Can stopping save me money on South Dakota to Knoxville flights?

You could potentially save up to 31% on your flight if you consider stops on a South Dakota to Knoxville flight.

Cheap South Dakota to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Knoxville

Fastest flight time	4h 41m
Direct flights	None

The fastest flight from South Dakota to Knoxville takes 4h 41m

There are no direct flights from South Dakota to Knoxville. There are no popular flight routes from South Dakota to Knoxville.

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Frequently asked questions about flying from South Dakota to Knoxville

When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?
Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?
There are 3 operators available for flights from South Dakota to Knoxville McGhee Tyson Airport as of July 2026.
How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.1 11,762 reviews	Search American Airlines flights
Delta	PriceFrom $274	Free Cancellation	Rating 7.8 8,451 reviews	Search Delta flights
United Airlines	PriceFrom $279	Free Cancellation	Rating 7.4 9,901 reviews	Search United Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Alcoa

Maryville

Murphy

Crossville

Oak Ridge

Kodak

Newport

Lenoir City

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Dakota to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Dakota to Knoxville with flexible booking policies on momondo?

Flights from South Dakota to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South Dakota to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from South Dakota. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Dakota to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Cheap flights from South Dakota to Knoxville from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Knoxville departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from South Dakota to Knoxville

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How to get the cheapest flight ticket from South Dakota to Knoxville

What is the cheapest month to fly to Knoxville?

Can stopping save me money on South Dakota to Knoxville flights?

What is the cheapest airline that flies from South Dakota to Knoxville McGhee Tyson?

What airlines fly to Knoxville?

How long does it take to fly to Knoxville?

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Why use momondo?

An easier way to manage your Knoxville trip

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