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Cheap flights from San Luis Obispo to Knoxville from $424

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Luis Obispo to Knoxville departing on 4/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Luis Obispo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:00 am - 3:06 pm
SBP
-
TYS
7h 06m
1 stop
United Airlines Logo
9:00 am - 5:56 pm
TYS
-
SBP
11h 56m
2 stops
$424United Airlines
Fri, Apr 3 - Wed, Apr 8
United Airlines Logo
5:00 am - 3:06 pm
SBP
-
TYS
7h 06m
1 stop
United Airlines Logo
7:05 am - 5:56 pm
TYS
-
SBP
13h 51m
2 stops
$434United Airlines
Fri, Apr 3 - Wed, Apr 8
United Airlines Logo
5:00 am - 3:06 pm
SBP
-
TYS
7h 06m
1 stop
United Airlines Logo
4:30 pm - 11:59 pm
TYS
-
SBP
10h 29m
2 stops
$435United Airlines
Tue, Mar 31 - Tue, Apr 14
United Airlines Logo
6:05 am - 7:56 pm
SBP
-
TYS
10h 51m
2 stops
United Airlines Logo
4:30 pm - 11:59 pm
TYS
-
SBP
10h 29m
2 stops
$440United Airlines
Tue, Mar 31 - Tue, Apr 14
United Airlines Logo
5:00 am - 3:06 pm
SBP
-
TYS
7h 06m
1 stop
United Airlines Logo
4:30 pm - 9:35 pm
TYS
-
SBP
8h 05m
1 stop
$449United Airlines
Fri, Apr 3 - Tue, Apr 7
American Airlines Logo
12:59 pm - 11:56 pm
SBP
-
TYS
7h 57m
1 stop
American Airlines Logo
6:00 am - 12:07 pm
TYS
-
SBP
9h 07m
1 stop
$450American Airlines
Tue, May 12 - Wed, May 20
United Airlines Logo
5:00 am - 3:06 pm
SBP
-
TYS
7h 06m
1 stop
United Airlines Logo
4:30 pm - 11:59 pm
TYS
-
SBP
10h 29m
2 stops
$454United Airlines
Fri, Apr 3 - Tue, Apr 7
American Airlines Logo
12:59 pm - 11:56 pm
SBP
-
TYS
7h 57m
1 stop
American Airlines Logo
6:00 am - 12:07 pm
TYS
-
SBP
9h 07m
1 stop
$460American Airlines
Tue, May 12 - Wed, May 20
American Airlines Logo
12:51 pm - 11:53 pm
SBP
-
TYS
8h 02m
1 stop
American Airlines Logo
5:36 am - 12:01 pm
TYS
-
SBP
9h 25m
1 stop
$469American Airlines
Wed, Jun 3 - Sat, Jun 13
United Airlines Logo
5:00 am - 3:06 pm
SBP
-
TYS
7h 06m
1 stop
United Airlines Logo
4:30 pm - 11:44 pm
TYS
-
SBP
10h 14m
2 stops
$474United Airlines
Mon, Mar 30 - Wed, Apr 15

United Airlines flights from San Luis Obispo to Knoxville

Our best United Airlines deals on San Luis Obispo to Knoxville flight tickets
United Airlines
Apr 3
SBP5:00 amSan Luis Obispo County
7h 06m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Apr 8
TYS9:00 amKnoxville McGhee Tyson
11h 56m
2 stops
SBP5:56 pmSan Luis Obispo County
$424
United Airlines
Apr 3
SBP5:00 amSan Luis Obispo County
7h 06m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Apr 8
TYS7:05 amKnoxville McGhee Tyson
13h 51m
2 stops
SBP5:56 pmSan Luis Obispo County
$434
United Airlines
Mar 31
SBP5:00 amSan Luis Obispo County
7h 06m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Apr 14
TYS4:30 pmKnoxville McGhee Tyson
10h 29m
2 stops
SBP11:59 pmSan Luis Obispo County
$435

