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Cheap flights from North Carolina to Santa Fe from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to Santa Fe departing on 7/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from North Carolina to Santa Fe

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:49 am - 5:13 pm
TYS
-
SAF
8h 24m
2 stops
United Airlines Logo
10:30 am - 11:41 pm
SAF
-
TYS
11h 11m
2 stops
$312United Airlines
Tue, Apr 14 - Tue, Apr 21
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
4:15 pm - 11:51 pm
SAF
-
TYS
5h 36m
1 stop
$334American Airlines
Fri, Apr 3 - Mon, Apr 6
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
4:09 pm - 11:56 pm
SAF
-
TYS
5h 47m
1 stop
$350American Airlines
Sat, Apr 4 - Tue, Apr 7
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
11:56 am - 11:56 pm
SAF
-
TYS
10h 00m
2 stops
$360American Airlines
Sat, Apr 4 - Tue, Apr 7
United Airlines Logo
4:30 pm - 9:13 pm
TYS
-
SAF
6h 43m
1 stop
United Airlines Logo
10:30 am - 11:41 pm
SAF
-
TYS
11h 11m
2 stops
$374United Airlines
Tue, Apr 14 - Tue, Apr 21
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
4:09 pm - 11:56 pm
SAF
-
TYS
5h 47m
1 stop
$382American Airlines
Thu, Apr 2 - Tue, Apr 7
American Airlines Logo
5:15 am - 10:07 am
CLT
-
SAF
6h 52m
1 stop
American Airlines Logo
6:30 pm - 6:06 am
SAF
-
CLT
9h 36m
1 stop
$385American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
5:30 am - 9:39 am
TRI
-
SAF
6h 09m
1 stop
American Airlines Logo
12:54 pm - 10:26 pm
SAF
-
TRI
7h 32m
1 stop
$389American Airlines
Tue, Mar 3 - Tue, Mar 10
American Airlines Logo
5:40 am - 9:39 am
TYS
-
SAF
5h 59m
1 stop
American Airlines Logo
11:56 am - 11:56 pm
SAF
-
TYS
10h 00m
2 stops
$392American Airlines
Thu, Apr 2 - Tue, Apr 7
American Airlines Logo
5:23 am - 9:55 am
RDU
-
SAF
6h 32m
1 stop
American Airlines Logo
5:52 pm - 6:43 am
SAF
-
RDU
10h 51m
1 stop
$395American Airlines
Wed, May 27 - Sat, May 30

United Airlines flights from North Carolina to Santa Fe

Our best United Airlines deals on North Carolina to Santa Fe flight tickets
United Airlines
Apr 14
TYS10:49 amKnoxville McGhee Tyson
8h 24m
2 stops
SAF5:13 pmSanta Fe
Apr 21
SAF10:30 amSanta Fe
11h 11m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
$312
United Airlines
Apr 14
TYS4:30 pmKnoxville McGhee Tyson
6h 43m
1 stop
SAF9:13 pmSanta Fe
Apr 21
SAF10:30 amSanta Fe
11h 11m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
$374
United Airlines
Jul 15
RDU4:22 pmRaleigh-Durham
6h 19m
1 stop
SAF8:41 pmSanta Fe
Jul 21
SAF3:19 pmSanta Fe
6h 10m
1 stop
RDU11:29 pmRaleigh-Durham
$403

American Airlines flights from North Carolina to Santa Fe

Our best American Airlines deals on North Carolina to Santa Fe flight tickets
American Airlines
Apr 3
TYS5:40 amKnoxville McGhee Tyson
5h 59m
1 stop
SAF9:39 amSanta Fe
Apr 6
SAF4:15 pmSanta Fe
5h 36m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$334
American Airlines
Apr 4
TYS5:40 amKnoxville McGhee Tyson
5h 59m
1 stop
SAF9:39 amSanta Fe
Apr 7
SAF4:09 pmSanta Fe
5h 47m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$350
American Airlines
Apr 4
TYS5:40 amKnoxville McGhee Tyson
5h 59m
1 stop
SAF9:39 amSanta Fe
Apr 7
SAF11:56 amSanta Fe
10h 00m
2 stops
TYS11:56 pmKnoxville McGhee Tyson
$360

momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from North Carolina to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Tue 4/14

