What is the cheapest airline that flies from Missouri to South America?

Avianca, Spirit Airlines, and Air Canada are the most popular carriers operating from Missouri to South America

What airlines fly to South America?

Delta, American Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Missouri according to our data. Delta is the first choice among our users, with 41% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 6 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

How long is the flight from Missouri to South America?

Average flight duration from Missouri to South America depends on which airport you fly into and out of. Flying from St. Louis to Incheon Intl Airport is 17h 50m on average, while flying from Kansas City to Incheon Intl Airport is 18h 30m on average. Incheon Intl Airport is the most popular airport in South America.

When did momondo last update prices for flights from Missouri to South America?

Prices for flights from Missouri to South America are updated daily.

How many operators does momondo search for flights from Missouri to South America?

There are 6 operators available for flights from Missouri to South America as of December 2025.

How old do you have to be to fly from Missouri to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$259 Cheap Flights from Missouri to South America in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Missouri to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:42 pm - 1:55 pm

STL

MDE

19h 13m1 stop

2:50 pm - 11:33 pm

MDE

STL

9h 43m1 stop

$332Multiple Airlines

Sat, Jan 31 - Sat, Feb 7

8:22 pm - 1:55 pm

STL

MDE

16h 33m2 stops

2:50 pm - 11:33 pm

MDE

STL

9h 43m1 stop

$370Multiple Airlines

Sat, Jan 31 - Sat, Feb 7

11:26 am - 10:35 pm

MCI

LIM

10h 09m1 stop

11:33 pm - 10:31 am

LIM

MCI

11h 58m1 stop

$374Spirit Airlines

Fri, Jan 30 - Sun, Feb 8

11:26 am - 10:35 pm

MCI

LIM

10h 09m1 stop

11:33 pm - 10:31 am

LIM

MCI

11h 58m1 stop

$378Spirit Airlines

Thu, Jan 29 - Sat, Feb 7

12:12 pm - 9:35 pm

MCI

LIM

33h 23m1 stop

10:30 pm - 11:07 am

LIM

MCI

12h 37m1 stop

$435Spirit Airlines

Tue, Apr 21 - Tue, May 5

8:30 am - 11:15 pm

STL

MDE

13h 45m2 stops

8:10 pm - 10:13 am

MDE

STL

15h 03m2 stops

$468Avianca

Sat, Jan 31 - Sat, Feb 7

11:19 am - 9:10 pm

STL

MDE

8h 51m1 stop

7:00 am - 5:40 pm

MDE

STL

10h 40m1 stop

$566American Airlines

Tue, Mar 3 - Wed, Mar 11

6:00 am - 9:10 pm

STL

MDE

14h 10m2 stops

12:20 am - 2:52 pm

MDE

STL

14h 32m1 stop

$571American Airlines

Tue, Mar 3 - Tue, Mar 10

6:49 pm - 9:10 pm

STL

MDE

26h 21m2 stops

9:45 am - 10:06 pm

MDE

STL

12h 21m1 stop

$581United Airlines

Sun, May 17 - Sun, May 31

7:40 am - 7:50 am

STL

SCL

22h 10m2 stops

9:45 pm - 9:21 am

SCL

STL

13h 36m1 stop

$755United Airlines

Wed, Mar 11 - Mon, Mar 23

GOL flights from Missouri to South America

Our best GOL deals on Missouri to South America flight tickets

GOL

Mar 22

STL6:20 pmLambert-St Louis

34h 00m

1 stop

GRU6:20 amSao Paulo Guarulhos Intl

Apr 4

GRU6:00 amSao Paulo Guarulhos Intl

17h 51m

2 stops

STL9:51 pmLambert-St Louis

$992

Find similar

GOL

Jan 29

STL3:37 pmLambert-St Louis

13h 33m

1 stop

GRU8:10 amSao Paulo Guarulhos Intl

Feb 5

GRU6:00 amSao Paulo Guarulhos Intl

20h 59m

2 stops

STL11:59 pmLambert-St Louis

$1,100

Find similar

GOL

Feb 14

STL3:31 pmLambert-St Louis

13h 39m

1 stop

GRU8:10 amSao Paulo Guarulhos Intl

Feb 21

GRU12:15 amSao Paulo Guarulhos Intl

13h 11m

1 stop

STL10:26 amLambert-St Louis

$1,330

Find similar

American Airlines flights from Missouri to South America

Our best American Airlines deals on Missouri to South America flight tickets

American Airlines

Mar 3

STL5:05 amLambert-St Louis

8h 01m

1 stop

MDE2:06 pmMedellín Jose Maria Cordova Intl

Mar 11

MDE7:00 amMedellín Jose Maria Cordova Intl

10h 40m

1 stop

STL5:40 pmLambert-St Louis

$566

Find similar

American Airlines

Mar 3

STL7:00 amLambert-St Louis

13h 10m

2 stops

MDE9:10 pmMedellín Jose Maria Cordova Intl

Mar 11

MDE7:00 amMedellín Jose Maria Cordova Intl

12h 30m

2 stops

STL7:30 pmLambert-St Louis

$571

Find similar

American Airlines

Feb 13

STL11:19 amLambert-St Louis

8h 51m

1 stop

MDE9:10 pmMedellín Jose Maria Cordova Intl

Feb 23

MDE3:10 pmMedellín Jose Maria Cordova Intl

20h 16m

1 stop

STL10:26 amLambert-St Louis

$588

Find similar

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/31

5:42 pm-1:55 pm

1 stop19h 13m

Medellín Jose Maria Cordova Intl

Sat 2/7

2:50 pm-11:33 pm

1 stop9h 43m

$332

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/31

8:22 pm-1:55 pm

2 stops16h 33m

Medellín Jose Maria Cordova Intl

Sat 2/7

2:50 pm-11:33 pm

1 stop9h 43m

$370

Kansas CityLima

