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Cheap flights from Myrtle Beach to Des Moines from $204

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 6/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
3:14 pm - 7:26 pm
MYR
-
DSM
5h 12m
1 stop
United Airlines Logo
6:15 am - 2:18 pm
DSM
-
MYR
7h 03m
1 stop
$397United Airlines
Sat, May 2 - Mon, May 4
Delta Logo
6:00 am - 10:14 am
MYR
-
DSM
5h 14m
1 stop
Delta Logo
6:30 pm - 11:38 pm
DSM
-
MYR
4h 08m
1 stop
$407Delta
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
12:19 pm - 6:36 pm
MYR
-
DSM
7h 17m
1 stop
American Airlines Logo
6:02 am - 3:32 pm
DSM
-
MYR
8h 30m
2 stops
$412American Airlines
Wed, Jun 17 - Tue, Jun 23
American Airlines Logo
4:17 pm - 12:08 am
MYR
-
DSM
8h 51m
2 stops
American Airlines Logo
6:02 am - 3:32 pm
DSM
-
MYR
8h 30m
2 stops
$417American Airlines
Wed, Jun 17 - Tue, Jun 23
Southwest Logo
7:15 pm - 11:30 pm
MYR
-
DSM
5h 15m
1 stop
Southwest Logo
5:10 am - 1:25 pm
DSM
-
MYR
7h 15m
2 stops
$422Southwest
Fri, Jul 17 - Fri, Jul 24
Southwest Logo
2:00 pm - 11:30 pm
MYR
-
DSM
10h 30m
2 stops
Southwest Logo
5:20 am - 6:25 pm
DSM
-
MYR
12h 05m
2 stops
$423Southwest
Thu, Jun 18 - Tue, Jun 23
United Airlines Logo
3:14 pm - 9:25 pm
MYR
-
DSM
7h 11m
1 stop
United Airlines Logo
6:15 am - 2:18 pm
DSM
-
MYR
7h 03m
1 stop
$426United Airlines
Sat, May 2 - Mon, May 4
Southwest Logo
11:55 am - 10:20 pm
MYR
-
DSM
11h 25m
2 stops
Southwest Logo
5:10 am - 1:25 pm
DSM
-
MYR
7h 15m
2 stops
$427Southwest
Fri, Jul 17 - Fri, Jul 24
American Airlines Logo
6:19 pm - 11:16 pm
MYR
-
DSM
5h 57m
1 stop
American Airlines Logo
7:11 am - 5:30 pm
DSM
-
MYR
9h 19m
2 stops
$432American Airlines
Fri, Jul 17 - Tue, Jul 21
United Airlines Logo
3:14 pm - 11:44 pm
MYR
-
DSM
9h 30m
2 stops
United Airlines Logo
6:15 am - 2:18 pm
DSM
-
MYR
7h 03m
1 stop
$438United Airlines
Sat, May 2 - Mon, May 4

Delta flights from Myrtle Beach to Des Moines

Our best Delta deals on Myrtle Beach to Des Moines flight tickets
Delta
Jun 17
MYR6:00 amMyrtle Beach Intl
5h 14m
1 stop
DSM10:14 amDes Moines
Jun 23
DSM6:30 pmDes Moines
4h 08m
1 stop
MYR11:38 pmMyrtle Beach Intl
$407
Delta
Apr 4
MYR10:23 amMyrtle Beach Intl
7h 10m
1 stop
DSM4:33 pmDes Moines
Apr 8
DSM5:20 pmDes Moines
5h 44m
1 stop
MYR12:04 amMyrtle Beach Intl
$487

Southwest flights from Myrtle Beach to Des Moines

Our best Southwest deals on Myrtle Beach to Des Moines flight tickets
Southwest
Jul 17
MYR7:15 pmMyrtle Beach Intl
5h 15m
1 stop
DSM11:30 pmDes Moines
Jul 24
DSM5:10 amDes Moines
7h 15m
2 stops
MYR1:25 pmMyrtle Beach Intl
$422
Southwest
Jun 18
MYR2:00 pmMyrtle Beach Intl
10h 30m
2 stops
DSM11:30 pmDes Moines
Jun 23
DSM5:20 amDes Moines
12h 05m
2 stops
MYR6:25 pmMyrtle Beach Intl
$423
Southwest
Jul 17
MYR11:55 amMyrtle Beach Intl
11h 25m
2 stops
DSM10:20 pmDes Moines
Jul 24
DSM5:10 amDes Moines
7h 15m
2 stops
MYR1:25 pmMyrtle Beach Intl
$427

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 5/2

3:14 pm-7:26 pm

1 stop5h 12m

Des Moines

Mon 5/4

6:15 am-2:18 pm

1 stop7h 03m

$397
Quickest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

6:00 am-10:14 am

1 stop5h 14m

Des Moines

Tue 6/23

6:30 pm-11:38 pm

1 stop4h 08m

$407

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

12:19 pm-6:36 pm

1 stop7h 17m

Des Moines

Tue 6/23

6:02 am-3:32 pm

2 stops8h 30m

$412

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 6/17

4:17 pm-12:08 am

2 stops8h 51m

Des Moines

Tue 6/23

6:02 am-3:32 pm

2 stops8h 30m

$417

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 7/17

7:15 pm-11:30 pm

1 stop5h 15m

Des Moines

Fri 7/24

5:10 am-1:25 pm

2 stops7h 15m

$422

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 6/18

2:00 pm-11:30 pm

2 stops10h 30m

Des Moines

Tue 6/23

5:20 am-6:25 pm

2 stops12h 05m

$423

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 5/2

3:14 pm-9:25 pm

1 stop7h 11m

Des Moines

Mon 5/4

6:15 am-2:18 pm

1 stop7h 03m

$426

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 7/17

11:55 am-10:20 pm

2 stops11h 25m

Des Moines

Fri 7/24

5:10 am-1:25 pm

2 stops7h 15m

$427

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 7/17

6:19 pm-11:16 pm

1 stop5h 57m

Des Moines

Tue 7/21

7:11 am-5:30 pm

2 stops9h 19m

$432

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 5/2

3:14 pm-11:44 pm

2 stops9h 30m

Des Moines

Mon 5/4

6:15 am-2:18 pm

1 stop7h 03m

$438

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Myrtle Beach Intl to Des Moines?

Southwest and American Airlines are the most popular carriers operating from Myrtle Beach Intl to Des Moines

When to book flights from Myrtle Beach to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Des Moines (MYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Des Moines

Fastest flight time

4h 41m

Direct flights

None
The fastest flight from Myrtle Beach to Des Moines takes 4h 41m
There are no direct flights from Myrtle Beach to Des Moines. There are no popular flight routes from Myrtle Beach to Des Moines.
Search flight deals

  • How far is Myrtle Beach Intl to Des Moines by plane?

    The distance between Myrtle Beach Intl and Des Moines is about 970.9 mi. Flights usually cover this in 4h 41m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Des Moines Airport?

    Prices for flights from Myrtle Beach Intl Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Des Moines?

Best airlines flying from Myrtle Beach to Des Moines

Compare and see reviews for airlines that fly from Myrtle Beach to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $238Free CancellationRating
7.1
11,491 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Des Moines?

It is quick and easy to find Myrtle Beach to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Myrtle Beach to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Des Moines?

Once all potential Myrtle Beach to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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