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Cheap flights from South Dakota to Knoxville from $212

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Knoxville departing on 2/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Dakota to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:17 pm - 9:21 pm
FSD
-
TYS
5h 04m
1 stop
American Airlines Logo
4:09 pm - 9:54 pm
TYS
-
FSD
6h 45m
1 stop
$269American Airlines
Sat, Apr 25 - Fri, May 1
American Airlines Logo
2:21 pm - 11:51 pm
RAP
-
TYS
7h 30m
1 stop
American Airlines Logo
6:00 am - 12:38 pm
TYS
-
RAP
8h 38m
1 stop
$279American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
5:19 pm - 12:28 am
FSD
-
TYS
6h 09m
1 stop
American Airlines Logo
7:51 am - 1:36 pm
TYS
-
FSD
6h 45m
1 stop
$279American Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
11:53 am - 11:59 pm
RAP
-
TYS
10h 06m
2 stops
American Airlines Logo
4:09 pm - 9:58 pm
TYS
-
RAP
7h 49m
1 stop
$284American Airlines
Wed, Apr 15 - Tue, Apr 21
United Airlines Logo
12:10 pm - 8:45 pm
RAP
-
TYS
6h 35m
1 stop
United Airlines Logo
4:20 pm - 9:55 pm
TYS
-
RAP
7h 35m
1 stop
$304United Airlines
Tue, May 5 - Sat, May 9
United Airlines Logo
11:21 am - 11:44 pm
FSD
-
TYS
11h 23m
2 stops
United Airlines Logo
6:45 am - 10:46 am
TYS
-
FSD
5h 01m
1 stop
$317United Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
2:21 pm - 11:51 pm
RAP
-
TYS
7h 30m
1 stop
American Airlines Logo
5:00 am - 11:23 am
TYS
-
RAP
8h 23m
2 stops
$330American Airlines
Sat, Apr 4 - Wed, Apr 8
United Airlines Logo
3:10 pm - 10:29 pm
FSD
-
TYS
6h 19m
1 stop
United Airlines Logo
7:00 am - 10:42 am
TYS
-
FSD
4h 42m
1 stop
$339United Airlines
Sat, Apr 25 - Sat, May 2
Delta Logo
1:44 pm - 10:21 am
FSD
-
TYS
19h 37m
2 stops
Delta Logo
5:24 pm - 11:02 pm
TYS
-
FSD
6h 38m
2 stops
$404Delta
Sat, Apr 25 - Fri, May 1
Delta Logo
4:29 pm - 11:12 pm
RAP
-
TYS
4h 43m
1 stop
Delta Logo
6:35 am - 10:09 am
TYS
-
RAP
5h 34m
1 stop
$501Delta
Sun, Feb 22 - Thu, Feb 26

American Airlines flights from South Dakota to Knoxville

Our best American Airlines deals on South Dakota to Knoxville flight tickets
American Airlines
Apr 25
FSD3:17 pmSioux Falls Joe Foss Field
5h 04m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
May 1
TYS4:09 pmKnoxville McGhee Tyson
6h 45m
1 stop
FSD9:54 pmSioux Falls Joe Foss Field
$269
American Airlines
Apr 4
RAP2:21 pmRapid City
7h 30m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Apr 8
TYS6:00 amKnoxville McGhee Tyson
8h 38m
1 stop
RAP12:38 pmRapid City
$279
American Airlines
Apr 15
RAP11:53 amRapid City
10h 06m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Apr 21
TYS4:09 pmKnoxville McGhee Tyson
7h 49m
1 stop
RAP9:58 pmRapid City
$284

Delta flights from South Dakota to Knoxville

Our best Delta deals on South Dakota to Knoxville flight tickets
Delta
Apr 25
FSD1:44 pmSioux Falls Joe Foss Field
19h 37m
2 stops
TYS10:21 amKnoxville McGhee Tyson
May 1
TYS5:24 pmKnoxville McGhee Tyson
6h 38m
2 stops
FSD11:02 pmSioux Falls Joe Foss Field
$404
Delta
Feb 22
RAP4:29 pmRapid City
4h 43m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
Feb 26
TYS6:35 amKnoxville McGhee Tyson
5h 34m
1 stop
RAP10:09 amRapid City
$501
Delta
Apr 3
RAP4:01 pmRapid City
5h 02m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
Apr 7
TYS8:33 amKnoxville McGhee Tyson
8h 45m
2 stops
RAP3:18 pmRapid City
$504

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 4/25

3:17 pm-9:21 pm

1 stop5h 04m

Knoxville McGhee Tyson

Fri 5/1

4:09 pm-9:54 pm

1 stop6h 45m

$269

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 4/4

2:21 pm-11:51 pm

1 stop7h 30m

Knoxville McGhee Tyson

Wed 4/8

6:00 am-12:38 pm

1 stop8h 38m

$279

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 2/21

5:19 pm-12:28 am

1 stop6h 09m

Knoxville McGhee Tyson

Wed 2/25

7:51 am-1:36 pm

1 stop6h 45m

$279

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Wed 4/15

11:53 am-11:59 pm

2 stops10h 06m

Knoxville McGhee Tyson

Tue 4/21

4:09 pm-9:58 pm

1 stop7h 49m

$284

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Tue 5/5

12:10 pm-8:45 pm

1 stop6h 35m

Knoxville McGhee Tyson

Sat 5/9

4:20 pm-9:55 pm

1 stop7h 35m

$304

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 2/21

11:21 am-11:44 pm

2 stops11h 23m

Knoxville McGhee Tyson

Wed 2/25

6:45 am-10:46 am

1 stop5h 01m

$317

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sat 4/4

2:21 pm-11:51 pm

1 stop7h 30m

Knoxville McGhee Tyson

Wed 4/8

5:00 am-11:23 am

2 stops8h 23m

$330

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 4/25

3:10 pm-10:29 pm

1 stop6h 19m

Knoxville McGhee Tyson

Sat 5/2

7:00 am-10:42 am

1 stop4h 42m

$339

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 4/25

1:44 pm-10:21 am

2 stops19h 37m

Knoxville McGhee Tyson

Fri 5/1

5:24 pm-11:02 pm

2 stops6h 38m

$404

Rapid CityKnoxville

RAP - TYS

RAPTYS

Rapid City

Sun 2/22

4:29 pm-11:12 pm

1 stop4h 43m

Knoxville McGhee Tyson

Thu 2/26

6:35 am-10:09 am

1 stop5h 34m

$501

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Dakota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from South Dakota, with most prices found around $263. If you aren’t able to travel during the month of October, then book flights to Knoxville from South Dakota during September instead. Flights to Knoxville in September, while not as cheap as those in October, still average around $286.

Can stopping save me money on South Dakota to Knoxville flights?

You could potentially save up to 2% on your flight if you consider stops on a South Dakota to Knoxville flight.

Cheap South Dakota to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Knoxville

Fastest flight time

4h 41m

Direct flights

None
The fastest flight from South Dakota to Knoxville takes 4h 41m
There are no direct flights from South Dakota to Knoxville. There are no popular flight routes from South Dakota to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from South Dakota to Knoxville McGhee Tyson Airport?

    Prices for flights from South Dakota to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from South Dakota to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Dakota to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Dakota to Knoxville

Compare and see reviews for airlines that fly from South Dakota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,255 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,173 reviews
Search Delta flights
United AirlinesPriceFrom $277Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Dakota to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Dakota to Knoxville with flexible booking policies on momondo?

Flights from South Dakota to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from South Dakota to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from South Dakota. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Dakota to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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