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Cheap flights from San Luis Obispo to Knoxville from $369

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Luis Obispo to Knoxville departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Luis Obispo to Knoxville

Cheap round-trip flights

American Airlines Logo
12:24 pm - 10:16 pmSBP-TYS
6h 52m1 stop
American Airlines Logo
6:00 am - 11:34 amTYS-SBP
8h 34m1 stop
$369American Airlines
Find Deal
Sat, Sep 6 - Tue, Sep 9
United Airlines Logo
5:15 am - 2:50 pmSBP-TYS
6h 35m1 stop
United Airlines Logo
9:30 am - 6:19 pmTYS-SBP
11h 49m2 stops
$374United Airlines
Find Deal
Sat, Sep 6 - Tue, Sep 9
United Airlines Logo
5:15 am - 8:56 pmSBP-TYS
12h 41m2 stops
United Airlines Logo
12:00 pm - 6:19 pmTYS-SBP
9h 19m2 stops
$379United Airlines
Find Deal
Sat, Sep 6 - Tue, Sep 9
American Airlines Logo
12:26 pm - 11:51 pmSBP-TYS
8h 25m1 stop
American Airlines Logo
5:10 am - 11:43 amTYS-SBP
9h 33m1 stop
$463American Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 3
American Airlines Logo
7:16 pm - 11:15 amSBP-TYS
12h 59m2 stops
American Airlines Logo
5:10 am - 11:43 amTYS-SBP
9h 33m1 stop
$468American Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 3
American Airlines Logo
12:24 pm - 12:21 amSBP-TYS
8h 57m1 stop
American Airlines Logo
7:28 am - 11:34 amTYS-SBP
7h 06m1 stop
$469American Airlines
Find Deal
Wed, Sep 3 - Tue, Sep 9
American Airlines Logo
12:53 pm - 12:21 amSBP-TYS
8h 28m2 stops
American Airlines Logo
6:00 am - 11:34 amTYS-SBP
8h 34m1 stop
$474American Airlines
Find Deal
Wed, Sep 3 - Tue, Sep 9
American Airlines Logo
6:00 am - 6:50 pmSBP-TYS
9h 50m2 stops
American Airlines Logo
12:15 pm - 6:43 pmTYS-SBP
9h 28m2 stops
$479American Airlines
Find Deal
Wed, Sep 3 - Tue, Sep 9
American Airlines Logo
12:24 pm - 11:51 pmSBP-TYS
8h 27m1 stop
American Airlines Logo
6:00 am - 11:34 amTYS-SBP
8h 34m1 stop
$487American Airlines
Find Deal
Thu, Sep 25 - Tue, Sep 30
American Airlines Logo
12:24 pm - 11:51 pmSBP-TYS
8h 27m1 stop
American Airlines Logo
6:00 am - 12:03 pmTYS-SBP
9h 03m2 stops
$492American Airlines
Find Deal
Thu, Sep 25 - Tue, Sep 30

American Airlines flights from San Luis Obispo to Knoxville

Our best American Airlines deals on San Luis Obispo to Knoxville flight tickets
American Airlines
Sep 6
SBP12:24 pmSan Luis Obispo County
6h 52m
1 stop
TYS10:16 pmKnoxville McGhee Tyson
Sep 9
TYS6:00 amKnoxville McGhee Tyson
8h 34m
1 stop
SBP11:34 amSan Luis Obispo County
$369
Find similar
American Airlines
Oct 30
SBP12:26 pmSan Luis Obispo County
8h 25m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Nov 3
TYS5:10 amKnoxville McGhee Tyson
9h 33m
1 stop
SBP11:43 amSan Luis Obispo County
$463
Find similar
American Airlines
Oct 30
SBP7:16 pmSan Luis Obispo County
12h 59m
2 stops
TYS11:15 amKnoxville McGhee Tyson
Nov 3
TYS5:10 amKnoxville McGhee Tyson
9h 33m
1 stop
SBP11:43 amSan Luis Obispo County
$468
Find similar

