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Cheap flights from Panama City, Florida to Greenville from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Greenville departing on 7/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:20 am - 11:45 am
ECP
-
GSP
3h 25m
1 stop
Southwest Logo
6:20 am - 9:35 am
GSP
-
ECP
4h 15m
1 stop
$280Southwest
Thu, Mar 12 - Tue, Mar 24
Southwest Logo
7:20 am - 11:45 am
ECP
-
GSP
3h 25m
1 stop
Southwest Logo
12:35 pm - 8:00 pm
GSP
-
ECP
8h 25m
2 stops
$285Southwest
Thu, Mar 12 - Tue, Mar 24
Delta Logo
7:05 am - 11:05 am
ECP
-
GSP
3h 00m
1 stop
Delta Logo
7:59 pm - 11:04 pm
GSP
-
ECP
4h 05m
1 stop
$289Delta
Mon, Mar 9 - Mon, Mar 16
Southwest Logo
1:55 pm - 10:45 pm
ECP
-
GSP
7h 50m
2 stops
Southwest Logo
12:25 pm - 8:35 pm
GSP
-
ECP
9h 10m
1 stop
$300Southwest
Mon, Mar 9 - Mon, Mar 16
Delta Logo
7:05 am - 1:45 pm
ECP
-
GSP
5h 40m
1 stop
Delta Logo
7:59 pm - 11:12 pm
GSP
-
ECP
4h 13m
1 stop
$304Delta
Wed, Apr 8 - Sun, Apr 19
Delta Logo
7:05 am - 11:05 am
ECP
-
GSP
3h 00m
1 stop
Delta Logo
5:40 am - 8:35 am
GSP
-
ECP
3h 55m
1 stop
$308Delta
Thu, Apr 9 - Sun, Apr 19
Delta Logo
7:05 am - 11:05 am
ECP
-
GSP
3h 00m
1 stop
Delta Logo
7:59 pm - 11:12 pm
GSP
-
ECP
4h 13m
1 stop
$313Delta
Thu, Apr 9 - Sun, Apr 19
Southwest Logo
7:15 am - 12:10 pm
ECP
-
GSP
3h 55m
1 stop
Southwest Logo
12:35 pm - 9:40 pm
GSP
-
ECP
10h 05m
2 stops
$324Southwest
Wed, Apr 22 - Fri, Apr 24
Southwest Logo
7:20 am - 9:50 pm
ECP
-
GSP
13h 30m
2 stops
Southwest Logo
12:35 pm - 8:00 pm
GSP
-
ECP
8h 25m
2 stops
$325Southwest
Thu, Mar 12 - Tue, Mar 24
Southwest Logo
10:10 am - 9:40 pm
ECP
-
GSP
10h 30m
2 stops
Southwest Logo
12:35 pm - 9:40 pm
GSP
-
ECP
10h 05m
2 stops
$329Southwest
Wed, Apr 22 - Fri, Apr 24

Southwest flights from Panama City, Florida to Greenville

Our best Southwest deals on Panama City, Florida to Greenville flight tickets
Southwest
Mar 12
ECP7:20 amPanama City NW Florida Beaches
3h 25m
1 stop
GSP11:45 amGreenville
Mar 24
GSP6:20 amGreenville
4h 15m
1 stop
ECP9:35 amPanama City NW Florida Beaches
$280
Southwest
Mar 12
ECP7:20 amPanama City NW Florida Beaches
3h 25m
1 stop
GSP11:45 amGreenville
Mar 24
GSP12:35 pmGreenville
8h 25m
2 stops
ECP8:00 pmPanama City NW Florida Beaches
$285
Southwest
Mar 9
ECP1:55 pmPanama City NW Florida Beaches
7h 50m
2 stops
GSP10:45 pmGreenville
Mar 16
GSP12:25 pmGreenville
9h 10m
1 stop
ECP8:35 pmPanama City NW Florida Beaches
$300

