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Cheap flights from Melbourne, Florida to Des Moines from $197

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Melbourne, Florida to Des Moines departing on 9/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Melbourne, Florida to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:58 pm - 7:48 pmMLB  Melbourne-DSM Des Moines
7h 50m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 5:44 pmDSM  Des Moines-MLB Melbourne
10h 44m2 stops Philadelphia Charlotte Douglas
$552American Airlines
Fri, Sep 25 - Sun, Sep 27
American Airlines Logo
12:58 pm - 7:48 pmMLB  Melbourne-DSM Des Moines
7h 50m1 stop Charlotte Douglas
American Airlines Logo
11:00 am - 5:44 pmDSM  Des Moines-MLB Melbourne
5h 44m1 stop Charlotte Douglas
$566American Airlines
Fri, Sep 25 - Sun, Sep 27
American Airlines Logo
12:58 pm - 7:48 pmMLB  Melbourne-DSM Des Moines
7h 50m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 5:44 pmDSM  Des Moines-MLB Melbourne
10h 44m2 stops Philadelphia Charlotte Douglas
$571American Airlines
Fri, Sep 25 - Sun, Sep 27
Delta Logo
6:40 pm - 10:26 pmMLB  Melbourne-DSM Des Moines
4h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:45 am - 1:51 pmDSM  Des Moines-MLB Melbourne
7h 06m1 stop Atlanta Hartsfield-Jackson
$588Delta
Fri, Sep 25 - Sun, Sep 27
Delta Logo
5:55 am - 10:18 amMLB  Melbourne-DSM Des Moines
5h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:15 pm - 10:42 pmDSM  Des Moines-MLB Melbourne
7h 27m1 stop Atlanta Hartsfield-Jackson
$616Delta
Wed, Dec 30 - Sun, Jan 3
American Airlines Logo
12:58 pm - 7:48 pmMLB  Melbourne-DSM Des Moines
7h 50m1 stop Charlotte Douglas
American Airlines Logo
11:00 am - 5:44 pmDSM  Des Moines-MLB Melbourne
5h 44m1 stop Charlotte Douglas
$637American Airlines
Fri, Sep 25 - Sun, Sep 27
American Airlines Logo
12:58 pm - 12:04 amMLB  Melbourne-DSM Des Moines
12h 06m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:00 am - 5:44 pmDSM  Des Moines-MLB Melbourne
10h 44m2 stops Philadelphia Charlotte Douglas
$645American Airlines
Fri, Sep 25 - Sun, Sep 27
Delta Logo
5:55 am - 10:18 amMLB  Melbourne-DSM Des Moines
5h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:15 pm - 10:42 pmDSM  Des Moines-MLB Melbourne
7h 27m1 stop Atlanta Hartsfield-Jackson
$648Delta
Thu, Dec 31 - Sun, Jan 3
Delta Logo
6:48 pm - 10:34 pmMLB  Melbourne-DSM Des Moines
4h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:58 pm - 11:02 pmDSM  Des Moines-MLB Melbourne
7h 04m1 stop Atlanta Hartsfield-Jackson
$851Delta
Tue, Nov 24 - Mon, Nov 30

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American Airlines flights from Melbourne, Florida to Des Moines

Our best American Airlines deals on Melbourne, Florida to Des Moines flight tickets
American Airlines
Sep 25
MLB12:58 pmMelbourne
7h 50m
1 stop
DSM7:48 pmDes Moines
Sep 27
DSM6:00 amDes Moines
10h 44m
2 stops
MLB5:44 pmMelbourne
$552
American Airlines
Sep 25
MLB12:58 pmMelbourne
7h 50m
1 stop
DSM7:48 pmDes Moines
Sep 27
DSM11:00 amDes Moines
5h 44m
1 stop
MLB5:44 pmMelbourne
$566
American Airlines
Sep 25
MLB12:58 pmMelbourne
7h 50m
1 stop
DSM7:48 pmDes Moines
Sep 27
DSM6:00 amDes Moines
10h 44m
2 stops
MLB5:44 pmMelbourne
$571

