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Cheap flights from San Francisco to Panama from $203

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Panama departing on 11/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
1:35 am - 6:55 pmSFO-PTY
14h 20m1 stop
Avianca Logo
2:55 am - 9:50 pmPTY-SFO
21h 55m2 stops
$496Avianca
Find Deal
Thu, Jan 15 - Sat, Jan 17
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
3:50 pm - 12:00 pmPTY-SFO
23h 10m1 stop
$500Avianca
Find Deal
Sat, Nov 15 - Sun, Nov 23
Avianca Logo
1:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
3:50 pm - 12:00 pmPTY-SFO
23h 10m1 stop
$503Avianca
Find Deal
Wed, Jan 14 - Wed, Jan 21
Avianca Logo
2:20 pm - 10:30 amSFO-PTY
18h 10m1 stop
Avianca Logo
3:50 pm - 11:40 pmPTY-SFO
9h 50m1 stop
$504Avianca
Find Deal
Sat, Mar 14 - Sat, Mar 21
Multiple Airlines Logo
7:00 am - 5:20 amSFO-PTY
19h 20m1 stop
Multiple Airlines Logo
3:50 pm - 11:20 pmPTY-SFO
10h 30m1 stop
$574Multiple Airlines
Find Deal
Wed, Dec 10 - Thu, Dec 11
Multiple Airlines Logo
2:23 pm - 5:20 amSFO-PTY
11h 57m1 stop
Multiple Airlines Logo
2:55 am - 9:50 pmPTY-SFO
21h 55m2 stops
$578Multiple Airlines
Find Deal
Mon, Dec 8 - Mon, Dec 15
United Airlines Logo
12:43 am - 5:31 pmSFO-DAV
37h 48m2 stops
United Airlines Logo
9:48 am - 6:50 pmDAV-SFO
36h 02m2 stops
$1,099United Airlines
Find Deal
Mon, Feb 2 - Tue, Feb 17
United Airlines Logo
8:45 am - 9:10 amSFO-DAV
21h 25m1 stop
United Airlines Logo
9:50 am - 8:29 pmDAV-SFO
13h 39m1 stop
$1,124United Airlines
Find Deal
Sat, Nov 29 - Sat, Dec 6
Copa Airlines Logo
12:36 am - 9:10 amSFO-DAV
29h 34m1 stop
Copa Airlines Logo
9:50 am - 11:17 pmDAV-SFO
16h 27m1 stop
$1,191Copa Airlines
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Fri, Nov 28 - Sat, Dec 6
Copa Airlines Logo
12:42 am - 7:50 amSFO-DAV
28h 08m1 stop
Copa Airlines Logo
9:48 am - 11:20 pmDAV-SFO
16h 32m1 stop
$1,363Copa Airlines
Find Deal
Sun, Feb 22 - Fri, Feb 27

Avianca flights from San Francisco to Panama

Our best Avianca deals on San Francisco to Panama flight tickets
Avianca
Jan 15
SFO1:35 amSan Francisco
14h 20m
1 stop
PTY6:55 pmPanama City Tocumen Intl
Jan 17
PTY2:55 amPanama City Tocumen Intl
21h 55m
2 stops
SFO9:50 pmSan Francisco
$496
Find similar
Avianca
Nov 15
SFO1:20 pmSan Francisco
18h 10m
1 stop
PTY10:30 amPanama City Tocumen Intl
Nov 23
PTY3:50 pmPanama City Tocumen Intl
23h 10m
1 stop
SFO12:00 pmSan Francisco
$500
Find similar
Avianca
Nov 9
SFO11:10 pmSan Francisco
8h 20m
1 stop
PTY10:30 amPanama City Tocumen Intl
Nov 12
PTY9:45 amPanama City Tocumen Intl
15h 05m
2 stops
SFO9:50 pmSan Francisco
$501
Find similar

Copa Airlines flights from San Francisco to Panama

Our best Copa Airlines deals on San Francisco to Panama flight tickets
Copa Airlines
Nov 14
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
Nov 23
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
$918
Find similar
Copa Airlines
Nov 8
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
Nov 14
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
$920
Find similar
Copa Airlines
Nov 14
SFO12:36 amSan Francisco
7h 10m
PTY10:46 amPanama City Tocumen Intl
Nov 23
PTY6:27 pmPanama City Tocumen Intl
7h 50m
SFO11:17 pmSan Francisco
$950
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from San Francisco to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Thu 1/15

