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Cheap flights from Missoula to Knoxville from $271

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missoula to Knoxville departing on 6/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missoula to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:28 pm - 11:56 pm
MSO
-
TYS
7h 28m
1 stop
American Airlines Logo
5:37 am - 4:14 pm
TYS
-
MSO
12h 37m
2 stops
$354American Airlines
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
2:28 pm - 11:56 pm
MSO
-
TYS
7h 28m
1 stop
American Airlines Logo
5:33 pm - 10:38 pm
TYS
-
MSO
7h 05m
1 stop
$384American Airlines
Tue, Jun 2 - Tue, Jun 9
Delta Logo
6:10 pm - 9:11 am
MSO
-
TYS
13h 01m
2 stops
Delta Logo
7:55 am - 5:27 pm
TYS
-
MSO
11h 32m
2 stops
$449Delta
Sat, Oct 3 - Sat, Oct 10
Delta Logo
6:10 pm - 9:11 am
MSO
-
TYS
13h 01m
2 stops
Delta Logo
7:55 am - 5:27 pm
TYS
-
MSO
11h 32m
2 stops
$454Delta
Sat, Oct 3 - Sat, Oct 10
Delta Logo
1:14 pm - 12:01 am
MSO
-
TYS
8h 47m
2 stops
Delta Logo
3:05 pm - 12:22 am
TYS
-
MSO
11h 17m
2 stops
$460Delta
Sat, May 23 - Wed, May 27
American Airlines Logo
2:18 pm - 11:56 pm
MSO
-
TYS
7h 38m
1 stop
American Airlines Logo
5:33 pm - 10:38 pm
TYS
-
MSO
7h 05m
1 stop
$480American Airlines
Sat, May 23 - Wed, May 27
American Airlines Logo
2:15 pm - 11:55 pm
MSO
-
TYS
7h 40m
1 stop
American Airlines Logo
5:37 am - 4:14 pm
TYS
-
MSO
12h 37m
2 stops
$481American Airlines
Tue, Jun 9 - Tue, Jun 16
United Airlines Logo
2:37 pm - 10:23 pm
MSO
-
TYS
5h 46m
1 stop
United Airlines Logo
6:30 am - 11:32 am
TYS
-
MSO
7h 02m
1 stop
$484United Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
2:18 pm - 11:56 pm
MSO
-
TYS
7h 38m
1 stop
American Airlines Logo
1:00 pm - 10:38 pm
TYS
-
MSO
11h 38m
2 stops
$485American Airlines
Sat, May 23 - Wed, May 27
United Airlines Logo
2:26 pm - 10:19 pm
MSO
-
TYS
5h 53m
1 stop
United Airlines Logo
4:56 pm - 9:34 pm
TYS
-
MSO
6h 38m
1 stop
$509United Airlines
Wed, May 27 - Sat, May 30

Delta flights from Missoula to Knoxville

Our best Delta deals on Missoula to Knoxville flight tickets
Delta
Oct 3
MSO6:10 pmMissoula Johnson-Bell Field
13h 01m
2 stops
TYS9:11 amKnoxville McGhee Tyson
Oct 10
TYS7:55 amKnoxville McGhee Tyson
11h 32m
2 stops
MSO5:27 pmMissoula Johnson-Bell Field
$449
Delta
Oct 3
MSO6:10 pmMissoula Johnson-Bell Field
13h 01m
2 stops
TYS9:11 amKnoxville McGhee Tyson
Oct 10
TYS7:55 amKnoxville McGhee Tyson
11h 32m
2 stops
MSO5:27 pmMissoula Johnson-Bell Field
$454
Delta
May 23
MSO1:14 pmMissoula Johnson-Bell Field
8h 47m
2 stops
TYS12:01 amKnoxville McGhee Tyson
May 27
TYS3:05 pmKnoxville McGhee Tyson
11h 17m
2 stops
MSO12:22 amMissoula Johnson-Bell Field
$460