Delta flights from Melbourne, Florida to Des Moines

Our best Delta deals on Melbourne, Florida to Des Moines flight tickets
Delta
Sep 25
MLB6:40 pmMelbourne
4h 46m
1 stop
DSM10:26 pmDes Moines
Sep 27
DSM5:45 amDes Moines
7h 06m
1 stop
MLB1:51 pmMelbourne
$588
Delta
Dec 30
MLB5:55 amMelbourne
5h 23m
1 stop
DSM10:18 amDes Moines
Jan 3
DSM2:15 pmDes Moines
7h 27m
1 stop
MLB10:42 pmMelbourne
$616
Delta
Aug 15
MLB6:15 amMelbourne
5h 28m
1 stop
DSM10:43 amDes Moines
Aug 22
DSM11:28 amDes Moines
5h 32m
1 stop
MLB6:00 pmMelbourne
$629

momondo Fare Finder

 
Customize your flight search to find flights from Melbourne, Florida to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Melbourne, Florida to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Fri 9/25

12:58 pm-7:48 pm

1 stop7h 50m

Des Moines

Sun 9/27

6:00 am-5:44 pm

2 stops10h 44m

$552

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Fri 9/25

12:58 pm-7:48 pm

1 stop7h 50m

Des Moines

Sun 9/27

11:00 am-5:44 pm

1 stop5h 44m

$566

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Fri 9/25

12:58 pm-7:48 pm

1 stop7h 50m

Des Moines

Sun 9/27

6:00 am-5:44 pm

2 stops10h 44m

$571

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Fri 9/25

6:40 pm-10:26 pm

1 stop4h 46m

Des Moines

Sun 9/27

5:45 am-1:51 pm

1 stop7h 06m

$588

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Wed 12/30

5:55 am-10:18 am

1 stop5h 23m

Des Moines

Sun 1/3

2:15 pm-10:42 pm

1 stop7h 27m

$616

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Fri 9/25

12:58 pm-7:48 pm

1 stop7h 50m

Des Moines

Sun 9/27

11:00 am-5:44 pm

1 stop5h 44m

$637

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Fri 9/25

12:58 pm-12:04 am

2 stops12h 06m

Des Moines

Sun 9/27

6:00 am-5:44 pm

2 stops10h 44m

$645

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Thu 12/31

5:55 am-10:18 am

1 stop5h 23m

Des Moines

Sun 1/3

2:15 pm-10:42 pm

1 stop7h 27m

$648
Quickest round-trip

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Tue 11/24

6:48 pm-10:34 pm

1 stop4h 46m

Des Moines

Mon 11/30

2:58 pm-11:02 pm

1 stop7h 04m

$851
Cheapest one-way

MelbourneDes Moines

MLB Melbourne - DSM Des Moines

MLBDSM

Melbourne

Thu 9/3

6:00 am-10:43 am

1 stop5h 43m

$197

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Melbourne, Florida to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Melbourne, Florida to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $157. Flights from Melbourne, Florida to Des Moines on a Monday will generally be more expensive and average around $394. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Melbourne, Florida to Des Moines in the afternoon for as low as $153. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $394. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Melbourne, Florida to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Melbourne, Florida to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Melbourne, Florida to Des Moines (MLB to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Melbourne, Florida to Des Moines

Fastest flight time

4h 46m

Direct flights

None
The fastest flight from Melbourne, Florida to Des Moines takes 4h 46m
There are no direct flights from Melbourne, Florida to Des Moines. There are no popular flight routes from Melbourne, Florida to Des Moines.
Search flight deals

Frequently asked questions about flying from Melbourne, Florida to Des Moines

  • How far is Melbourne to Des Moines by plane?

    There are 1186.0 mi between Melbourne and Des Moines. A reasonable flight in good conditions will take 4h 46m.

  • When did momondo last update prices for flights from Melbourne Airport to Des Moines Airport?

    Prices for flights from Melbourne Airport to Des Moines Airport refresh daily.

  • How old do you have to be to fly from Melbourne Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Melbourne Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Melbourne to Des Moines?

Finding the right flight to Des Moines from Melbourne is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Melbourne to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Melbourne on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Melbourne to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Melbourne. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Melbourne to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Melbourne to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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