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Cheap flights from Santo Domingo to South Carolina from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to South Carolina departing on 2/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santo Domingo to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$312Spirit Airlines
Sun, Feb 1 - Sat, Feb 7
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$314Spirit Airlines
Wed, Jan 21 - Sun, Jan 25
Spirit Airlines Logo
3:32 pm - 12:40 am
SDQ
-
CLT
10h 08m1 stop
Spirit Airlines Logo
6:00 am - 2:27 pm
CLT
-
SDQ
7h 27m1 stop
$318Spirit Airlines
Wed, Jan 28 - Wed, Feb 4
Multiple Airlines Logo
6:04 pm - 4:38 pm
SDQ
-
CLT
23h 34m1 stop
Multiple Airlines Logo
9:04 pm - 1:57 pm
CLT
-
SDQ
39h 53m2 stops
$323Multiple Airlines
Mon, Dec 29 - Wed, Jan 7
Multiple Airlines Logo
2:25 pm - 8:01 am
SDQ
-
CLT
18h 36m1 stop
Multiple Airlines Logo
7:00 am - 2:20 pm
CLT
-
SDQ
6h 20m1 stop
$331Multiple Airlines
Sat, Feb 14 - Mon, Feb 23
American Airlines Logo
3:25 pm - 10:42 pm
SDQ
-
CHS
7h 17m1 stop
American Airlines Logo
8:08 pm - 10:50 am
CHS
-
SDQ
14h 42m1 stop
$344American Airlines
Fri, May 1 - Mon, May 4
JetBlue Logo
9:50 pm - 9:20 am
SDQ
-
CHS
12h 30m1 stop
JetBlue Logo
10:10 am - 8:21 pm
CHS
-
SDQ
9h 11m1 stop
$421JetBlue
Thu, Jan 29 - Mon, Feb 2
American Airlines Logo
1:28 pm - 11:28 pm
SDQ
-
CHS
10h 00m2 stops
American Airlines Logo
8:08 pm - 10:50 am
CHS
-
SDQ
14h 42m1 stop
$455American Airlines
Fri, May 1 - Mon, May 4
Delta Logo
2:40 pm - 9:10 pm
SDQ
-
CAE
6h 30m1 stop
Delta Logo
7:00 am - 1:15 pm
CAE
-
SDQ
6h 15m1 stop
$952Delta
Sun, Mar 29 - Sun, Apr 5
Delta Logo
2:40 pm - 9:10 pm
SDQ
-
CAE
6h 30m1 stop
Delta Logo
5:30 am - 5:35 pm
CAE
-
SDQ
12h 05m2 stops
$1,070Delta
Sun, Mar 29 - Sun, Apr 5

Spirit Airlines flights from Santo Domingo to South Carolina

Our best Spirit Airlines deals on Santo Domingo to South Carolina flight tickets
Spirit Airlines
Feb 1
SDQ3:32 pmSanto Domingo Las Americas
10h 08m
1 stop
CLT12:40 amCharlotte Douglas
Feb 7
CLT6:00 amCharlotte Douglas
7h 27m
1 stop
SDQ2:27 pmSanto Domingo Las Americas
$312
Find similar
Spirit Airlines
Jan 21
SDQ3:32 pmSanto Domingo Las Americas
10h 08m
1 stop
CLT12:40 amCharlotte Douglas
Jan 25
CLT6:00 amCharlotte Douglas
7h 27m
1 stop
SDQ2:27 pmSanto Domingo Las Americas
$314
Find similar
Spirit Airlines
Jan 28
SDQ3:32 pmSanto Domingo Las Americas
10h 08m
1 stop
CLT12:40 amCharlotte Douglas
Feb 4
CLT6:00 amCharlotte Douglas
7h 27m
1 stop
SDQ2:27 pmSanto Domingo Las Americas
$318
Find similar

