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Cheap flights from Santo Domingo to South Carolina from $116

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santo Domingo to South Carolina departing on 9/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santo Domingo to South Carolina

Cheap round-trip flights

Spirit Airlines Logo
3:47 pm - 10:59 pmSDQ-CLT
7h 12m1 stop
Spirit Airlines Logo
5:45 am - 2:42 pmCLT-SDQ
8h 57m1 stop
$272Spirit Airlines
Find Deal
Sat, Sep 6 - Sat, Sep 20
Spirit Airlines Logo
5:05 pm - 9:22 amSDQ-CLT
16h 17m1 stop
Spirit Airlines Logo
10:46 am - 4:00 pmCLT-SDQ
5h 14m1 stop
$281Spirit Airlines
Find Deal
Tue, Sep 9 - Wed, Sep 24
Logo
5:05 pm - 7:55 amSDQ-CLT
14h 50m2 stops
Logo
6:15 am - 2:48 pmCLT-SDQ
8h 33m1 stop
$352
Find Deal
Wed, Oct 1 - Wed, Oct 8
JetBlue Logo
2:34 pm - 8:54 amSDQ-CHS
18h 20m1 stop
JetBlue Logo
9:40 am - 1:17 pmCHS-SDQ
27h 37m1 stop
$377JetBlue
Find Deal
Thu, Oct 16 - Sat, Oct 25
Logo
3:54 pm - 9:26 amSDQ-CHS
17h 32m1 stop
Logo
7:36 pm - 9:45 pmCHS-SDQ
26h 09m2 stops
$392
Find Deal
Thu, Oct 16 - Sat, Oct 25
JetBlue Logo
4:10 am - 10:27 pmSDQ-CHS
19h 17m1 stop
JetBlue Logo
5:20 pm - 10:32 amCHS-SDQ
16h 12m1 stop
$479JetBlue
Find Deal
Fri, Nov 7 - Fri, Nov 14
American Airlines Logo
10:25 am - 12:05 amSDQ-CHS
13h 40m2 stops
American Airlines Logo
5:00 am - 3:20 pmCHS-SDQ
10h 20m2 stops
$490American Airlines
Find Deal
Thu, Oct 16 - Sat, Oct 25
Delta Logo
3:40 pm - 10:03 pmSDQ-CHS
7h 23m1 stop
Delta Logo
12:15 pm - 11:59 pmCHS-SDQ
10h 44m2 stops
$492Delta
Find Deal
Thu, Feb 5 - Sat, Feb 7
American Airlines Logo
6:00 am - 6:03 pmSDQ-CHS
13h 03m2 stops
American Airlines Logo
5:45 am - 3:55 pmCHS-SDQ
9h 10m2 stops
$536American Airlines
Find Deal
Sat, Nov 8 - Fri, Nov 14
Delta Logo
2:47 pm - 11:41 pmSDQ-CAE
8h 54m1 stop
Delta Logo
1:00 pm - 12:57 amCAE-SDQ
11h 57m2 stops
$1,186Delta
Find Deal
Fri, Aug 29 - Sun, Sep 7

Spirit Airlines flights from Santo Domingo to South Carolina

Our best Spirit Airlines deals on Santo Domingo to South Carolina flight tickets
Spirit Airlines
Sep 6
SDQ3:47 pmSanto Domingo Las Americas
7h 12m
1 stop
CLT10:59 pmCharlotte Douglas
Sep 20
CLT5:45 amCharlotte Douglas
8h 57m
1 stop
SDQ2:42 pmSanto Domingo Las Americas
$272
Find similar
Spirit Airlines
Sep 9
SDQ5:05 pmSanto Domingo Las Americas
16h 17m
1 stop
CLT9:22 amCharlotte Douglas
Sep 24
CLT10:46 amCharlotte Douglas
5h 14m
1 stop
SDQ4:00 pmSanto Domingo Las Americas
$281
Find similar
Spirit Airlines
Aug 29
SDQ5:05 pmSanto Domingo Las Americas
6h 50m
1 stop
CLT11:55 pmCharlotte Douglas
Sep 1
CLT6:00 amCharlotte Douglas
5h 56m
1 stop
SDQ11:56 amSanto Domingo Las Americas
$285
Find similar