American Airlines flights from San Luis Obispo to Knoxville

Our best American Airlines deals on San Luis Obispo to Knoxville flight tickets
American Airlines
May 12
SBP12:59 pmSan Luis Obispo County
7h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
May 20
TYS6:00 amKnoxville McGhee Tyson
9h 07m
1 stop
SBP12:07 pmSan Luis Obispo County
$450
American Airlines
May 12
SBP12:59 pmSan Luis Obispo County
7h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
May 20
TYS6:00 amKnoxville McGhee Tyson
9h 07m
1 stop
SBP12:07 pmSan Luis Obispo County
$460
American Airlines
Jun 3
SBP12:51 pmSan Luis Obispo County
8h 02m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
Jun 13
TYS5:36 amKnoxville McGhee Tyson
9h 25m
1 stop
SBP12:01 pmSan Luis Obispo County
$469

momondo Fare Finder

 
Customize your flight search to find flights from San Luis Obispo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from San Luis Obispo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Fri 4/3

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Wed 4/8

9:00 am-5:56 pm

2 stops11h 56m

$424

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Fri 4/3

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Wed 4/8

7:05 am-5:56 pm

2 stops13h 51m

$434

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 3/31

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Tue 4/14

4:30 pm-11:59 pm

2 stops10h 29m

$435

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 3/31

6:05 am-7:56 pm

2 stops10h 51m

Knoxville McGhee Tyson

Tue 4/14

4:30 pm-11:59 pm

2 stops10h 29m

$440
Quickest round-trip

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Fri 4/3

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Tue 4/7

4:30 pm-9:35 pm

1 stop8h 05m

$449

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 5/12

12:59 pm-11:56 pm

1 stop7h 57m

Knoxville McGhee Tyson

Wed 5/20

6:00 am-12:07 pm

1 stop9h 07m

$450

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Fri 4/3

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Tue 4/7

4:30 pm-11:59 pm

2 stops10h 29m

$454

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 5/12

12:59 pm-11:56 pm

1 stop7h 57m

Knoxville McGhee Tyson

Wed 5/20

6:00 am-12:07 pm

1 stop9h 07m

$460

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Wed 6/3

12:51 pm-11:53 pm

1 stop8h 02m

Knoxville McGhee Tyson

Sat 6/13

5:36 am-12:01 pm

1 stop9h 25m

$469

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Mon 3/30

5:00 am-3:06 pm

1 stop7h 06m

Knoxville McGhee Tyson

Wed 4/15

4:30 pm-11:44 pm

2 stops10h 14m

$474

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from San Luis Obispo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from San Luis Obispo, with most prices found around $308. If you aren’t able to travel during the month of October, then book flights to Knoxville from San Luis Obispo during August instead. Flights to Knoxville in August, while not as cheap as those in October, still average around $324.

When to book flights from San Luis Obispo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Luis Obispo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Luis Obispo to Knoxville (SBP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Luis Obispo to Knoxville

Fastest flight time

7h 06m

Direct flights

None
The fastest flight from San Luis Obispo to Knoxville takes 7h 06m
There are no direct flights from San Luis Obispo to Knoxville. There are no popular flight routes from San Luis Obispo to Knoxville.
Search flight deals

  • How far is San Luis Obispo County to Knoxville McGhee Tyson by plane?

    The distance between San Luis Obispo County and Knoxville McGhee Tyson is about 2050.2 mi. In terms of flight time, this usually takes a little over 7h 06m.

  • When did momondo last update prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Luis Obispo to Knoxville?

Best airlines flying from San Luis Obispo to Knoxville

Compare and see reviews for airlines that fly from San Luis Obispo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $278Free CancellationRating
7.4
9,451 reviews
Search United Airlines flights
American AirlinesPriceFrom $287Free CancellationRating
7.1
11,480 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Luis Obispo to Knoxville?

It is quick and easy to find San Luis Obispo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Luis Obispo to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from San Luis Obispo with this policy.

How can momondo help me find flights from San Luis Obispo to Knoxville?

momondo helps you find the best flight between San Luis Obispo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Luis Obispo to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from San Luis Obispo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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