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Cheap flights from McAllen to Knoxville from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from McAllen to Knoxville departing on 4/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from McAllen to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:00 pm - 10:24 pm
MFE
-
TYS
26h 24m
1 stop
Allegiant Air Logo
8:20 am - 5:40 pm
TYS
-
MFE
10h 20m
1 stop
$325Allegiant Air
Thu, Apr 30 - Sun, May 3
American Airlines Logo
3:48 pm - 11:51 pm
MFE
-
TYS
7h 03m
1 stop
American Airlines Logo
5:05 am - 10:15 am
TYS
-
MFE
6h 10m
1 stop
$329American Airlines
Fri, Mar 20 - Tue, Mar 24
American Airlines Logo
5:44 am - 12:30 pm
MFE
-
TYS
5h 46m
1 stop
American Airlines Logo
5:33 pm - 12:21 am
TYS
-
MFE
7h 48m
1 stop
$427American Airlines
Mon, May 11 - Sun, May 24
Multiple Airlines Logo
12:15 pm - 10:51 pm
MFE
-
TYS
9h 36m
1 stop
Multiple Airlines Logo
3:46 pm - 7:59 am
TYS
-
MFE
17h 13m
2 stops
$440Multiple Airlines
Mon, May 11 - Sun, May 24
American Airlines Logo
3:48 pm - 11:51 pm
MFE
-
TYS
7h 03m
1 stop
American Airlines Logo
8:50 am - 6:25 pm
TYS
-
MFE
10h 35m
2 stops
$446American Airlines
Fri, Mar 20 - Tue, Mar 24
American Airlines Logo
9:37 am - 5:31 pm
MFE
-
TYS
6h 54m
1 stop
American Airlines Logo
5:40 am - 10:15 am
TYS
-
MFE
5h 35m
1 stop
$474American Airlines
Fri, Mar 20 - Sun, Mar 22
American Airlines Logo
3:48 pm - 11:51 pm
MFE
-
TYS
7h 03m
1 stop
American Airlines Logo
5:40 am - 10:15 am
TYS
-
MFE
5h 35m
1 stop
$476American Airlines
Fri, Mar 20 - Sun, Mar 22
Allegiant Air Logo
8:44 pm - 1:57 pm
MFE
-
TYS
16h 13m
1 stop
Allegiant Air Logo
6:54 pm - 7:53 am
TYS
-
MFE
13h 59m
1 stop
$505Allegiant Air
Thu, Jul 2 - Sun, Jul 12
Delta Logo
1:20 pm - 11:57 pm
MFE
-
TYS
9h 37m
2 stops
Delta Logo
11:18 am - 11:59 pm
TYS
-
MFE
13h 41m
2 stops
$514Delta
Fri, Mar 20 - Tue, Mar 24
American Airlines Logo
3:45 pm - 11:56 pm
MFE
-
TYS
7h 11m
1 stop
American Airlines Logo
1:20 pm - 6:52 pm
TYS
-
MFE
6h 32m
1 stop
$535American Airlines
Mon, Apr 20 - Mon, Apr 27

United Airlines flights from McAllen to Knoxville

Our best United Airlines deals on McAllen to Knoxville flight tickets
United Airlines
Apr 30
MFE6:59 pmMcAllen Miller Intl
20h 50m
2 stops
TYS4:49 pmKnoxville McGhee Tyson
May 3
TYS5:55 pmKnoxville McGhee Tyson
30h 04m
3 stops
MFE10:59 pmMcAllen Miller Intl
$838
United Airlines
Apr 30
MFE6:59 pmMcAllen Miller Intl
20h 50m
2 stops
TYS4:49 pmKnoxville McGhee Tyson
May 3
TYS5:55 pmKnoxville McGhee Tyson
30h 04m
3 stops
MFE10:59 pmMcAllen Miller Intl
$909
United Airlines
Apr 30
MFE6:59 pmMcAllen Miller Intl
20h 50m
2 stops
TYS4:49 pmKnoxville McGhee Tyson
May 3
TYS5:55 pmKnoxville McGhee Tyson
30h 04m
3 stops
MFE10:59 pmMcAllen Miller Intl
$929

