What airlines fly to Knoxville?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Knoxville from South Dakota according to our data. American Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

How long does it take to fly to Knoxville?

Average flight duration from South Dakota to Knoxville depends on which airport you fly into and out of. Flying from Sioux Falls to Knoxville is 5h on average, while flying from Rapid City to Knoxville is 5h 12m on average. Knoxville is the most popular airport in Knoxville.

How many flights depart from South Dakota to Knoxville on average per week?

The number of flights available between South Dakota and Knoxville is 2 per week as of September 2026. The most frequent departure day is Mon, with 50% of weekly flights leaving on this day.

What is the cheapest airline that flies from South Dakota to Knoxville McGhee Tyson?

United Airlines, Delta, and Allegiant Air are the most popular carriers operating from South Dakota to Knoxville McGhee Tyson

When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?

Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?

There are 3 operators available for flights from South Dakota to Knoxville McGhee Tyson Airport as of September 2026.

How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$245 Cheap Flights from South Dakota to Knoxville in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Dakota to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:09 pm - 11:40 pmRAP Rapid City-TYS Knoxville McGhee Tyson

8h 31m1 stop Dallas/Fort Worth

5:32 pm - 9:32 pmTYS Knoxville McGhee Tyson-RAP Rapid City

6h 00m1 stop Dallas/Fort Worth

$281American Airlines

Sat, Dec 5 - Tue, Dec 8

4:36 pm - 11:24 pmRAP Rapid City-TYS Knoxville McGhee Tyson

4h 48m1 stop Minneapolis St Paul

5:10 pm - 10:46 pmTYS Knoxville McGhee Tyson-RAP Rapid City

7h 36m2 stops Detroit Metropolitan Wayne County Minneapolis St Paul

$286Delta

Sat, Dec 5 - Tue, Dec 8

6:42 am - 8:00 pmRAP Rapid City-TYS Knoxville McGhee Tyson

11h 18m2 stops Minneapolis St Paul Detroit Metropolitan Wayne County

5:10 pm - 10:46 pmTYS Knoxville McGhee Tyson-RAP Rapid City

7h 36m2 stops Detroit Metropolitan Wayne County Minneapolis St Paul

$291Delta

Sat, Dec 5 - Tue, Dec 8

6:11 am - 4:39 pmRAP Rapid City-TYS Knoxville McGhee Tyson

8h 28m1 stop Dallas/Fort Worth

5:32 pm - 9:32 pmTYS Knoxville McGhee Tyson-RAP Rapid City

6h 00m1 stop Dallas/Fort Worth

$315American Airlines

Fri, Dec 4 - Tue, Dec 8

2:40 pm - 11:24 pmRAP Rapid City-TYS Knoxville McGhee Tyson

6h 44m1 stop Minneapolis St Paul

5:10 pm - 10:46 pmTYS Knoxville McGhee Tyson-RAP Rapid City

7h 36m2 stops Detroit Metropolitan Wayne County Minneapolis St Paul

$320Delta

Fri, Dec 4 - Tue, Dec 8

12:07 pm - 6:20 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

5h 13m1 stop Chicago O'Hare Intl

6:55 pm - 12:41 amTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

6h 46m1 stop Chicago O'Hare Intl

$369American Airlines

Tue, Oct 13 - Sat, Oct 17

12:39 pm - 10:32 pmRAP Rapid City-TYS Knoxville McGhee Tyson

7h 53m1 stop Denver Intl

5:03 pm - 8:43 pmTYS Knoxville McGhee Tyson-RAP Rapid City

5h 40m1 stop Denver Intl

$389United Airlines

Mon, Nov 2 - Sat, Nov 7

5:00 am - 4:59 pmRAP Rapid City-TYS Knoxville McGhee Tyson

9h 59m2 stops Denver Intl Chicago O'Hare Intl

5:03 pm - 8:43 pmTYS Knoxville McGhee Tyson-RAP Rapid City

5h 40m1 stop Denver Intl

$394United Airlines

Mon, Nov 2 - Sat, Nov 7

10:29 am - 7:57 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

8h 28m1 stop Tampa St. Petersburg

9:11 pm - 9:09 amTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

12h 58m1 stop Tampa St. Petersburg

$428Allegiant Air

Mon, Oct 26 - Thu, Oct 29

7:50 pm - 10:46 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

25h 56m2 stops Nashville Intl Orlando

9:06 pm - 9:07 amTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

13h 01m1 stop Tampa St. Petersburg

$461Multiple Airlines

Mon, Dec 21 - Thu, Jan 7

Cheap last minute flights

Enter your travel dates to find the best prices.