1:35 am-6:55 pm

1 stop14h 20m

Panama City Tocumen Intl

Sat 1/17

2:55 am-9:50 pm

2 stops21h 55m

$496

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 11/15

1:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Sun 11/23

3:50 pm-12:00 pm

1 stop23h 10m

$500

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 1/14

1:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Wed 1/21

3:50 pm-12:00 pm

1 stop23h 10m

$503

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Sat 3/14

2:20 pm-10:30 am

1 stop18h 10m

Panama City Tocumen Intl

Sat 3/21

3:50 pm-11:40 pm

1 stop9h 50m

$504

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Wed 12/10

7:00 am-5:20 am

1 stop19h 20m

Panama City Tocumen Intl

Thu 12/11

3:50 pm-11:20 pm

1 stop10h 30m

$574

San FranciscoPanama City

SFO - PTY

SFOPTY

San Francisco

Mon 12/8

2:23 pm-5:20 am

1 stop11h 57m

Panama City Tocumen Intl

Mon 12/15

2:55 am-9:50 pm

2 stops21h 55m

$578

San FranciscoDavid

SFO - DAV

SFODAV

San Francisco

Mon 2/2

12:43 am-5:31 pm

2 stops37h 48m

David Enrique Malek

Tue 2/17

9:48 am-6:50 pm

2 stops36h 02m

$1,099

San FranciscoDavid

SFO - DAV

SFODAV

San Francisco

Sat 11/29

8:45 am-9:10 am

1 stop21h 25m

David Enrique Malek

Sat 12/6

9:50 am-8:29 pm

1 stop13h 39m

$1,124

San FranciscoDavid

SFO - DAV

SFODAV

San Francisco

Fri 11/28

12:36 am-9:10 am

1 stop29h 34m

David Enrique Malek

Sat 12/6

9:50 am-11:17 pm

1 stop16h 27m

$1,191

San FranciscoDavid

SFO - DAV

SFODAV

San Francisco

Sun 2/22

12:42 am-7:50 am

1 stop28h 08m

David Enrique Malek

Fri 2/27

9:48 am-11:20 pm

1 stop16h 32m

$1,363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from San Francisco to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of October is, on average, the cheapest month to fly to Panama from San Francisco, with most prices found around $576. If you don’t want to visit Panama in October, then you should wait until August to fly from San Francisco, when ticket prices are also cheap, with an average price of $583.

What is the cheapest day to depart on your flight to Panama?

According to our data, Tuesday is the cheapest day to fly to Panama from San Francisco. The lowest ticket price found for a Tuesday departure recently was $634. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Panama for around $741.

What is the cheapest time of day to depart on your flight to Panama?

At noon is the cheapest time of day to fly from San Francisco to Panama when you can find flight prices for as low as $498. Flying to Panama at noon is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Panama, so prices are often more expensive at around $806 per ticket.

What is the cheapest San Francisco to Panama flight route?

Fly from San Francisco to Panama City Tocumen Intl for the best San Francisco - Panama flight prices

How far in advance should I book a flight to Panama?

You are more likely to see cheaper flights to Panama from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $643 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Francisco for as low as $592 on momondo.

What cabin class options are available on San Francisco to Panama flights?

There are 3 cabin classes available to choose from on San Francisco to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap San Francisco to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Panama

Best Price Found

$240

Fastest flight time

6h 52m

Direct flights

Every day

Airports in Panama

1 airport
The best one-way flight to Panama from San Francisco in the past 72 hours is $240. The best round-trip flight deal from San Francisco to Panama found on momondo in the last 72 hours is $573.
The fastest flight from San Francisco to Panama takes 6h 52m
Direct flights go from San Francisco to Panama every day.
There is 1 airport near Panama: Panama City Tocumen Intl (PTY)
Search flight deals

  • When did momondo last update prices for flights from San Francisco Airport to Panama?

    Prices for flights from San Francisco Airport to Panama are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Panama?

  • How old do you have to be to fly from San Francisco Airport to Panama?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The travel and health documents required for your trip to Panama can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from San Francisco to Panama?

Best airlines flying from San Francisco to Panama

Compare and see reviews for airlines that fly from San Francisco to Panama with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $387Free CancellationRating
7.9
8,001 reviews
Search Delta flights
AviancaPriceFrom $413Free CancellationRating
6.6
2,467 reviews
Search Avianca flights
Copa AirlinesPriceFrom $503Free CancellationRating
7.6
1,561 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $535Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
American AirlinesPriceFrom $544Free CancellationRating
7.2
11,036 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Panama?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Panama. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Panama with flexible booking policies on momondo?

Flights from San Francisco to Panama with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Francisco to Panama?

momondo provides multiple filters to help you find the best flight to Panama from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to Panama right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Panama flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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