Allegiant Air flights from McAllen to Knoxville

Our best Allegiant Air deals on McAllen to Knoxville flight tickets
Allegiant Air
Apr 30
MFE7:00 pmMcAllen Miller Intl
26h 24m
1 stop
TYS10:24 pmKnoxville McGhee Tyson
May 3
TYS8:20 amKnoxville McGhee Tyson
10h 20m
1 stop
MFE5:40 pmMcAllen Miller Intl
$325
Allegiant Air
Jul 2
MFE8:44 pmMcAllen Miller Intl
16h 13m
1 stop
TYS1:57 pmKnoxville McGhee Tyson
Jul 12
TYS6:54 pmKnoxville McGhee Tyson
13h 59m
1 stop
MFE7:53 amMcAllen Miller Intl
$505

momondo Fare Finder

 
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Thu 4/30

7:00 pm-10:24 pm

1 stop26h 24m

Knoxville McGhee Tyson

Sun 5/3

8:20 am-5:40 pm

1 stop10h 20m

$325

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 3/20

3:48 pm-11:51 pm

1 stop7h 03m

Knoxville McGhee Tyson

Tue 3/24

5:05 am-10:15 am

1 stop6h 10m

$329

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 5/11

5:44 am-12:30 pm

1 stop5h 46m

Knoxville McGhee Tyson

Sun 5/24

5:33 pm-12:21 am

1 stop7h 48m

$427

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 5/11

12:15 pm-10:51 pm

1 stop9h 36m

Knoxville McGhee Tyson

Sun 5/24

3:46 pm-7:59 am

2 stops17h 13m

$440

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 3/20

3:48 pm-11:51 pm

1 stop7h 03m

Knoxville McGhee Tyson

Tue 3/24

8:50 am-6:25 pm

2 stops10h 35m

$446
Quickest round-trip

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 3/20

9:37 am-5:31 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sun 3/22

5:40 am-10:15 am

1 stop5h 35m

$474

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 3/20

3:48 pm-11:51 pm

1 stop7h 03m

Knoxville McGhee Tyson

Sun 3/22

5:40 am-10:15 am

1 stop5h 35m

$476

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Thu 7/2

8:44 pm-1:57 pm

1 stop16h 13m

Knoxville McGhee Tyson

Sun 7/12

6:54 pm-7:53 am

1 stop13h 59m

$505

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 3/20

1:20 pm-11:57 pm

2 stops9h 37m

Knoxville McGhee Tyson

Tue 3/24

11:18 am-11:59 pm

2 stops13h 41m

$514

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 4/20

3:45 pm-11:56 pm

1 stop7h 11m

Knoxville McGhee Tyson

Mon 4/27

1:20 pm-6:52 pm

1 stop6h 32m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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How to get the cheapest flight ticket from McAllen to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on McAllen to Knoxville flights?

You could potentially save up to 2% on your flight if you consider stops on a McAllen to Knoxville flight.

When to book flights from McAllen to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from McAllen to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap McAllen to Knoxville (MFE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from McAllen to Knoxville

Fastest flight time

5h 46m

Direct flights

None
The fastest flight from McAllen to Knoxville takes 5h 46m
There are no direct flights from McAllen to Knoxville. There are no popular flight routes from McAllen to Knoxville.
Search flight deals

  • How far is McAllen Miller Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 1079.4 mi away from McAllen Miller Intl. Typically, this will take 5h 46m by plane in normal conditions.

  • When did momondo last update prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from McAllen to Knoxville?

Best airlines flying from McAllen to Knoxville

Compare and see reviews for airlines that fly from McAllen to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $252Free CancellationRating
7.1
11,399 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from McAllen to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from McAllen.

Can I find flights from McAllen to Knoxville with flexible booking policies on momondo?

All flight searches from McAllen to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from McAllen to Knoxville?

Once all potential McAllen to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from McAllen to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of McAllen to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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