Cheap flights from South Carolina to Chicago from $48

The month of August is, on average, the cheapest month to fly to Chicago from South Carolina, with most prices found around $284. If you’re not able to fly to Chicago in August, then September is your next best option. Flight prices from South Carolina to Chicago during September average around $294.

The cheapest day to depart on your flight to Chicago is on a Friday when prices can be found for as low as $403. This is often the case because there is less demand to fly during this day of the week. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Chicago for around $655.

Our most recent data shows that the best time of day to fly to Chicago is in the evening. Flights from South Carolina to Chicago during this time can be as low as $386. In contrast, the most expensive time of day to depart to Chicago is at noon when prices are around $600.

Fly from Myrtle Beach Intl to Chicago Midway for the best South Carolina - Chicago flight prices

You are more likely to see cheaper flights to Chicago from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $361 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from South Carolina for as low as $268 on momondo.

There are 4 cabin classes available to choose from on South Carolina to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Southwest, and Delta are the most popular carriers operating from South Carolina to Chicago

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Chicago from South Carolina according to our data. United Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 5 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

As of February 2026, 87 flights take off from South Carolina and land in Chicago each day. The most common flight departure time for this route is 6:00AM, with 50% of daily flights taking off at noon.

The number of flights available between South Carolina and Chicago is 614 per week as of February 2026. The most frequent departure day is Thu, with 17% of weekly flights leaving on this day.