Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from McAllen to Knoxville from $229

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from McAllen to Knoxville departing on 12/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from McAllen to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:14 pm - 1:11 pmMFE-TYS
21h 57m2 stops
Multiple Airlines Logo
5:46 pm - 10:12 amTYS-MFE
17h 26m1 stop
$445Multiple Airlines
Find Deal
Wed, Dec 17 - Mon, Dec 29
American Airlines Logo
5:29 am - 11:35 amMFE-TYS
5h 06m1 stop
American Airlines Logo
6:20 pm - 10:59 pmTYS-MFE
5h 39m1 stop
$452American Airlines
Find Deal
Wed, Dec 17 - Tue, Dec 30
American Airlines Logo
5:29 am - 11:35 amMFE-TYS
5h 06m1 stop
American Airlines Logo
5:23 am - 10:31 amTYS-MFE
6h 08m1 stop
$469American Airlines
Find Deal
Wed, Dec 17 - Thu, Jan 1
American Airlines Logo
5:29 am - 11:35 amMFE-TYS
5h 06m1 stop
American Airlines Logo
12:18 pm - 6:35 pmTYS-MFE
7h 17m1 stop
$476American Airlines
Find Deal
Wed, Dec 17 - Wed, Dec 31
American Airlines Logo
5:29 am - 11:35 amMFE-TYS
5h 06m1 stop
American Airlines Logo
7:00 am - 4:15 pmTYS-MFE
10h 15m2 stops
$481American Airlines
Find Deal
Wed, Dec 17 - Wed, Dec 31
Delta Logo
5:28 am - 1:52 pmMFE-TYS
7h 24m2 stops
Delta Logo
5:30 am - 4:54 pmTYS-MFE
12h 24m2 stops
$493Delta
Find Deal
Tue, Mar 3 - Sat, Mar 7
American Airlines Logo
5:29 am - 11:35 amMFE-TYS
5h 06m1 stop
American Airlines Logo
5:00 am - 2:54 pmTYS-MFE
10h 54m2 stops
$494American Airlines
Find Deal
Wed, Dec 17 - Thu, Jan 1
Allegiant Air Logo
9:12 am - 4:52 pmMFE-TYS
6h 40m1 stop
Allegiant Air Logo
5:46 pm - 10:12 amTYS-MFE
17h 26m1 stop
$495Allegiant Air
Find Deal
Thu, Dec 18 - Mon, Dec 29
American Airlines Logo
5:29 am - 11:35 amMFE-TYS
5h 06m1 stop
American Airlines Logo
5:23 am - 10:31 amTYS-MFE
6h 08m1 stop
$498American Airlines
Find Deal
Wed, Dec 17 - Mon, Dec 29
Multiple Airlines Logo
2:14 pm - 1:11 pmMFE-TYS
21h 57m2 stops
Multiple Airlines Logo
6:30 am - 5:46 pmTYS-MFE
12h 16m1 stop
$501Multiple Airlines
Find Deal
Wed, Dec 17 - Fri, Jan 2

American Airlines flights from McAllen to Knoxville

Our best American Airlines deals on McAllen to Knoxville flight tickets
American Airlines
Dec 17
MFE5:29 amMcAllen Miller Intl
5h 06m
1 stop
TYS11:35 amKnoxville McGhee Tyson
Dec 30
TYS6:20 pmKnoxville McGhee Tyson
5h 39m
1 stop
MFE10:59 pmMcAllen Miller Intl
$452
Find similar
American Airlines
Dec 17
MFE5:29 amMcAllen Miller Intl
5h 06m
1 stop
TYS11:35 amKnoxville McGhee Tyson
Jan 1
TYS5:23 amKnoxville McGhee Tyson
6h 08m
1 stop
MFE10:31 amMcAllen Miller Intl
$469
Find similar
American Airlines
Dec 17
MFE5:29 amMcAllen Miller Intl
5h 06m
1 stop
TYS11:35 amKnoxville McGhee Tyson
Dec 31
TYS12:18 pmKnoxville McGhee Tyson
7h 17m
1 stop
MFE6:35 pmMcAllen Miller Intl
$476
Find similar

