Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Myrtle Beach to Des Moines from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 12/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Myrtle Beach to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:34 pm - 6:21 pm
MYR
-
DSM
4h 47m1 stop
American Airlines Logo
6:26 pm - 11:55 pm
DSM
-
MYR
4h 29m1 stop
$368American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
6:00 am - 12:26 pm
MYR
-
DSM
7h 26m2 stops
American Airlines Logo
6:26 pm - 11:55 pm
DSM
-
MYR
4h 29m1 stop
$373American Airlines
Wed, Dec 31 - Sun, Jan 4
Southwest Logo
7:00 am - 11:10 pm
MYR
-
DSM
17h 10m2 stops
Southwest Logo
6:10 am - 2:25 pm
DSM
-
MYR
7h 15m2 stops
$417Southwest
Sun, Jan 4 - Thu, Jan 8
American Airlines Logo
7:46 pm - 12:37 am
MYR
-
DSM
5h 51m1 stop
American Airlines Logo
7:43 am - 6:49 pm
DSM
-
MYR
10h 06m2 stops
$423American Airlines
Sun, Jan 4 - Thu, Jan 8
Southwest Logo
7:15 pm - 11:20 pm
MYR
-
DSM
5h 05m1 stop
Southwest Logo
4:15 pm - 10:45 pm
DSM
-
MYR
5h 30m1 stop
$427Southwest
Fri, Jun 5 - Sun, Jun 7
Southwest Logo
2:05 pm - 11:20 pm
MYR
-
DSM
10h 15m2 stops
Southwest Logo
4:15 pm - 10:45 pm
DSM
-
MYR
5h 30m1 stop
$432Southwest
Fri, Jun 5 - Sun, Jun 7
Southwest Logo
2:05 pm - 11:20 pm
MYR
-
DSM
10h 15m2 stops
Southwest Logo
5:10 am - 2:30 pm
DSM
-
MYR
8h 20m2 stops
$437Southwest
Fri, Jun 5 - Sun, Jun 7
American Airlines Logo
6:00 am - 12:26 pm
MYR
-
DSM
7h 26m2 stops
American Airlines Logo
12:56 pm - 11:55 pm
DSM
-
MYR
9h 59m2 stops
$523American Airlines
Wed, Dec 31 - Sun, Jan 4
United Airlines Logo
12:26 pm - 9:41 pm
MYR
-
DSM
10h 15m2 stops
United Airlines Logo
3:24 pm - 12:19 pm
DSM
-
MYR
19h 55m2 stops
$623United Airlines
Sat, Feb 21 - Mon, Feb 23
United Airlines Logo
5:30 pm - 2:27 pm
MYR
-
DSM
21h 57m2 stops
United Airlines Logo
3:24 pm - 12:19 pm
DSM
-
MYR
19h 55m2 stops
$664United Airlines
Thu, Feb 19 - Mon, Feb 23

United Airlines flights from Myrtle Beach to Des Moines

Our best United Airlines deals on Myrtle Beach to Des Moines flight tickets
United Airlines
Feb 21
MYR12:26 pmMyrtle Beach Intl
10h 15m
2 stops
DSM9:41 pmDes Moines
Feb 23
DSM3:24 pmDes Moines
19h 55m
2 stops
MYR12:19 pmMyrtle Beach Intl
$623
Find similar
United Airlines
Feb 19
MYR5:30 pmMyrtle Beach Intl
21h 57m
2 stops
DSM2:27 pmDes Moines
Feb 23
DSM3:24 pmDes Moines
19h 55m
2 stops
MYR12:19 pmMyrtle Beach Intl
$664
Find similar
United Airlines
Feb 19
MYR5:30 pmMyrtle Beach Intl
21h 57m
2 stops
DSM2:27 pmDes Moines
Feb 23
DSM3:24 pmDes Moines
19h 55m
2 stops
MYR12:19 pmMyrtle Beach Intl
$681
Find similar

