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Cheap flights from Myrtle Beach to Des Moines from $118

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Des Moines departing on 8/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to Des Moines

Cheap round-trip flights

Delta Logo
6:00 am - 10:38 amMYR-DSM
5h 38m1 stop
Delta Logo
6:30 pm - 11:49 pmDSM-MYR
4h 19m1 stop
$237Delta
Find Deal
Thu, Sep 4 - Mon, Sep 8
Delta Logo
6:00 am - 2:09 pmMYR-DSM
9h 09m2 stops
Delta Logo
6:30 pm - 11:49 pmDSM-MYR
4h 19m1 stop
$242Delta
Find Deal
Thu, Sep 4 - Mon, Sep 8
Delta Logo
6:55 pm - 10:37 pmMYR-DSM
4h 42m1 stop
Delta Logo
6:30 pm - 11:49 pmDSM-MYR
4h 19m1 stop
$243Delta
Find Deal
Thu, Oct 2 - Sun, Oct 5
American Airlines Logo
8:06 am - 3:33 pmMYR-DSM
8h 27m2 stops
American Airlines Logo
1:40 pm - 11:09 pmDSM-MYR
8h 29m2 stops
$247American Airlines
Find Deal
Thu, Sep 4 - Mon, Sep 8
Delta Logo
11:34 am - 10:37 pmMYR-DSM
12h 03m2 stops
Delta Logo
6:30 pm - 11:49 pmDSM-MYR
4h 19m1 stop
$248Delta
Find Deal
Thu, Oct 2 - Sun, Oct 5
Delta Logo
12:35 pm - 7:14 pmMYR-DSM
7h 39m1 stop
Delta Logo
6:30 pm - 11:49 pmDSM-MYR
4h 19m1 stop
$249Delta
Find Deal
Fri, Oct 3 - Sun, Oct 5
American Airlines Logo
12:12 pm - 6:29 pmMYR-DSM
7h 17m2 stops
American Airlines Logo
6:11 pm - 11:54 pmDSM-MYR
4h 43m1 stop
$254American Airlines
Find Deal
Fri, Oct 3 - Sun, Oct 5
American Airlines Logo
12:12 pm - 6:29 pmMYR-DSM
7h 17m2 stops
American Airlines Logo
5:00 am - 3:35 pmDSM-MYR
9h 35m2 stops
$294American Airlines
Find Deal
Fri, Oct 3 - Sun, Oct 5
United Airlines Logo
4:45 pm - 9:45 pmMYR-DSM
6h 00m1 stop
United Airlines Logo
8:00 am - 2:42 pmDSM-MYR
5h 42m1 stop
$362United Airlines
Find Deal
Wed, Aug 27 - Sun, Aug 31
United Airlines Logo
12:47 pm - 11:41 pmMYR-DSM
11h 54m2 stops
United Airlines Logo
6:15 pm - 11:51 amDSM-MYR
16h 36m3 stops
$656United Airlines
Find Deal
Wed, Aug 27 - Sun, Aug 31

American Airlines flights from Myrtle Beach to Des Moines

Our best American Airlines deals on Myrtle Beach to Des Moines flight tickets
American Airlines
Sep 4
MYR8:06 amMyrtle Beach Intl
8h 27m
2 stops
DSM3:33 pmDes Moines
Sep 8
DSM1:40 pmDes Moines
8h 29m
2 stops
MYR11:09 pmMyrtle Beach Intl
$247
Find similar
American Airlines
Oct 3
MYR12:12 pmMyrtle Beach Intl
7h 17m
2 stops
DSM6:29 pmDes Moines
Oct 5
DSM6:11 pmDes Moines
4h 43m
1 stop
MYR11:54 pmMyrtle Beach Intl
$254
Find similar
American Airlines
Oct 3
MYR12:12 pmMyrtle Beach Intl
7h 17m
2 stops
DSM6:29 pmDes Moines
Oct 5
DSM5:00 amDes Moines
9h 35m
2 stops
MYR3:35 pmMyrtle Beach Intl
$294
Find similar

