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Cheap flights from Santiago to Knoxville from $428

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Knoxville departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

American Airlines Logo
9:55 pm - 11:39 pmSCL-TYS
26h 44m1 stop
American Airlines Logo
12:34 pm - 8:05 amTYS-SCL
18h 31m1 stop
$697American Airlines
Find Deal
Mon, Oct 20 - Mon, Oct 27
American Airlines Logo
9:55 pm - 11:39 pmSCL-TYS
26h 44m1 stop
American Airlines Logo
12:34 pm - 8:05 amTYS-SCL
18h 31m1 stop
$698American Airlines
Find Deal
Mon, Oct 20 - Mon, Oct 27
American Airlines Logo
9:55 pm - 5:33 pmSCL-TYS
20h 38m2 stops
American Airlines Logo
12:34 pm - 8:05 amTYS-SCL
18h 31m1 stop
$702American Airlines
Find Deal
Mon, Oct 20 - Mon, Oct 27
Delta Logo
12:20 am - 8:10 pmSCL-TYS
20h 50m2 stops
Delta Logo
10:05 am - 7:40 amTYS-SCL
19h 35m1 stop
$705Delta
Find Deal
Wed, Oct 29 - Thu, Nov 6
LATAM Airlines Logo
12:10 am - 9:56 pmSCL-TYS
22h 46m2 stops
LATAM Airlines Logo
5:16 pm - 5:25 pmTYS-SCL
23h 09m2 stops
$717LATAM Airlines
Find Deal
Sun, Oct 19 - Mon, Oct 27
LATAM Airlines Logo
12:10 am - 11:46 pmSCL-TYS
24h 36m2 stops
LATAM Airlines Logo
11:35 am - 7:40 amTYS-SCL
19h 05m1 stop
$718LATAM Airlines
Find Deal
Sun, Oct 19 - Mon, Oct 27
Delta Logo
11:25 pm - 3:06 pmSCL-TYS
17h 41m2 stops
Delta Logo
12:00 pm - 5:35 amTYS-SCL
16h 35m2 stops
$725Delta
Find Deal
Tue, Mar 3 - Wed, Mar 18
United Airlines Logo
10:45 pm - 11:19 pmSCL-TYS
26h 34m1 stop
United Airlines Logo
7:00 am - 7:50 amTYS-SCL
23h 50m1 stop
$729United Airlines
Find Deal
Wed, Mar 4 - Wed, Mar 18
American Airlines Logo
9:55 pm - 11:39 pmSCL-TYS
26h 44m1 stop
American Airlines Logo
6:00 am - 8:05 amTYS-SCL
25h 05m1 stop
$737American Airlines
Find Deal
Tue, Oct 21 - Sun, Oct 26
American Airlines Logo
9:55 pm - 11:39 pmSCL-TYS
26h 44m1 stop
American Airlines Logo
12:34 pm - 8:05 amTYS-SCL
18h 31m1 stop
$738American Airlines
Find Deal
Tue, Oct 21 - Sun, Oct 26

American Airlines flights from Santiago to Knoxville

Our best American Airlines deals on Santiago to Knoxville flight tickets
American Airlines
Oct 20
SCL9:55 pmSantiago Arturo Merino Benitez
26h 44m
1 stop
TYS11:39 pmKnoxville McGhee Tyson
Oct 27
TYS12:34 pmKnoxville McGhee Tyson
18h 31m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
$697
Find similar
American Airlines
Oct 20
SCL9:55 pmSantiago Arturo Merino Benitez
26h 44m
1 stop
TYS11:39 pmKnoxville McGhee Tyson
Oct 27
TYS12:34 pmKnoxville McGhee Tyson
18h 31m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
$698
Find similar
American Airlines
Oct 20
SCL9:55 pmSantiago Arturo Merino Benitez
20h 38m
2 stops
TYS5:33 pmKnoxville McGhee Tyson
Oct 27
TYS12:34 pmKnoxville McGhee Tyson
18h 31m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
$702
Find similar

