What is the cheapest airline that flies from Ohio to South America?

Spirit Airlines is the most popular carrier operating from Ohio to South America

How long is the flight from Ohio to South America?

Average flight duration from Ohio to South America depends on which airport you fly into and out of. Flying from Cincinnati to Los Angeles is 4h 49m on average, while flying from Columbus to Los Angeles is 5h 05m on average. Los Angeles is the most popular airport in South America.

What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Ohio according to our data. Delta is the first choice among our users, with 41% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 7 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Ohio to South America?

Prices for flights from Ohio to South America are updated daily.

How many operators does momondo search for flights from Ohio to South America?

As of November 2025, there are 7 operators available to choose from for flights from Ohio to South America.

How old do you have to be to fly from Ohio to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Ohio to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$113 Cheap Flights from Ohio to South America in 2025/26

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 2:14 pmDTW-MDE

8h 14m1 stop

3:11 pm - 12:25 amMDE-DTW

9h 14m1 stop

$274Spirit Airlines

Find Deal

Mon, Jan 5 - Tue, Feb 10

7:42 pm - 10:55 amDTW-MDE

15h 13m1 stop

3:10 pm - 9:33 amMDE-DTW

18h 23m1 stop

$282Spirit Airlines

Find Deal

Wed, Dec 10 - Wed, Dec 24

11:57 am - 1:09 amCVG-MDE

37h 12m2 stops

2:05 am - 1:36 pmMDE-CVG

11h 31m1 stop

$321Multiple Airlines

Find Deal

Wed, Dec 10 - Tue, Dec 16

11:57 am - 1:09 amCVG-MDE

37h 12m2 stops

3:10 pm - 3:02 pmMDE-CVG

23h 52m1 stop

$325Multiple Airlines

Find Deal

Wed, Dec 10 - Wed, Dec 17

6:15 pm - 2:15 amDTW-LIM

32h 00m2 stops

8:00 am - 5:35 pmLIM-DTW

33h 35m2 stops

$513Air Canada

Find Deal

Fri, Jan 16 - Wed, Jan 28

8:28 am - 9:10 pmCVG-MDE

12h 42m1 stop

7:00 am - 9:29 pmMDE-CVG

14h 29m1 stop

$573American Airlines

Find Deal

Wed, Jan 28 - Mon, Feb 2

8:28 am - 9:10 pmCVG-MDE

12h 42m1 stop

7:00 am - 11:28 pmMDE-CVG

16h 28m2 stops

$578American Airlines

Find Deal

Wed, Jan 28 - Mon, Feb 2

9:00 am - 8:18 amCVG-MDE

23h 18m2 stops

5:00 am - 8:45 pmMDE-CVG

15h 45m2 stops

$581Copa Airlines

Find Deal

Tue, Dec 2 - Mon, Dec 8

6:15 pm - 9:00 amDTW-GRU

36h 45m2 stops

9:45 pm - 5:35 pmGRU-DTW

21h 50m2 stops

$774Air Canada

Find Deal

Tue, Dec 2 - Tue, Dec 9

11:05 am - 7:59 amDTW-EZE

18h 54m2 stops

9:03 am - 10:02 amEZE-DTW

26h 59m2 stops

$1,063Copa Airlines

Find Deal

Fri, Dec 5 - Sat, Dec 13

Spirit Airlines flights from Ohio to South America

Our best Spirit Airlines deals on Ohio to South America flight tickets

Spirit Airlines

Jan 5

DTW6:00 amDetroit Metropolitan Wayne County

8h 14m

1 stop

MDE2:14 pmMedellín Jose Maria Cordova Intl

Feb 10

MDE3:11 pmMedellín Jose Maria Cordova Intl

9h 14m

1 stop

DTW12:25 amDetroit Metropolitan Wayne County

$274

Find similar

Spirit Airlines

Dec 10

DTW7:42 pmDetroit Metropolitan Wayne County

15h 13m

1 stop

MDE10:55 amMedellín Jose Maria Cordova Intl

Dec 24

MDE3:10 pmMedellín Jose Maria Cordova Intl

18h 23m

1 stop

