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Cheap flights from McAllen to Knoxville from $165

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from McAllen to Knoxville departing on 3/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from McAllen to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:20 pm - 11:51 pm
MFE
-
TYS
9h 31m2 stops
Delta Logo
5:30 am - 12:40 pm
TYS
-
MFE
8h 10m2 stops
$312Delta
Mon, Mar 23 - Fri, Mar 27
American Airlines Logo
3:45 pm - 11:56 pm
MFE
-
TYS
7h 11m1 stop
American Airlines Logo
1:20 pm - 5:28 pm
TYS
-
MFE
5h 08m1 stop
$319American Airlines
Mon, Apr 13 - Wed, Apr 15
United Airlines Logo
5:25 pm - 11:44 pm
MFE
-
TYS
5h 19m1 stop
United Airlines Logo
4:55 pm - 9:57 pm
TYS
-
MFE
6h 02m1 stop
$328United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
5:25 pm - 11:44 pm
MFE
-
TYS
5h 19m1 stop
United Airlines Logo
1:59 pm - 9:57 pm
TYS
-
MFE
8h 58m2 stops
$333United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
7:00 am - 4:48 pm
MFE
-
TYS
8h 48m2 stops
United Airlines Logo
1:59 pm - 9:57 pm
TYS
-
MFE
8h 58m2 stops
$339United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
7:00 am - 4:48 pm
MFE
-
TYS
8h 48m2 stops
United Airlines Logo
4:55 pm - 9:57 pm
TYS
-
MFE
6h 02m1 stop
$344United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
7:00 am - 4:48 pm
MFE
-
TYS
8h 48m2 stops
United Airlines Logo
11:07 am - 9:57 pm
TYS
-
MFE
11h 50m2 stops
$350United Airlines
Tue, Feb 3 - Sat, Feb 7
United Airlines Logo
5:15 pm - 11:41 pm
MFE
-
TYS
5h 26m1 stop
United Airlines Logo
1:53 pm - 9:48 pm
TYS
-
MFE
8h 55m2 stops
$402United Airlines
Mon, Apr 13 - Wed, Apr 15
American Airlines Logo
5:28 am - 11:31 am
MFE
-
TYS
5h 03m1 stop
American Airlines Logo
12:21 pm - 6:25 pm
TYS
-
MFE
7h 04m1 stop
$479American Airlines
Mon, Mar 23 - Fri, Mar 27
United Airlines Logo
7:00 am - 4:52 pm
MFE
-
TYS
8h 52m2 stops
United Airlines Logo
1:53 pm - 9:48 pm
TYS
-
MFE
8h 55m2 stops
$489United Airlines
Mon, Apr 13 - Wed, Apr 15

American Airlines flights from McAllen to Knoxville

Our best American Airlines deals on McAllen to Knoxville flight tickets
American Airlines
Jan 26
MFE6:04 amMcAllen Miller Intl
8h 16m
2 stops
TYS3:20 pmKnoxville McGhee Tyson
Jan 30
TYS1:36 pmKnoxville McGhee Tyson
10h 41m
2 stops
MFE11:17 pmMcAllen Miller Intl
$468
American Airlines
Apr 30
MFE6:40 amMcAllen Miller Intl
4h 50m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
May 3
TYS4:09 pmKnoxville McGhee Tyson
7h 36m
1 stop
MFE10:45 pmMcAllen Miller Intl
$543
American Airlines
Apr 30
MFE6:40 amMcAllen Miller Intl
4h 50m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
May 3
TYS5:00 amKnoxville McGhee Tyson
8h 29m
2 stops
MFE12:29 pmMcAllen Miller Intl
$723