1:37 pm - 8:49 pmRAP Rapid City-TYS Knoxville McGhee Tyson

5h 12m1 stop Chicago O'Hare Intl

6:00 am - 10:15 amTYS Knoxville McGhee Tyson-RAP Rapid City

6h 15m1 stop Chicago O'Hare Intl

$432United Airlines

Fri, Oct 2 - Tue, Oct 6

1:37 pm - 8:49 pmRAP Rapid City-TYS Knoxville McGhee Tyson

5h 12m1 stop Chicago O'Hare Intl

1:55 pm - 10:30 pmTYS Knoxville McGhee Tyson-RAP Rapid City

10h 35m2 stops Chicago O'Hare Intl Denver Intl

$503United Airlines

Fri, Oct 2 - Tue, Oct 6

10:19 am - 11:07 pmRAP Rapid City-TYS Knoxville McGhee Tyson

10h 48m2 stops Dallas/Fort Worth Miami

1:58 pm - 10:02 pmTYS Knoxville McGhee Tyson-RAP Rapid City

10h 04m2 stops Charlotte Douglas Dallas/Fort Worth

$747American Airlines

Fri, Oct 2 - Tue, Oct 6

1:46 pm - 10:14 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

7h 28m1 stop Denver Intl

6:03 pm - 11:11 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

6h 08m1 stop Chicago O'Hare Intl

$857United Airlines

Fri, Oct 2 - Sun, Oct 4

7:50 am - 9:55 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

13h 05m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

6:03 pm - 11:11 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

6h 08m1 stop Chicago O'Hare Intl

$869United Airlines

Fri, Oct 2 - Sun, Oct 4

6:00 am - 12:53 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

5h 53m1 stop Dallas/Fort Worth

8:02 pm - 12:13 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

17h 11m1 stop Dallas/Fort Worth

$953American Airlines

Thu, Oct 1 - Sun, Oct 4

9:42 am - 8:49 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

10h 07m2 stops Denver Intl Chicago O'Hare Intl

6:03 pm - 11:11 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

6h 08m1 stop Chicago O'Hare Intl

$1,016United Airlines

Thu, Oct 1 - Sun, Oct 4

6:00 am - 12:53 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

5h 53m1 stop Dallas/Fort Worth

8:02 pm - 12:13 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

17h 11m1 stop Dallas/Fort Worth

$1,019American Airlines

Thu, Oct 1 - Sun, Oct 4

12:56 pm - 11:07 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

9h 11m2 stops Dallas/Fort Worth Miami

8:02 pm - 12:13 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

17h 11m1 stop Dallas/Fort Worth

$1,031American Airlines

Thu, Oct 1 - Sun, Oct 4

12:56 pm - 11:07 pmFSD Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson

9h 11m2 stops Dallas/Fort Worth Miami

8:02 pm - 12:13 pmTYS Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field

17h 11m1 stop Dallas/Fort Worth

$1,043American Airlines

Thu, Oct 1 - Sun, Oct 4

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

American Airlines flights from South Dakota to Knoxville

Our best American Airlines deals on South Dakota to Knoxville flight tickets

American Airlines

Dec 5

RAP1:09 pmRapid City

8h 31m

1 stop

TYS11:40 pmKnoxville McGhee Tyson

Dec 8

TYS5:32 pmKnoxville McGhee Tyson

6h 00m

1 stop

RAP9:32 pmRapid City

$281

American Airlines

Dec 4

RAP6:11 amRapid City

8h 28m

1 stop

TYS4:39 pmKnoxville McGhee Tyson

Dec 8

TYS5:32 pmKnoxville McGhee Tyson

6h 00m

1 stop

RAP9:32 pmRapid City

$315

American Airlines

Oct 13

FSD12:07 pmSioux Falls Joe Foss Field

5h 13m

1 stop

TYS6:20 pmKnoxville McGhee Tyson

Oct 17

TYS6:55 pmKnoxville McGhee Tyson

6h 46m

1 stop

FSD12:41 amSioux Falls Joe Foss Field

$369

Delta flights from South Dakota to Knoxville

Our best Delta deals on South Dakota to Knoxville flight tickets

Delta

Dec 5

RAP4:36 pmRapid City

4h 48m

1 stop

TYS11:24 pmKnoxville McGhee Tyson

Dec 8

TYS5:10 pmKnoxville McGhee Tyson

7h 36m

2 stops

RAP10:46 pmRapid City

$286

Delta

Dec 5

RAP6:42 amRapid City

11h 18m

2 stops

TYS8:00 pmKnoxville McGhee Tyson

Dec 8

TYS5:10 pmKnoxville McGhee Tyson

7h 36m

2 stops

RAP10:46 pmRapid City

$291

Delta

Dec 4

RAP2:40 pmRapid City

6h 44m

1 stop

TYS11:24 pmKnoxville McGhee Tyson

Dec 8

TYS5:10 pmKnoxville McGhee Tyson

7h 36m

2 stops

RAP10:46 pmRapid City

$320

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Sat 12/5

1:09 pm-11:40 pm

1 stop8h 31m

Knoxville McGhee Tyson

Tue 12/8

5:32 pm-9:32 pm

1 stop6h 00m

$281

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Sat 12/5

4:36 pm-11:24 pm

1 stop4h 48m

Knoxville McGhee Tyson

Tue 12/8

5:10 pm-10:46 pm

2 stops7h 36m

$286

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Sat 12/5

6:42 am-8:00 pm

2 stops11h 18m

Knoxville McGhee Tyson

Tue 12/8

5:10 pm-10:46 pm

2 stops7h 36m

$291

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Fri 12/4

6:11 am-4:39 pm

1 stop8h 28m

Knoxville McGhee Tyson

Tue 12/8

5:32 pm-9:32 pm

1 stop6h 00m

$315

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Fri 12/4

2:40 pm-11:24 pm

1 stop6h 44m

Knoxville McGhee Tyson

Tue 12/8

5:10 pm-10:46 pm

2 stops7h 36m

$320

Quickest round-trip

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Tue 10/13

12:07 pm-6:20 pm

1 stop5h 13m

Knoxville McGhee Tyson

Sat 10/17

6:55 pm-12:41 am

1 stop6h 46m

$369

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Mon 11/2

12:39 pm-10:32 pm

1 stop7h 53m

Knoxville McGhee Tyson

Sat 11/7

5:03 pm-8:43 pm

1 stop5h 40m