10:49 am-5:13 pm

2 stops8h 24m

Santa Fe

Tue 4/21

10:30 am-11:41 pm

2 stops11h 11m

$312

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Fri 4/3

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Mon 4/6

4:15 pm-11:51 pm

1 stop5h 36m

$334

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 4/4

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Tue 4/7

4:09 pm-11:56 pm

1 stop5h 47m

$350

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 4/4

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Tue 4/7

11:56 am-11:56 pm

2 stops10h 00m

$360

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Tue 4/14

4:30 pm-9:13 pm

1 stop6h 43m

Santa Fe

Tue 4/21

10:30 am-11:41 pm

2 stops11h 11m

$374

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 4/2

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Tue 4/7

4:09 pm-11:56 pm

1 stop5h 47m

$382

CharlotteSanta Fe

CLT - SAF

CLTSAF

Charlotte Douglas

Tue 4/7

5:15 am-10:07 am

1 stop6h 52m

Santa Fe

Sat 4/11

6:30 pm-6:06 am

1 stop9h 36m

$385

BlountvilleSanta Fe

TRI - SAF

TRISAF

Blountville Tri Cities TN/VA

Tue 3/3

5:30 am-9:39 am

1 stop6h 09m

Santa Fe

Tue 3/10

12:54 pm-10:26 pm

1 stop7h 32m

$389

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 4/2

5:40 am-9:39 am

1 stop5h 59m

Santa Fe

Tue 4/7

11:56 am-11:56 pm

2 stops10h 00m

$392

RaleighSanta Fe

RDU - SAF

RDUSAF

Raleigh-Durham

Wed 5/27

5:23 am-9:55 am

1 stop6h 32m

Santa Fe

Sat 5/30

5:52 pm-6:43 am

1 stop10h 51m

$395

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santa Fe from

How to get the cheapest flight ticket from North Carolina to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Fe?

The month of January is, on average, the cheapest month to fly to Santa Fe from North Carolina, with most prices found around $334. If you’re not able to fly to Santa Fe in January, then October is your next best option. Flight prices from North Carolina to Santa Fe during October average around $349.

Can stopping save me money on North Carolina to Santa Fe flights?

You could potentially save up to 49% on your flight if you consider stops on a North Carolina to Santa Fe flight.

Cheap North Carolina to Santa Fe flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Santa Fe

Fastest flight time

5h 44m

Direct flights

None
The fastest flight from North Carolina to Santa Fe takes 5h 44m
There are no direct flights from North Carolina to Santa Fe. There are no popular flight routes from North Carolina to Santa Fe.
Search flight deals

  • When did momondo last update prices for flights from North Carolina to Santa Fe Airport?

    Prices for flights from North Carolina to Santa Fe Airport refresh daily.

  • How many operators does momondo search for flights from North Carolina to Santa Fe Airport?

  • How old do you have to be to fly from North Carolina to Santa Fe Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from North Carolina to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The travel and health documents you'll need for your trip to Santa Fe Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Fe Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from North Carolina to Santa Fe

Compare and see reviews for airlines that fly from North Carolina to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights
United AirlinesPriceFrom $284Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa
Los Alamos

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Santa Fe?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from North Carolina to Santa Fe. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from North Carolina to Santa Fe with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santa Fe from North Carolina with this policy.

How can momondo help me find flights from North Carolina to Santa Fe?

Once you have performed a search for North Carolina to Santa Fe flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from North Carolina to Santa Fe right now. Can momondo alert me if prices change?

If you are not ready to book a flight from North Carolina to Santa Fe now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santa Fe and let you know when they change.

An easier way to manage your Santa Fe trip

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