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Cheap flights from Santiago to Knoxville from $419

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Knoxville departing on 7/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santiago to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
4:14 am - 6:17 pm
SCL
-
TYS
38h 03m
2 stops
United Airlines Logo
7:15 am - 3:00 am
TYS
-
SCL
19h 45m
2 stops
$1,149United Airlines
Thu, Aug 20 - Mon, Aug 24
United Airlines Logo
4:14 am - 9:45 pm
SCL
-
TYS
41h 31m
2 stops
United Airlines Logo
12:45 pm - 11:26 pm
TYS
-
SCL
34h 41m
2 stops
$1,200United Airlines
Thu, Aug 20 - Mon, Aug 24
United Airlines Logo
4:14 am - 9:30 pm
SCL
-
TYS
41h 16m
2 stops
United Airlines Logo
12:05 pm - 4:59 am
TYS
-
SCL
40h 54m
2 stops
$1,240United Airlines
Fri, Aug 28 - Tue, Sep 1
United Airlines Logo
2:27 am - 6:05 pm
SCL
-
TYS
39h 38m
2 stops
United Airlines Logo
7:15 am - 4:59 am
TYS
-
SCL
21h 44m
2 stops
$1,366United Airlines
Thu, Aug 27 - Tue, Sep 1

United Airlines flights from Santiago to Knoxville

Our best United Airlines deals on Santiago to Knoxville flight tickets
United Airlines
Aug 20
SCL4:14 amSantiago Arturo Merino Benitez
38h 03m
2 stops
TYS6:17 pmKnoxville McGhee Tyson
Aug 24
TYS7:15 amKnoxville McGhee Tyson
19h 45m
2 stops
SCL3:00 amSantiago Arturo Merino Benitez
$1,149
United Airlines
Aug 20
SCL4:14 amSantiago Arturo Merino Benitez
41h 31m
2 stops
TYS9:45 pmKnoxville McGhee Tyson
Aug 24
TYS12:45 pmKnoxville McGhee Tyson
34h 41m
2 stops
SCL11:26 pmSantiago Arturo Merino Benitez
$1,200
United Airlines
Aug 28
SCL4:14 amSantiago Arturo Merino Benitez
41h 16m
2 stops
TYS9:30 pmKnoxville McGhee Tyson
Sep 1
TYS12:05 pmKnoxville McGhee Tyson
40h 54m
2 stops
SCL4:59 amSantiago Arturo Merino Benitez
$1,240

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 8/20

4:14 am-6:17 pm

2 stops38h 03m

Knoxville McGhee Tyson

Mon 8/24

7:15 am-3:00 am

2 stops19h 45m

$1,149

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 8/20

4:14 am-9:45 pm

2 stops41h 31m

Knoxville McGhee Tyson

Mon 8/24

12:45 pm-11:26 pm

2 stops34h 41m

$1,200

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/28

4:14 am-9:30 pm

2 stops41h 16m

Knoxville McGhee Tyson

Tue 9/1

12:05 pm-4:59 am

2 stops40h 54m

$1,240

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 8/27

2:27 am-6:05 pm

2 stops39h 38m

Knoxville McGhee Tyson

Tue 9/1

7:15 am-4:59 am

2 stops21h 44m

$1,366
Cheapest one-way

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 7/5

11:35 am-4:10 pm

2 stops52h 35m

$419

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 7/5

4:56 am-10:42 am

3 stops53h 46m

$453

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 7/5

11:05 pm-10:37 am

2 stops35h 32m

$470
Quickest one-way

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 7/5

8:40 pm-9:38 am

1 stop12h 58m

$651

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 7/5

8:40 pm-6:45 pm

1 stop22h 05m

$672

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santiago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson?

LATAM Airlines is the most popular carrier operating from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson

When to book flights from Santiago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Knoxville (SCL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Knoxville

Fastest flight time

38h 03m

Direct flights

None
The fastest flight from Santiago to Knoxville takes 38h 03m
There are no direct flights from Santiago to Knoxville. There are no popular flight routes from Santiago to Knoxville.
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Frequently asked questions about flying from Santiago to Knoxville

  • How far is Santiago Arturo Merino Benitez to Knoxville McGhee Tyson by plane?

    The distance between Santiago Arturo Merino Benitez and Knoxville McGhee Tyson is about 4868.2 mi. By plane, this route typically takes 38h 03m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santiago to Knoxville for you.

Can I find flights from Santiago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Santiago with this policy.

How can momondo help me find flights from Santiago to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santiago.

I’m not ready to book a flight from Santiago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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