LATAM Airlines flights from Santiago to Knoxville

Our best LATAM Airlines deals on Santiago to Knoxville flight tickets
LATAM Airlines
Oct 19
SCL12:10 amSantiago Arturo Merino Benitez
22h 46m
2 stops
TYS9:56 pmKnoxville McGhee Tyson
Oct 27
TYS5:16 pmKnoxville McGhee Tyson
23h 09m
2 stops
SCL5:25 pmSantiago Arturo Merino Benitez
$717
Find similar
LATAM Airlines
Oct 19
SCL12:10 amSantiago Arturo Merino Benitez
24h 36m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
Oct 27
TYS11:35 amKnoxville McGhee Tyson
19h 05m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$718
Find similar
LATAM Airlines
Oct 20
SCL12:10 amSantiago Arturo Merino Benitez
23h 57m
2 stops
TYS11:07 pmKnoxville McGhee Tyson
Oct 26
TYS8:10 pmKnoxville McGhee Tyson
16h 45m
2 stops
SCL1:55 pmSantiago Arturo Merino Benitez
$758
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 10/20

9:55 pm-11:39 pm

1 stop26h 44m

Knoxville McGhee Tyson

Mon 10/27

12:34 pm-8:05 am

1 stop18h 31m

$697

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 10/20

9:55 pm-11:39 pm

1 stop26h 44m

Knoxville McGhee Tyson

Mon 10/27

12:34 pm-8:05 am

1 stop18h 31m

$698

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 10/20

9:55 pm-5:33 pm

2 stops20h 38m

Knoxville McGhee Tyson

Mon 10/27

12:34 pm-8:05 am

1 stop18h 31m

$702

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 10/29

12:20 am-8:10 pm

2 stops20h 50m

Knoxville McGhee Tyson

Thu 11/6

10:05 am-7:40 am

1 stop19h 35m

$705

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 10/19

12:10 am-9:56 pm

2 stops22h 46m

Knoxville McGhee Tyson

Mon 10/27

5:16 pm-5:25 pm

2 stops23h 09m

$717

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 10/19

12:10 am-11:46 pm

2 stops24h 36m

Knoxville McGhee Tyson

Mon 10/27

11:35 am-7:40 am

1 stop19h 05m

$718

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 3/3

11:25 pm-3:06 pm

2 stops17h 41m

Knoxville McGhee Tyson

Wed 3/18

12:00 pm-5:35 am

2 stops16h 35m

$725

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 3/4

10:45 pm-11:19 pm

1 stop26h 34m

Knoxville McGhee Tyson

Wed 3/18

7:00 am-7:50 am

1 stop23h 50m

$729

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 10/21

9:55 pm-11:39 pm

1 stop26h 44m

Knoxville McGhee Tyson

Sun 10/26

6:00 am-8:05 am

1 stop25h 05m

$737

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 10/21

9:55 pm-11:39 pm

1 stop26h 44m

Knoxville McGhee Tyson

Sun 10/26

12:34 pm-8:05 am

1 stop18h 31m

$738

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santiago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson?

LATAM Airlines, Delta, and United Airlines are the most popular carriers operating from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson

When to book flights from Santiago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Knoxville (SCL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Knoxville

Direct flights

None
There are no direct flights from Santiago to Knoxville. There are no popular flight routes from Santiago to Knoxville.
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  • How far is Santiago Arturo Merino Benitez to Knoxville McGhee Tyson by plane?

    The distance between Santiago Arturo Merino Benitez and Knoxville McGhee Tyson is about 4868.2 mi. By plane, this route typically takes 11h 58m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santiago to Knoxville for you.

Can I find flights from Santiago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Santiago with this policy.

How can momondo help me find flights from Santiago to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santiago.

I’m not ready to book a flight from Santiago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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