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Cheap flights from Santiago to Knoxville from $373

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Knoxville departing on 5/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:55 pm - 2:33 pm
SCL
-
TYS
18h 38m
2 stops
Delta Logo
11:56 am - 6:55 am
TYS
-
SCL
18h 59m
2 stops
$981Delta
Sun, May 10 - Sun, May 17
American Airlines Logo
8:35 pm - 3:38 pm
SCL
-
TYS
19h 03m
2 stops
American Airlines Logo
6:30 am - 7:05 am
TYS
-
SCL
24h 35m
1 stop
$1,045American Airlines
Sun, May 10 - Sun, May 17
American Airlines Logo
8:35 pm - 11:59 pm
SCL
-
TYS
27h 24m
1 stop
American Airlines Logo
6:30 am - 7:05 am
TYS
-
SCL
24h 35m
1 stop
$1,051American Airlines
Sun, May 10 - Sun, May 17
LATAM Airlines Logo
5:40 am - 11:47 pm
SCL
-
TYS
18h 07m
2 stops
LATAM Airlines Logo
12:00 pm - 5:25 am
TYS
-
SCL
17h 25m
2 stops
$1,195LATAM Airlines
Thu, Aug 27 - Mon, Aug 31
United Airlines Logo
12:09 am - 11:41 pm
SCL
-
TYS
23h 32m
2 stops
United Airlines Logo
7:05 am - 5:10 am
TYS
-
SCL
22h 05m
2 stops
$1,358United Airlines
Wed, Apr 22 - Mon, Apr 27
LATAM Airlines Logo
8:30 am - 11:09 am
SCL
-
TYS
26h 39m
3 stops
LATAM Airlines Logo
7:33 pm - 6:55 am
TYS
-
SCL
35h 22m
2 stops
$1,372LATAM Airlines
Sun, May 10 - Sun, May 17
United Airlines Logo
12:46 am - 11:41 pm
SCL
-
TYS
22h 55m
2 stops
United Airlines Logo
7:05 am - 5:10 am
TYS
-
SCL
22h 05m
2 stops
$1,398United Airlines
Wed, Apr 22 - Mon, Apr 27
United Airlines Logo
2:27 am - 11:17 am
SCL
-
TYS
32h 50m
2 stops
United Airlines Logo
5:57 pm - 11:22 pm
TYS
-
SCL
29h 25m
3 stops
$1,453United Airlines
Wed, Aug 26 - Mon, Aug 31

LATAM Airlines flights from Santiago to Knoxville

Our best LATAM Airlines deals on Santiago to Knoxville flight tickets
LATAM Airlines
Aug 27
SCL5:40 amSantiago Arturo Merino Benitez
18h 07m
2 stops
TYS11:47 pmKnoxville McGhee Tyson
Aug 31
TYS12:00 pmKnoxville McGhee Tyson
17h 25m
2 stops
SCL5:25 amSantiago Arturo Merino Benitez
$1,195
LATAM Airlines
May 10
SCL8:30 amSantiago Arturo Merino Benitez
26h 39m
3 stops
TYS11:09 amKnoxville McGhee Tyson
May 17
TYS7:33 pmKnoxville McGhee Tyson
35h 22m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$1,372

United Airlines flights from Santiago to Knoxville

Our best United Airlines deals on Santiago to Knoxville flight tickets
United Airlines
Apr 22
SCL12:09 amSantiago Arturo Merino Benitez
23h 32m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
Apr 27
TYS7:05 amKnoxville McGhee Tyson
22h 05m
2 stops
SCL5:10 amSantiago Arturo Merino Benitez
$1,358
United Airlines
Apr 22
SCL12:46 amSantiago Arturo Merino Benitez
22h 55m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
Apr 27
TYS7:05 amKnoxville McGhee Tyson
22h 05m
2 stops
SCL5:10 amSantiago Arturo Merino Benitez
$1,398
United Airlines
Aug 26
SCL2:27 amSantiago Arturo Merino Benitez
32h 50m
2 stops
TYS11:17 amKnoxville McGhee Tyson
Aug 31
TYS5:57 pmKnoxville McGhee Tyson
29h 25m
3 stops
SCL11:22 pmSantiago Arturo Merino Benitez
$1,453

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 5/10

7:55 pm-2:33 pm

2 stops18h 38m

Knoxville McGhee Tyson

Sun 5/17

11:56 am-6:55 am

2 stops18h 59m

$981

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 5/10

8:35 pm-3:38 pm

2 stops19h 03m

Knoxville McGhee Tyson

Sun 5/17

6:30 am-7:05 am

1 stop24h 35m

$1,045

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 5/10

8:35 pm-11:59 pm

1 stop27h 24m

Knoxville McGhee Tyson

Sun 5/17

6:30 am-7:05 am

1 stop24h 35m

$1,051
Quickest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 8/27

5:40 am-11:47 pm

2 stops18h 07m

Knoxville McGhee Tyson

Mon 8/31

12:00 pm-5:25 am

2 stops17h 25m

$1,195

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 4/22

12:09 am-11:41 pm

2 stops23h 32m

Knoxville McGhee Tyson

Mon 4/27

7:05 am-5:10 am

2 stops22h 05m

$1,358

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 5/10

8:30 am-11:09 am

3 stops26h 39m

Knoxville McGhee Tyson

Sun 5/17

7:33 pm-6:55 am

2 stops35h 22m

$1,372

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 4/22

12:46 am-11:41 pm

2 stops22h 55m

Knoxville McGhee Tyson

Mon 4/27

7:05 am-5:10 am

2 stops22h 05m

$1,398

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 8/26

2:27 am-11:17 am

2 stops32h 50m

Knoxville McGhee Tyson

Mon 8/31

5:57 pm-11:22 pm

3 stops29h 25m

$1,453
Cheapest one-way

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sat 5/9

3:20 pm-3:41 pm

2 stops24h 21m

$373

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 5/7

12:30 am-9:48 pm

2 stops21h 18m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santiago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson?

Delta is the most popular carrier operating from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson

When to book flights from Santiago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Knoxville (SCL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Knoxville

Fastest flight time

18h 38m

Direct flights

None
The fastest flight from Santiago to Knoxville takes 18h 38m
There are no direct flights from Santiago to Knoxville. There are no popular flight routes from Santiago to Knoxville.
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Knoxville McGhee Tyson by plane?

    The distance between Santiago Arturo Merino Benitez and Knoxville McGhee Tyson is about 4868.2 mi. By plane, this route typically takes 18h 38m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santiago to Knoxville for you.

Can I find flights from Santiago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Santiago with this policy.

How can momondo help me find flights from Santiago to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Santiago.

I’m not ready to book a flight from Santiago to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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