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Cheap flights from Santa Fe to South Carolina from $300

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to South Carolina departing on 3/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Fe to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:35 pm - 11:23 pm
SAF
-
CHS
6h 48m
1 stop
American Airlines Logo
6:00 am - 3:05 pm
CHS
-
SAF
11h 05m
2 stops
$319American Airlines
Fri, Mar 13 - Tue, Mar 17
American Airlines Logo
2:35 pm - 11:23 pm
SAF
-
CHS
6h 48m
1 stop
American Airlines Logo
3:48 pm - 8:48 pm
CHS
-
SAF
7h 00m
1 stop
$334American Airlines
Fri, Mar 13 - Tue, Mar 17
American Airlines Logo
10:09 am - 6:31 pm
SAF
-
CHS
6h 22m
1 stop
American Airlines Logo
6:00 am - 3:05 pm
CHS
-
SAF
11h 05m
2 stops
$344American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
12:54 pm - 10:45 pm
SAF
-
GSP
7h 51m
1 stop
American Airlines Logo
5:20 am - 3:05 pm
GSP
-
SAF
11h 45m
2 stops
$344American Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:42 pm - 8:33 am
SAF
-
CHS
11h 51m
2 stops
American Airlines Logo
6:00 am - 3:05 pm
CHS
-
SAF
11h 05m
2 stops
$349American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
10:09 am - 6:31 pm
SAF
-
CHS
6h 22m
1 stop
American Airlines Logo
3:45 pm - 8:48 pm
CHS
-
SAF
7h 03m
1 stop
$410American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
12:54 pm - 10:45 pm
SAF
-
GSP
7h 51m
1 stop
American Airlines Logo
6:01 am - 12:24 pm
GSP
-
SAF
8h 23m
1 stop
$410American Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
12:54 pm - 11:54 pm
SAF
-
GSP
9h 00m
2 stops
American Airlines Logo
5:20 am - 3:05 pm
GSP
-
SAF
11h 45m
2 stops
$426American Airlines
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
7:00 am - 11:30 pm
SAF
-
CHS
14h 30m
2 stops
United Airlines Logo
8:00 am - 2:45 pm
CHS
-
SAF
8h 45m
1 stop
$496United Airlines
Mon, Mar 9 - Sat, Mar 14
United Airlines Logo
1:24 pm - 9:10 pm
SAF
-
CHS
5h 46m
1 stop
United Airlines Logo
8:00 am - 2:45 pm
CHS
-
SAF
8h 45m
1 stop
$497United Airlines
Tue, Mar 10 - Sat, Mar 14

United Airlines flights from Santa Fe to South Carolina

Our best United Airlines deals on Santa Fe to South Carolina flight tickets
United Airlines
Feb 10
SAF7:00 amSanta Fe
6h 20m
1 stop
GSP3:20 pmGreenville
Feb 14
GSP4:16 pmGreenville
6h 15m
1 stop
SAF8:31 pmSanta Fe
$434
United Airlines
Feb 10
SAF7:00 amSanta Fe
10h 29m
2 stops
GSP7:29 pmGreenville
Feb 14
GSP4:16 pmGreenville
6h 15m
1 stop
SAF8:31 pmSanta Fe
$444
United Airlines
Feb 10
SAF7:00 amSanta Fe
6h 20m
1 stop
GSP3:20 pmGreenville
Feb 14
GSP4:16 pmGreenville
6h 15m
1 stop
SAF8:31 pmSanta Fe
$484

American Airlines flights from Santa Fe to South Carolina

Our best American Airlines deals on Santa Fe to South Carolina flight tickets
American Airlines
Mar 13
SAF2:35 pmSanta Fe
6h 48m
1 stop
CHS11:23 pmCharleston
Mar 17
CHS6:00 amCharleston
11h 05m
2 stops
SAF3:05 pmSanta Fe
$319
American Airlines
Mar 13
SAF2:35 pmSanta Fe
6h 48m
1 stop
CHS11:23 pmCharleston
Mar 17
CHS3:48 pmCharleston
7h 00m
1 stop
SAF8:48 pmSanta Fe
$334
American Airlines
Feb 20
SAF10:09 amSanta Fe
6h 22m
1 stop
CHS6:31 pmCharleston
Feb 24
CHS6:00 amCharleston
11h 05m
2 stops
SAF3:05 pmSanta Fe
$344

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Santa Fe to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Fri 3/13

2:35 pm-11:23 pm

1 stop6h 48m

Charleston

Tue 3/17

6:00 am-3:05 pm

2 stops11h 05m

$319

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Fri 3/13

2:35 pm-11:23 pm

1 stop6h 48m

Charleston

Tue 3/17

3:48 pm-8:48 pm

1 stop7h 00m

$334

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Fri 2/20

10:09 am-6:31 pm

1 stop6h 22m

Charleston

Tue 2/24

6:00 am-3:05 pm

2 stops11h 05m

$344

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 2/21

12:54 pm-10:45 pm

1 stop7h 51m

Greenville

Wed 2/25

5:20 am-3:05 pm

2 stops11h 45m

$344

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Fri 2/20

6:42 pm-8:33 am

2 stops11h 51m

Charleston

Tue 2/24

6:00 am-3:05 pm

2 stops11h 05m

$349

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Fri 2/20

10:09 am-6:31 pm

1 stop6h 22m

Charleston

Tue 2/24

3:45 pm-8:48 pm

1 stop7h 03m

$410

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 2/21

12:54 pm-10:45 pm

1 stop7h 51m

Greenville

Wed 2/25

6:01 am-12:24 pm

1 stop8h 23m

$410

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 2/21

12:54 pm-11:54 pm

2 stops9h 00m

Greenville

Wed 2/25

5:20 am-3:05 pm

2 stops11h 45m

$426

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Mon 3/9

7:00 am-11:30 pm

2 stops14h 30m

Charleston

Sat 3/14

8:00 am-2:45 pm

1 stop8h 45m

$496

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Tue 3/10

1:24 pm-9:10 pm

1 stop5h 46m

Charleston

Sat 3/14

8:00 am-2:45 pm

1 stop8h 45m

$497

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Santa Fe to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Santa Fe to South Carolina flights?

You could potentially save up to 42% on your flight if you consider stops on a Santa Fe to South Carolina flight.

Cheap Santa Fe to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to South Carolina

Fastest flight time

5h 29m

Direct flights

None
The fastest flight from Santa Fe to South Carolina takes 5h 29m
There are no direct flights from Santa Fe to South Carolina. There are no popular flight routes from Santa Fe to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Santa Fe Airport to South Carolina?

    Prices for flights from Santa Fe Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Fe Airport to South Carolina?

  • How old do you have to be to fly from Santa Fe Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Fe Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Santa Fe to South Carolina

Compare and see reviews for airlines that fly from Santa Fe to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,246 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Fe to South Carolina for you.

Can I find flights from Santa Fe to South Carolina with flexible booking policies on momondo?

All flight searches from Santa Fe to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Fe to South Carolina?

Once all potential Santa Fe to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Santa Fe to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Santa Fe are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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