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Cheap flights from Melbourne, Florida to Des Moines from $220

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Melbourne, Florida to Des Moines departing on 3/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Melbourne, Florida to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:19 am - 1:07 pm
MLB
-
DSM
7h 48m
1 stop
American Airlines Logo
10:04 am - 11:51 pm
DSM
-
MLB
12h 47m
2 stops
$412American Airlines
Wed, Mar 11 - Wed, Mar 18
American Airlines Logo
11:52 am - 10:34 pm
MLB
-
DSM
11h 42m
2 stops
American Airlines Logo
10:04 am - 11:51 pm
DSM
-
MLB
12h 47m
2 stops
$417American Airlines
Wed, Mar 11 - Wed, Mar 18
Delta Logo
6:43 pm - 10:28 pm
MLB
-
DSM
4h 45m
1 stop
Delta Logo
5:35 am - 2:12 pm
DSM
-
MLB
7h 37m
1 stop
$453Delta
Thu, Mar 5 - Sun, Mar 8
Delta Logo
6:00 am - 3:40 pm
MLB
-
DSM
10h 40m
2 stops
Delta Logo
5:20 pm - 10:56 pm
DSM
-
MLB
4h 36m
1 stop
$458Delta
Thu, Mar 5 - Sun, Mar 8
Delta Logo
11:25 am - 4:33 pm
MLB
-
DSM
6h 08m
1 stop
Delta Logo
5:20 pm - 10:56 pm
DSM
-
MLB
4h 36m
1 stop
$603Delta
Wed, Mar 11 - Wed, Mar 18
American Airlines Logo
6:02 pm - 9:01 am
MLB
-
DSM
15h 59m
2 stops
American Airlines Logo
7:45 am - 5:32 pm
DSM
-
MLB
8h 47m
2 stops
$664American Airlines
Mon, Feb 23 - Fri, Feb 27
Delta Logo
11:25 am - 4:33 pm
MLB
-
DSM
6h 08m
1 stop
Delta Logo
10:28 am - 10:56 pm
DSM
-
MLB
11h 28m
2 stops
$677Delta
Wed, Mar 11 - Wed, Mar 18
Delta Logo
6:38 pm - 10:28 pm
MLB
-
DSM
4h 50m
1 stop
Delta Logo
5:15 pm - 10:45 pm
DSM
-
MLB
4h 30m
1 stop
$756Delta
Mon, Feb 23 - Fri, Feb 27
Delta Logo
6:38 pm - 10:28 pm
MLB
-
DSM
4h 50m
1 stop
Delta Logo
10:57 am - 10:45 pm
DSM
-
MLB
10h 48m
2 stops
$761Delta
Mon, Feb 23 - Fri, Feb 27

American Airlines flights from Melbourne, Florida to Des Moines

Our best American Airlines deals on Melbourne, Florida to Des Moines flight tickets
American Airlines
Mar 11
MLB6:19 amMelbourne
7h 48m
1 stop
DSM1:07 pmDes Moines
Mar 18
DSM10:04 amDes Moines
12h 47m
2 stops
MLB11:51 pmMelbourne
$412
American Airlines
Mar 11
MLB11:52 amMelbourne
11h 42m
2 stops
DSM10:34 pmDes Moines
Mar 18
DSM10:04 amDes Moines
12h 47m
2 stops
MLB11:51 pmMelbourne
$417
American Airlines
Feb 23
MLB6:02 pmMelbourne
15h 59m
2 stops
DSM9:01 amDes Moines
Feb 27
DSM7:45 amDes Moines
8h 47m
2 stops
MLB5:32 pmMelbourne
$664

Delta flights from Melbourne, Florida to Des Moines

Our best Delta deals on Melbourne, Florida to Des Moines flight tickets
Delta
Mar 5
MLB6:43 pmMelbourne
4h 45m
1 stop
DSM10:28 pmDes Moines
Mar 8
DSM5:35 amDes Moines
7h 37m
1 stop
MLB2:12 pmMelbourne
$453
Delta
Mar 5
MLB6:00 amMelbourne
10h 40m
2 stops
DSM3:40 pmDes Moines
Mar 8
DSM5:20 pmDes Moines
4h 36m
1 stop
MLB10:56 pmMelbourne
$458
Delta
Mar 11
MLB11:25 amMelbourne
6h 08m
1 stop
DSM4:33 pmDes Moines
Mar 18
DSM5:20 pmDes Moines
4h 36m
1 stop
MLB10:56 pmMelbourne
$603

momondo Fare Finder

 
Customize your flight search to find flights from Melbourne, Florida to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from Melbourne, Florida to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Wed 3/11

6:19 am-1:07 pm

1 stop7h 48m

Des Moines

Wed 3/18

10:04 am-11:51 pm

2 stops12h 47m

$412

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Wed 3/11

11:52 am-10:34 pm

2 stops11h 42m

Des Moines

Wed 3/18

10:04 am-11:51 pm

2 stops12h 47m

$417

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Thu 3/5

6:43 pm-10:28 pm

1 stop4h 45m

Des Moines

Sun 3/8

5:35 am-2:12 pm

1 stop7h 37m

$453

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Thu 3/5

6:00 am-3:40 pm

2 stops10h 40m

Des Moines

Sun 3/8

5:20 pm-10:56 pm

1 stop4h 36m

$458

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Wed 3/11

11:25 am-4:33 pm

1 stop6h 08m

Des Moines

Wed 3/18

5:20 pm-10:56 pm

1 stop4h 36m

$603

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Mon 2/23

6:02 pm-9:01 am

2 stops15h 59m

Des Moines

Fri 2/27

7:45 am-5:32 pm

2 stops8h 47m

$664

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Wed 3/11

11:25 am-4:33 pm

1 stop6h 08m

Des Moines

Wed 3/18

10:28 am-10:56 pm

2 stops11h 28m

$677

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Mon 2/23

6:38 pm-10:28 pm

1 stop4h 50m

Des Moines

Fri 2/27

5:15 pm-10:45 pm

1 stop4h 30m

$756

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Mon 2/23

6:38 pm-10:28 pm

1 stop4h 50m

Des Moines

Fri 2/27

10:57 am-10:45 pm

2 stops10h 48m

$761

MelbourneDes Moines

MLB - DSM

MLBDSM

Melbourne

Thu 3/26

6:19 am-1:07 pm

1 stop7h 48m

$220

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Melbourne, Florida to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Melbourne, Florida to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $139. Flights from Melbourne, Florida to Des Moines on a Saturday will generally be more expensive and average around $324. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Melbourne, Florida to Des Moines in the afternoon for as low as $168. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $212. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Melbourne, Florida to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Melbourne, Florida to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Melbourne, Florida to Des Moines (MLB to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Melbourne, Florida to Des Moines

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Melbourne, Florida to Des Moines takes 4h 45m
There are no direct flights from Melbourne, Florida to Des Moines. There are no popular flight routes from Melbourne, Florida to Des Moines.
Search flight deals

  • How far is Melbourne to Des Moines by plane?

    There are 1186.0 mi between Melbourne and Des Moines. A reasonable flight in good conditions will take 4h 45m.

  • When did momondo last update prices for flights from Melbourne Airport to Des Moines Airport?

    Prices for flights from Melbourne Airport to Des Moines Airport refresh daily.

  • How old do you have to be to fly from Melbourne Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Melbourne Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents required for your trip to Des Moines Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Des Moines Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Melbourne to Des Moines?

Finding the right flight to Des Moines from Melbourne is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Melbourne to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Melbourne on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Melbourne to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Melbourne. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Melbourne to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Melbourne to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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