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Cheap flights from San Luis Obispo to Knoxville from $369

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Luis Obispo to Knoxville departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Luis Obispo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:34 pm - 11:18 pm
SBP
-
TYS
7h 44m
1 stop
American Airlines Logo
5:10 am - 11:43 am
TYS
-
SBP
9h 33m
1 stop
$369American Airlines
Sat, Oct 24 - Sat, Nov 7
United Airlines Logo
5:00 am - 3:46 pm
SBP
-
TYS
7h 46m
1 stop
United Airlines Logo
8:45 am - 5:19 pm
TYS
-
SBP
11h 34m
2 stops
$374United Airlines
Sat, Oct 24 - Sat, Nov 7
United Airlines Logo
10:52 am - 11:57 pm
SBP
-
TYS
10h 05m
2 stops
United Airlines Logo
4:56 pm - 8:50 pm
TYS
-
SBP
6h 54m
1 stop
$384United Airlines
Tue, Sep 15 - Sat, Sep 19
American Airlines Logo
12:34 pm - 11:18 pm
SBP
-
TYS
7h 44m
1 stop
American Airlines Logo
7:30 am - 11:45 am
TYS
-
SBP
7h 15m
1 stop
$394American Airlines
Tue, Sep 15 - Tue, Sep 22
United Airlines Logo
10:52 am - 10:43 pm
SBP
-
TYS
8h 51m
2 stops
United Airlines Logo
8:45 am - 5:19 pm
TYS
-
SBP
11h 34m
2 stops
$401United Airlines
Sat, Oct 24 - Sat, Nov 7
United Airlines Logo
10:52 am - 11:57 pm
SBP
-
TYS
10h 05m
2 stops
United Airlines Logo
4:56 pm - 8:50 pm
TYS
-
SBP
6h 54m
1 stop
$430United Airlines
Tue, Sep 15 - Tue, Sep 22
American Airlines Logo
12:52 pm - 11:55 pm
SBP
-
TYS
8h 03m
1 stop
American Airlines Logo
5:37 am - 12:00 pm
TYS
-
SBP
9h 23m
1 stop
$444American Airlines
Thu, Jun 4 - Tue, Jun 16
American Airlines Logo
12:52 pm - 11:55 pm
SBP
-
TYS
8h 03m
1 stop
American Airlines Logo
5:37 am - 12:00 pm
TYS
-
SBP
9h 23m
1 stop
$476American Airlines
Wed, Jun 10 - Wed, Jun 24
American Airlines Logo
12:52 pm - 11:55 pm
SBP
-
TYS
8h 03m
1 stop
American Airlines Logo
5:37 am - 12:00 pm
TYS
-
SBP
9h 23m
1 stop
$509American Airlines
Wed, Jun 10 - Wed, Jun 24
American Airlines Logo
12:52 pm - 11:55 pm
SBP
-
TYS
8h 03m
1 stop
American Airlines Logo
5:37 am - 12:00 pm
TYS
-
SBP
9h 23m
1 stop
$529American Airlines
Thu, Jun 4 - Tue, Jun 16

American Airlines flights from San Luis Obispo to Knoxville

Our best American Airlines deals on San Luis Obispo to Knoxville flight tickets
American Airlines
Oct 24
SBP12:34 pmSan Luis Obispo County
7h 44m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Nov 7
TYS5:10 amKnoxville McGhee Tyson
9h 33m
1 stop
SBP11:43 amSan Luis Obispo County
$369
American Airlines
Sep 15
SBP12:34 pmSan Luis Obispo County
7h 44m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Sep 22
TYS7:30 amKnoxville McGhee Tyson
7h 15m
1 stop
SBP11:45 amSan Luis Obispo County
$394
American Airlines
Jun 4
SBP12:52 pmSan Luis Obispo County
8h 03m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Jun 16
TYS5:37 amKnoxville McGhee Tyson
9h 23m
1 stop
SBP12:00 pmSan Luis Obispo County
$444

