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Cheap flights from South Dakota to Knoxville from $319

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Knoxville departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Dakota to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:20 am - 11:11 am
FSD
-
TYS
4h 51m
1 stop
Delta Logo
6:30 am - 10:20 am
TYS
-
FSD
4h 50m
1 stop
$319Delta
Mon, Aug 3 - Mon, Aug 10
American Airlines Logo
5:35 pm - 11:55 pm
FSD
-
TYS
5h 20m
1 stop
American Airlines Logo
11:29 am - 4:10 pm
TYS
-
FSD
5h 41m
1 stop
$327American Airlines
Wed, Jun 10 - Wed, Jun 17
Delta Logo
4:28 pm - 11:00 pm
FSD
-
TYS
5h 32m
1 stop
Delta Logo
4:38 pm - 7:59 pm
TYS
-
FSD
4h 21m
1 stop
$329Delta
Mon, Aug 3 - Mon, Aug 10
United Airlines Logo
1:31 pm - 8:53 pm
RAP
-
TYS
5h 22m
1 stop
United Airlines Logo
7:00 am - 10:26 am
TYS
-
RAP
5h 26m
1 stop
$336United Airlines
Sat, Aug 22 - Tue, Aug 25
American Airlines Logo
5:35 pm - 11:55 pm
FSD
-
TYS
5h 20m
1 stop
American Airlines Logo
6:43 pm - 12:20 am
TYS
-
FSD
6h 37m
1 stop
$345American Airlines
Sat, Jun 13 - Tue, Jun 16
United Airlines Logo
1:31 pm - 8:53 pm
RAP
-
TYS
5h 22m
1 stop
United Airlines Logo
7:00 am - 5:53 pm
TYS
-
RAP
12h 53m
2 stops
$346United Airlines
Sat, Aug 22 - Tue, Aug 25
United Airlines Logo
7:00 am - 3:54 pm
RAP
-
TYS
6h 54m
1 stop
United Airlines Logo
4:50 pm - 10:23 pm
TYS
-
RAP
7h 33m
1 stop
$351United Airlines
Sat, Aug 22 - Tue, Aug 25
United Airlines Logo
7:00 am - 3:54 pm
RAP
-
TYS
6h 54m
1 stop
United Airlines Logo
5:45 am - 5:08 pm
TYS
-
RAP
13h 23m
2 stops
$356United Airlines
Sat, Aug 22 - Tue, Aug 25
American Airlines Logo
12:47 pm - 10:02 pm
RAP
-
TYS
7h 15m
1 stop
American Airlines Logo
5:36 am - 9:49 am
TYS
-
RAP
6h 13m
1 stop
$374American Airlines
Sat, May 23 - Wed, May 27
United Airlines Logo
1:19 pm - 10:38 pm
FSD
-
TYS
8h 19m
1 stop
United Airlines Logo
5:57 pm - 9:52 pm
TYS
-
FSD
4h 55m
1 stop
$374United Airlines
Sat, Sep 19 - Tue, Sep 22

Allegiant Air flights from South Dakota to Knoxville

Our best Allegiant Air deals on South Dakota to Knoxville flight tickets
Allegiant Air
Sep 17
FSD10:02 pmSioux Falls Joe Foss Field
19h 11m
1 stop
TYS6:13 pmKnoxville McGhee Tyson
Sep 24
TYS2:34 pmKnoxville McGhee Tyson
22h 04m
1 stop
FSD11:38 amSioux Falls Joe Foss Field
$438
Allegiant Air
Sep 20
FSD10:02 pmSioux Falls Joe Foss Field
16h 26m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
Sep 24
TYS2:34 pmKnoxville McGhee Tyson
22h 04m
1 stop
FSD11:38 amSioux Falls Joe Foss Field
$443
Allegiant Air
Jun 6
FSD6:10 pmSioux Falls Joe Foss Field
40h 06m
2 stops
TYS11:16 amKnoxville McGhee Tyson
Jun 12
TYS7:00 pmKnoxville McGhee Tyson
23h 20m
1 stop
FSD5:20 pmSioux Falls Joe Foss Field
$462