United Airlines flights from McAllen to Knoxville

Our best United Airlines deals on McAllen to Knoxville flight tickets
United Airlines
Feb 3
MFE5:25 pmMcAllen Miller Intl
5h 19m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Feb 7
TYS4:55 pmKnoxville McGhee Tyson
6h 02m
1 stop
MFE9:57 pmMcAllen Miller Intl
$339
United Airlines
Feb 3
MFE7:00 amMcAllen Miller Intl
8h 48m
2 stops
TYS4:48 pmKnoxville McGhee Tyson
Feb 7
TYS4:55 pmKnoxville McGhee Tyson
6h 02m
1 stop
MFE9:57 pmMcAllen Miller Intl
$344
United Airlines
Feb 3
MFE7:00 amMcAllen Miller Intl
8h 48m
2 stops
TYS4:48 pmKnoxville McGhee Tyson
Feb 7
TYS11:07 amKnoxville McGhee Tyson
11h 50m
2 stops
MFE9:57 pmMcAllen Miller Intl
$350

momondo Fare Finder

 
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 11, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 3/23

1:20 pm-11:51 pm

2 stops9h 31m

Knoxville McGhee Tyson

Fri 3/27

5:30 am-12:40 pm

2 stops8h 10m

$312

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 4/13

3:45 pm-11:56 pm

1 stop7h 11m

Knoxville McGhee Tyson

Wed 4/15

1:20 pm-5:28 pm

1 stop5h 08m

$319

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/3

5:25 pm-11:44 pm

1 stop5h 19m

Knoxville McGhee Tyson

Sat 2/7

4:55 pm-9:57 pm

1 stop6h 02m

$328

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/3

5:25 pm-11:44 pm

1 stop5h 19m

Knoxville McGhee Tyson

Sat 2/7

1:59 pm-9:57 pm

2 stops8h 58m

$333

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/3

7:00 am-4:48 pm

2 stops8h 48m

Knoxville McGhee Tyson

Sat 2/7

1:59 pm-9:57 pm

2 stops8h 58m

$339

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/3

7:00 am-4:48 pm

2 stops8h 48m

Knoxville McGhee Tyson

Sat 2/7

4:55 pm-9:57 pm

1 stop6h 02m

$344

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/3

7:00 am-4:48 pm

2 stops8h 48m

Knoxville McGhee Tyson

Sat 2/7

11:07 am-9:57 pm

2 stops11h 50m

$350

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 4/13

5:15 pm-11:41 pm

1 stop5h 26m

Knoxville McGhee Tyson

Wed 4/15

1:53 pm-9:48 pm

2 stops8h 55m

$402

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 3/23

5:28 am-11:31 am

1 stop5h 03m

Knoxville McGhee Tyson

Fri 3/27

12:21 pm-6:25 pm

1 stop7h 04m

$479

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 4/13

7:00 am-4:52 pm

2 stops8h 52m

Knoxville McGhee Tyson

Wed 4/15

1:53 pm-9:48 pm

2 stops8h 55m

$489

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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How to get the cheapest flight ticket from McAllen to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on McAllen to Knoxville flights?

You could potentially save up to 14% on your flight if you consider stops on a McAllen to Knoxville flight.

When to book flights from McAllen to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from McAllen to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap McAllen to Knoxville (MFE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from McAllen to Knoxville

Fastest flight time

5h 00m

Direct flights

None
The fastest flight from McAllen to Knoxville takes 5h 00m
There are no direct flights from McAllen to Knoxville. There are no popular flight routes from McAllen to Knoxville.
Search flight deals

  • How far is McAllen Miller Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 1079.4 mi away from McAllen Miller Intl. Typically, this will take 5h 00m by plane in normal conditions.

  • When did momondo last update prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from McAllen to Knoxville?

Best airlines flying from McAllen to Knoxville

Compare and see reviews for airlines that fly from McAllen to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,101 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from McAllen to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from McAllen.

Can I find flights from McAllen to Knoxville with flexible booking policies on momondo?

All flight searches from McAllen to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from McAllen to Knoxville?

Once all potential McAllen to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from McAllen to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of McAllen to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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