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Cheap flights from San Luis Obispo to Knoxville from $379

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Luis Obispo to Knoxville departing on 10/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Luis Obispo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:38 pm - 11:18 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
7h 40m1 stop Dallas/Fort Worth
American Airlines Logo
7:25 am - 11:48 amTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
7h 23m1 stop Dallas/Fort Worth
$379American Airlines
Tue, Oct 13 - Tue, Oct 27
American Airlines Logo
9:45 am - 11:18 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
10h 33m2 stops Phoenix Sky Harbor Intl Dallas/Fort Worth
American Airlines Logo
7:25 am - 11:48 amTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
7h 23m1 stop Dallas/Fort Worth
$384American Airlines
Tue, Oct 13 - Tue, Oct 27
American Airlines Logo
9:45 am - 11:18 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
10h 33m2 stops Phoenix Sky Harbor Intl Dallas/Fort Worth
American Airlines Logo
6:20 am - 6:18 pmTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
14h 58m2 stops Charlotte Douglas Phoenix Sky Harbor Intl
$389American Airlines
Tue, Oct 13 - Tue, Oct 27
United Airlines Logo
12:55 pm - 10:29 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
6h 34m1 stop Denver Intl
United Airlines Logo
9:00 am - 1:24 pmTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
7h 24m1 stop Denver Intl
$489United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
8:00 am - 10:29 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
11h 29m2 stops San Francisco Denver Intl
United Airlines Logo
4:50 pm - 9:00 pmTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
7h 10m1 stop Denver Intl
$494United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
8:00 am - 10:29 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
11h 29m2 stops San Francisco Denver Intl
United Airlines Logo
5:45 am - 12:32 pmTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
9h 47m2 stops Washington, D.C. Dulles Intl Los Angeles
$499United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
12:55 pm - 10:29 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
6h 34m1 stop Denver Intl
United Airlines Logo
9:00 am - 1:24 pmTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
7h 24m1 stop Denver Intl
$529United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
8:00 am - 10:29 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
11h 29m2 stops San Francisco Denver Intl
United Airlines Logo
4:50 pm - 9:00 pmTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
7h 10m1 stop Denver Intl
$534United Airlines
Tue, Sep 1 - Sat, Sep 5
American Airlines Logo
12:36 pm - 11:32 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
7h 56m1 stop Dallas/Fort Worth
American Airlines Logo
6:50 am - 11:58 amTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
8h 08m1 stop Dallas/Fort Worth
$830American Airlines
Fri, Nov 20 - Sat, Nov 28
American Airlines Logo
12:36 pm - 11:32 pmSBP  San Luis Obispo County-TYS Knoxville McGhee Tyson
7h 56m1 stop Dallas/Fort Worth
American Airlines Logo
6:50 am - 11:58 amTYS  Knoxville McGhee Tyson-SBP San Luis Obispo County
8h 08m1 stop Dallas/Fort Worth
$878American Airlines
Fri, Nov 20 - Sat, Nov 28

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United Airlines flights from San Luis Obispo to Knoxville

Our best United Airlines deals on San Luis Obispo to Knoxville flight tickets
United Airlines
Sep 1
SBP12:55 pmSan Luis Obispo County
6h 34m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Sep 5
TYS9:00 amKnoxville McGhee Tyson
7h 24m
1 stop
SBP1:24 pmSan Luis Obispo County
$489
United Airlines
Sep 1
SBP8:00 amSan Luis Obispo County
11h 29m
2 stops
TYS10:29 pmKnoxville McGhee Tyson
Sep 5
TYS4:50 pmKnoxville McGhee Tyson
7h 10m
1 stop
SBP9:00 pmSan Luis Obispo County
$494
United Airlines
Sep 1
SBP8:00 amSan Luis Obispo County
11h 29m
2 stops
TYS10:29 pmKnoxville McGhee Tyson
Sep 5
TYS5:45 amKnoxville McGhee Tyson
9h 47m
2 stops
SBP12:32 pmSan Luis Obispo County
$499