DTW9:33 amDetroit Metropolitan Wayne County

$282

Find similar

Spirit Airlines

Dec 10

CMH11:14 amColumbus

37h 55m

2 stops

MDE1:09 amMedellín Jose Maria Cordova Intl

Dec 17

MDE3:10 pmMedellín Jose Maria Cordova Intl

26h 23m

1 stop

CMH5:33 pmColumbus

$318

Find similar

United Airlines flights from Ohio to South America

Our best United Airlines deals on Ohio to South America flight tickets

United Airlines

Jan 23

CVG6:25 amCincinnati Cinci./N. Kentucky

15h 40m

1 stop

MDE10:05 pmMedellín Jose Maria Cordova Intl

Jan 28

MDE10:45 amMedellín Jose Maria Cordova Intl

12h 59m

1 stop

CVG11:44 pmCincinnati Cinci./N. Kentucky

$583

Find similar

United Airlines

Jan 23

CVG6:25 amCincinnati Cinci./N. Kentucky

15h 40m

1 stop

MDE10:05 pmMedellín Jose Maria Cordova Intl

Jan 28

MDE10:45 amMedellín Jose Maria Cordova Intl

23h 15m

2 stops

CVG10:00 amCincinnati Cinci./N. Kentucky

$588

Find similar

United Airlines

Dec 2

CVG6:30 amCincinnati Cinci./N. Kentucky

15h 35m

1 stop

MDE10:05 pmMedellín Jose Maria Cordova Intl

Dec 7

MDE1:15 amMedellín Jose Maria Cordova Intl

9h 39m

1 stop

CVG10:54 amCincinnati Cinci./N. Kentucky

$596

Find similar

Fly from

Fly to

Route

Depart

Return

Price

DetroitMedellín

DTW - MDE

DTWMDE

Detroit Metropolitan Wayne County

Mon 1/5

6:00 am-2:14 pm

1 stop8h 14m

Medellín Jose Maria Cordova Intl

Tue 2/10

3:11 pm-12:25 am

1 stop9h 14m

$274

DetroitMedellín

DTW - MDE

DTWMDE

Detroit Metropolitan Wayne County

Wed 12/10

7:42 pm-10:55 am

1 stop15h 13m

Medellín Jose Maria Cordova Intl

Wed 12/24

3:10 pm-9:33 am

1 stop18h 23m

$282

CincinnatiMedellín

CVG - MDE

CVGMDE

Cincinnati Cinci./N. Kentucky

Wed 12/10

11:57 am-1:09 am

2 stops37h 12m

Medellín Jose Maria Cordova Intl

Tue 12/16

2:05 am-1:36 pm

1 stop11h 31m

$321

CincinnatiMedellín

CVG - MDE

CVGMDE

Cincinnati Cinci./N. Kentucky

Wed 12/10

11:57 am-1:09 am

2 stops37h 12m

Medellín Jose Maria Cordova Intl

Wed 12/17

3:10 pm-3:02 pm

1 stop23h 52m

$325

DetroitLima

DTW - LIM

DTWLIM

Detroit Metropolitan Wayne County

Fri 1/16

6:15 pm-2:15 am

2 stops32h 00m

Lima J Chavez Intl

Wed 1/28

8:00 am-5:35 pm

2 stops33h 35m

$513

CincinnatiMedellín

CVG - MDE

CVGMDE

Cincinnati Cinci./N. Kentucky

Wed 1/28

8:28 am-9:10 pm

1 stop12h 42m

Medellín Jose Maria Cordova Intl

Mon 2/2

7:00 am-9:29 pm

1 stop14h 29m

$573

CincinnatiMedellín

CVG - MDE

CVGMDE

Cincinnati Cinci./N. Kentucky

Wed 1/28

8:28 am-9:10 pm

1 stop12h 42m

Medellín Jose Maria Cordova Intl

Mon 2/2

7:00 am-11:28 pm

2 stops16h 28m

$578

CincinnatiMedellín

CVG - MDE

CVGMDE

Cincinnati Cinci./N. Kentucky

Tue 12/2

9:00 am-8:18 am

2 stops23h 18m

Medellín Jose Maria Cordova Intl

Mon 12/8

5:00 am-8:45 pm

2 stops15h 45m

$581

DetroitSao Paulo

DTW - GRU

DTWGRU

Detroit Metropolitan Wayne County

Tue 12/2

6:15 pm-9:00 am

2 stops36h 45m

Sao Paulo Guarulhos Intl

Tue 12/9

9:45 pm-5:35 pm

2 stops21h 50m

$774

DetroitBuenos Aires

DTW - EZE

DTWEZE

Detroit Metropolitan Wayne County

Fri 12/5

11:05 am-7:59 am

2 stops18h 54m

Buenos Aires Ministro Pistarini

Sat 12/13

9:03 am-10:02 am

2 stops26h 59m

$1,063

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Ohio to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South America?

