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Cheap flights from South Dakota to Knoxville from $249

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Knoxville departing on 10/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Dakota to Knoxville

Cheap round-trip flights

American Airlines Logo
5:05 pm - 12:23 amFSD-TYS
6h 18m1 stop
American Airlines Logo
5:37 pm - 10:42 pmTYS-FSD
6h 05m1 stop
$249American Airlines
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Sat, Oct 25 - Tue, Oct 28
American Airlines Logo
5:05 pm - 12:23 amFSD-TYS
6h 18m1 stop
American Airlines Logo
11:44 am - 9:16 pmTYS-FSD
10h 32m2 stops
$254American Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
American Airlines Logo
1:27 pm - 11:50 pmFSD-TYS
9h 23m2 stops
American Airlines Logo
5:00 am - 12:45 pmTYS-FSD
8h 45m2 stops
$259American Airlines
Find Deal
Sat, Oct 25 - Wed, Oct 29
United Airlines Logo
8:00 am - 7:53 pmFSD-TYS
10h 53m2 stops
United Airlines Logo
7:00 am - 10:45 amTYS-FSD
4h 45m1 stop
$264United Airlines
Find Deal
Tue, Aug 26 - Sat, Aug 30
Delta Logo
5:30 am - 10:56 amFSD-TYS
4h 26m1 stop
Delta Logo
5:45 am - 1:51 pmTYS-FSD
9h 06m2 stops
$276Delta
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Tue, Sep 23 - Wed, Sep 24
Delta Logo
12:56 pm - 11:44 pmFSD-TYS
9h 48m2 stops
Delta Logo
5:45 am - 1:51 pmTYS-FSD
9h 06m2 stops
$281Delta
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Tue, Sep 23 - Wed, Sep 24
United Airlines Logo
12:43 pm - 10:30 pmRAP-TYS
7h 47m1 stop
United Airlines Logo
4:40 pm - 9:59 pmTYS-RAP
7h 19m1 stop
$284United Airlines
Find Deal
Tue, Aug 26 - Sat, Aug 30
Frontier Logo
2:54 pm - 7:45 pmFSD-TYS
27h 51m1 stop
Frontier Logo
5:08 pm - 2:09 pmTYS-FSD
22h 01m1 stop
$310Frontier
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Sun, Sep 21 - Sun, Sep 28
Logo
7:40 pm - 10:42 pmRAP-TYS
25h 02m1 stop
Logo
7:00 am - 5:08 pmTYS-RAP
12h 08m2 stops
$398
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Sat, Oct 18 - Sun, Oct 26
Logo
8:30 pm - 2:04 pmRAP-TYS
15h 34m1 stop
Logo
3:24 pm - 4:16 pmTYS-RAP
26h 52m3 stops
$439
Find Deal
Sun, Aug 24 - Thu, Aug 28

Delta flights from South Dakota to Knoxville

Our best Delta deals on South Dakota to Knoxville flight tickets
Delta
Sep 23
FSD5:30 amSioux Falls Joe Foss Field
4h 26m
1 stop
TYS10:56 amKnoxville McGhee Tyson
Sep 24
TYS5:45 amKnoxville McGhee Tyson
9h 06m
2 stops
FSD1:51 pmSioux Falls Joe Foss Field
$276
Find similar
Delta
Sep 23
FSD12:56 pmSioux Falls Joe Foss Field
9h 48m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Sep 24
TYS5:45 amKnoxville McGhee Tyson
9h 06m
2 stops
FSD1:51 pmSioux Falls Joe Foss Field
$281
Find similar
Delta
Sep 21
FSD5:30 amSioux Falls Joe Foss Field
6h 37m
1 stop
TYS1:07 pmKnoxville McGhee Tyson
Sep 27
TYS6:40 amKnoxville McGhee Tyson
4h 27m
1 stop
FSD10:07 amSioux Falls Joe Foss Field
$294
Find similar

Allegiant Air flights from South Dakota to Knoxville

Our best Allegiant Air deals on South Dakota to Knoxville flight tickets
Allegiant Air
Oct 18
RAP7:40 pmRapid City
25h 02m
1 stop
TYS10:42 pmKnoxville McGhee Tyson
Oct 26
TYS2:23 pmKnoxville McGhee Tyson
26h 26m
1 stop
RAP2:49 pmRapid City
$418
Find similar
Allegiant Air
Sep 19
FSD12:13 pmSioux Falls Joe Foss Field
9h 17m
1 stop
TYS10:30 pmKnoxville McGhee Tyson
Sep 28
TYS11:00 amKnoxville McGhee Tyson
30h 12m
2 stops
FSD4:12 pmSioux Falls Joe Foss Field
$454
Find similar
Allegiant Air
Oct 16
RAP5:58 pmRapid City
17h 25m
1 stop
TYS1:23 pmKnoxville McGhee Tyson
Oct 26
TYS2:23 pmKnoxville McGhee Tyson
26h 26m
1 stop
RAP2:49 pmRapid City
$553
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2025.
Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

5:05 pm-12:23 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/28

5:37 pm-10:42 pm

1 stop6h 05m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

5:05 pm-12:23 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/28

11:44 am-9:16 pm

2 stops10h 32m

$254

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

1:27 pm-11:50 pm

2 stops9h 23m

Knoxville McGhee Tyson

Wed 10/29

5:00 am-12:45 pm

2 stops8h 45m

$259

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 8/26

8:00 am-7:53 pm

2 stops10h 53m

Knoxville McGhee Tyson

Sat 8/30

7:00 am-10:45 am

1 stop4h 45m

$264

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 9/23

5:30 am-10:56 am

1 stop4h 26m

Knoxville McGhee Tyson

Wed 9/24

5:45 am-1:51 pm

2 stops9h 06m

$276

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 9/23

12:56 pm-11:44 pm

2 stops9h 48m

Knoxville McGhee Tyson

Wed 9/24

5:45 am-1:51 pm

2 stops9h 06m

$281

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 8/26

12:43 pm-10:30 pm

1 stop7h 47m

Knoxville McGhee Tyson

Sat 8/30

4:40 pm-9:59 pm

1 stop7h 19m

$284

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sun 9/21

2:54 pm-7:45 pm

1 stop27h 51m

Knoxville McGhee Tyson

Sun 9/28

5:08 pm-2:09 pm

1 stop22h 01m

$310

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 10/18

7:40 pm-10:42 pm

1 stop25h 02m

Knoxville McGhee Tyson

Sun 10/26

7:00 am-5:08 pm

2 stops12h 08m

$398

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sun 8/24

8:30 pm-2:04 pm

1 stop15h 34m

Knoxville McGhee Tyson

Thu 8/28

3:24 pm-4:16 pm

3 stops26h 52m

$439

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Dakota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from South Dakota, with most prices found around $293. If you aren’t able to travel during the month of September, then book flights to Knoxville from South Dakota during August instead. Flights to Knoxville in August, while not as cheap as those in September, still average around $323.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from South Dakota to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $250. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from South Dakota to Knoxville for around $551.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from South Dakota to Knoxville when you can find flight prices for as low as $271. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $442.

Cheap South Dakota to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Knoxville

Best Price Found

$256

Fastest flight time

4h 21m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from South Dakota in the past 72 hours is $256. The best round-trip flight deal from South Dakota to Knoxville found on momondo in the last 72 hours is $249.
The fastest flight from South Dakota to Knoxville takes 4h 21m
There are no direct flights from South Dakota to Knoxville. Popular non-direct routes for this connection are Rapid City Airport - Knoxville McGhee Tyson Airport and Sioux Falls Joe Foss Field Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?

    Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $221Free CancellationRating
8.0
7,979 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
8,920 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Dakota to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Dakota to Knoxville with flexible booking policies on momondo?

Flights from South Dakota to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South Dakota to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from South Dakota. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Dakota to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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