MCI - LIM

MCILIM

Kansas City

Fri 1/30

11:26 am-10:35 pm

1 stop10h 09m

Lima J Chavez Intl

Sun 2/8

11:33 pm-10:31 am

1 stop11h 58m

$374

Kansas CityLima

MCI - LIM

MCILIM

Kansas City

Thu 1/29

11:26 am-10:35 pm

1 stop10h 09m

Lima J Chavez Intl

Sat 2/7

11:33 pm-10:31 am

1 stop11h 58m

$378

Kansas CityLima

MCI - LIM

MCILIM

Kansas City

Tue 4/21

12:12 pm-9:35 pm

1 stop33h 23m

Lima J Chavez Intl

Tue 5/5

10:30 pm-11:07 am

1 stop12h 37m

$435

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/31

8:30 am-11:15 pm

2 stops13h 45m

Medellín Jose Maria Cordova Intl

Sat 2/7

8:10 pm-10:13 am

2 stops15h 03m

$468

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 3/3

11:19 am-9:10 pm

1 stop8h 51m

Medellín Jose Maria Cordova Intl

Wed 3/11

7:00 am-5:40 pm

1 stop10h 40m

$566

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 3/3

6:00 am-9:10 pm

2 stops14h 10m

Medellín Jose Maria Cordova Intl

Tue 3/10

12:20 am-2:52 pm

1 stop14h 32m

$571

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 5/17

6:49 pm-9:10 pm

2 stops26h 21m

Medellín Jose Maria Cordova Intl

Sun 5/31

9:45 am-10:06 pm

1 stop12h 21m

$581

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

7:40 am-7:50 am

2 stops22h 10m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$755

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Missouri to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Missouri to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $663. If you aren’t able to travel during the month of February, then book flights to South America from Missouri during August instead. Flights to South America in August, while not as cheap as those in February, still average around $724.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Missouri to South America is on a Tuesday when prices can be found for as low as $758. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to South America for around $957.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Missouri to South America flights are usually those with departure times at noon. Our users have found flights to South America at noon for as low as $715. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $845 on average. Flights to South America from Missouri in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $801 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Missouri for as low as $671 on momondo.

Can stopping save me money on Missouri to South America flights?

You could potentially save up to 25% on your flight if you consider stops on a Missouri to South America flight.

Cheap Missouri to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South America

Fastest flight time	7h 25m
Direct flights	None

The fastest flight from Missouri to South America takes 7h 25m

There are no direct flights from Missouri to South America. There are no popular flight routes from Missouri to South America.

Search flight deals

When did momondo last update prices for flights from Missouri to South America?
Prices for flights from Missouri to South America are updated daily.
How many operators does momondo search for flights from Missouri to South America?
There are 6 operators available for flights from Missouri to South America as of December 2025.
How old do you have to be to fly from Missouri to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents required for your trip to South America can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South America. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to South America

Compare and see reviews for airlines that fly from Missouri to South America with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $303	Free Cancellation	Rating 6.3 8,190 reviews	Search Spirit Airlines flights
Delta	PriceFrom $444	Free Cancellation	Rating 7.9 8,005 reviews	Search Delta flights
American Airlines	PriceFrom $474	Free Cancellation	Rating 7.2 11,054 reviews	Search American Airlines flights
United Airlines	PriceFrom $507	Free Cancellation	Rating 7.4 9,091 reviews	Search United Airlines flights
LATAM Airlines	PriceFrom $563	Free Cancellation	Rating 7.5 1,892 reviews	Search LATAM Airlines flights
Air Canada	PriceFrom $758	Free Cancellation	Rating 7.1 10,534 reviews	Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South America?

Finding the right flight to South America from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Missouri to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Missouri to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from Missouri to South America?

Once all potential Missouri to South America flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missouri to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.