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Cheap flights from Missoula to Knoxville from $228

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missoula to Knoxville departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missoula to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:24 am - 1:57 pm
MSO
-
TYS
25h 33m
1 stop
Allegiant Air Logo
6:00 pm - 9:34 am
TYS
-
MSO
17h 34m
2 stops
$444Allegiant Air
Thu, Aug 13 - Sat, Aug 15
American Airlines Logo
1:45 pm - 11:59 pm
MSO
-
TYS
8h 14m
1 stop
American Airlines Logo
7:30 am - 12:35 pm
TYS
-
MSO
7h 05m
1 stop
$448American Airlines
Thu, Oct 22 - Sun, Oct 25
United Airlines Logo
2:27 pm - 10:38 pm
MSO
-
TYS
6h 11m
1 stop
United Airlines Logo
5:01 pm - 9:35 pm
TYS
-
MSO
6h 34m
1 stop
$449United Airlines
Sat, Nov 14 - Wed, Nov 18
United Airlines Logo
2:27 pm - 10:38 pm
MSO
-
TYS
6h 11m
1 stop
United Airlines Logo
8:30 am - 9:35 pm
TYS
-
MSO
15h 05m
2 stops
$454United Airlines
Sat, Nov 14 - Wed, Nov 18
United Airlines Logo
2:27 pm - 10:38 pm
MSO
-
TYS
6h 11m
1 stop
United Airlines Logo
5:01 pm - 9:35 pm
TYS
-
MSO
6h 34m
1 stop
$459United Airlines
Sat, Nov 14 - Wed, Nov 18
United Airlines Logo
2:27 pm - 10:38 pm
MSO
-
TYS
6h 11m
1 stop
United Airlines Logo
8:30 am - 9:35 pm
TYS
-
MSO
15h 05m
2 stops
$464United Airlines
Sat, Nov 14 - Wed, Nov 18
United Airlines Logo
6:15 am - 8:54 pm
MSO
-
TYS
12h 39m
2 stops
United Airlines Logo
8:30 am - 9:35 pm
TYS
-
MSO
15h 05m
2 stops
$469United Airlines
Sat, Nov 14 - Wed, Nov 18
American Airlines Logo
1:45 pm - 11:59 pm
MSO
-
TYS
8h 14m
1 stop
American Airlines Logo
7:30 am - 12:35 pm
TYS
-
MSO
7h 05m
1 stop
$483American Airlines
Wed, Oct 14 - Thu, Oct 15
American Airlines Logo
1:45 pm - 11:59 pm
MSO
-
TYS
8h 14m
1 stop
American Airlines Logo
7:30 am - 12:35 pm
TYS
-
MSO
7h 05m
1 stop
$532American Airlines
Tue, Oct 13 - Thu, Oct 15
American Airlines Logo
1:45 pm - 11:59 pm
MSO
-
TYS
8h 14m
1 stop
American Airlines Logo
7:30 am - 12:35 pm
TYS
-
MSO
7h 05m
1 stop
$568American Airlines
Tue, Oct 13 - Thu, Oct 15

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Alaska Airlines flights from Missoula to Knoxville

Our best Alaska Airlines deals on Missoula to Knoxville flight tickets
Alaska Airlines
Oct 13
MSO7:03 amMissoula Johnson-Bell Field
12h 42m
2 stops
TYS9:45 pmKnoxville McGhee Tyson
Oct 15
TYS6:00 amKnoxville McGhee Tyson
18h 04m
2 stops
MSO10:04 pmMissoula Johnson-Bell Field
$797
Alaska Airlines
Oct 22
MSO2:06 pmMissoula Johnson-Bell Field
18h 41m
2 stops
TYS10:47 amKnoxville McGhee Tyson
Oct 25
TYS3:56 pmKnoxville McGhee Tyson
22h 30m
2 stops
MSO12:26 pmMissoula Johnson-Bell Field
$798
Alaska Airlines
Nov 25
MSO4:00 pmMissoula Johnson-Bell Field
17h 18m
2 stops
TYS11:18 amKnoxville McGhee Tyson
Nov 29
TYS5:06 pmKnoxville McGhee Tyson
21h 18m
2 stops
MSO12:24 pmMissoula Johnson-Bell Field
$1,427