United Airlines flights from Missoula to Knoxville

Our best United Airlines deals on Missoula to Knoxville flight tickets
United Airlines
May 19
MSO2:37 pmMissoula Johnson-Bell Field
5h 46m
1 stop
TYS10:23 pmKnoxville McGhee Tyson
May 26
TYS6:30 amKnoxville McGhee Tyson
7h 02m
1 stop
MSO11:32 amMissoula Johnson-Bell Field
$484
United Airlines
May 27
MSO2:26 pmMissoula Johnson-Bell Field
5h 53m
1 stop
TYS10:19 pmKnoxville McGhee Tyson
May 30
TYS4:56 pmKnoxville McGhee Tyson
6h 38m
1 stop
MSO9:34 pmMissoula Johnson-Bell Field
$509
United Airlines
May 27
MSO2:26 pmMissoula Johnson-Bell Field
5h 53m
1 stop
TYS10:19 pmKnoxville McGhee Tyson
May 30
TYS10:45 amKnoxville McGhee Tyson
13h 53m
2 stops
MSO10:38 pmMissoula Johnson-Bell Field
$515

momondo Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/2

2:28 pm-11:56 pm

1 stop7h 28m

Knoxville McGhee Tyson

Tue 6/9

5:37 am-4:14 pm

2 stops12h 37m

$354

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/2

2:28 pm-11:56 pm

1 stop7h 28m

Knoxville McGhee Tyson

Tue 6/9

5:33 pm-10:38 pm

1 stop7h 05m

$384

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 10/3

6:10 pm-9:11 am

2 stops13h 01m

Knoxville McGhee Tyson

Sat 10/10

7:55 am-5:27 pm

2 stops11h 32m

$449

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 10/3

6:10 pm-9:11 am

2 stops13h 01m

Knoxville McGhee Tyson

Sat 10/10

7:55 am-5:27 pm

2 stops11h 32m

$454

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 5/23

1:14 pm-12:01 am

2 stops8h 47m

Knoxville McGhee Tyson

Wed 5/27

3:05 pm-12:22 am

2 stops11h 17m

$460

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 5/23

2:18 pm-11:56 pm

1 stop7h 38m

Knoxville McGhee Tyson

Wed 5/27

5:33 pm-10:38 pm

1 stop7h 05m

$480

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/9

2:15 pm-11:55 pm

1 stop7h 40m

Knoxville McGhee Tyson

Tue 6/16

5:37 am-4:14 pm

2 stops12h 37m

$481

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

2:37 pm-10:23 pm

1 stop5h 46m

Knoxville McGhee Tyson

Tue 5/26

6:30 am-11:32 am

1 stop7h 02m

$484

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 5/23

2:18 pm-11:56 pm

1 stop7h 38m

Knoxville McGhee Tyson

Wed 5/27

1:00 pm-10:38 pm

2 stops11h 38m

$485
Quickest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 5/27

2:26 pm-10:19 pm

1 stop5h 53m

Knoxville McGhee Tyson

Sat 5/30

4:56 pm-9:34 pm

1 stop6h 38m

$509

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missoula to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from Missoula, with most prices found around $0. If you aren’t able to travel during the month of November, then book flights to Knoxville from Missoula during September instead. Flights to Knoxville in September, while not as cheap as those in November, still average around $378.

Can stopping save me money on Missoula to Knoxville flights?

You could potentially save up to 9% on your flight if you consider stops on a Missoula to Knoxville flight.

When to book flights from Missoula to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Missoula to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Missoula to Knoxville (MSO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missoula to Knoxville

Fastest flight time

5h 24m

Direct flights

None
The fastest flight from Missoula to Knoxville takes 5h 24m
There are no direct flights from Missoula to Knoxville. There are no popular flight routes from Missoula to Knoxville.
Search flight deals

Frequently asked questions about flying from Missoula to Knoxville

  • How far is Missoula Johnson-Bell Field to Knoxville McGhee Tyson by plane?

    A flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson will travel around 1715.6 mi. By plane, this route typically takes 5h 24m.

  • When did momondo last update prices for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Missoula to Knoxville?

Best airlines flying from Missoula to Knoxville

Compare and see reviews for airlines that fly from Missoula to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights
United AirlinesPriceFrom $343Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missoula to Knoxville?

Finding the right flight to Knoxville from Missoula is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Missoula to Knoxville with flexible booking policies on momondo?

All flight searches from Missoula to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Missoula to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Missoula.

I’m not ready to book a flight from Missoula to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missoula to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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