Cheap flights from San Francisco to Panama from $321

The month of October is, on average, the cheapest month to fly to Panama from San Francisco, with most prices found around $207. If you don’t want to visit Panama in October, then you should wait until February to fly from San Francisco, when ticket prices are also cheap, with an average price of $212.

According to our data, Monday is the cheapest day to fly to Panama from San Francisco. The lowest ticket price found for a Monday departure recently was $663. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Panama for around $755.

In the morning is the cheapest time of day to fly from San Francisco to Panama when you can find flight prices for as low as $693. Flying to Panama in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Panama, so prices are often more expensive at around $702 per ticket.

Fly from San Francisco to Panama City Tocumen Intl for the best San Francisco - Panama flight prices

You are more likely to see cheaper flights to Panama from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama for around $666 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama from San Francisco for as low as $582 on momondo.

There are 3 cabin classes available to choose from on San Francisco to Panama flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Avianca and Copa Airlines are the most popular carriers operating from San Francisco to Panama

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to Panama from San Francisco according to our data. Copa Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Panama. Keep in mind that there are 4 different airlines that fly to Panama on a routine basis, so you have a few additional options to choose from.

Historically, on average around 9% of flights between San Francisco and Panama have experienced a delay on any given week. The average delay length over the past 12 months has been 114 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week which experiences the fewest number of delays on this flight route. Wednesday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 6% of their flights experiencing any sort of delay.

The number of flights available between San Francisco and Panama is 2 per day as of May 2026. The most frequent departure time is 1:00AM, with 100% of daily flights leaving in the morning.

18 flights are operational weekly from San Francisco to Panama as of May 2026. The most popular departure day for this route is Wed, with 22% of flights per week taking off on this day.