American Airlines flights from Missoula to Knoxville

Our best American Airlines deals on Missoula to Knoxville flight tickets
American Airlines
Oct 22
MSO1:45 pmMissoula Johnson-Bell Field
8h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Oct 25
TYS7:30 amKnoxville McGhee Tyson
7h 05m
1 stop
MSO12:35 pmMissoula Johnson-Bell Field
$448
American Airlines
Oct 14
MSO1:45 pmMissoula Johnson-Bell Field
8h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Oct 15
TYS7:30 amKnoxville McGhee Tyson
7h 05m
1 stop
MSO12:35 pmMissoula Johnson-Bell Field
$483
American Airlines
Oct 13
MSO1:45 pmMissoula Johnson-Bell Field
8h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Oct 15
TYS7:30 amKnoxville McGhee Tyson
7h 05m
1 stop
MSO12:35 pmMissoula Johnson-Bell Field
$532

momondo Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 8/13

10:24 am-1:57 pm

1 stop25h 33m

Knoxville McGhee Tyson

Sat 8/15

6:00 pm-9:34 am

2 stops17h 34m

$444

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 10/22

1:45 pm-11:59 pm

1 stop8h 14m

Knoxville McGhee Tyson

Sun 10/25

7:30 am-12:35 pm

1 stop7h 05m

$448
Quickest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 11/14

2:27 pm-10:38 pm

1 stop6h 11m

Knoxville McGhee Tyson

Wed 11/18

5:01 pm-9:35 pm

1 stop6h 34m

$449

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 11/14

2:27 pm-10:38 pm

1 stop6h 11m

Knoxville McGhee Tyson

Wed 11/18

8:30 am-9:35 pm

2 stops15h 05m

$454

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 11/14

2:27 pm-10:38 pm

1 stop6h 11m

Knoxville McGhee Tyson

Wed 11/18

5:01 pm-9:35 pm

1 stop6h 34m

$459

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 11/14

2:27 pm-10:38 pm

1 stop6h 11m

Knoxville McGhee Tyson

Wed 11/18

8:30 am-9:35 pm

2 stops15h 05m

$464

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 11/14

6:15 am-8:54 pm

2 stops12h 39m

Knoxville McGhee Tyson

Wed 11/18

8:30 am-9:35 pm

2 stops15h 05m

$469

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Wed 10/14

1:45 pm-11:59 pm

1 stop8h 14m

Knoxville McGhee Tyson

Thu 10/15

7:30 am-12:35 pm

1 stop7h 05m

$483

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 10/13

1:45 pm-11:59 pm

1 stop8h 14m

Knoxville McGhee Tyson

Thu 10/15

7:30 am-12:35 pm

1 stop7h 05m

$532

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 10/13

1:45 pm-11:59 pm

1 stop8h 14m

Knoxville McGhee Tyson

Thu 10/15

7:30 am-12:35 pm

1 stop7h 05m

$568

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missoula to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from Missoula, with most prices found around $0. If you aren’t able to travel during the month of November, then book flights to Knoxville from Missoula during September instead. Flights to Knoxville in September, while not as cheap as those in November, still average around $378.

When to book flights from Missoula to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Missoula to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Missoula to Knoxville (MSO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missoula to Knoxville

Fastest flight time

5h 52m

Direct flights

None
The fastest flight from Missoula to Knoxville takes 5h 52m
There are no direct flights from Missoula to Knoxville. There are no popular flight routes from Missoula to Knoxville.
Search flight deals

Frequently asked questions about flying from Missoula to Knoxville

  • How far is Missoula Johnson-Bell Field to Knoxville McGhee Tyson by plane?

    A flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson will travel around 1715.6 mi. By plane, this route typically takes 5h 52m.

  • When did momondo last update prices for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Missoula to Knoxville?

Best airlines flying from Missoula to Knoxville

Compare and see reviews for airlines that fly from Missoula to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $380Free CancellationRating
7.4
10,030 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Maryville
Corbin
Alcoa
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Clinton
Dandridge
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missoula to Knoxville?

Finding the right flight to Knoxville from Missoula is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Missoula to Knoxville with flexible booking policies on momondo?

All flight searches from Missoula to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Missoula to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Missoula.

I’m not ready to book a flight from Missoula to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missoula to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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