American Airlines flights from South Dakota to Knoxville

Our best American Airlines deals on South Dakota to Knoxville flight tickets
American Airlines
Jun 10
FSD5:35 pmSioux Falls Joe Foss Field
5h 20m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Jun 17
TYS11:29 amKnoxville McGhee Tyson
5h 41m
1 stop
FSD4:10 pmSioux Falls Joe Foss Field
$327
American Airlines
Jun 13
FSD5:35 pmSioux Falls Joe Foss Field
5h 20m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Jun 16
TYS6:43 pmKnoxville McGhee Tyson
6h 37m
1 stop
FSD12:20 amSioux Falls Joe Foss Field
$345
American Airlines
May 23
RAP12:47 pmRapid City
7h 15m
1 stop
TYS10:02 pmKnoxville McGhee Tyson
May 27
TYS5:36 amKnoxville McGhee Tyson
6h 13m
1 stop
RAP9:49 amRapid City
$374

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 8/3

5:20 am-11:11 am

1 stop4h 51m

Knoxville McGhee Tyson

Mon 8/10

6:30 am-10:20 am

1 stop4h 50m

$319

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 6/10

5:35 pm-11:55 pm

1 stop5h 20m

Knoxville McGhee Tyson

Wed 6/17

11:29 am-4:10 pm

1 stop5h 41m

$327

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 8/3

4:28 pm-11:00 pm

1 stop5h 32m

Knoxville McGhee Tyson

Mon 8/10

4:38 pm-7:59 pm

1 stop4h 21m

$329

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 8/22

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-10:26 am

1 stop5h 26m

$336

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 6/13

5:35 pm-11:55 pm

1 stop5h 20m

Knoxville McGhee Tyson

Tue 6/16

6:43 pm-12:20 am

1 stop6h 37m

$345

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 8/22

1:31 pm-8:53 pm

1 stop5h 22m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-5:53 pm

2 stops12h 53m

$346

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 8/22

7:00 am-3:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Tue 8/25

4:50 pm-10:23 pm

1 stop7h 33m

$351

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 8/22

7:00 am-3:54 pm

1 stop6h 54m

Knoxville McGhee Tyson

Tue 8/25

5:45 am-5:08 pm

2 stops13h 23m

$356

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 5/23

12:47 pm-10:02 pm

1 stop7h 15m

Knoxville McGhee Tyson

Wed 5/27

5:36 am-9:49 am

1 stop6h 13m

$374

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 9/19

1:19 pm-10:38 pm

1 stop8h 19m

Knoxville McGhee Tyson

Tue 9/22

5:57 pm-9:52 pm

1 stop4h 55m

$374

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from South Dakota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from South Dakota, with most prices found around $248. If you aren’t able to travel during the month of December, then book flights to Knoxville from South Dakota during November instead. Flights to Knoxville in November, while not as cheap as those in December, still average around $248.

Can stopping save me money on South Dakota to Knoxville flights?

You could potentially save up to 21% on your flight if you consider stops on a South Dakota to Knoxville flight.

Cheap South Dakota to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Knoxville

Fastest flight time

4h 24m

Direct flights

None
The fastest flight from South Dakota to Knoxville takes 4h 24m
There are no direct flights from South Dakota to Knoxville. There are no popular flight routes from South Dakota to Knoxville.
Search flight deals

Frequently asked questions about flying from South Dakota to Knoxville

  • When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?

    Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,661 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,446 reviews
Search Delta flights
United AirlinesPriceFrom $277Free CancellationRating
7.4
9,701 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Dakota to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Dakota to Knoxville with flexible booking policies on momondo?

Flights from South Dakota to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South Dakota to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from South Dakota. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Dakota to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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