Frontier flights from Santo Domingo to South Carolina

Our best Frontier deals on Santo Domingo to South Carolina flight tickets
Frontier
Dec 29
SDQ6:04 pmSanto Domingo Las Americas
23h 34m
1 stop
CLT4:38 pmCharlotte Douglas
Jan 5
CLT10:38 pmCharlotte Douglas
13h 17m
1 stop
SDQ12:55 pmSanto Domingo Las Americas
$341
Find similar
Frontier
Dec 23
SDQ12:35 pmSanto Domingo Las Americas
8h 54m
1 stop
CLT8:29 pmCharlotte Douglas
Jan 4
CLT10:26 amCharlotte Douglas
8h 01m
1 stop
SDQ7:27 pmSanto Domingo Las Americas
$354
Find similar
Frontier
Dec 20
SDQ12:25 pmSanto Domingo Las Americas
21h 04m
1 stop
CLT8:29 amCharlotte Douglas
Jan 8
CLT1:30 pmCharlotte Douglas
23h 27m
1 stop
SDQ1:57 pmSanto Domingo Las Americas
$379
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sun 2/1

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Sat 2/7

6:00 am-2:27 pm

1 stop7h 27m

$312

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 1/21

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Sun 1/25

6:00 am-2:27 pm

1 stop7h 27m

$314

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 1/28

3:32 pm-12:40 am

1 stop10h 08m

Charlotte Douglas

Wed 2/4

6:00 am-2:27 pm

1 stop7h 27m

$318

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Mon 12/29

6:04 pm-4:38 pm

1 stop23h 34m

Charlotte Douglas

Wed 1/7

9:04 pm-1:57 pm

2 stops39h 53m

$323

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sat 2/14

2:25 pm-8:01 am

1 stop18h 36m

Charlotte Douglas

Mon 2/23

7:00 am-2:20 pm

1 stop6h 20m

$331

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

3:25 pm-10:42 pm

1 stop7h 17m

Charleston

Mon 5/4

8:08 pm-10:50 am

1 stop14h 42m

$344

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 1/29

9:50 pm-9:20 am

1 stop12h 30m

Charleston

Mon 2/2

10:10 am-8:21 pm

1 stop9h 11m

$421

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 5/1

1:28 pm-11:28 pm

2 stops10h 00m

Charleston

Mon 5/4

8:08 pm-10:50 am

1 stop14h 42m

$455

Santo DomingoColumbia

SDQ - CAE

SDQCAE

Santo Domingo Las Americas

Sun 3/29

2:40 pm-9:10 pm

1 stop6h 30m

Columbia Metropolitan

Sun 4/5

7:00 am-1:15 pm

1 stop6h 15m

$952

Santo DomingoColumbia

SDQ - CAE

SDQCAE

Santo Domingo Las Americas

Sun 3/29

2:40 pm-9:10 pm

1 stop6h 30m

Columbia Metropolitan

Sun 4/5

5:30 am-5:35 pm

2 stops12h 05m

$1,070

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Santo Domingo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $344. The most expensive day to fly to South Carolina is Tuesday, with ticket prices averaging around $542.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Santo Domingo to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $365. Try not to purchase tickets in the morning because they tend to be around $542. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Santo Domingo to South Carolina flights?

You could potentially save up to 25% on your flight if you consider stops on a Santo Domingo to South Carolina flight.

Cheap Santo Domingo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to South Carolina

Fastest flight time

6h 30m

Direct flights

None
The fastest flight from Santo Domingo to South Carolina takes 6h 30m
There are no direct flights from Santo Domingo to South Carolina. There are no popular flight routes from Santo Domingo to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to South Carolina?

    Prices for flights from Santo Domingo Las Americas Airport to South Carolina were last updated today.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to South Carolina?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santo Domingo Las Americas Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Santo Domingo to South Carolina

Compare and see reviews for airlines that fly from Santo Domingo to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $494Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Santo Domingo.

Can I find flights from Santo Domingo to South Carolina with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South Carolina from Santo Domingo with this policy.

How can momondo help me find flights from Santo Domingo to South Carolina?

momondo helps you find the best flight between Santo Domingo and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santo Domingo to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santo Domingo to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

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