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Cheap flights from South Dakota to Knoxville from $236

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Knoxville departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from South Dakota to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:10 pm - 10:44 pm
FSD
-
TYS
26h 34m
1 stop
Allegiant Air Logo
7:15 pm - 9:43 am
TYS
-
FSD
15h 28m
1 stop
$307Allegiant Air
Thu, Aug 6 - Fri, Aug 14
Delta Logo
5:15 am - 11:05 am
FSD
-
TYS
4h 50m
1 stop
Delta Logo
6:15 pm - 10:46 pm
TYS
-
FSD
5h 31m
1 stop
$311Delta
Tue, Aug 4 - Wed, Aug 12
Delta Logo
5:15 am - 11:05 am
FSD
-
TYS
4h 50m
1 stop
Delta Logo
5:30 am - 12:28 pm
TYS
-
FSD
7h 58m
2 stops
$316Delta
Tue, Aug 4 - Wed, Aug 12
Delta Logo
5:15 am - 11:05 am
FSD
-
TYS
4h 50m
1 stop
Delta Logo
6:15 pm - 10:46 pm
TYS
-
FSD
5h 31m
1 stop
$320Delta
Tue, Aug 4 - Thu, Aug 13
Delta Logo
1:30 pm - 11:52 pm
FSD
-
TYS
9h 22m
2 stops
Delta Logo
3:54 pm - 7:56 pm
TYS
-
FSD
5h 02m
1 stop
$330Delta
Tue, Jul 14 - Wed, Jul 22
Allegiant Air Logo
1:13 pm - 12:31 pm
FSD
-
TYS
22h 18m
1 stop
Allegiant Air Logo
7:15 pm - 9:43 am
TYS
-
FSD
15h 28m
1 stop
$336Allegiant Air
Wed, Aug 5 - Fri, Aug 14
United Airlines Logo
6:50 pm - 12:35 am
FSD
-
TYS
4h 45m
1 stop
United Airlines Logo
5:55 pm - 10:07 pm
TYS
-
FSD
5h 12m
1 stop
$337United Airlines
Fri, Jul 24 - Tue, Jul 28
American Airlines Logo
5:28 pm - 11:56 pm
FSD
-
TYS
5h 28m
1 stop
American Airlines Logo
7:50 am - 11:59 am
TYS
-
FSD
5h 09m
1 stop
$339American Airlines
Fri, Apr 10 - Tue, Apr 14
United Airlines Logo
12:00 pm - 11:41 pm
RAP
-
TYS
9h 41m
2 stops
United Airlines Logo
4:30 pm - 9:04 pm
TYS
-
RAP
6h 34m
1 stop
$344United Airlines
Wed, Apr 15 - Sat, Apr 18
American Airlines Logo
3:17 pm - 11:59 pm
FSD
-
TYS
7h 42m
2 stops
American Airlines Logo
12:11 pm - 7:09 pm
TYS
-
FSD
7h 58m
2 stops
$349American Airlines
Fri, Apr 10 - Tue, Apr 14

United Airlines flights from South Dakota to Knoxville

Our best United Airlines deals on South Dakota to Knoxville flight tickets
United Airlines
Jul 24
FSD6:50 pmSioux Falls Joe Foss Field
4h 45m
1 stop
TYS12:35 amKnoxville McGhee Tyson
Jul 28
TYS5:55 pmKnoxville McGhee Tyson
5h 12m
1 stop
FSD10:07 pmSioux Falls Joe Foss Field
$337
United Airlines
Apr 15
RAP12:00 pmRapid City
9h 41m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
Apr 18
TYS4:30 pmKnoxville McGhee Tyson
6h 34m
1 stop
RAP9:04 pmRapid City
$344
United Airlines
Apr 11
RAP7:00 amRapid City
6h 06m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Apr 15
TYS4:30 pmKnoxville McGhee Tyson
7h 58m
1 stop
RAP10:28 pmRapid City
$349

