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Cheap flights from Portland, Maine to South Carolina from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to South Carolina departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland, Maine to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Breeze Airways Logo
5:06 pm - 7:48 pm
PWM
-
CHS
2h 42mnonstop
Breeze Airways Logo
2:02 pm - 4:26 pm
CHS
-
PWM
2h 24mnonstop
$117Breeze Airways
Mon, Jan 19 - Fri, Jan 30
Breeze Airways Logo
5:06 pm - 7:48 pm
PWM
-
CHS
2h 42mnonstop
Breeze Airways Logo
2:02 pm - 4:26 pm
CHS
-
PWM
2h 24mnonstop
$127Breeze Airways
Fri, Jan 23 - Mon, Jan 26
American Airlines Logo
7:06 am - 4:33 pm
PWM
-
CLT
9h 27m1 stop
American Airlines Logo
8:15 pm - 10:25 pm
CLT
-
PWM
2h 10mnonstop
$177American Airlines
Mon, Apr 13 - Mon, Apr 13
Delta Logo
6:00 am - 11:35 am
PWM
-
MYR
5h 35m1 stop
Delta Logo
4:07 pm - 10:27 pm
MYR
-
PWM
6h 20m1 stop
$256Delta
Tue, Jan 13 - Tue, Jan 20
Delta Logo
6:00 am - 3:11 pm
PWM
-
MYR
9h 11m2 stops
Delta Logo
4:07 pm - 10:27 pm
MYR
-
PWM
6h 20m1 stop
$261Delta
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
5:31 am - 11:49 am
PWM
-
MYR
6h 18m1 stop
American Airlines Logo
5:38 pm - 10:16 pm
MYR
-
PWM
4h 38m1 stop
$277American Airlines
Sat, Feb 21 - Tue, Feb 24
United Airlines Logo
6:46 pm - 11:56 pm
PWM
-
GSP
5h 10m1 stop
United Airlines Logo
6:35 am - 2:39 pm
GSP
-
PWM
8h 04m1 stop
$305United Airlines
Thu, Jan 1 - Thu, Jan 8
Southwest Logo
5:45 am - 10:35 am
PWM
-
SAV
4h 50m1 stop
Southwest Logo
5:40 pm - 10:15 pm
SAV
-
PWM
4h 35m1 stop
$309Southwest
Thu, Jan 8 - Thu, Jan 29
United Airlines Logo
6:46 pm - 11:56 pm
PWM
-
GSP
5h 10m1 stop
United Airlines Logo
10:51 am - 6:50 pm
GSP
-
PWM
7h 59m2 stops
$310United Airlines
Thu, Jan 1 - Thu, Jan 8
Southwest Logo
3:30 pm - 8:15 pm
PWM
-
SAV
4h 45m1 stop
Southwest Logo
11:15 am - 10:15 pm
SAV
-
PWM
11h 00m2 stops
$314Southwest
Thu, Jan 8 - Thu, Jan 29

Southwest flights from Portland, Maine to South Carolina

Our best Southwest deals on Portland, Maine to South Carolina flight tickets
Southwest
Jan 13
PWM5:45 amPortland
10h 35m
2 stops
CLT4:20 pmCharlotte Douglas
Jan 27
CLT11:05 amCharlotte Douglas
11h 10m
2 stops
PWM10:15 pmPortland
$331
Find similar
Southwest
Jan 25
PWM5:35 amPortland
13h 05m
2 stops
SAV6:40 pmSavannah/Hilton Head
Jan 28
SAV11:15 amSavannah/Hilton Head
11h 00m
2 stops
PWM10:15 pmPortland
$339
Find similar
Southwest
Jan 11
PWM3:55 pmPortland
4h 30m
1 stop
CLT8:25 pmCharlotte Douglas
Jan 14
CLT11:05 amCharlotte Douglas
11h 10m
2 stops
PWM10:15 pmPortland
$344
Find similar

American Airlines flights from Portland, Maine to South Carolina

Our best American Airlines deals on Portland, Maine to South Carolina flight tickets
American Airlines
Apr 13
PWM7:06 amPortland
9h 27m
1 stop
CLT4:33 pmCharlotte Douglas
Apr 13
CLT8:15 pmCharlotte Douglas
2h 10m
PWM10:25 pmPortland
$177
Find similar
American Airlines
Jan 13
PWM12:40 pmPortland
8h 28m
2 stops
CHS9:08 pmCharleston
Jan 18
CHS6:10 amCharleston
5h 56m
2 stops
PWM12:06 pmPortland
$241
Find similar
American Airlines
Feb 27
PWM5:31 amPortland
4h 44m
1 stop
CHS10:15 amCharleston
Mar 4
CHS3:54 pmCharleston
6h 22m
1 stop
PWM10:16 pmPortland
$254
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Portland, Maine to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandCharleston

PWM - CHS

PWMCHS

Portland

Mon 1/19

5:06 pm-7:48 pm

Nonstop2h 42m

Charleston

Fri 1/30

2:02 pm-4:26 pm

Nonstop2h 24m

$117

PortlandCharleston

PWM - CHS

PWMCHS

Portland

Fri 1/23

5:06 pm-7:48 pm

Nonstop2h 42m

Charleston

Mon 1/26

2:02 pm-4:26 pm

Nonstop2h 24m

$127

PortlandCharlotte

PWM - CLT

PWMCLT

Portland

Mon 4/13

7:06 am-4:33 pm

1 stop9h 27m

Charlotte Douglas

Mon 4/13

8:15 pm-10:25 pm

Nonstop2h 10m

$177

PortlandMyrtle Beach

PWM - MYR

PWMMYR

Portland

Tue 1/13

6:00 am-11:35 am

1 stop5h 35m

Myrtle Beach Intl

Tue 1/20

4:07 pm-10:27 pm

1 stop6h 20m

$256

PortlandMyrtle Beach

PWM - MYR

PWMMYR

Portland

Tue 1/13

6:00 am-3:11 pm

2 stops9h 11m

Myrtle Beach Intl

Tue 1/20

4:07 pm-10:27 pm

1 stop6h 20m

$261

PortlandMyrtle Beach

PWM - MYR

PWMMYR

Portland

Sat 2/21

5:31 am-11:49 am

1 stop6h 18m

Myrtle Beach Intl

Tue 2/24

5:38 pm-10:16 pm

1 stop4h 38m

$277

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 1/1

6:46 pm-11:56 pm

1 stop5h 10m

Greenville

Thu 1/8

6:35 am-2:39 pm

1 stop8h 04m

$305

PortlandSavannah

PWM - SAV

PWMSAV

Portland

Thu 1/8

5:45 am-10:35 am

1 stop4h 50m

Savannah/Hilton Head

Thu 1/29

5:40 pm-10:15 pm

1 stop4h 35m

$309

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 1/1

6:46 pm-11:56 pm

1 stop5h 10m

Greenville

Thu 1/8

10:51 am-6:50 pm

2 stops7h 59m

$310

PortlandSavannah

PWM - SAV

PWMSAV

Portland

Thu 1/8

3:30 pm-8:15 pm

1 stop4h 45m

Savannah/Hilton Head

Thu 1/29

11:15 am-10:15 pm

2 stops11h 00m

$314

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Portland, Maine to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Portland, Maine is in March. Flight prices, which tend to average around $155, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of March, then book flights to South Carolina from Portland, Maine during February instead. Flights to South Carolina in February, while not as cheap as those in March, still average around $174.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Sunday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $130. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $204.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Portland, Maine to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $147. Try not to purchase tickets in the afternoon because they tend to be around $196. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Portland to South Carolina flight route?

Fly from Portland to Charleston for the best Portland - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Portland, Maine when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $244 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Portland, Maine for as low as $149 on momondo.

What cabin class options are available on Portland to South Carolina flights?

There are 2 cabin classes available to choose from on Portland to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Portland, Maine to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Portland, Maine to South Carolina.

Cheap Portland, Maine to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to South Carolina

Best Price Found

$59

Fastest flight time

2h 28m

Direct flights

Every day

Airports in South Carolina

57 airports
The best one-way flight to South Carolina from Portland, Maine in the past 72 hours is $59. The best round-trip flight deal from Portland, Maine to South Carolina found on momondo in the last 72 hours is $150.
The fastest flight from Portland, Maine to South Carolina takes 2h 28m
Direct flights go from Portland, Maine to South Carolina every day.
There are 57 airports in South Carolina. From Portland, Maine there are direct flights to Charlotte Douglas (CLT), Charleston (CHS).
Search flight deals

  • When did momondo last update prices for flights from Portland Airport to South Carolina?

    Prices for flights from Portland Airport to South Carolina are updated daily.

  • How many operators does momondo search for flights from Portland Airport to South Carolina?

  • How old do you have to be to fly from Portland Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Portland, Maine to South Carolina?

Best airlines flying from Portland, Maine to South Carolina

Compare and see reviews for airlines that fly from Portland, Maine to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Breeze AirwaysPriceFrom $90Free CancellationRating
8.2
244 reviews
Search Breeze Airways flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,007 reviews
Search Delta flights
SouthwestPriceFrom $236Free CancellationRating
7.9
4,253 reviews
Search Southwest flights
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Portland to South Carolina?

It is quick and easy to find Portland to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Portland to South Carolina with flexible booking policies on momondo?

Flights from Portland to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to South Carolina?

Once all potential Portland to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Portland to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Portland and alert you when they change.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
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