In general, October is the cheapest month to fly from Ohio to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $684. If you aren’t able to travel during the month of October, then book flights to South America from Ohio during February instead. Flights to South America in February, while not as cheap as those in October, still average around $701.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Ohio to South America is on a Sunday when prices can be found for as low as $683. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Ohio to South America for around $853.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Ohio to South America flights are usually those with departure times in the evening. Our users have found flights to South America in the evening for as low as $707. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $847 on average. Flights to South America from Ohio in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Ohio when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $780 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Ohio for as low as $702 on momondo.

Can stopping save me money on Ohio to South America flights?

You could potentially save up to 60% on your flight if you consider stops on a Ohio to South America flight.

Cheap Ohio to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to South America

Direct flights	None

There are no direct flights from Ohio to South America. There are no popular flight routes from Ohio to South America.

Search flight deals

When did momondo last update prices for flights from Ohio to South America?
Prices for flights from Ohio to South America are updated daily.
How many operators does momondo search for flights from Ohio to South America?
As of November 2025, there are 7 operators available to choose from for flights from Ohio to South America.
How old do you have to be to fly from Ohio to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Ohio to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Ohio to South America

Compare and see reviews for airlines that fly from Ohio to South America with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $276	Free Cancellation	Rating 6.3 8,113 reviews	Search Spirit Airlines flights
Delta	PriceFrom $413	Free Cancellation	Rating 7.9 8,002 reviews	Search Delta flights
United Airlines	PriceFrom $462	Free Cancellation	Rating 7.4 8,998 reviews	Search United Airlines flights
American Airlines	PriceFrom $469	Free Cancellation	Rating 7.2 11,038 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $513	Free Cancellation	Rating 7.5 1,873 reviews	Search LATAM Airlines flights
Copa Airlines	PriceFrom $659	Free Cancellation	Rating 7.6 1,561 reviews	Search Copa Airlines flights
Air Canada	PriceFrom $744	Free Cancellation	Rating 7.1 10,400 reviews	Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Ohio to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Ohio to South America with flexible booking policies on momondo?

Yes. All flights to South America from Ohio on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Ohio to South America?

momondo provides multiple filters to help you find the best flight to South America from Ohio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Ohio to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Ohio are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

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Find better results for your trip to South America

Popular cities in South America

Flights to Limafrom $298

Flights to Buenos Airesfrom $503

Flights to Bogotáfrom $182

Flights to Sao Paulofrom $402

Flights to Rio de Janeirofrom $447

Flights to Medellínfrom $166

Flights to Santiagofrom $380

Flights to Cartagenafrom $175

Flights to Quitofrom $330

Flights to Cuscofrom $380

Flights to Guayaquilfrom $233

Flights to Califrom $202

Cheap flights from Ohio to South America from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Ohio to South America departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

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Price Alerts

Find the cheapest flights from Ohio to South America

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Spirit Airlines flights from Ohio to South America

Our best Spirit Airlines deals on Ohio to South America flight tickets

United Airlines flights from Ohio to South America

Our best United Airlines deals on Ohio to South America flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Ohio to South America that are best for you.

How to get the cheapest flight ticket from Ohio to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Ohio to South America is on a Sunday when prices can be found for as low as $683. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Ohio to South America for around $853.

What is the cheapest time of day to depart on your flight to South America?

How far in advance should I book a flight to South America?

Can stopping save me money on Ohio to South America flights?

You could potentially save up to 60% on your flight if you consider stops on a Ohio to South America flight.

What is the cheapest airline that flies from Ohio to South America?

Spirit Airlines is the most popular carrier operating from Ohio to South America

What airlines fly to South America?

How long is the flight from Ohio to South America?

Average flight duration from Ohio to South America depends on which airport you fly into and out of. Flying from Cincinnati to Los Angeles is 4h 49m on average, while flying from Columbus to Los Angeles is 5h 05m on average. Los Angeles is the most popular airport in South America.

Cheap Ohio to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Ohio to South America

Direct flights

When did momondo last update prices for flights from Ohio to South America?

How many operators does momondo search for flights from Ohio to South America?

How old do you have to be to fly from Ohio to South America?

What documentation or ID do you need to fly to South America?

Best airlines flying from Ohio to South America

Compare and see reviews for airlines that fly from Ohio to South America with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Ohio to South America?

Can I find flights from Ohio to South America with flexible booking policies on momondo?

How can momondo help me find flights from Ohio to South America?

I’m not ready to book a flight from Ohio to South America right now. Can momondo alert me if prices change?

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo