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Cheap flights from Santiago to Knoxville from $332

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Knoxville departing on 4/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santiago to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:45 pm - 4:45 pm
SCL
-
TYS
20h 00m
2 stops
United Airlines Logo
5:43 pm - 7:50 am
TYS
-
SCL
37h 07m
2 stops
$847United Airlines
Wed, Mar 4 - Sun, Mar 8
LATAM Airlines Logo
11:10 pm - 5:54 pm
SCL
-
TYS
20h 44m
1 stop
LATAM Airlines Logo
12:03 pm - 7:40 am
TYS
-
SCL
18h 37m
1 stop
$875LATAM Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
10:45 pm - 8:47 pm
SCL
-
TYS
24h 02m
2 stops
United Airlines Logo
2:21 pm - 7:50 am
TYS
-
SCL
40h 29m
2 stops
$915United Airlines
Wed, Mar 4 - Sun, Mar 8
LATAM Airlines Logo
11:10 pm - 5:54 pm
SCL
-
TYS
20h 44m
1 stop
LATAM Airlines Logo
5:10 pm - 7:40 am
TYS
-
SCL
13h 30m
1 stop
$943LATAM Airlines
Wed, Mar 4 - Sun, Mar 8

United Airlines flights from Santiago to Knoxville

Our best United Airlines deals on Santiago to Knoxville flight tickets
United Airlines
Mar 4
SCL10:45 pmSantiago Arturo Merino Benitez
20h 00m
2 stops
TYS4:45 pmKnoxville McGhee Tyson
Mar 8
TYS5:43 pmKnoxville McGhee Tyson
37h 07m
2 stops
SCL7:50 amSantiago Arturo Merino Benitez
$847
United Airlines
Feb 16
SCL10:45 pmSantiago Arturo Merino Benitez
16h 30m
2 stops
TYS1:15 pmKnoxville McGhee Tyson
Mar 3
TYS1:50 pmKnoxville McGhee Tyson
41h 00m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
$896
United Airlines
Mar 4
SCL10:45 pmSantiago Arturo Merino Benitez
24h 02m
2 stops
TYS8:47 pmKnoxville McGhee Tyson
Mar 8
TYS2:21 pmKnoxville McGhee Tyson
40h 29m
2 stops
SCL7:50 amSantiago Arturo Merino Benitez
$915

LATAM Airlines flights from Santiago to Knoxville

Our best LATAM Airlines deals on Santiago to Knoxville flight tickets
LATAM Airlines
Mar 4
SCL11:10 pmSantiago Arturo Merino Benitez
20h 44m
1 stop
TYS5:54 pmKnoxville McGhee Tyson
Mar 8
TYS12:03 pmKnoxville McGhee Tyson
18h 37m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$875
LATAM Airlines
Feb 16
SCL6:30 pmSantiago Arturo Merino Benitez
31h 22m
2 stops
TYS11:52 pmKnoxville McGhee Tyson
Mar 3
TYS5:00 pmKnoxville McGhee Tyson
40h 06m
3 stops
SCL11:06 amSantiago Arturo Merino Benitez
$933
LATAM Airlines
Mar 4
SCL11:10 pmSantiago Arturo Merino Benitez
20h 44m
1 stop
TYS5:54 pmKnoxville McGhee Tyson
Mar 8
TYS5:10 pmKnoxville McGhee Tyson
13h 30m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$943

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 3/4

10:45 pm-4:45 pm

2 stops20h 00m

Knoxville McGhee Tyson

Sun 3/8

5:43 pm-7:50 am

2 stops37h 07m

$847

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 3/4

11:10 pm-5:54 pm

1 stop20h 44m

Knoxville McGhee Tyson

Sun 3/8

12:03 pm-7:40 am

1 stop18h 37m

$875

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 3/4

10:45 pm-8:47 pm

2 stops24h 02m

Knoxville McGhee Tyson

Sun 3/8

2:21 pm-7:50 am

2 stops40h 29m

$915

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 3/4

11:10 pm-5:54 pm

1 stop20h 44m

Knoxville McGhee Tyson

Sun 3/8

5:10 pm-7:40 am

1 stop13h 30m

$943

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 4/2

6:01 am-8:36 am

2 stops51h 35m

$332

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sat 4/4

5:56 am-8:10 am

2 stops51h 14m

$356

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 4/2

6:01 am-8:36 am

2 stops51h 35m

$377

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 4/2

6:01 am-8:36 am

2 stops51h 35m

$388

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sat 4/4

5:56 am-12:44 pm

3 stops55h 48m

$389

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sat 4/4

12:35 pm-8:10 am

2 stops44h 35m

$390

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

When to book flights from Santiago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Knoxville (SCL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Knoxville

Fastest flight time

21h 25m

Direct flights

None
The fastest flight from Santiago to Knoxville takes 21h 25m
There are no direct flights from Santiago to Knoxville. There are no popular flight routes from Santiago to Knoxville.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Knoxville McGhee Tyson by plane?

    The distance between Santiago Arturo Merino Benitez and Knoxville McGhee Tyson is about 4868.2 mi. By plane, this route typically takes 21h 25m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • How do I get Price Alerts for flights from Santiago to Knoxville?

    Search flight deals from Santiago to Knoxville. While viewing offers you’ll have the option to create a Price Alert.

  • How can I save money on flights from Santiago to Knoxville with momondo?

    Leverage our AI within our “Price Forecast” tool, which predicts if it’s better to book now or wait until prices decrease. You can strategically pick the best days to fly and save money on your trip by using our “Price Calendar” tool. “Explore” shows an overview of how much it costs to fly to anywhere from a selected city or airport. Our “Discover” content is a great option for travel inspiration and money-saving tips, while “Price Alerts” will update you when prices change, so you can book when fares are right.

  • How does momondo find its flight prices?

    We aggregate our prices from over 700+ competitors from airlines to OTAs. We operate in over 30 markets worldwide to show you a wide range of travel options.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santiago to Knoxville for you.

Can I find flights from Santiago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Santiago with this policy.

How can momondo help me find flights from Santiago to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santiago.

I’m not ready to book a flight from Santiago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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