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Cheap flights from Myrtle Beach to Des Moines from $293

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:30 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
6h 34m1 stop Charlotte Douglas
American Airlines Logo
11:22 am - 7:27 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 05m1 stop Charlotte Douglas
$293American Airlines
Wed, Sep 30 - Mon, Oct 5
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
11:22 am - 7:27 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 05m1 stop Charlotte Douglas
$293American Airlines
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
1:56 pm - 7:48 pmMYR  Myrtle Beach Intl-DSM Des Moines
6h 52m1 stop Charlotte Douglas
American Airlines Logo
11:00 am - 5:25 pmDSM  Des Moines-MYR Myrtle Beach Intl
5h 25m1 stop Charlotte Douglas
$343American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
1:56 pm - 7:48 pmMYR  Myrtle Beach Intl-DSM Des Moines
6h 52m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 2:37 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 37m1 stop Philadelphia
$343American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
1:15 pm - 10:15 pmDSM  Des Moines-MYR Myrtle Beach Intl
8h 00m2 stops Philadelphia Charlotte Douglas
$343American Airlines
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
7:19 pm - 11:41 pmMYR  Myrtle Beach Intl-DSM Des Moines
5h 22m1 stop Washington, D.C. Reagan-National
American Airlines Logo
1:15 pm - 10:15 pmDSM  Des Moines-MYR Myrtle Beach Intl
8h 00m2 stops Philadelphia Charlotte Douglas
$343American Airlines
Wed, Sep 30 - Mon, Oct 5
Delta Logo
11:43 am - 3:16 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 33m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:11 pm - 9:41 pmDSM  Des Moines-MYR Myrtle Beach Intl
4h 30m1 stop Atlanta Hartsfield-Jackson
$347Delta
Thu, Sep 3 - Wed, Sep 9
American Airlines Logo
6:30 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
6h 34m1 stop Charlotte Douglas
American Airlines Logo
11:22 am - 7:27 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 05m1 stop Charlotte Douglas
$347American Airlines
Wed, Sep 30 - Mon, Oct 5
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
American Airlines Logo
11:22 am - 7:27 pmDSM  Des Moines-MYR Myrtle Beach Intl
7h 05m1 stop Charlotte Douglas
$347American Airlines
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
1:55 pm - 10:15 pmMYR  Myrtle Beach Intl-DSM Des Moines
9h 20m2 stops Lambert-St Louis Chicago Midway
Southwest Logo
7:15 am - 7:15 pmDSM  Des Moines-MYR Myrtle Beach Intl
11h 00m2 stops Denver Intl Baltimore/Washington
$403Southwest
Thu, Sep 3 - Wed, Sep 9

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United Airlines flights from Myrtle Beach to Des Moines

Our best United Airlines deals on Myrtle Beach to Des Moines flight tickets
United Airlines
Sep 30
MYR10:23 amMyrtle Beach Intl
25h 08m
3 stops
DSM10:31 amDes Moines
Oct 5
DSM5:22 pmDes Moines
17h 16m
2 stops
MYR11:38 amMyrtle Beach Intl
$617
United Airlines
Sep 30
MYR10:23 amMyrtle Beach Intl
12h 52m
2 stops
DSM10:15 pmDes Moines
Oct 5
DSM8:00 amDes Moines
24h 42m
3 stops
MYR9:42 amMyrtle Beach Intl
$673
United Airlines
Aug 28
MYR10:23 amMyrtle Beach Intl
12h 00m
2 stops
DSM9:23 pmDes Moines
Aug 30
DSM8:00 amDes Moines
24h 00m
3 stops
MYR9:00 amMyrtle Beach Intl
$678

Southwest flights from Myrtle Beach to Des Moines

Our best Southwest deals on Myrtle Beach to Des Moines flight tickets
Southwest
Sep 3
MYR1:55 pmMyrtle Beach Intl
9h 20m
2 stops
DSM10:15 pmDes Moines
Sep 9
DSM7:15 amDes Moines
11h 00m
2 stops
MYR7:15 pmMyrtle Beach Intl
$403
Southwest
Oct 12
MYR10:25 amMyrtle Beach Intl
12h 30m
2 stops
DSM9:55 pmDes Moines
Oct 18
DSM5:30 amDes Moines
8h 55m
2 stops
MYR3:25 pmMyrtle Beach Intl
$577

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Wed 9/30

6:30 am-12:04 pm

1 stop6h 34m

Des Moines

Mon 10/5

11:22 am-7:27 pm

1 stop7h 05m

$293

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 10/1

8:08 am-12:04 pm

1 stop4h 56m

Des Moines

Mon 10/5

11:22 am-7:27 pm

1 stop7h 05m

$293

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 10/1

1:56 pm-7:48 pm

1 stop6h 52m

Des Moines

Sun 10/4

11:00 am-5:25 pm

1 stop5h 25m

$343

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 10/1

1:56 pm-7:48 pm

1 stop6h 52m

Des Moines

Sun 10/4

6:00 am-2:37 pm

1 stop7h 37m

$343

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 10/1

8:08 am-12:04 pm

1 stop4h 56m

Des Moines

Mon 10/5

1:15 pm-10:15 pm

2 stops8h 00m

$343

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Wed 9/30

7:19 pm-11:41 pm

1 stop5h 22m

Des Moines

Mon 10/5

1:15 pm-10:15 pm

2 stops8h 00m

$343
Quickest round-trip

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 9/3

11:43 am-3:16 pm

1 stop4h 33m

Des Moines

Wed 9/9

4:11 pm-9:41 pm

1 stop4h 30m

$347

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Wed 9/30

6:30 am-12:04 pm

1 stop6h 34m

Des Moines

Mon 10/5

11:22 am-7:27 pm

1 stop7h 05m

$347

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 10/1

8:08 am-12:04 pm

1 stop4h 56m

Des Moines

Mon 10/5

11:22 am-7:27 pm

1 stop7h 05m

$347

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Thu 9/3

1:55 pm-10:15 pm

2 stops9h 20m

Des Moines

Wed 9/9

7:15 am-7:15 pm

2 stops11h 00m

$403

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Myrtle Beach to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in March, then January is your next best option. Flight prices from Myrtle Beach to Des Moines during January average around $0.

When to book flights from Myrtle Beach to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Des Moines (MYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Des Moines

Fastest flight time

4h 28m

Direct flights

None
The fastest flight from Myrtle Beach to Des Moines takes 4h 28m
There are no direct flights from Myrtle Beach to Des Moines. There are no popular flight routes from Myrtle Beach to Des Moines.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Des Moines

  • How far is Myrtle Beach Intl to Des Moines by plane?

    The distance between Myrtle Beach Intl and Des Moines is about 970.9 mi. Flights usually cover this in 4h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Des Moines Airport?

    Prices for flights from Myrtle Beach Intl Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Des Moines?

Best airlines flying from Myrtle Beach to Des Moines

Compare and see reviews for airlines that fly from Myrtle Beach to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $312Free CancellationRating
7.1
11,903 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Des Moines?

It is quick and easy to find Myrtle Beach to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Myrtle Beach to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Des Moines?

Once all potential Myrtle Beach to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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