United Airlines flights from San Luis Obispo to Knoxville

Our best United Airlines deals on San Luis Obispo to Knoxville flight tickets
United Airlines
Sep 6
SBP5:15 amSan Luis Obispo County
6h 35m
1 stop
TYS2:50 pmKnoxville McGhee Tyson
Sep 9
TYS9:30 amKnoxville McGhee Tyson
11h 49m
2 stops
SBP6:19 pmSan Luis Obispo County
$374
Find similar
United Airlines
Sep 6
SBP5:15 amSan Luis Obispo County
12h 41m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
Sep 9
TYS12:00 pmKnoxville McGhee Tyson
9h 19m
2 stops
SBP6:19 pmSan Luis Obispo County
$379
Find similar
United Airlines
Sep 25
SBP4:00 pmSan Luis Obispo County
15h 29m
2 stops
TYS10:29 amKnoxville McGhee Tyson
Sep 30
TYS4:40 pmKnoxville McGhee Tyson
22h 36m
3 stops
SBP12:16 pmSan Luis Obispo County
$716
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Luis Obispo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from San Luis Obispo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Sat 9/6

12:24 pm-10:16 pm

1 stop6h 52m

Knoxville McGhee Tyson

Tue 9/9

6:00 am-11:34 am

1 stop8h 34m

$369

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Sat 9/6

5:15 am-2:50 pm

1 stop6h 35m

Knoxville McGhee Tyson

Tue 9/9

9:30 am-6:19 pm

2 stops11h 49m

$374

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Sat 9/6

5:15 am-8:56 pm

2 stops12h 41m

Knoxville McGhee Tyson

Tue 9/9

12:00 pm-6:19 pm

2 stops9h 19m

$379

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Thu 10/30

12:26 pm-11:51 pm

1 stop8h 25m

Knoxville McGhee Tyson

Mon 11/3

5:10 am-11:43 am

1 stop9h 33m

$463

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Thu 10/30

7:16 pm-11:15 am

2 stops12h 59m

Knoxville McGhee Tyson

Mon 11/3

5:10 am-11:43 am

1 stop9h 33m

$468

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Wed 9/3

12:24 pm-12:21 am

1 stop8h 57m

Knoxville McGhee Tyson

Tue 9/9

7:28 am-11:34 am

1 stop7h 06m

$469

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Wed 9/3

12:53 pm-12:21 am

2 stops8h 28m

Knoxville McGhee Tyson

Tue 9/9

6:00 am-11:34 am

1 stop8h 34m

$474

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Wed 9/3

6:00 am-6:50 pm

2 stops9h 50m

Knoxville McGhee Tyson

Tue 9/9

12:15 pm-6:43 pm

2 stops9h 28m

$479

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Thu 9/25

12:24 pm-11:51 pm

1 stop8h 27m

Knoxville McGhee Tyson

Tue 9/30

6:00 am-11:34 am

1 stop8h 34m

$487

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Thu 9/25

12:24 pm-11:51 pm

1 stop8h 27m

Knoxville McGhee Tyson

Tue 9/30

6:00 am-12:03 pm

2 stops9h 03m

$492

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from San Luis Obispo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Luis Obispo and Knoxville?

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Luis Obispo to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $398. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Luis Obispo to Knoxville for around $552.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from San Luis Obispo to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $485.

When to book flights from San Luis Obispo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Luis Obispo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Luis Obispo to Knoxville (SBP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Luis Obispo to Knoxville

Direct flights

None
There are no direct flights from San Luis Obispo to Knoxville. There are no popular flight routes from San Luis Obispo to Knoxville.
Search flight deals

  • How far is San Luis Obispo County to Knoxville McGhee Tyson by plane?

    The distance between San Luis Obispo County and Knoxville McGhee Tyson is about 2050.2 mi. In terms of flight time, this usually takes a little over 6h 35m.

  • When did momondo last update prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Luis Obispo to Knoxville?

Best airlines flying from San Luis Obispo to Knoxville

Compare and see reviews for airlines that fly from San Luis Obispo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $254Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Luis Obispo to Knoxville?

It is quick and easy to find San Luis Obispo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Luis Obispo to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from San Luis Obispo with this policy.

How can momondo help me find flights from San Luis Obispo to Knoxville?

momondo helps you find the best flight between San Luis Obispo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Luis Obispo to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from San Luis Obispo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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