Delta flights from McAllen to Knoxville

Our best Delta deals on McAllen to Knoxville flight tickets
Delta
Mar 3
MFE5:28 amMcAllen Miller Intl
7h 24m
2 stops
TYS1:52 pmKnoxville McGhee Tyson
Mar 7
TYS5:30 amKnoxville McGhee Tyson
12h 24m
2 stops
MFE4:54 pmMcAllen Miller Intl
$493
Find similar
Delta
Dec 17
MFE5:25 amMcAllen Miller Intl
8h 27m
2 stops
TYS2:52 pmKnoxville McGhee Tyson
Jan 2
TYS7:05 amKnoxville McGhee Tyson
17h 53m
2 stops
MFE11:58 pmMcAllen Miller Intl
$565
Find similar
Delta
Mar 3
MFE5:28 amMcAllen Miller Intl
7h 24m
2 stops
TYS1:52 pmKnoxville McGhee Tyson
Mar 7
TYS5:30 amKnoxville McGhee Tyson
7h 55m
2 stops
MFE12:25 pmMcAllen Miller Intl
$589
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

2:14 pm-1:11 pm

2 stops21h 57m

Knoxville McGhee Tyson

Mon 12/29

5:46 pm-10:12 am

1 stop17h 26m

$445

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

5:29 am-11:35 am

1 stop5h 06m

Knoxville McGhee Tyson

Tue 12/30

6:20 pm-10:59 pm

1 stop5h 39m

$452

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

5:29 am-11:35 am

1 stop5h 06m

Knoxville McGhee Tyson

Thu 1/1

5:23 am-10:31 am

1 stop6h 08m

$469

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

5:29 am-11:35 am

1 stop5h 06m

Knoxville McGhee Tyson

Wed 12/31

12:18 pm-6:35 pm

1 stop7h 17m

$476

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

5:29 am-11:35 am

1 stop5h 06m

Knoxville McGhee Tyson

Wed 12/31

7:00 am-4:15 pm

2 stops10h 15m

$481

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 3/3

5:28 am-1:52 pm

2 stops7h 24m

Knoxville McGhee Tyson

Sat 3/7

5:30 am-4:54 pm

2 stops12h 24m

$493

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

5:29 am-11:35 am

1 stop5h 06m

Knoxville McGhee Tyson

Thu 1/1

5:00 am-2:54 pm

2 stops10h 54m

$494

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Thu 12/18

9:12 am-4:52 pm

1 stop6h 40m

Knoxville McGhee Tyson

Mon 12/29

5:46 pm-10:12 am

1 stop17h 26m

$495

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

5:29 am-11:35 am

1 stop5h 06m

Knoxville McGhee Tyson

Mon 12/29

5:23 am-10:31 am

1 stop6h 08m

$498

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 12/17

2:14 pm-1:11 pm

2 stops21h 57m

Knoxville McGhee Tyson

Fri 1/2

6:30 am-5:46 pm

1 stop12h 16m

$501

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from McAllen to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from McAllen to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $278. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from McAllen to Knoxville for around $541.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from McAllen to Knoxville when you can find flight prices for as low as $327. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $377.

Can stopping save me money on McAllen to Knoxville flights?

You could potentially save up to 54% on your flight if you consider stops on a McAllen to Knoxville flight.

When to book flights from McAllen to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from McAllen to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap McAllen to Knoxville (MFE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from McAllen to Knoxville

Direct flights

None
There are no direct flights from McAllen to Knoxville. There are no popular flight routes from McAllen to Knoxville.
Search flight deals

  • How far is McAllen Miller Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 1079.4 mi away from McAllen Miller Intl. Typically, this will take 4h 54m by plane in normal conditions.

  • When did momondo last update prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from McAllen to Knoxville?

Best airlines flying from McAllen to Knoxville

Compare and see reviews for airlines that fly from McAllen to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $242Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from McAllen to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from McAllen.

Can I find flights from McAllen to Knoxville with flexible booking policies on momondo?

All flight searches from McAllen to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from McAllen to Knoxville?

Once all potential McAllen to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from McAllen to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of McAllen to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 12/17
Wed 12/24
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States