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Cheap flights from Santiago to Knoxville from $592

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Knoxville departing on 10/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Delta Logo
11:15 pm - 1:25 pmSCL-TYS
16h 10m1 stop
Delta Logo
4:00 pm - 7:00 amTYS-SCL
13h 00m1 stop
$743Delta
Find Deal
Wed, Nov 26 - Tue, Dec 9
LATAM Airlines Logo
4:35 am - 11:46 pmSCL-TYS
21h 11m2 stops
LATAM Airlines Logo
4:00 pm - 7:00 amTYS-SCL
13h 00m1 stop
$754LATAM Airlines
Find Deal
Tue, Nov 25 - Thu, Dec 4
United Airlines Logo
10:45 pm - 8:09 pmSCL-TYS
23h 24m1 stop
United Airlines Logo
7:05 am - 8:50 amTYS-SCL
23h 45m1 stop
$782United Airlines
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Wed, Nov 26 - Sat, Dec 6
Delta Logo
11:25 pm - 3:05 pmSCL-TYS
17h 40m2 stops
Delta Logo
12:00 pm - 5:35 amTYS-SCL
15h 35m2 stops
$785Delta
Find Deal
Thu, Nov 27 - Fri, Dec 5
LATAM Airlines Logo
8:50 am - 11:46 pmSCL-TYS
16h 56m2 stops
LATAM Airlines Logo
11:20 am - 6:40 amTYS-SCL
17h 20m2 stops
$794LATAM Airlines
Find Deal
Wed, Nov 26 - Sat, Dec 6
LATAM Airlines Logo
11:25 pm - 11:29 pmSCL-TYS
26h 04m2 stops
LATAM Airlines Logo
7:15 pm - 3:30 pmTYS-SCL
18h 15m2 stops
$798LATAM Airlines
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Thu, Nov 27 - Fri, Dec 5
United Airlines Logo
10:45 pm - 11:44 pmSCL-TYS
26h 59m1 stop
United Airlines Logo
11:42 am - 8:50 amTYS-SCL
19h 08m1 stop
$812United Airlines
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Tue, Nov 25 - Thu, Dec 4
Delta Logo
11:15 pm - 3:05 pmSCL-TYS
17h 50m1 stop
Delta Logo
2:30 pm - 7:00 amTYS-SCL
14h 30m1 stop
$822Delta
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Fri, Nov 28 - Sat, Dec 6
Delta Logo
11:25 pm - 3:05 pmSCL-TYS
17h 40m2 stops
Delta Logo
9:30 am - 7:00 amTYS-SCL
19h 30m2 stops
$825Delta
Find Deal
Fri, Nov 28 - Sat, Dec 6
United Airlines Logo
10:45 pm - 1:19 pmSCL-TYS
16h 34m1 stop
United Airlines Logo
11:42 am - 8:50 amTYS-SCL
19h 08m1 stop
$852United Airlines
Find Deal
Tue, Nov 25 - Fri, Dec 5

LATAM Airlines flights from Santiago to Knoxville

Our best LATAM Airlines deals on Santiago to Knoxville flight tickets
LATAM Airlines
Nov 25
SCL4:35 amSantiago Arturo Merino Benitez
21h 11m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
Dec 4
TYS4:00 pmKnoxville McGhee Tyson
13h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
$754
Find similar
LATAM Airlines
Nov 26
SCL8:50 amSantiago Arturo Merino Benitez
16h 56m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
Dec 6
TYS11:20 amKnoxville McGhee Tyson
17h 20m
2 stops
SCL6:40 amSantiago Arturo Merino Benitez
$794
Find similar
LATAM Airlines
Nov 27
SCL11:25 pmSantiago Arturo Merino Benitez
26h 04m
2 stops
TYS11:29 pmKnoxville McGhee Tyson
Dec 5
TYS7:15 pmKnoxville McGhee Tyson
18h 15m
2 stops
SCL3:30 pmSantiago Arturo Merino Benitez
$798
Find similar

American Airlines flights from Santiago to Knoxville

Our best American Airlines deals on Santiago to Knoxville flight tickets
American Airlines
Aug 4
SCL9:50 pmSantiago Arturo Merino Benitez
26h 09m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Dec 23
TYS4:25 pmKnoxville McGhee Tyson
13h 25m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
$1,178
Find similar
American Airlines
Aug 4
SCL9:50 pmSantiago Arturo Merino Benitez
26h 09m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Dec 23
TYS5:28 amKnoxville McGhee Tyson
24h 22m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
$1,378
Find similar
American Airlines
Aug 4
SCL9:50 pmSantiago Arturo Merino Benitez
26h 09m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Dec 23
TYS4:25 pmKnoxville McGhee Tyson
13h 25m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
$1,379
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/26

11:15 pm-1:25 pm

1 stop16h 10m

Knoxville McGhee Tyson

Tue 12/9

4:00 pm-7:00 am

1 stop13h 00m

$743

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 11/25

4:35 am-11:46 pm

2 stops21h 11m

Knoxville McGhee Tyson

Thu 12/4

4:00 pm-7:00 am

1 stop13h 00m

$754

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/26

10:45 pm-8:09 pm

1 stop23h 24m

Knoxville McGhee Tyson

Sat 12/6

7:05 am-8:50 am

1 stop23h 45m

$782

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 11/27

11:25 pm-3:05 pm

2 stops17h 40m

Knoxville McGhee Tyson

Fri 12/5

12:00 pm-5:35 am

2 stops15h 35m

$785

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/26

8:50 am-11:46 pm

2 stops16h 56m

Knoxville McGhee Tyson

Sat 12/6

11:20 am-6:40 am

2 stops17h 20m

$794

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 11/27

11:25 pm-11:29 pm

2 stops26h 04m

Knoxville McGhee Tyson

Fri 12/5

7:15 pm-3:30 pm

2 stops18h 15m

$798

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 11/25

10:45 pm-11:44 pm

1 stop26h 59m

Knoxville McGhee Tyson

Thu 12/4

11:42 am-8:50 am

1 stop19h 08m

$812

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 11/28

11:15 pm-3:05 pm

1 stop17h 50m

Knoxville McGhee Tyson

Sat 12/6

2:30 pm-7:00 am

1 stop14h 30m

$822

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 11/28

11:25 pm-3:05 pm

2 stops17h 40m

Knoxville McGhee Tyson

Sat 12/6

9:30 am-7:00 am

2 stops19h 30m

$825

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 11/25

10:45 pm-1:19 pm

1 stop16h 34m

Knoxville McGhee Tyson

Fri 12/5

11:42 am-8:50 am

1 stop19h 08m

$852

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santiago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson?

Delta and LATAM Airlines are the most popular carriers operating from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson

When to book flights from Santiago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Knoxville (SCL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Knoxville

Best Price Found

$592

Fastest flight time

11h 56m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Santiago in the past 72 hours is $592. The best round-trip flight deal from Santiago to Knoxville found on momondo in the last 72 hours is $743.
The fastest flight from Santiago to Knoxville takes 11h 56m
There are no direct flights from Santiago to Knoxville. Popular non-direct route for this connection is Santiago Arturo Merino Benitez Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
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  • How far is Santiago Arturo Merino Benitez to Knoxville McGhee Tyson by plane?

    The distance between Santiago Arturo Merino Benitez and Knoxville McGhee Tyson is about 4868.2 mi. By plane, this route typically takes 11h 56m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santiago to Knoxville for you.

Can I find flights from Santiago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Santiago with this policy.

How can momondo help me find flights from Santiago to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santiago.

I’m not ready to book a flight from Santiago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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