What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Missouri according to our data. Delta is the first choice among our users, with 37% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 6 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Missouri to South America?

Spirit Airlines, United Airlines, and LATAM Airlines are the most popular carriers operating from Missouri to South America

How long is the flight from Missouri to South America?

Average flight duration from Missouri to South America depends on which airport you fly into and out of. Flying from St. Louis to Copenhagen is 14h 10m on average, while flying from Kansas City to Copenhagen is 16h 23m on average. Copenhagen is the most popular airport in South America.

When did momondo last update prices for flights from Missouri to South America?

Prices for flights from Missouri to South America are updated daily.

How many operators does momondo search for flights from Missouri to South America?

There are 6 operators available for flights from Missouri to South America as of February 2026.

How old do you have to be to fly from Missouri to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$198 Cheap Flights from Missouri to South America in 2026

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Find the cheapest flights from Missouri to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

12:24 pm - 12:21 am

MCI

MDE

11h 57m

1 stop

1:17 am - 11:29 am

MDE

MCI

10h 12m

1 stop

$282Spirit Airlines

Wed, Apr 1 - Tue, Apr 7

12:24 pm - 12:21 am

MCI

MDE

11h 57m

1 stop

1:52 pm - 11:29 am

MDE

MCI

21h 37m

2 stops

$315Spirit Airlines

Wed, Apr 1 - Wed, Apr 8

5:08 pm - 1:10 pm

MCI

BOG

20h 02m

2 stops

2:10 pm - 11:29 am

BOG

MCI

21h 19m

1 stop

$344Multiple Airlines

Mon, Mar 9 - Mon, Mar 16

11:00 am - 2:10 pm

MCI

BOG

26h 10m

2 stops

2:10 pm - 11:29 am

BOG

MCI

21h 19m

1 stop

$387Multiple Airlines

Fri, Feb 27 - Sun, Mar 15

6:00 am - 1:20 pm

STL

CTG

7h 20m

1 stop

2:35 pm - 11:34 pm

CTG

STL

8h 59m

1 stop

$543Delta

Tue, Apr 14 - Tue, Apr 21

5:24 am - 12:09 pm

STL

CTG

6h 45m

1 stop

1:25 pm - 11:37 am

CTG

STL

22h 12m

2 stops

$548American Airlines

Tue, Apr 14 - Tue, Apr 21

6:00 am - 11:35 pm

STL

CTG

17h 35m

2 stops

2:30 pm - 11:34 pm

CTG

STL

9h 04m

1 stop

$550Delta

Tue, Apr 14 - Thu, Apr 23

6:50 pm - 1:20 pm

STL

CTG

18h 30m

1 stop

2:30 pm - 11:34 pm

CTG

STL

9h 04m

1 stop

$552LATAM Airlines

Mon, Apr 13 - Thu, Apr 23

6:00 am - 1:15 pm

STL

CTG

7h 15m

1 stop

2:35 pm - 8:30 am

CTG

STL

17h 55m

1 stop

$553LATAM Airlines

Sun, Apr 12 - Tue, Apr 21

4:30 pm - 12:09 pm

STL

CTG

19h 39m

2 stops

1:25 pm - 10:16 am

CTG

STL

20h 51m

1 stop

$560American Airlines

Sat, Apr 11 - Sat, Apr 18

Spirit Airlines flights from Missouri to South America

Our best Spirit Airlines deals on Missouri to South America flight tickets

Spirit Airlines

Apr 1

MCI12:24 pmKansas City

11h 57m

1 stop

MDE12:21 amMedellín Jose Maria Cordova Intl

Apr 7

MDE1:17 amMedellín Jose Maria Cordova Intl

10h 12m

1 stop

MCI11:29 amKansas City

$282

Spirit Airlines

Apr 1

MCI12:24 pmKansas City

11h 57m

1 stop

MDE12:21 amMedellín Jose Maria Cordova Intl

Apr 8

MDE1:52 pmMedellín Jose Maria Cordova Intl

21h 37m

2 stops

MCI11:29 amKansas City

$315

Spirit Airlines

Feb 27

MCI11:26 amKansas City

25h 44m

1 stop

BOG2:10 pmBogotá El Dorado

Mar 15

BOG2:10 pmBogotá El Dorado

21h 19m

1 stop

MCI11:29 amKansas City

$338

United Airlines flights from Missouri to South America

Our best United Airlines deals on Missouri to South America flight tickets

United Airlines

Apr 15

STL6:00 amLambert-St Louis

16h 58m

2 stops

CTG10:58 pmCartagena Rafael Nunez

Apr 23

CTG6:21 amCartagena Rafael Nunez

16h 07m

2 stops

STL10:28 pmLambert-St Louis

$613

United Airlines

Apr 12

STL6:00 amLambert-St Louis

16h 58m

2 stops

CTG10:58 pmCartagena Rafael Nunez

Apr 21

CTG6:21 amCartagena Rafael Nunez

16h 07m

2 stops

STL10:28 pmLambert-St Louis

$623

United Airlines

Mar 26

MCI6:15 amKansas City

14h 50m

1 stop

MDE9:05 pmMedellín Jose Maria Cordova Intl

Apr 2

MDE9:45 amMedellín Jose Maria Cordova Intl

12h 45m

1 stop

MCI10:30 pmKansas City

$631

Fly from

Fly to

Route

Depart

Return

Price

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 4/1

