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Cheap flights from Santiago to Knoxville from $537

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Knoxville departing on 2/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
8:10 am - 11:52 pm
SCL
-
TYS
17h 42m2 stops
LATAM Airlines Logo
6:41 pm - 3:30 pm
TYS
-
SCL
18h 49m2 stops
$714LATAM Airlines
Thu, Feb 26 - Mon, Mar 2
LATAM Airlines Logo
10:15 pm - 11:45 pm
SCL
-
TYS
27h 30m2 stops
LATAM Airlines Logo
11:58 am - 2:20 pm
TYS
-
SCL
24h 22m2 stops
$715LATAM Airlines
Wed, Jan 21 - Thu, Jan 29
United Airlines Logo
10:45 pm - 1:46 pm
SCL
-
TYS
17h 01m1 stop
United Airlines Logo
4:55 pm - 8:50 am
TYS
-
SCL
13h 55m1 stop
$764United Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
10:30 pm - 11:34 am
SCL
-
TYS
15h 04m1 stop
American Airlines Logo
12:19 pm - 8:15 am
TYS
-
SCL
17h 56m1 stop
$765American Airlines
Wed, Jan 21 - Thu, Jan 29
United Airlines Logo
10:45 pm - 3:15 pm
SCL
-
TYS
18h 30m2 stops
United Airlines Logo
4:55 pm - 8:50 am
TYS
-
SCL
13h 55m1 stop
$769United Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
10:30 pm - 2:32 pm
SCL
-
TYS
18h 02m2 stops
American Airlines Logo
2:17 pm - 9:00 am
TYS
-
SCL
16h 43m2 stops
$804American Airlines
Wed, Jan 21 - Thu, Jan 29
United Airlines Logo
10:45 pm - 4:52 pm
SCL
-
TYS
20h 07m2 stops
United Airlines Logo
11:41 am - 8:50 am
TYS
-
SCL
19h 09m1 stop
$819United Airlines
Thu, Feb 26 - Mon, Mar 2
United Airlines Logo
10:45 pm - 7:50 pm
SCL
-
TYS
23h 05m1 stop
United Airlines Logo
11:40 am - 8:50 am
TYS
-
SCL
19h 10m1 stop
$835United Airlines
Wed, Jan 21 - Thu, Jan 29

United Airlines flights from Santiago to Knoxville

Our best United Airlines deals on Santiago to Knoxville flight tickets
United Airlines
Feb 26
SCL10:45 pmSantiago Arturo Merino Benitez
17h 01m
1 stop
TYS1:46 pmKnoxville McGhee Tyson
Mar 2
TYS4:55 pmKnoxville McGhee Tyson
13h 55m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
$764
Find similar
United Airlines
Feb 26
SCL10:45 pmSantiago Arturo Merino Benitez
18h 30m
2 stops
TYS3:15 pmKnoxville McGhee Tyson
Mar 2
TYS4:55 pmKnoxville McGhee Tyson
13h 55m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
$769
Find similar
United Airlines
Feb 26
SCL10:45 pmSantiago Arturo Merino Benitez
20h 07m
2 stops
TYS4:52 pmKnoxville McGhee Tyson
Mar 2
TYS11:41 amKnoxville McGhee Tyson
19h 09m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
$819
Find similar

LATAM Airlines flights from Santiago to Knoxville

Our best LATAM Airlines deals on Santiago to Knoxville flight tickets
LATAM Airlines
Feb 26
SCL8:10 amSantiago Arturo Merino Benitez
17h 42m
2 stops
TYS11:52 pmKnoxville McGhee Tyson
Mar 2
TYS6:41 pmKnoxville McGhee Tyson
18h 49m
2 stops
SCL3:30 pmSantiago Arturo Merino Benitez
$714
Find similar
LATAM Airlines
Jan 21
SCL10:15 pmSantiago Arturo Merino Benitez
27h 30m
2 stops
TYS11:45 pmKnoxville McGhee Tyson
Jan 29
TYS11:58 amKnoxville McGhee Tyson
24h 22m
2 stops
SCL2:20 pmSantiago Arturo Merino Benitez
$715
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

8:10 am-11:52 pm

2 stops17h 42m

Knoxville McGhee Tyson

Mon 3/2

6:41 pm-3:30 pm

2 stops18h 49m

$714

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:15 pm-11:45 pm

2 stops27h 30m

Knoxville McGhee Tyson

Thu 1/29

11:58 am-2:20 pm

2 stops24h 22m

$715

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-1:46 pm

1 stop17h 01m

Knoxville McGhee Tyson

Mon 3/2

4:55 pm-8:50 am

1 stop13h 55m

$764

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:30 pm-11:34 am

1 stop15h 04m

Knoxville McGhee Tyson

Thu 1/29

12:19 pm-8:15 am

1 stop17h 56m

$765

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-3:15 pm

2 stops18h 30m

Knoxville McGhee Tyson

Mon 3/2

4:55 pm-8:50 am

1 stop13h 55m

$769

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:30 pm-2:32 pm

2 stops18h 02m

Knoxville McGhee Tyson

Thu 1/29

2:17 pm-9:00 am

2 stops16h 43m

$804

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-4:52 pm

2 stops20h 07m

Knoxville McGhee Tyson

Mon 3/2

11:41 am-8:50 am

1 stop19h 09m

$819

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:45 pm-7:50 pm

1 stop23h 05m

Knoxville McGhee Tyson

Thu 1/29

11:40 am-8:50 am

1 stop19h 10m

$835

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 2/9

10:35 am-11:45 pm

2 stops15h 10m

$537

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 2/9

6:30 pm-9:24 am

2 stops16h 54m

$552

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santiago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson?

LATAM Airlines and Delta are the most popular carriers operating from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson

When to book flights from Santiago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Knoxville (SCL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Knoxville

Fastest flight time

18h 04m

Direct flights

None
The fastest flight from Santiago to Knoxville takes 18h 04m
There are no direct flights from Santiago to Knoxville. There are no popular flight routes from Santiago to Knoxville.
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  • How far is Santiago Arturo Merino Benitez to Knoxville McGhee Tyson by plane?

    The distance between Santiago Arturo Merino Benitez and Knoxville McGhee Tyson is about 4868.2 mi. By plane, this route typically takes 18h 04m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santiago to Knoxville for you.

Can I find flights from Santiago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Santiago with this policy.

How can momondo help me find flights from Santiago to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santiago.

I’m not ready to book a flight from Santiago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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