Allegiant Air flights from South Dakota to Knoxville

Our best Allegiant Air deals on South Dakota to Knoxville flight tickets
Allegiant Air
Aug 6
FSD7:10 pmSioux Falls Joe Foss Field
26h 34m
1 stop
TYS10:44 pmKnoxville McGhee Tyson
Aug 14
TYS7:15 pmKnoxville McGhee Tyson
15h 28m
1 stop
FSD9:43 amSioux Falls Joe Foss Field
$307
Allegiant Air
Mar 31
FSD2:31 pmSioux Falls Joe Foss Field
21h 14m
1 stop
TYS12:45 pmKnoxville McGhee Tyson
Apr 9
TYS5:10 pmKnoxville McGhee Tyson
25h 11m
1 stop
FSD5:21 pmSioux Falls Joe Foss Field
$309
Allegiant Air
Aug 5
FSD1:13 pmSioux Falls Joe Foss Field
22h 18m
1 stop
TYS12:31 pmKnoxville McGhee Tyson
Aug 14
TYS7:15 pmKnoxville McGhee Tyson
15h 28m
1 stop
FSD9:43 amSioux Falls Joe Foss Field
$336

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 8/6

7:10 pm-10:44 pm

1 stop26h 34m

Knoxville McGhee Tyson

Fri 8/14

7:15 pm-9:43 am

1 stop15h 28m

$307

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 8/4

5:15 am-11:05 am

1 stop4h 50m

Knoxville McGhee Tyson

Wed 8/12

6:15 pm-10:46 pm

1 stop5h 31m

$311

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 8/4

5:15 am-11:05 am

1 stop4h 50m

Knoxville McGhee Tyson

Wed 8/12

5:30 am-12:28 pm

2 stops7h 58m

$316

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 8/4

5:15 am-11:05 am

1 stop4h 50m

Knoxville McGhee Tyson

Thu 8/13

6:15 pm-10:46 pm

1 stop5h 31m

$320

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 7/14

1:30 pm-11:52 pm

2 stops9h 22m

Knoxville McGhee Tyson

Wed 7/22

3:54 pm-7:56 pm

1 stop5h 02m

$330

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 8/5

1:13 pm-12:31 pm

1 stop22h 18m

Knoxville McGhee Tyson

Fri 8/14

7:15 pm-9:43 am

1 stop15h 28m

$336
Quickest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 7/24

6:50 pm-12:35 am

1 stop4h 45m

Knoxville McGhee Tyson

Tue 7/28

5:55 pm-10:07 pm

1 stop5h 12m

$337

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 4/10

5:28 pm-11:56 pm

1 stop5h 28m

Knoxville McGhee Tyson

Tue 4/14

7:50 am-11:59 am

1 stop5h 09m

$339

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Wed 4/15

12:00 pm-11:41 pm

2 stops9h 41m

Knoxville McGhee Tyson

Sat 4/18

4:30 pm-9:04 pm

1 stop6h 34m

$344

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 4/10

3:17 pm-11:59 pm

2 stops7h 42m

Knoxville McGhee Tyson

Tue 4/14

12:11 pm-7:09 pm

2 stops7h 58m

$349

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Dakota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from South Dakota, with most prices found around $277. If you aren’t able to travel during the month of October, then book flights to Knoxville from South Dakota during September instead. Flights to Knoxville in September, while not as cheap as those in October, still average around $286.

Can stopping save me money on South Dakota to Knoxville flights?

You could potentially save up to 21% on your flight if you consider stops on a South Dakota to Knoxville flight.

Cheap South Dakota to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Knoxville

Fastest flight time

4h 40m

Direct flights

None
The fastest flight from South Dakota to Knoxville takes 4h 40m
There are no direct flights from South Dakota to Knoxville. There are no popular flight routes from South Dakota to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?

    Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,520 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,356 reviews
Search Delta flights
United AirlinesPriceFrom $277Free CancellationRating
7.4
9,499 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Dakota to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Dakota to Knoxville with flexible booking policies on momondo?

Flights from South Dakota to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South Dakota to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from South Dakota. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Dakota to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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