United Airlines flights from San Luis Obispo to Knoxville

Our best United Airlines deals on San Luis Obispo to Knoxville flight tickets
United Airlines
Oct 24
SBP5:00 amSan Luis Obispo County
7h 46m
1 stop
TYS3:46 pmKnoxville McGhee Tyson
Nov 7
TYS8:45 amKnoxville McGhee Tyson
11h 34m
2 stops
SBP5:19 pmSan Luis Obispo County
$374
United Airlines
Sep 15
SBP10:52 amSan Luis Obispo County
10h 05m
2 stops
TYS11:57 pmKnoxville McGhee Tyson
Sep 19
TYS4:56 pmKnoxville McGhee Tyson
6h 54m
1 stop
SBP8:50 pmSan Luis Obispo County
$384
United Airlines
Oct 24
SBP10:52 amSan Luis Obispo County
8h 51m
2 stops
TYS10:43 pmKnoxville McGhee Tyson
Nov 7
TYS8:45 amKnoxville McGhee Tyson
11h 34m
2 stops
SBP5:19 pmSan Luis Obispo County
$401

momondo Fare Finder

 
Customize your flight search to find flights from San Luis Obispo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from San Luis Obispo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Sat 10/24

12:34 pm-11:18 pm

1 stop7h 44m

Knoxville McGhee Tyson

Sat 11/7

5:10 am-11:43 am

1 stop9h 33m

$369

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Sat 10/24

5:00 am-3:46 pm

1 stop7h 46m

Knoxville McGhee Tyson

Sat 11/7

8:45 am-5:19 pm

2 stops11h 34m

$374

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 9/15

10:52 am-11:57 pm

2 stops10h 05m

Knoxville McGhee Tyson

Sat 9/19

4:56 pm-8:50 pm

1 stop6h 54m

$384
Quickest round-trip

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 9/15

12:34 pm-11:18 pm

1 stop7h 44m

Knoxville McGhee Tyson

Tue 9/22

7:30 am-11:45 am

1 stop7h 15m

$394

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Sat 10/24

10:52 am-10:43 pm

2 stops8h 51m

Knoxville McGhee Tyson

Sat 11/7

8:45 am-5:19 pm

2 stops11h 34m

$401

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Tue 9/15

10:52 am-11:57 pm

2 stops10h 05m

Knoxville McGhee Tyson

Tue 9/22

4:56 pm-8:50 pm

1 stop6h 54m

$430

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Thu 6/4

12:52 pm-11:55 pm

1 stop8h 03m

Knoxville McGhee Tyson

Tue 6/16

5:37 am-12:00 pm

1 stop9h 23m

$444

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Wed 6/10

12:52 pm-11:55 pm

1 stop8h 03m

Knoxville McGhee Tyson

Wed 6/24

5:37 am-12:00 pm

1 stop9h 23m

$476

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Wed 6/10

12:52 pm-11:55 pm

1 stop8h 03m

Knoxville McGhee Tyson

Wed 6/24

5:37 am-12:00 pm

1 stop9h 23m

$509

San Luis ObispoKnoxville

SBP - TYS

SBPTYS

San Luis Obispo County

Thu 6/4

12:52 pm-11:55 pm

1 stop8h 03m

Knoxville McGhee Tyson

Tue 6/16

5:37 am-12:00 pm

1 stop9h 23m

$529

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Luis Obispo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Luis Obispo and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from San Luis Obispo, with most prices found around $308. If you aren’t able to travel during the month of October, then book flights to Knoxville from San Luis Obispo during August instead. Flights to Knoxville in August, while not as cheap as those in October, still average around $334.

When to book flights from San Luis Obispo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Luis Obispo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Luis Obispo to Knoxville (SBP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Luis Obispo to Knoxville

Fastest flight time

6h 37m

Direct flights

None
The fastest flight from San Luis Obispo to Knoxville takes 6h 37m
There are no direct flights from San Luis Obispo to Knoxville. There are no popular flight routes from San Luis Obispo to Knoxville.
Search flight deals

Frequently asked questions about flying from San Luis Obispo to Knoxville

  • How far is San Luis Obispo County to Knoxville McGhee Tyson by plane?

    The distance between San Luis Obispo County and Knoxville McGhee Tyson is about 2050.2 mi. In terms of flight time, this usually takes a little over 6h 37m.

  • When did momondo last update prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Luis Obispo County Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Luis Obispo to Knoxville?

Best airlines flying from San Luis Obispo to Knoxville

Compare and see reviews for airlines that fly from San Luis Obispo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,664 reviews
Search American Airlines flights
United AirlinesPriceFrom $349Free CancellationRating
7.4
9,711 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Luis Obispo to Knoxville?

It is quick and easy to find San Luis Obispo to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Luis Obispo to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from San Luis Obispo with this policy.

How can momondo help me find flights from San Luis Obispo to Knoxville?

momondo helps you find the best flight between San Luis Obispo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Luis Obispo to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from San Luis Obispo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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