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Cheap flights from Missouri to South America from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to South America departing on 9/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to South America

Cheap round-trip flights

Spirit Airlines Logo
10:57 am - 12:17 amSTL-MDE
13h 20m1 stop
Spirit Airlines Logo
1:12 am - 10:02 amMDE-STL
8h 50m1 stop
$296Spirit Airlines
Find Deal
Thu, Oct 16 - Sat, Oct 18
Spirit Airlines Logo
10:57 am - 1:11 pmSTL-MDE
26h 14m1 stop
Spirit Airlines Logo
1:12 am - 10:02 amMDE-STL
8h 50m1 stop
$307Spirit Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
Logo
10:57 am - 12:17 amSTL-MDE
13h 20m1 stop
Logo
6:59 pm - 10:12 amMDE-STL
40h 13m2 stops
$379
Find Deal
Thu, Oct 30 - Tue, Nov 11
Logo
10:18 am - 1:11 pmSTL-MDE
26h 53m2 stops
Logo
3:22 pm - 10:02 amMDE-STL
19h 40m1 stop
$424
Find Deal
Mon, Oct 27 - Mon, Nov 3
United Airlines Logo
6:15 am - 9:10 pmSTL-MDE
14h 55m1 stop
United Airlines Logo
10:45 am - 9:59 pmMDE-STL
12h 14m1 stop
$566United Airlines
Find Deal
Wed, Oct 22 - Mon, Nov 3
United Airlines Logo
5:00 am - 9:10 pmSTL-MDE
16h 10m2 stops
United Airlines Logo
10:45 am - 9:59 pmMDE-STL
12h 14m1 stop
$570United Airlines
Find Deal
Wed, Oct 22 - Mon, Nov 3
American Airlines Logo
5:23 am - 8:15 pmSTL-MDE
14h 52m1 stop
American Airlines Logo
1:30 am - 10:32 pmMDE-STL
22h 02m1 stop
$578American Airlines
Find Deal
Wed, Oct 22 - Sun, Nov 2
American Airlines Logo
6:00 am - 9:10 pmSTL-MDE
14h 10m2 stops
American Airlines Logo
1:30 am - 1:14 pmMDE-STL
12h 44m2 stops
$594American Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10
Delta Logo
11:51 am - 5:00 amSTL-LIM
16h 09m1 stop
Delta Logo
12:05 am - 4:40 pmLIM-STL
17h 35m1 stop
$645Delta
Find Deal
Mon, Nov 24 - Sun, Dec 7
Delta Logo
1:30 pm - 6:25 amSTL-LIM
15h 55m2 stops
Delta Logo
8:25 am - 8:49 pmLIM-STL
13h 24m2 stops
$649Delta
Find Deal
Sun, Nov 23 - Thu, Dec 4

American Airlines flights from Missouri to South America

Our best American Airlines deals on Missouri to South America flight tickets
American Airlines
Oct 22
STL5:23 amLambert-St Louis
14h 52m
1 stop
MDE8:15 pmMedellín Jose Maria Cordova Intl
Nov 2
MDE1:30 amMedellín Jose Maria Cordova Intl
22h 02m
1 stop
STL10:32 pmLambert-St Louis
$578
Find similar
American Airlines
Nov 6
STL6:00 amLambert-St Louis
14h 10m
2 stops
MDE9:10 pmMedellín Jose Maria Cordova Intl
Nov 10
MDE1:30 amMedellín Jose Maria Cordova Intl
12h 44m
2 stops
STL1:14 pmLambert-St Louis
$594
Find similar
American Airlines
Nov 8
STL5:21 amLambert-St Louis
17h 18m
1 stop
MDE11:39 pmMedellín Jose Maria Cordova Intl
Nov 15
MDE1:30 amMedellín Jose Maria Cordova Intl
22h 02m
1 stop
STL10:32 pmLambert-St Louis
$598
Find similar