American Airlines flights from San Luis Obispo to Knoxville

Our best American Airlines deals on San Luis Obispo to Knoxville flight tickets
American Airlines
Oct 13
SBP12:38 pmSan Luis Obispo County
7h 40m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Oct 27
TYS7:25 amKnoxville McGhee Tyson
7h 23m
1 stop
SBP11:48 amSan Luis Obispo County
$379
American Airlines
Oct 13
SBP9:45 amSan Luis Obispo County
10h 33m
2 stops
TYS11:18 pmKnoxville McGhee Tyson
Oct 27
TYS7:25 amKnoxville McGhee Tyson
7h 23m
1 stop
SBP11:48 amSan Luis Obispo County
$384
American Airlines
Oct 13
SBP9:45 amSan Luis Obispo County
10h 33m
2 stops
TYS11:18 pmKnoxville McGhee Tyson
Oct 27
TYS6:20 amKnoxville McGhee Tyson
14h 58m
2 stops
SBP6:18 pmSan Luis Obispo County
$389

momondo Fare Finder

 
Customize your flight search to find flights from San Luis Obispo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from San Luis Obispo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 10/13

12:38 pm-11:18 pm

1 stop7h 40m

Knoxville McGhee Tyson

Tue 10/27

7:25 am-11:48 am

1 stop7h 23m

$379

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 10/13

9:45 am-11:18 pm

2 stops10h 33m

Knoxville McGhee Tyson

Tue 10/27

7:25 am-11:48 am

1 stop7h 23m

$384

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 10/13

9:45 am-11:18 pm

2 stops10h 33m

Knoxville McGhee Tyson

Tue 10/27

6:20 am-6:18 pm

2 stops14h 58m

$389
Quickest round-trip

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 9/1

12:55 pm-10:29 pm

1 stop6h 34m

Knoxville McGhee Tyson

Sat 9/5

9:00 am-1:24 pm

1 stop7h 24m

$489

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 9/1

8:00 am-10:29 pm

2 stops11h 29m

Knoxville McGhee Tyson

Sat 9/5

4:50 pm-9:00 pm

1 stop7h 10m

$494

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 9/1

8:00 am-10:29 pm

2 stops11h 29m

Knoxville McGhee Tyson

Sat 9/5

5:45 am-12:32 pm

2 stops9h 47m

$499

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 9/1

12:55 pm-10:29 pm

1 stop6h 34m

Knoxville McGhee Tyson

Sat 9/5

9:00 am-1:24 pm

1 stop7h 24m

$529

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Tue 9/1

8:00 am-10:29 pm

2 stops11h 29m

Knoxville McGhee Tyson

Sat 9/5

4:50 pm-9:00 pm

1 stop7h 10m

$534

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Fri 11/20

12:36 pm-11:32 pm

1 stop7h 56m

Knoxville McGhee Tyson

Sat 11/28

6:50 am-11:58 am

1 stop8h 08m

$830

San Luis ObispoKnoxville

SBP San Luis Obispo County - TYS Knoxville McGhee Tyson

SBPTYS

San Luis Obispo County

Fri 11/20

12:36 pm-11:32 pm

1 stop7h 56m

Knoxville McGhee Tyson

Sat 11/28

6:50 am-11:58 am

1 stop8h 08m

$878

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Luis Obispo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from San Luis Obispo, with most prices found around $0. If you aren’t able to travel during the month of November, then book flights to Knoxville from San Luis Obispo during October instead. Flights to Knoxville in October, while not as cheap as those in November, still average around $308.

When to book flights from San Luis Obispo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Luis Obispo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Luis Obispo to Knoxville (SBP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Luis Obispo to Knoxville

Fastest flight time

6h 34m

Direct flights

None
The fastest flight from San Luis Obispo to Knoxville takes 6h 34m
There are no direct flights from San Luis Obispo to Knoxville. There are no popular flight routes from San Luis Obispo to Knoxville.
Search flight deals

Frequently asked questions about flying from San Luis Obispo to Knoxville

  • How far is San Luis Obispo County to Knoxville McGhee Tyson by plane?

    The distance between San Luis Obispo County and Knoxville McGhee Tyson is about 2050.2 mi. In terms of flight time, this usually takes a little over 6h 34m.

  • When did momondo last update prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Luis Obispo to Knoxville?

Best airlines flying from San Luis Obispo to Knoxville

Compare and see reviews for airlines that fly from San Luis Obispo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights
United AirlinesPriceFrom $349Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Luis Obispo to Knoxville?

It is quick and easy to find San Luis Obispo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Luis Obispo to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from San Luis Obispo with this policy.

How can momondo help me find flights from San Luis Obispo to Knoxville?

momondo helps you find the best flight between San Luis Obispo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Luis Obispo to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from San Luis Obispo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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