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Cheap flights from McAllen to Knoxville from $250

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from McAllen to Knoxville departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from McAllen to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
8:43 am - 9:15 pm
MFE
-
TYS
11h 32m
1 stop
Allegiant Air Logo
6:54 pm - 7:53 am
TYS
-
MFE
13h 59m
1 stop
$300Allegiant Air
Fri, Jul 24 - Sun, Aug 2
Allegiant Air Logo
10:43 am - 10:01 pm
MFE
-
TYS
10h 18m
1 stop
Allegiant Air Logo
6:54 pm - 7:53 am
TYS
-
MFE
13h 59m
1 stop
$343Allegiant Air
Sat, Jul 25 - Sun, Aug 2
American Airlines Logo
7:00 am - 12:51 pm
MFE
-
TYS
4h 51m
1 stop
American Airlines Logo
1:46 pm - 7:16 pm
TYS
-
MFE
6h 30m
1 stop
$367American Airlines
Tue, Jul 28 - Wed, Aug 26
American Airlines Logo
7:00 am - 12:51 pm
MFE
-
TYS
4h 51m
1 stop
American Airlines Logo
7:07 am - 3:28 pm
TYS
-
MFE
9h 21m
2 stops
$372American Airlines
Tue, Jul 28 - Wed, Aug 26
Delta Logo
5:20 am - 2:48 pm
MFE
-
TYS
8h 28m
2 stops
Delta Logo
7:07 am - 3:59 pm
TYS
-
MFE
9h 52m
2 stops
$375Delta
Tue, Jul 28 - Wed, Aug 26
Multiple Airlines Logo
8:43 am - 9:15 pm
MFE
-
TYS
11h 32m
1 stop
Multiple Airlines Logo
3:38 pm - 7:53 am
TYS
-
MFE
17h 15m
2 stops
$388Multiple Airlines
Fri, Jul 24 - Sun, Aug 2
United Airlines Logo
9:38 am - 6:05 pm
MFE
-
TYS
7h 27m
1 stop
United Airlines Logo
7:15 am - 11:23 am
TYS
-
MFE
5h 08m
1 stop
$401United Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
12:07 pm - 6:05 pm
MFE
-
TYS
4h 58m
1 stop
United Airlines Logo
6:30 am - 3:59 pm
TYS
-
MFE
10h 29m
2 stops
$406United Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
5:25 pm - 11:56 pm
MFE
-
TYS
5h 31m
1 stop
American Airlines Logo
5:33 pm - 12:21 am
TYS
-
MFE
7h 48m
1 stop
$423American Airlines
Sat, May 30 - Wed, Jun 3
Multiple Airlines Logo
10:43 am - 10:01 pm
MFE
-
TYS
10h 18m
1 stop
Multiple Airlines Logo
3:38 pm - 7:53 am
TYS
-
MFE
17h 15m
2 stops
$426Multiple Airlines
Sat, Jul 25 - Sun, Aug 2

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American Airlines flights from McAllen to Knoxville

Our best American Airlines deals on McAllen to Knoxville flight tickets
American Airlines
Jul 28
MFE7:00 amMcAllen Miller Intl
4h 51m
1 stop
TYS12:51 pmKnoxville McGhee Tyson
Aug 26
TYS1:46 pmKnoxville McGhee Tyson
6h 30m
1 stop
MFE7:16 pmMcAllen Miller Intl
$367
American Airlines
Jul 28
MFE7:00 amMcAllen Miller Intl
4h 51m
1 stop
TYS12:51 pmKnoxville McGhee Tyson
Aug 26
TYS7:07 amKnoxville McGhee Tyson
9h 21m
2 stops
MFE3:28 pmMcAllen Miller Intl
$372
American Airlines
May 30
MFE5:25 pmMcAllen Miller Intl
5h 31m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Jun 3
TYS5:33 pmKnoxville McGhee Tyson
7h 48m
1 stop
MFE12:21 amMcAllen Miller Intl
$423

