Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Myrtle Beach to Des Moines from $204

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:44 pm - 12:09 am
MYR
-
DSM
4h 25m
1 stop
American Airlines Logo
1:41 pm - 8:03 pm
DSM
-
MYR
5h 22m
1 stop
$317American Airlines
Sat, Jul 25 - Sat, Aug 1
Multiple Airlines Logo
1:06 pm - 11:07 pm
MYR
-
DSM
11h 01m
2 stops
Multiple Airlines Logo
4:40 pm - 9:50 am
DSM
-
MYR
16h 10m
1 stop
$325Multiple Airlines
Thu, Jul 9 - Mon, Jul 13
American Airlines Logo
7:10 pm - 11:41 pm
MYR
-
DSM
5h 31m
1 stop
American Airlines Logo
6:04 am - 11:56 am
DSM
-
MYR
4h 52m
1 stop
$327American Airlines
Wed, Sep 30 - Mon, Oct 5
American Airlines Logo
8:30 pm - 11:52 pm
MYR
-
DSM
4h 22m
1 stop
American Airlines Logo
6:04 am - 11:56 am
DSM
-
MYR
4h 52m
1 stop
$337American Airlines
Thu, Oct 1 - Mon, Oct 5
Southwest Logo
3:50 pm - 10:55 pm
MYR
-
DSM
8h 05m
2 stops
Southwest Logo
3:35 pm - 9:10 pm
DSM
-
MYR
4h 35m
1 stop
$353Southwest
Sat, Jul 25 - Sat, Aug 1
American Airlines Logo
6:10 pm - 12:09 am
MYR
-
DSM
6h 59m
1 stop
American Airlines Logo
5:00 am - 12:22 pm
DSM
-
MYR
6h 22m
1 stop
$362American Airlines
Wed, Jul 29 - Sun, Aug 2
American Airlines Logo
8:08 am - 12:04 pm
MYR
-
DSM
4h 56m
1 stop
American Airlines Logo
2:37 pm - 11:27 pm
DSM
-
MYR
7h 50m
2 stops
$363American Airlines
Wed, Sep 30 - Mon, Oct 5
American Airlines Logo
6:10 pm - 12:09 am
MYR
-
DSM
6h 59m
1 stop
American Airlines Logo
6:12 am - 3:31 pm
DSM
-
MYR
8h 19m
2 stops
$367American Airlines
Wed, Jul 29 - Sun, Aug 2
Multiple Airlines Logo
12:01 pm - 3:50 pm
MYR
-
DSM
28h 49m
1 stop
Multiple Airlines Logo
4:40 pm - 9:50 am
DSM
-
MYR
16h 10m
1 stop
$368Multiple Airlines
Thu, Jul 9 - Mon, Jul 13
American Airlines Logo
8:30 pm - 11:52 pm
MYR
-
DSM
4h 22m
1 stop
American Airlines Logo
11:00 am - 5:25 pm
DSM
-
MYR
5h 25m
1 stop
$372American Airlines
Thu, Oct 1 - Sun, Oct 4

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

United Airlines flights from Myrtle Beach to Des Moines

Our best United Airlines deals on Myrtle Beach to Des Moines flight tickets
United Airlines
Nov 17
MYR11:30 amMyrtle Beach Intl
11h 05m
2 stops
DSM9:35 pmDes Moines
Nov 18
DSM5:35 amDes Moines
10h 48m
2 stops
MYR5:23 pmMyrtle Beach Intl
$407
United Airlines
Jun 28
MYR3:15 pmMyrtle Beach Intl
5h 10m
1 stop
DSM7:25 pmDes Moines
Jul 15
DSM8:00 amDes Moines
5h 19m
1 stop
MYR2:19 pmMyrtle Beach Intl
$687
United Airlines
Jul 17
MYR10:34 amMyrtle Beach Intl
11h 48m
2 stops
DSM9:22 pmDes Moines
Jul 21
DSM6:00 amDes Moines
26h 59m
3 stops
MYR9:59 amMyrtle Beach Intl
$769

