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Cheap flights from Missoula to Knoxville from $358

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missoula to Knoxville departing on 7/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missoula to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
2:38 pm - 10:29 pm
MSO
-
TYS
5h 51m
1 stop
United Airlines Logo
10:49 am - 9:30 pm
TYS
-
MSO
12h 41m
2 stops
$374United Airlines
Mon, Apr 13 - Sat, Apr 18
American Airlines Logo
1:08 pm - 9:21 pm
MSO
-
TYS
6h 13m
1 stop
American Airlines Logo
5:36 am - 1:28 pm
TYS
-
MSO
9h 52m
1 stop
$389American Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
6:45 am - 3:19 pm
MSO
-
TYS
6h 34m
1 stop
American Airlines Logo
5:36 am - 1:18 pm
TYS
-
MSO
9h 42m
1 stop
$402American Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
1:08 pm - 9:21 pm
MSO
-
TYS
6h 13m
1 stop
American Airlines Logo
7:01 am - 1:18 pm
TYS
-
MSO
8h 17m
1 stop
$422American Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
6:45 am - 6:04 pm
MSO
-
TYS
9h 19m
1 stop
American Airlines Logo
4:09 pm - 9:45 pm
TYS
-
MSO
7h 36m
1 stop
$434American Airlines
Mon, Apr 13 - Sat, Apr 18
American Airlines Logo
2:08 pm - 11:53 pm
MSO
-
TYS
7h 45m
1 stop
American Airlines Logo
5:33 pm - 10:38 pm
TYS
-
MSO
7h 05m
1 stop
$435American Airlines
Thu, May 21 - Sun, May 24
American Airlines Logo
6:45 am - 3:19 pm
MSO
-
TYS
6h 34m
1 stop
American Airlines Logo
5:36 am - 1:18 pm
TYS
-
MSO
9h 42m
1 stop
$441American Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
6:45 am - 3:19 pm
MSO
-
TYS
6h 34m
1 stop
American Airlines Logo
7:07 am - 12:49 pm
TYS
-
MSO
7h 42m
1 stop
$461American Airlines
Tue, May 19 - Tue, May 26
American Airlines Logo
2:08 pm - 11:53 pm
MSO
-
TYS
7h 45m
1 stop
American Airlines Logo
5:36 am - 1:18 pm
TYS
-
MSO
9h 42m
1 stop
$510American Airlines
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
1:08 pm - 9:21 pm
MSO
-
TYS
6h 13m
1 stop
American Airlines Logo
5:00 am - 1:28 pm
TYS
-
MSO
10h 28m
2 stops
$533American Airlines
Tue, May 19 - Tue, May 26

American Airlines flights from Missoula to Knoxville

Our best American Airlines deals on Missoula to Knoxville flight tickets
American Airlines
May 19
MSO1:08 pmMissoula Johnson-Bell Field
6h 13m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
May 26
TYS5:36 amKnoxville McGhee Tyson
9h 52m
1 stop
MSO1:28 pmMissoula Johnson-Bell Field
$389
American Airlines
May 19
MSO6:45 amMissoula Johnson-Bell Field
6h 34m
1 stop
TYS3:19 pmKnoxville McGhee Tyson
May 26
TYS5:36 amKnoxville McGhee Tyson
9h 42m
1 stop
MSO1:18 pmMissoula Johnson-Bell Field
$402
American Airlines
May 19
MSO1:08 pmMissoula Johnson-Bell Field
6h 13m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
May 26
TYS7:01 amKnoxville McGhee Tyson
8h 17m
1 stop
MSO1:18 pmMissoula Johnson-Bell Field
$422

United Airlines flights from Missoula to Knoxville

Our best United Airlines deals on Missoula to Knoxville flight tickets
United Airlines
Apr 13
MSO2:38 pmMissoula Johnson-Bell Field
5h 51m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Apr 18
TYS10:49 amKnoxville McGhee Tyson
12h 41m
2 stops
MSO9:30 pmMissoula Johnson-Bell Field
$374
United Airlines
Jun 15
MSO12:33 pmMissoula Johnson-Bell Field
6h 23m
1 stop
TYS8:56 pmKnoxville McGhee Tyson
Jun 16
TYS6:30 amKnoxville McGhee Tyson
7h 02m
1 stop
MSO11:32 amMissoula Johnson-Bell Field
$573
United Airlines
Jun 15
MSO7:15 amMissoula Johnson-Bell Field
13h 04m
2 stops
TYS10:19 pmKnoxville McGhee Tyson
Jun 16
TYS6:30 amKnoxville McGhee Tyson
7h 02m
1 stop
MSO11:32 amMissoula Johnson-Bell Field
$593

momondo Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Mon 4/13

2:38 pm-10:29 pm

1 stop5h 51m

Knoxville McGhee Tyson

Sat 4/18

10:49 am-9:30 pm

2 stops12h 41m

$374

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

1:08 pm-9:21 pm

1 stop6h 13m

Knoxville McGhee Tyson

Tue 5/26

5:36 am-1:28 pm

1 stop9h 52m

$389

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

6:45 am-3:19 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 5/26

5:36 am-1:18 pm

1 stop9h 42m

$402

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

1:08 pm-9:21 pm

1 stop6h 13m

Knoxville McGhee Tyson

Tue 5/26

7:01 am-1:18 pm

1 stop8h 17m

$422

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Mon 4/13

6:45 am-6:04 pm

1 stop9h 19m

Knoxville McGhee Tyson

Sat 4/18

4:09 pm-9:45 pm

1 stop7h 36m

$434

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 5/21

2:08 pm-11:53 pm

1 stop7h 45m

Knoxville McGhee Tyson

Sun 5/24

5:33 pm-10:38 pm

1 stop7h 05m

$435

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

6:45 am-3:19 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 5/26

5:36 am-1:18 pm

1 stop9h 42m

$441
Quickest round-trip

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

6:45 am-3:19 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 5/26

7:07 am-12:49 pm

1 stop7h 42m

$461

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/9

2:08 pm-11:53 pm

1 stop7h 45m

Knoxville McGhee Tyson

Tue 6/16

5:36 am-1:18 pm

1 stop9h 42m

$510

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

1:08 pm-9:21 pm

1 stop6h 13m

Knoxville McGhee Tyson

Tue 5/26

5:00 am-1:28 pm

2 stops10h 28m

$533

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missoula to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Missoula to Knoxville flights?

You could potentially save up to 9% on your flight if you consider stops on a Missoula to Knoxville flight.

When to book flights from Missoula to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Missoula to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Missoula to Knoxville (MSO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missoula to Knoxville

Fastest flight time

5h 46m

Direct flights

None
The fastest flight from Missoula to Knoxville takes 5h 46m
There are no direct flights from Missoula to Knoxville. There are no popular flight routes from Missoula to Knoxville.
Search flight deals

  • How far is Missoula Johnson-Bell Field to Knoxville McGhee Tyson by plane?

    A flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson will travel around 1715.6 mi. By plane, this route typically takes 5h 46m.

  • When did momondo last update prices for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missoula Johnson-Bell Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Missoula to Knoxville?

Best airlines flying from Missoula to Knoxville

Compare and see reviews for airlines that fly from Missoula to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
United AirlinesPriceFrom $343Free CancellationRating
7.4
9,461 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missoula to Knoxville?

Finding the right flight to Knoxville from Missoula is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Missoula to Knoxville with flexible booking policies on momondo?

All flight searches from Missoula to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Missoula to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Missoula.

I’m not ready to book a flight from Missoula to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missoula to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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