Delta flights from McAllen to Knoxville

Our best Delta deals on McAllen to Knoxville flight tickets
Delta
Jul 28
MFE5:20 amMcAllen Miller Intl
8h 28m
2 stops
TYS2:48 pmKnoxville McGhee Tyson
Aug 26
TYS7:07 amKnoxville McGhee Tyson
9h 52m
2 stops
MFE3:59 pmMcAllen Miller Intl
$375
Delta
Jul 24
MFE12:35 pmMcAllen Miller Intl
10h 17m
2 stops
TYS11:52 pmKnoxville McGhee Tyson
Aug 2
TYS5:40 amKnoxville McGhee Tyson
7h 15m
2 stops
MFE11:55 amMcAllen Miller Intl
$489
Delta
May 30
MFE12:56 pmMcAllen Miller Intl
10h 05m
2 stops
TYS12:01 amKnoxville McGhee Tyson
Jun 3
TYS5:40 amKnoxville McGhee Tyson
11h 57m
2 stops
MFE4:37 pmMcAllen Miller Intl
$532

momondo Fare Finder

 
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 7/24

8:43 am-9:15 pm

1 stop11h 32m

Knoxville McGhee Tyson

Sun 8/2

6:54 pm-7:53 am

1 stop13h 59m

$300

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 7/25

10:43 am-10:01 pm

1 stop10h 18m

Knoxville McGhee Tyson

Sun 8/2

6:54 pm-7:53 am

1 stop13h 59m

$343
Quickest round-trip

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 7/28

7:00 am-12:51 pm

1 stop4h 51m

Knoxville McGhee Tyson

Wed 8/26

1:46 pm-7:16 pm

1 stop6h 30m

$367

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 7/28

7:00 am-12:51 pm

1 stop4h 51m

Knoxville McGhee Tyson

Wed 8/26

7:07 am-3:28 pm

2 stops9h 21m

$372

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 7/28

5:20 am-2:48 pm

2 stops8h 28m

Knoxville McGhee Tyson

Wed 8/26

7:07 am-3:59 pm

2 stops9h 52m

$375

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Fri 7/24

8:43 am-9:15 pm

1 stop11h 32m

Knoxville McGhee Tyson

Sun 8/2

3:38 pm-7:53 am

2 stops17h 15m

$388

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 8/29

9:38 am-6:05 pm

1 stop7h 27m

Knoxville McGhee Tyson

Wed 9/2

7:15 am-11:23 am

1 stop5h 08m

$401

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 8/29

12:07 pm-6:05 pm

1 stop4h 58m

Knoxville McGhee Tyson

Wed 9/2

6:30 am-3:59 pm

2 stops10h 29m

$406

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 5/30

5:25 pm-11:56 pm

1 stop5h 31m

Knoxville McGhee Tyson

Wed 6/3

5:33 pm-12:21 am

1 stop7h 48m

$423

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 7/25

10:43 am-10:01 pm

1 stop10h 18m

Knoxville McGhee Tyson

Sun 8/2

3:38 pm-7:53 am

2 stops17h 15m

$426

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from McAllen to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between McAllen and Knoxville?

Can stopping save me money on McAllen to Knoxville flights?

You could potentially save up to 11% on your flight if you consider stops on a McAllen to Knoxville flight.

When to book flights from McAllen to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from McAllen to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap McAllen to Knoxville (MFE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from McAllen to Knoxville

Fastest flight time

5h 34m

Direct flights

None
The fastest flight from McAllen to Knoxville takes 5h 34m
There are no direct flights from McAllen to Knoxville. There are no popular flight routes from McAllen to Knoxville.
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Frequently asked questions about flying from McAllen to Knoxville

  • How far is McAllen Miller Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 1079.4 mi away from McAllen Miller Intl. Typically, this will take 5h 34m by plane in normal conditions.

  • When did momondo last update prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from McAllen Miller Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from McAllen to Knoxville?

Best airlines flying from McAllen to Knoxville

Compare and see reviews for airlines that fly from McAllen to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $355Free CancellationRating
7.1
11,659 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from McAllen to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from McAllen.

Can I find flights from McAllen to Knoxville with flexible booking policies on momondo?

All flight searches from McAllen to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from McAllen to Knoxville?

Once all potential McAllen to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from McAllen to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of McAllen to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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