United Airlines flights from Myrtle Beach to Des Moines

Our best United Airlines deals on Myrtle Beach to Des Moines flight tickets
United Airlines
Aug 27
MYR4:45 pmMyrtle Beach Intl
6h 00m
1 stop
DSM9:45 pmDes Moines
Aug 31
DSM8:00 amDes Moines
5h 42m
1 stop
MYR2:42 pmMyrtle Beach Intl
$362
Find similar
United Airlines
Aug 27
MYR12:47 pmMyrtle Beach Intl
11h 54m
2 stops
DSM11:41 pmDes Moines
Aug 31
DSM6:15 pmDes Moines
16h 36m
3 stops
MYR11:51 amMyrtle Beach Intl
$656
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 9/4

6:00 am-10:38 am

1 stop5h 38m

Des Moines

Mon 9/8

6:30 pm-11:49 pm

1 stop4h 19m

$237

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 9/4

6:00 am-2:09 pm

2 stops9h 09m

Des Moines

Mon 9/8

6:30 pm-11:49 pm

1 stop4h 19m

$242

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/2

6:55 pm-10:37 pm

1 stop4h 42m

Des Moines

Sun 10/5

6:30 pm-11:49 pm

1 stop4h 19m

$243

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 9/4

8:06 am-3:33 pm

2 stops8h 27m

Des Moines

Mon 9/8

1:40 pm-11:09 pm

2 stops8h 29m

$247

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 10/2

11:34 am-10:37 pm

2 stops12h 03m

Des Moines

Sun 10/5

6:30 pm-11:49 pm

1 stop4h 19m

$248

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 10/3

12:35 pm-7:14 pm

1 stop7h 39m

Des Moines

Sun 10/5

6:30 pm-11:49 pm

1 stop4h 19m

$249

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 10/3

12:12 pm-6:29 pm

2 stops7h 17m

Des Moines

Sun 10/5

6:11 pm-11:54 pm

1 stop4h 43m

$254

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Fri 10/3

12:12 pm-6:29 pm

2 stops7h 17m

Des Moines

Sun 10/5

5:00 am-3:35 pm

2 stops9h 35m

$294

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 8/27

4:45 pm-9:45 pm

1 stop6h 00m

Des Moines

Sun 8/31

8:00 am-2:42 pm

1 stop5h 42m

$362

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 8/27

12:47 pm-11:41 pm

2 stops11h 54m

Des Moines

Sun 8/31

6:15 pm-11:51 am

3 stops16h 36m

$656

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Myrtle Beach to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Myrtle Beach to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $258. Flights from Myrtle Beach to Des Moines on a Thursday will generally be more expensive and average around $306. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Myrtle Beach to Des Moines in the morning for as low as $296. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $306. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Myrtle Beach to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Des Moines (MYR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Des Moines

Best Price Found

$118

Fastest flight time

4h 34m

Direct flights

None

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Myrtle Beach in the past 72 hours is $118. The best round-trip flight deal from Myrtle Beach to Des Moines found on momondo in the last 72 hours is $237.
The fastest flight from Myrtle Beach to Des Moines takes 4h 34m
There are no direct flights from Myrtle Beach to Des Moines. Popular non-direct route for this connection is Myrtle Beach Intl Airport - Des Moines Airport.
There is 1 airport near Des Moines: Des Moines (DSM)
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  • How far is Myrtle Beach Intl to Des Moines by plane?

    The distance between Myrtle Beach Intl and Des Moines is about 970.9 mi. Flights usually cover this in 4h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Des Moines Airport?

    Prices for flights from Myrtle Beach Intl Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Des Moines?

Best airlines flying from Myrtle Beach to Des Moines

Compare and see reviews for airlines that fly from Myrtle Beach to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $256Free CancellationRating
8.0
7,980 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Des Moines?

It is quick and easy to find Myrtle Beach to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Myrtle Beach to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Des Moines?

Once all potential Myrtle Beach to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Myrtle Beach to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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