United Airlines flights from Panama City, Florida to Greenville

Our best United Airlines deals on Panama City, Florida to Greenville flight tickets
United Airlines
Mar 12
ECP10:24 amPanama City NW Florida Beaches
12h 35m
2 stops
GSP11:59 pmGreenville
Mar 24
GSP6:52 amGreenville
6h 12m
1 stop
ECP12:04 pmPanama City NW Florida Beaches
$464
United Airlines
Feb 14
ECP1:01 pmPanama City NW Florida Beaches
7h 58m
1 stop
GSP9:59 pmGreenville
Feb 18
GSP6:50 amGreenville
6h 14m
1 stop
ECP12:04 pmPanama City NW Florida Beaches
$592
United Airlines
Apr 22
ECP10:19 amPanama City NW Florida Beaches
11h 26m
2 stops
GSP10:45 pmGreenville
Apr 24
GSP7:42 pmGreenville
18h 41m
3 stops
ECP1:23 pmPanama City NW Florida Beaches
$605

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 3/12

7:20 am-11:45 am

1 stop3h 25m

Greenville

Tue 3/24

6:20 am-9:35 am

1 stop4h 15m

$280

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 3/12

7:20 am-11:45 am

1 stop3h 25m

Greenville

Tue 3/24

12:35 pm-8:00 pm

2 stops8h 25m

$285

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 3/9

7:05 am-11:05 am

1 stop3h 00m

Greenville

Mon 3/16

7:59 pm-11:04 pm

1 stop4h 05m

$289

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 3/9

1:55 pm-10:45 pm

2 stops7h 50m

Greenville

Mon 3/16

12:25 pm-8:35 pm

1 stop9h 10m

$300

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 4/8

7:05 am-1:45 pm

1 stop5h 40m

Greenville

Sun 4/19

7:59 pm-11:12 pm

1 stop4h 13m

$304

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 4/9

7:05 am-11:05 am

1 stop3h 00m

Greenville

Sun 4/19

5:40 am-8:35 am

1 stop3h 55m

$308

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 4/9

7:05 am-11:05 am

1 stop3h 00m

Greenville

Sun 4/19

7:59 pm-11:12 pm

1 stop4h 13m

$313

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 4/22

7:15 am-12:10 pm

1 stop3h 55m

Greenville

Fri 4/24

12:35 pm-9:40 pm

2 stops10h 05m

$324

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 3/12

7:20 am-9:50 pm

2 stops13h 30m

Greenville

Tue 3/24

12:35 pm-8:00 pm

2 stops8h 25m

$325

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 4/22

10:10 am-9:40 pm

2 stops10h 30m

Greenville

Fri 4/24

12:35 pm-9:40 pm

2 stops10h 05m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Panama City, Florida to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to Greenville?

Southwest is the most popular carrier operating from Panama City NW Florida Beaches to Greenville

What airlines fly to Greenville?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Greenville from Panama City, Florida according to our data. American Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When to book flights from Panama City, Florida to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Greenville (ECP to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Greenville

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Panama City, Florida to Greenville takes 4h 05m
There are no direct flights from Panama City, Florida to Greenville. There are no popular flight routes from Panama City, Florida to Greenville.
Search flight deals

  • How far is Panama City NW Florida Beaches to Greenville by plane?

    Panama City NW Florida Beaches and Greenville are 375.7 mi apart from one another. Typically, this will take 4h 05m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Greenville Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Greenville Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Greenville?

Best airlines flying from Panama City, Florida to Greenville

Compare and see reviews for airlines that fly from Panama City, Florida to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $202Free CancellationRating
7.9
8,179 reviews
Search Delta flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Greenville?

Finding the right flight to Greenville from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Greenville quick and easy, saving you time and money.

Can I find flights from Panama City to Greenville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Greenville from Panama City with this policy.

How can momondo help me find flights from Panama City to Greenville?

momondo helps you find the best flight between Panama City and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Panama City are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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