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Cheap flights from Santa Fe to Des Moines from $294

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Fe to Des Moines departing on 3/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:36 pm - 11:40 pm
SAF
-
DSM
8h 04m
1 stop
American Airlines Logo
5:00 am - 9:39 am
DSM
-
SAF
5h 39m
1 stop
$294American Airlines
Wed, Mar 25 - Sun, Mar 29
American Airlines Logo
3:35 pm - 11:59 pm
SAF
-
DSM
7h 24m
1 stop
American Airlines Logo
5:05 am - 9:39 am
DSM
-
SAF
5h 34m
1 stop
$344American Airlines
Fri, Mar 27 - Tue, Mar 31
United Airlines Logo
5:49 pm - 11:42 pm
SAF
-
DSM
4h 53m
1 stop
United Airlines Logo
1:32 pm - 5:08 pm
DSM
-
SAF
4h 36m
1 stop
$354United Airlines
Wed, Apr 8 - Sat, Apr 11
United Airlines Logo
5:49 pm - 11:42 pm
SAF
-
DSM
4h 53m
1 stop
United Airlines Logo
1:32 pm - 5:08 pm
DSM
-
SAF
4h 36m
1 stop
$374United Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
7:30 am - 4:00 pm
SAF
-
DSM
7h 30m
1 stop
American Airlines Logo
2:26 pm - 6:33 pm
DSM
-
SAF
5h 07m
1 stop
$428American Airlines
Fri, Jul 17 - Tue, Jul 21
American Airlines Logo
3:35 pm - 11:59 pm
SAF
-
DSM
7h 24m
1 stop
American Airlines Logo
5:05 am - 3:05 pm
DSM
-
SAF
11h 00m
2 stops
$460American Airlines
Fri, Mar 27 - Tue, Mar 31
American Airlines Logo
2:36 pm - 11:40 pm
SAF
-
DSM
8h 04m
1 stop
American Airlines Logo
5:00 am - 3:05 pm
DSM
-
SAF
11h 05m
2 stops
$508American Airlines
Wed, Mar 25 - Sun, Mar 29
United Airlines Logo
6:00 pm - 10:35 pm
SAF
-
DSM
27h 35m
2 stops
United Airlines Logo
5:50 am - 9:44 am
DSM
-
SAF
4h 54m
1 stop
$528United Airlines
Fri, Jul 17 - Tue, Jul 21
United Airlines Logo
5:49 pm - 11:42 pm
SAF
-
DSM
4h 53m
1 stop
United Airlines Logo
1:10 pm - 9:09 am
DSM
-
SAF
20h 59m
2 stops
$542United Airlines
Wed, Apr 8 - Sat, Apr 11
United Airlines Logo
3:24 pm - 11:42 pm
SAF
-
DSM
7h 18m
1 stop
United Airlines Logo
7:16 pm - 5:08 pm
DSM
-
SAF
22h 52m
2 stops
$568United Airlines
Wed, Apr 8 - Sat, Apr 11

American Airlines flights from Santa Fe to Des Moines

Our best American Airlines deals on Santa Fe to Des Moines flight tickets
American Airlines
Mar 25
SAF2:36 pmSanta Fe
8h 04m
1 stop
DSM11:40 pmDes Moines
Mar 29
DSM5:00 amDes Moines
5h 39m
1 stop
SAF9:39 amSanta Fe
$294
American Airlines
Mar 27
SAF3:35 pmSanta Fe
7h 24m
1 stop
DSM11:59 pmDes Moines
Mar 31
DSM5:05 amDes Moines
5h 34m
1 stop
SAF9:39 amSanta Fe
$344
American Airlines
Jul 17
SAF7:30 amSanta Fe
7h 30m
1 stop
DSM4:00 pmDes Moines
Jul 21
DSM2:26 pmDes Moines
5h 07m
1 stop
SAF6:33 pmSanta Fe
$428

United Airlines flights from Santa Fe to Des Moines

Our best United Airlines deals on Santa Fe to Des Moines flight tickets
United Airlines
Apr 8
SAF5:49 pmSanta Fe
4h 53m
1 stop
DSM11:42 pmDes Moines
Apr 11
DSM1:32 pmDes Moines
4h 36m
1 stop
SAF5:08 pmSanta Fe
$354
United Airlines
Apr 8
SAF5:49 pmSanta Fe
4h 53m
1 stop
DSM11:42 pmDes Moines
Apr 11
DSM1:32 pmDes Moines
4h 36m
1 stop
SAF5:08 pmSanta Fe
$374
United Airlines
Jul 17
SAF6:00 pmSanta Fe
27h 35m
2 stops
DSM10:35 pmDes Moines
Jul 21
DSM5:50 amDes Moines
4h 54m
1 stop
SAF9:44 amSanta Fe
$528

momondo Fare Finder

 
Customize your flight search to find flights from Santa Fe to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Santa Fe to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 3/25

2:36 pm-11:40 pm

1 stop8h 04m

Des Moines

Sun 3/29

5:00 am-9:39 am

1 stop5h 39m

$294

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 3/27

3:35 pm-11:59 pm

1 stop7h 24m

Des Moines

Tue 3/31

5:05 am-9:39 am

1 stop5h 34m

$344
Quickest round-trip

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 4/8

5:49 pm-11:42 pm

1 stop4h 53m

Des Moines

Sat 4/11

1:32 pm-5:08 pm

1 stop4h 36m

$354

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 4/8

5:49 pm-11:42 pm

1 stop4h 53m

Des Moines

Sat 4/11

1:32 pm-5:08 pm

1 stop4h 36m

$374

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 7/17

7:30 am-4:00 pm

1 stop7h 30m

Des Moines

Tue 7/21

2:26 pm-6:33 pm

1 stop5h 07m

$428

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 3/27

3:35 pm-11:59 pm

1 stop7h 24m

Des Moines

Tue 3/31

5:05 am-3:05 pm

2 stops11h 00m

$460

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 3/25

2:36 pm-11:40 pm

1 stop8h 04m

Des Moines

Sun 3/29

5:00 am-3:05 pm

2 stops11h 05m

$508

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 7/17

6:00 pm-10:35 pm

2 stops27h 35m

Des Moines

Tue 7/21

5:50 am-9:44 am

1 stop4h 54m

$528

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 4/8

5:49 pm-11:42 pm

1 stop4h 53m

Des Moines

Sat 4/11

1:10 pm-9:09 am

2 stops20h 59m

$542

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 4/8

3:24 pm-11:42 pm

1 stop7h 18m

Des Moines

Sat 4/11

7:16 pm-5:08 pm

2 stops22h 52m

$568

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Santa Fe to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Des Moines?

American Airlines, United Airlines and Southwest are the top three most popular airlines that fly to Des Moines from Santa Fe according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 3 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When to book flights from Santa Fe to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Fe to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Fe to Des Moines (SAF to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Fe to Des Moines

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Santa Fe to Des Moines takes 4h 31m
There are no direct flights from Santa Fe to Des Moines. There are no popular flight routes from Santa Fe to Des Moines.
Search flight deals

  • How far is Santa Fe to Des Moines by plane?

    There are 777.7 mi between Santa Fe and Des Moines. Flights usually cover this in 4h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santa Fe Airport to Des Moines Airport?

    Prices for flights from Santa Fe Airport to Des Moines Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Santa Fe Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Fe Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Santa Fe to Des Moines?

Finding the right flight to Des Moines from Santa Fe is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Santa Fe to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Fe to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Fe to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Santa Fe.

I’m not ready to book a flight from Santa Fe to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Santa Fe and alert you when they change.

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