$389

Rapid CityKnoxville

RAP Rapid City - TYS Knoxville McGhee Tyson

RAPTYS

Rapid City

Mon 11/2

5:00 am-4:59 pm

2 stops9h 59m

Knoxville McGhee Tyson

Sat 11/7

5:03 pm-8:43 pm

1 stop5h 40m

$394

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Mon 10/26

10:29 am-7:57 pm

1 stop8h 28m

Knoxville McGhee Tyson

Thu 10/29

9:11 pm-9:09 am

1 stop12h 58m

$428

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Mon 12/21

7:50 pm-10:46 pm

2 stops25h 56m

Knoxville McGhee Tyson

Thu 1/7

9:06 pm-9:07 am

1 stop13h 01m

$461

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Dakota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from South Dakota, with most prices found around $0. If you aren’t able to travel during the month of March, then book flights to Knoxville from South Dakota during April instead. Flights to Knoxville in April, while not as cheap as those in March, still average around $289.

Can stopping save me money on South Dakota to Knoxville flights?

You could potentially save up to 28% on your flight if you consider stops on a South Dakota to Knoxville flight.

Cheap South Dakota to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Knoxville

Best Price Found	$245
Fastest flight time	4h 41m
Direct flights	None

The best one-way flight to Knoxville from South Dakota in the past 72 hours is $245. The best round-trip flight deal from South Dakota to Knoxville found on momondo in the last 72 hours is $281.

The fastest flight from South Dakota to Knoxville takes 4h 41m

There are no direct flights from South Dakota to Knoxville. There are no popular flight routes from South Dakota to Knoxville.

Search flight deals

Frequently asked questions about flying from South Dakota to Knoxville

When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?
Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?
There are 3 operators available for flights from South Dakota to Knoxville McGhee Tyson Airport as of September 2026.
How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.0 12,097 reviews	Search American Airlines flights
Delta	PriceFrom $274	Free Cancellation	Rating 7.8 8,605 reviews	Search Delta flights
United Airlines	PriceFrom $279	Free Cancellation	Rating 7.4 10,245 reviews	Search United Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Alcoa

Crossville

Maryville

Murphy

Oak Ridge

Kodak

Newport

Lenoir City

Dandridge

Clinton

Rockford

Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Dakota to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Dakota to Knoxville with flexible booking policies on momondo?

Flights from South Dakota to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South Dakota to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from South Dakota. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Dakota to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

Thu 10/29

Thu 11/5

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States

Nearby airports

Airlines

Cabin classes

Other United States destinations

Other flights from South Dakota

Complete your trip

Feeling lucky

Airports servicing Tennessee

Nashville Intl Airport

Chattanooga Lovell Field Airport

Memphis Airport

Jackson Mckellar Field Airport

Blountville Tri Cities TN/VA Airport

Cheap flights from South Dakota to Knoxville from $245

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Knoxville departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Find the cheapest flights from South Dakota to Knoxville

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

American Airlines flights from South Dakota to Knoxville

Our best American Airlines deals on South Dakota to Knoxville flight tickets

Delta flights from South Dakota to Knoxville

Our best Delta deals on South Dakota to Knoxville flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

See travel insights to Knoxville from

How to get the cheapest flight ticket from South Dakota to Knoxville

What is the cheapest month to fly to Knoxville?

Can stopping save me money on South Dakota to Knoxville flights?

What is the cheapest airline that flies from South Dakota to Knoxville McGhee Tyson?

What airlines fly to Knoxville?

How many flights depart from South Dakota to Knoxville on average per week?

How long does it take to fly to Knoxville?

Cheap South Dakota to Knoxville flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from South Dakota to Knoxville

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo

Traveling to a place near Knoxville?

Why use momondo?

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Tennessee

Fly your favorite airline to Knoxville

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Knoxville

List of cabin classes available on flights landing in Knoxville. Availability may vary depending on flight origin and airline.

Popular cities in the United States

Popular flights according to clicks in the last 7 days on momondo

Fly to other destinations from South Dakota

According to popular flight searches on momondo this year

Complete your trip to Knoxville

Explore popular destinations other users love

According to popular flight searches on momondo this year