12:24 pm-12:21 am

1 stop11h 57m

Medellín Jose Maria Cordova Intl

Tue 4/7

1:17 am-11:29 am

1 stop10h 12m

$282

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 4/1

12:24 pm-12:21 am

1 stop11h 57m

Medellín Jose Maria Cordova Intl

Wed 4/8

1:52 pm-11:29 am

2 stops21h 37m

$315

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Mon 3/9

5:08 pm-1:10 pm

2 stops20h 02m

Bogotá El Dorado

Mon 3/16

2:10 pm-11:29 am

1 stop21h 19m

$344

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Fri 2/27

11:00 am-2:10 pm

2 stops26h 10m

Bogotá El Dorado

Sun 3/15

2:10 pm-11:29 am

1 stop21h 19m

$387

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 4/14

6:00 am-1:20 pm

1 stop7h 20m

Cartagena Rafael Nunez

Tue 4/21

2:35 pm-11:34 pm

1 stop8h 59m

$543

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 4/14

5:24 am-12:09 pm

1 stop6h 45m

Cartagena Rafael Nunez

Tue 4/21

1:25 pm-11:37 am

2 stops22h 12m

$548

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 4/14

6:00 am-11:35 pm

2 stops17h 35m

Cartagena Rafael Nunez

Thu 4/23

2:30 pm-11:34 pm

1 stop9h 04m

$550

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Mon 4/13

6:50 pm-1:20 pm

1 stop18h 30m

Cartagena Rafael Nunez

Thu 4/23

2:30 pm-11:34 pm

1 stop9h 04m

$552

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sun 4/12

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

Tue 4/21

2:35 pm-8:30 am

1 stop17h 55m

$553

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sat 4/11

4:30 pm-12:09 pm

2 stops19h 39m

Cartagena Rafael Nunez

Sat 4/18

1:25 pm-10:16 am

1 stop20h 51m

$560

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Missouri to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Missouri to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $664. If you aren’t able to travel during the month of February, then book flights to South America from Missouri during January instead. Flights to South America in January, while not as cheap as those in February, still average around $709.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $807 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Missouri for as low as $661 on momondo.

Can stopping save me money on Missouri to South America flights?

You could potentially save up to 25% on your flight if you consider stops on a Missouri to South America flight.

Cheap Missouri to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South America

Fastest flight time	7h 03m
Direct flights	None

The fastest flight from Missouri to South America takes 7h 03m

There are no direct flights from Missouri to South America. There are no popular flight routes from Missouri to South America.

Search flight deals

When did momondo last update prices for flights from Missouri to South America?
Prices for flights from Missouri to South America are updated daily.
How many operators does momondo search for flights from Missouri to South America?
There are 6 operators available for flights from Missouri to South America as of February 2026.
How old do you have to be to fly from Missouri to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to South America

Compare and see reviews for airlines that fly from Missouri to South America with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $303	Free Cancellation	Rating 6.3 8,446 reviews	Search Spirit Airlines flights
LATAM Airlines	PriceFrom $351	Free Cancellation	Rating 7.5 1,921 reviews	Search LATAM Airlines flights
Delta	PriceFrom $444	Free Cancellation	Rating 7.9 8,182 reviews	Search Delta flights
American Airlines	PriceFrom $452	Free Cancellation	Rating 7.2 11,272 reviews	Search American Airlines flights
United Airlines	PriceFrom $462	Free Cancellation	Rating 7.4 9,282 reviews	Search United Airlines flights
Air Canada	PriceFrom $758	Free Cancellation	Rating 7.1 10,709 reviews	Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South America?

Finding the right flight to South America from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Missouri to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Missouri to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from Missouri to South America?

Once all potential Missouri to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missouri to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.