Avianca flights from Missouri to South America

Our best Avianca deals on Missouri to South America flight tickets
Avianca
Aug 26
STL8:15 amLambert-St Louis
35h 05m
2 stops
LIM7:20 pmLima J Chavez Intl
Sep 8
LIM2:50 amLima J Chavez Intl
15h 33m
2 stops
STL6:23 pmLambert-St Louis
$876
Find similar
Avianca
Aug 26
STL8:15 amLambert-St Louis
19h 25m
2 stops
AEP5:40 amBuenos Aires Jorge Newbery
Sep 4
AEP7:00 amBuenos Aires Jorge Newbery
53h 02m
2 stops
STL10:02 amLambert-St Louis
$1,116
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 10/16

10:57 am-12:17 am

1 stop13h 20m

Medellín Jose Maria Cordova Intl

Sat 10/18

1:12 am-10:02 am

1 stop8h 50m

$296

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 10/23

10:57 am-1:11 pm

1 stop26h 14m

Medellín Jose Maria Cordova Intl

Mon 10/27

1:12 am-10:02 am

1 stop8h 50m

$307

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 10/30

10:57 am-12:17 am

1 stop13h 20m

Medellín Jose Maria Cordova Intl

Tue 11/11

6:59 pm-10:12 am

2 stops40h 13m

$379

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Mon 10/27

10:18 am-1:11 pm

2 stops26h 53m

Medellín Jose Maria Cordova Intl

Mon 11/3

3:22 pm-10:02 am

1 stop19h 40m

$424

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 10/22

6:15 am-9:10 pm

1 stop14h 55m

Medellín Jose Maria Cordova Intl

Mon 11/3

10:45 am-9:59 pm

1 stop12h 14m

$566

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 10/22

5:00 am-9:10 pm

2 stops16h 10m

Medellín Jose Maria Cordova Intl

Mon 11/3

10:45 am-9:59 pm

1 stop12h 14m

$570

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 10/22

5:23 am-8:15 pm

1 stop14h 52m

Medellín Jose Maria Cordova Intl

Sun 11/2

1:30 am-10:32 pm

1 stop22h 02m

$578

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 11/6

6:00 am-9:10 pm

2 stops14h 10m

Medellín Jose Maria Cordova Intl

Mon 11/10

1:30 am-1:14 pm

2 stops12h 44m

$594

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Mon 11/24

11:51 am-5:00 am

1 stop16h 09m

Lima J Chavez Intl

Sun 12/7

12:05 am-4:40 pm

1 stop17h 35m

$645

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Sun 11/23

1:30 pm-6:25 am

2 stops15h 55m

Lima J Chavez Intl

Thu 12/4

8:25 am-8:49 pm

2 stops13h 24m

$649

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Missouri to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Missouri to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $665. If you aren’t able to travel during the month of February, then book flights to South America from Missouri during September instead. Flights to South America in September, while not as cheap as those in February, still average around $693.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Missouri to South America is on a Wednesday when prices can be found for as low as $741. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to South America for around $967.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Missouri to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $785. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $831 on average. Flights to South America from Missouri at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $780 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Missouri for as low as $698 on momondo.

Can stopping save me money on Missouri to South America flights?

You could potentially save up to 36% on your flight if you consider stops on a Missouri to South America flight.

Cheap Missouri to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South America

Direct flights

None
There are no direct flights from Missouri to South America. There are no popular flight routes from Missouri to South America.
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  • When did momondo last update prices for flights from Missouri to South America?

    Prices for flights from Missouri to South America are updated daily.

  • How many operators does momondo search for flights from Missouri to South America?

  • How old do you have to be to fly from Missouri to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to South America

Compare and see reviews for airlines that fly from Missouri to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $307Free CancellationRating
6.3
8,035 reviews
Search Spirit Airlines flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
DeltaPriceFrom $413Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $456Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $466Free CancellationRating
7.5
1,844 reviews
Search LATAM Airlines flights
Air CanadaPriceFrom $758Free CancellationRating
7.1
10,000 reviews
Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South America?

Finding the right flight to South America from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Missouri to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Missouri to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from Missouri to South America?

Once all potential Missouri to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missouri to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $283
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Flights to Bogotáfrom $180
Flights to Sao Paulofrom $366
Flights to Medellínfrom $171
Flights to Rio de Janeirofrom $460
Flights to Santiagofrom $403
Flights to Cartagenafrom $180
Flights to Quitofrom $318
Flights to Cuscofrom $365
Flights to Califrom $186
Flights to Guayaquilfrom $242