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Cheap flights from Myrtle Beach to Des Moines from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:25 pm - 7:54 am
MYR
-
DSM
14h 29m
1 stop
Multiple Airlines Logo
1:37 pm - 7:58 am
DSM
-
MYR
17h 21m
1 stop
$321Multiple Airlines
Thu, Oct 1 - Sun, Oct 4
Multiple Airlines Logo
6:25 pm - 7:54 am
MYR
-
DSM
14h 29m
1 stop
Multiple Airlines Logo
1:37 pm - 7:58 am
DSM
-
MYR
17h 21m
1 stop
$327Multiple Airlines
Thu, Oct 1 - Sun, Oct 4
Delta Logo
11:32 am - 5:23 pm
MYR
-
DSM
6h 51m
1 stop
Delta Logo
6:39 pm - 11:59 pm
DSM
-
MYR
4h 20m
1 stop
$335Delta
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
6:06 pm - 12:35 am
MYR
-
DSM
7h 29m
2 stops
American Airlines Logo
4:48 pm - 11:51 pm
DSM
-
MYR
6h 03m
1 stop
$340American Airlines
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
1:02 pm - 8:43 pm
MYR
-
DSM
8h 41m
2 stops
American Airlines Logo
9:23 am - 5:26 pm
DSM
-
MYR
7h 03m
2 stops
$345American Airlines
Wed, Jun 17 - Tue, Jun 23
Delta Logo
11:32 am - 5:23 pm
MYR
-
DSM
6h 51m
1 stop
Delta Logo
6:39 pm - 11:59 pm
DSM
-
MYR
4h 20m
1 stop
$351Delta
Wed, Jun 17 - Tue, Jun 23
Delta Logo
6:45 pm - 10:26 pm
MYR
-
DSM
4h 41m
1 stop
Delta Logo
6:30 pm - 11:39 pm
DSM
-
MYR
4h 09m
1 stop
$353Delta
Wed, Sep 30 - Mon, Oct 5
Delta Logo
6:00 am - 10:14 am
MYR
-
DSM
5h 14m
1 stop
Delta Logo
6:30 pm - 11:39 pm
DSM
-
MYR
4h 09m
1 stop
$355Delta
Thu, Oct 1 - Mon, Oct 5
American Airlines Logo
1:02 pm - 8:43 pm
MYR
-
DSM
8h 41m
2 stops
American Airlines Logo
4:48 pm - 11:51 pm
DSM
-
MYR
6h 03m
1 stop
$356American Airlines
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
4:15 pm - 11:28 pm
MYR
-
DSM
8h 13m
2 stops
American Airlines Logo
6:00 am - 12:58 pm
DSM
-
MYR
5h 58m
1 stop
$358American Airlines
Wed, Sep 30 - Mon, Oct 5

United Airlines flights from Myrtle Beach to Des Moines

Our best United Airlines deals on Myrtle Beach to Des Moines flight tickets
United Airlines
Sep 15
MYR11:25 amMyrtle Beach Intl
6h 37m
1 stop
DSM5:02 pmDes Moines
Sep 16
DSM6:00 amDes Moines
7h 15m
1 stop
MYR2:15 pmMyrtle Beach Intl
$415
United Airlines
Sep 15
MYR10:00 amMyrtle Beach Intl
8h 02m
2 stops
DSM5:02 pmDes Moines
Sep 16
DSM6:00 amDes Moines
7h 15m
1 stop
MYR2:15 pmMyrtle Beach Intl
$420
United Airlines
Sep 15
MYR3:21 pmMyrtle Beach Intl
9h 34m
2 stops
DSM11:55 pmDes Moines
Sep 16
DSM6:00 amDes Moines
7h 15m
1 stop
MYR2:15 pmMyrtle Beach Intl
$436

Delta flights from Myrtle Beach to Des Moines

Our best Delta deals on Myrtle Beach to Des Moines flight tickets
Delta
Jun 17
MYR11:32 amMyrtle Beach Intl
6h 51m
1 stop
DSM5:23 pmDes Moines
Jun 23
DSM6:39 pmDes Moines
4h 20m
1 stop
MYR11:59 pmMyrtle Beach Intl
$335
Delta
Jun 17
MYR11:32 amMyrtle Beach Intl
6h 51m
1 stop
DSM5:23 pmDes Moines
Jun 23
DSM6:39 pmDes Moines
4h 20m
1 stop
MYR11:59 pmMyrtle Beach Intl
$351
Delta
Sep 30
MYR6:45 pmMyrtle Beach Intl
4h 41m
1 stop
DSM10:26 pmDes Moines
Oct 5
DSM6:30 pmDes Moines
4h 09m
1 stop
MYR11:39 pmMyrtle Beach Intl
$353

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

6:25 pm-7:54 am

1 stop14h 29m

Des Moines

Sun 10/4

1:37 pm-7:58 am

1 stop17h 21m

$321

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

6:25 pm-7:54 am

1 stop14h 29m

Des Moines

Sun 10/4

1:37 pm-7:58 am

1 stop17h 21m

$327

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

11:32 am-5:23 pm

1 stop6h 51m

Des Moines

Tue 6/23

6:39 pm-11:59 pm

1 stop4h 20m

$335

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

6:06 pm-12:35 am

2 stops7h 29m

Des Moines

Tue 6/23

4:48 pm-11:51 pm

1 stop6h 03m

$340

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

1:02 pm-8:43 pm

2 stops8h 41m

Des Moines

Tue 6/23

9:23 am-5:26 pm

2 stops7h 03m

$345

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

11:32 am-5:23 pm

1 stop6h 51m

Des Moines

Tue 6/23

6:39 pm-11:59 pm

1 stop4h 20m

$351
Quickest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/30

6:45 pm-10:26 pm

1 stop4h 41m

Des Moines

Mon 10/5

6:30 pm-11:39 pm

1 stop4h 09m

$353

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Mon 10/5

6:30 pm-11:39 pm

1 stop4h 09m

$355

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

1:02 pm-8:43 pm

2 stops8h 41m

Des Moines

Tue 6/23

4:48 pm-11:51 pm

1 stop6h 03m

$356

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/30

4:15 pm-11:28 pm

2 stops8h 13m

Des Moines

Mon 10/5

6:00 am-12:58 pm

1 stop5h 58m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Myrtle Beach to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in March, then January is your next best option. Flight prices from Myrtle Beach to Des Moines during January average around $0.

When to book flights from Myrtle Beach to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Des Moines (MYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Des Moines

Fastest flight time

4h 20m

Direct flights

None
The fastest flight from Myrtle Beach to Des Moines takes 4h 20m
There are no direct flights from Myrtle Beach to Des Moines. There are no popular flight routes from Myrtle Beach to Des Moines.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Des Moines

  • How far is Myrtle Beach Intl to Des Moines by plane?

    The distance between Myrtle Beach Intl and Des Moines is about 970.9 mi. Flights usually cover this in 4h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Des Moines Airport?

    Prices for flights from Myrtle Beach Intl Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Des Moines?

Best airlines flying from Myrtle Beach to Des Moines

Compare and see reviews for airlines that fly from Myrtle Beach to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $238Free CancellationRating
7.1
11,668 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Des Moines?

It is quick and easy to find Myrtle Beach to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Myrtle Beach to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Des Moines?

Once all potential Myrtle Beach to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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