Southwest flights from Myrtle Beach to Des Moines

Our best Southwest deals on Myrtle Beach to Des Moines flight tickets
Southwest
Jul 25
MYR3:50 pmMyrtle Beach Intl
8h 05m
2 stops
DSM10:55 pmDes Moines
Aug 1
DSM3:35 pmDes Moines
4h 35m
1 stop
MYR9:10 pmMyrtle Beach Intl
$353
Southwest
Aug 16
MYR2:45 pmMyrtle Beach Intl
9h 05m
2 stops
DSM10:50 pmDes Moines
Aug 20
DSM5:40 amDes Moines
6h 30m
2 stops
MYR1:10 pmMyrtle Beach Intl
$382
Southwest
Oct 16
MYR7:05 amMyrtle Beach Intl
5h 15m
1 stop
DSM11:20 amDes Moines
Oct 19
DSM5:35 amDes Moines
12h 55m
2 stops
MYR7:30 pmMyrtle Beach Intl
$383

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 25, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 7/25

8:44 pm-12:09 am

1 stop4h 25m

Des Moines

Sat 8/1

1:41 pm-8:03 pm

1 stop5h 22m

$317

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 7/9

1:06 pm-11:07 pm

2 stops11h 01m

Des Moines

Mon 7/13

4:40 pm-9:50 am

1 stop16h 10m

$325

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/30

7:10 pm-11:41 pm

1 stop5h 31m

Des Moines

Mon 10/5

6:04 am-11:56 am

1 stop4h 52m

$327
Quickest round-trip

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

8:30 pm-11:52 pm

1 stop4h 22m

Des Moines

Mon 10/5

6:04 am-11:56 am

1 stop4h 52m

$337

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Sat 7/25

3:50 pm-10:55 pm

2 stops8h 05m

Des Moines

Sat 8/1

3:35 pm-9:10 pm

1 stop4h 35m

$353

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 7/29

6:10 pm-12:09 am

1 stop6h 59m

Des Moines

Sun 8/2

5:00 am-12:22 pm

1 stop6h 22m

$362

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/30

8:08 am-12:04 pm

1 stop4h 56m

Des Moines

Mon 10/5

2:37 pm-11:27 pm

2 stops7h 50m

$363

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 7/29

6:10 pm-12:09 am

1 stop6h 59m

Des Moines

Sun 8/2

6:12 am-3:31 pm

2 stops8h 19m

$367

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 7/9

12:01 pm-3:50 pm

1 stop28h 49m

Des Moines

Mon 7/13

4:40 pm-9:50 am

1 stop16h 10m

$368

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/1

8:30 pm-11:52 pm

1 stop4h 22m

Des Moines

Sun 10/4

11:00 am-5:25 pm

1 stop5h 25m

$372

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from Myrtle Beach to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Myrtle Beach Intl to Des Moines?

Delta and Southwest are the most popular carriers operating from Myrtle Beach Intl to Des Moines

When to book flights from Myrtle Beach to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Des Moines (MYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Des Moines

Fastest flight time

4h 30m

Direct flights

None
The fastest flight from Myrtle Beach to Des Moines takes 4h 30m
There are no direct flights from Myrtle Beach to Des Moines. There are no popular flight routes from Myrtle Beach to Des Moines.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Des Moines

  • How far is Myrtle Beach Intl to Des Moines by plane?

    The distance between Myrtle Beach Intl and Des Moines is about 970.9 mi. Flights usually cover this in 4h 30m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Des Moines Airport?

    Prices for flights from Myrtle Beach Intl Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Des Moines?

Best airlines flying from Myrtle Beach to Des Moines

Compare and see reviews for airlines that fly from Myrtle Beach to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $295Free CancellationRating
7.1
11,751 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Osceola
Urbandale
Newton
Johnston
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Des Moines?

It is quick and easy to find Myrtle Beach to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Myrtle Beach to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Des Moines?

Once all potential Myrtle Beach to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 7/25
Sat 8/1
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States