Cheap flights from Orlando Airport to Panama City from $281

In general, April is the cheapest month to fly from Orlando Airport to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $411. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from Orlando Airport to Panama City during May average around $470.

Our data shows that Thursday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $501. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $570. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Orlando Airport to Panama City during this time can be as low as $511. Try not to purchase tickets in the morning because they tend to be around $552. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Orlando to Panama City Tocumen Intl for the best Orlando - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Orlando Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $563 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Orlando Airport for as low as $489 on momondo.

There are 3 cabin classes available to choose from on Orlando Airport to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 6% on your flight if you consider stops on a Orlando Airport to Panama City flight.

As of September 2026, prices for Orlando Airport to Panama City flights are approximately 79% more expensive when compared to flights at the same time last year.

United Airlines and American Airlines are the most popular carriers operating from Orlando to Panama City Tocumen Intl

Copa Airlines, American Airlines and Avianca are the top three most popular airlines that fly to Panama City from Orlando Airport according to our data. Copa Airlines is the first choice among our users, with 89% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 7% of flights between Orlando and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 133 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 7% of their flights experiencing any sort of delay.

Houston (IAH) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Miami (MIA) offer the lowest average round-trip price of $587.

Flights connecting via Miami (MIA) have the shortest average one-way travel time: 6h 18m.

Miami (MIA) has the shortest average layover time for this route: 1h 53m.

As of September 2026, 10 flights take off from Orlando Airport and land in Panama City each day. The most common flight departure time for this route is 2:00PM, with 63% of daily flights taking off in the afternoon.

74 flights are operational weekly from Orlando Airport to Panama City as of September 2026. The most popular departure day for this route is Fri, with 18% of flights per week taking off on this day.