Cheap flights from Maine to South Carolina from $64

The cheapest month to fly to South Carolina from Maine is in January. Flight prices, which tend to average around $198, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Maine during March instead. Flights to South Carolina in March, while not as cheap as those in January, still average around $229.

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $191. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $236.

Our data shows that the cheapest Maine to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $147. Try not to purchase tickets in the afternoon because they tend to be around $229. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Portland to Charleston for the best Maine - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Maine when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $270 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Maine for as low as $156 on momondo.

There is only 1 cabin class available to choose from on Maine to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Breeze Airways, Spirit Airlines, and Delta are the most popular carriers operating from Maine to South Carolina

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to South Carolina from Maine according to our data. American Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of March 2026, there are 26 flights per day flying from Maine to South Carolina. The most common time of day flights depart is 5:00PM, with 100% of flights taking off in the afternoon.

182 flights are operational weekly from Maine to South Carolina as of March 2026. The most popular departure day for this route is Sun, with 23% of flights per week taking off on this day.