Southwest flights from Myrtle Beach to Des Moines

Our best Southwest deals on Myrtle Beach to Des Moines flight tickets
Southwest
Jan 4
MYR7:00 amMyrtle Beach Intl
17h 10m
2 stops
DSM11:10 pmDes Moines
Jan 8
DSM6:10 amDes Moines
7h 15m
2 stops
MYR2:25 pmMyrtle Beach Intl
$417
Find similar
Southwest
Jun 5
MYR7:15 pmMyrtle Beach Intl
5h 05m
1 stop
DSM11:20 pmDes Moines
Jun 7
DSM4:15 pmDes Moines
5h 30m
1 stop
MYR10:45 pmMyrtle Beach Intl
$427
Find similar
Southwest
Jun 5
MYR2:05 pmMyrtle Beach Intl
10h 15m
2 stops
DSM11:20 pmDes Moines
Jun 7
DSM4:15 pmDes Moines
5h 30m
1 stop
MYR10:45 pmMyrtle Beach Intl
$432
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 12/31

2:34 pm-6:21 pm

1 stop4h 47m

Des Moines

Sun 1/4

6:26 pm-11:55 pm

1 stop4h 29m

$368

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 12/31

6:00 am-12:26 pm

2 stops7h 26m

Des Moines

Sun 1/4

6:26 pm-11:55 pm

1 stop4h 29m

$373

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 1/4

7:00 am-11:10 pm

2 stops17h 10m

Des Moines

Thu 1/8

6:10 am-2:25 pm

2 stops7h 15m

$417

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sun 1/4

7:46 pm-12:37 am

1 stop5h 51m

Des Moines

Thu 1/8

7:43 am-6:49 pm

2 stops10h 06m

$423

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 6/5

7:15 pm-11:20 pm

1 stop5h 05m

Des Moines

Sun 6/7

4:15 pm-10:45 pm

1 stop5h 30m

$427

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 6/5

2:05 pm-11:20 pm

2 stops10h 15m

Des Moines

Sun 6/7

4:15 pm-10:45 pm

1 stop5h 30m

$432

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 6/5

2:05 pm-11:20 pm

2 stops10h 15m

Des Moines

Sun 6/7

5:10 am-2:30 pm

2 stops8h 20m

$437

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 12/31

6:00 am-12:26 pm

2 stops7h 26m

Des Moines

Sun 1/4

12:56 pm-11:55 pm

2 stops9h 59m

$523

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 2/21

12:26 pm-9:41 pm

2 stops10h 15m

Des Moines

Mon 2/23

3:24 pm-12:19 pm

2 stops19h 55m

$623

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 2/19

5:30 pm-2:27 pm

2 stops21h 57m

Des Moines

Mon 2/23

3:24 pm-12:19 pm

2 stops19h 55m

$664

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from Myrtle Beach to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Myrtle Beach to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $258. Flights from Myrtle Beach to Des Moines on a Thursday will generally be more expensive and average around $306. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Myrtle Beach to Des Moines in the morning for as low as $296. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $306. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Myrtle Beach to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Des Moines (MYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Des Moines

Fastest flight time

7h 11m

Direct flights

None
The fastest flight from Myrtle Beach to Des Moines takes 7h 11m
There are no direct flights from Myrtle Beach to Des Moines. There are no popular flight routes from Myrtle Beach to Des Moines.
Search flight deals

  • How far is Myrtle Beach Intl to Des Moines by plane?

    The distance between Myrtle Beach Intl and Des Moines is about 970.9 mi. Flights usually cover this in 7h 11m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Des Moines Airport?

    Prices for flights from Myrtle Beach Intl Airport to Des Moines Airport are updated daily.

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Des Moines?

It is quick and easy to find Myrtle Beach to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Myrtle Beach to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Des Moines?

Once all potential Myrtle Beach to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 1/15
Thu 1/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States