JetBlue flights from Santo Domingo to South Carolina

Our best JetBlue deals on Santo Domingo to South Carolina flight tickets
JetBlue
Oct 16
SDQ2:34 pmSanto Domingo Las Americas
18h 20m
1 stop
CHS8:54 amCharleston
Oct 25
CHS9:40 amCharleston
27h 37m
1 stop
SDQ1:17 pmSanto Domingo Las Americas
$377
Find similar
JetBlue
Nov 7
SDQ4:10 amSanto Domingo Las Americas
19h 17m
1 stop
CHS10:27 pmCharleston
Nov 14
CHS5:20 pmCharleston
16h 12m
1 stop
SDQ10:32 amSanto Domingo Las Americas
$479
Find similar
JetBlue
Feb 4
SDQ2:35 amSanto Domingo Las Americas
9h 44m
1 stop
CHS11:19 amCharleston
Feb 7
CHS6:19 pmCharleston
8h 35m
1 stop
SDQ3:54 amSanto Domingo Las Americas
$488
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santo Domingo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Santo Domingo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Sat 9/6

3:47 pm-10:59 pm

1 stop7h 12m

Charlotte Douglas

Sat 9/20

5:45 am-2:42 pm

1 stop8h 57m

$272

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Tue 9/9

5:05 pm-9:22 am

1 stop16h 17m

Charlotte Douglas

Wed 9/24

10:46 am-4:00 pm

1 stop5h 14m

$281

Santo DomingoCharlotte

SDQ - CLT

SDQCLT

Santo Domingo Las Americas

Wed 10/1

5:05 pm-7:55 am

2 stops14h 50m

Charlotte Douglas

Wed 10/8

6:15 am-2:48 pm

1 stop8h 33m

$352

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 10/16

2:34 pm-8:54 am

1 stop18h 20m

Charleston

Sat 10/25

9:40 am-1:17 pm

1 stop27h 37m

$377

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 10/16

3:54 pm-9:26 am

1 stop17h 32m

Charleston

Sat 10/25

7:36 pm-9:45 pm

2 stops26h 09m

$392

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Fri 11/7

4:10 am-10:27 pm

1 stop19h 17m

Charleston

Fri 11/14

5:20 pm-10:32 am

1 stop16h 12m

$479

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 10/16

10:25 am-12:05 am

2 stops13h 40m

Charleston

Sat 10/25

5:00 am-3:20 pm

2 stops10h 20m

$490

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Thu 2/5

3:40 pm-10:03 pm

1 stop7h 23m

Charleston

Sat 2/7

12:15 pm-11:59 pm

2 stops10h 44m

$492

Santo DomingoCharleston

SDQ - CHS

SDQCHS

Santo Domingo Las Americas

Sat 11/8

6:00 am-6:03 pm

2 stops13h 03m

Charleston

Fri 11/14

5:45 am-3:55 pm

2 stops9h 10m

$536

Santo DomingoColumbia

SDQ - CAE

SDQCAE

Santo Domingo Las Americas

Fri 8/29

2:47 pm-11:41 pm

1 stop8h 54m

Columbia Metropolitan

Sun 9/7

1:00 pm-12:57 am

2 stops11h 57m

$1,186

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Santo Domingo to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $344. The most expensive day to fly to South Carolina is Tuesday, with ticket prices averaging around $542.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Santo Domingo to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $365. Try not to purchase tickets in the morning because they tend to be around $542. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Santo Domingo to South Carolina flights?

You could potentially save up to 53% on your flight if you consider stops on a Santo Domingo to South Carolina flight.

Cheap Santo Domingo to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santo Domingo to South Carolina

Best Price Found

$116

Fastest flight time

5h 53m

Direct flights

None

Airports in South Carolina

3 airports
The best one-way flight to South Carolina from Santo Domingo in the past 72 hours is $116. The best round-trip flight deal from Santo Domingo to South Carolina found on momondo in the last 72 hours is $272.
The fastest flight from Santo Domingo to South Carolina takes 5h 53m
There are no direct flights from Santo Domingo to South Carolina. Popular non-direct routes for this connection are Santo Domingo Las Americas Airport - Charleston Airport and Santo Domingo Las Americas Airport - Charlotte Douglas Airport.
There are 3 airports near South Carolina: Columbia Metropolitan (CAE), Charlotte Douglas (CLT), Charleston (CHS)
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  • When did momondo last update prices for flights from Santo Domingo Las Americas Airport to South Carolina?

    Prices for flights from Santo Domingo Las Americas Airport to South Carolina were last updated today.

  • How many operators does momondo search for flights from Santo Domingo Las Americas Airport to South Carolina?

  • How old do you have to be to fly from Santo Domingo Las Americas Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santo Domingo Las Americas Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Santo Domingo to South Carolina

Compare and see reviews for airlines that fly from Santo Domingo to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $264Free CancellationRating
8.0
7,981 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Santo Domingo to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Santo Domingo.

Can I find flights from Santo Domingo to South Carolina with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South Carolina from Santo Domingo with this policy.

How can momondo help me find flights from Santo Domingo to South Carolina?

momondo helps you find the best flight between Santo Domingo and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santo Domingo to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santo Domingo to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

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