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Cheap flights from Lafayette to Knoxville from $271

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Lafayette to Knoxville departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Lafayette to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:01 pm - 11:22 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
5h 21m1 stop Dallas/Fort Worth
American Airlines Logo
6:00 am - 10:10 amTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
5h 10m1 stop Dallas/Fort Worth
$271American Airlines
Wed, Sep 9 - Wed, Sep 16
United Airlines Logo
2:04 pm - 9:57 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
6h 53m1 stop Houston George Bush Intcntl
United Airlines Logo
3:45 pm - 7:33 pmTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
4h 48m1 stop Houston George Bush Intcntl
$271United Airlines
Sat, Nov 14 - Tue, Nov 17
American Airlines Logo
5:27 pm - 11:22 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
4h 55m1 stop Dallas/Fort Worth
American Airlines Logo
6:00 am - 10:10 amTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
5h 10m1 stop Dallas/Fort Worth
$295American Airlines
Sun, Sep 13 - Sat, Sep 19
Delta Logo
5:17 pm - 11:55 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
5h 38m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 10:41 amTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
6h 01m1 stop Atlanta Hartsfield-Jackson
$310Delta
Wed, Sep 23 - Sat, Sep 26
Delta Logo
11:00 am - 6:13 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
6h 13m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:30 am - 10:33 amTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
6h 03m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Jan 7 - Fri, Jan 15
American Airlines Logo
10:35 am - 8:43 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
9h 08m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
5:19 pm - 9:13 pmTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
4h 54m1 stop Charlotte Douglas
$319American Airlines
Sat, Nov 14 - Tue, Nov 17
American Airlines Logo
5:45 am - 4:49 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
10h 04m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
5:25 pm - 10:56 pmTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
6h 31m1 stop Dallas/Fort Worth
$324American Airlines
Thu, Jan 7 - Fri, Jan 15
Delta Logo
5:10 pm - 11:52 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
5h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:12 pm - 9:41 pmTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
4h 29m1 stop Atlanta Hartsfield-Jackson
$349Delta
Thu, Aug 27 - Mon, Aug 31
United Airlines Logo
4:04 pm - 9:45 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
4h 41m1 stop Houston George Bush Intcntl
United Airlines Logo
2:21 pm - 7:32 pmTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
6h 11m1 stop Houston George Bush Intcntl
$349United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
2:00 pm - 7:34 pmLFT  Lafayette Regional-TYS Knoxville McGhee Tyson
4h 34m1 stop Houston George Bush Intcntl
United Airlines Logo
7:00 am - 1:21 pmTYS  Knoxville McGhee Tyson-LFT Lafayette Regional
7h 21m1 stop Houston George Bush Intcntl
$351United Airlines
Wed, Jan 6 - Sat, Jan 9

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American Airlines flights from Lafayette to Knoxville

Our best American Airlines deals on Lafayette to Knoxville flight tickets
American Airlines
Sep 9
LFT5:01 pmLafayette Regional
5h 21m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
Sep 16
TYS6:00 amKnoxville McGhee Tyson
5h 10m
1 stop
LFT10:10 amLafayette Regional
$271
American Airlines
Sep 13
LFT5:27 pmLafayette Regional
4h 55m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
Sep 19
TYS6:00 amKnoxville McGhee Tyson
5h 10m
1 stop
LFT10:10 amLafayette Regional
$295
American Airlines
Jan 7
LFT5:45 amLafayette Regional
10h 04m
2 stops
TYS4:49 pmKnoxville McGhee Tyson
Jan 15
TYS5:25 pmKnoxville McGhee Tyson
6h 31m
1 stop
LFT10:56 pmLafayette Regional
$324

Delta flights from Lafayette to Knoxville

Our best Delta deals on Lafayette to Knoxville flight tickets
Delta
Sep 23
LFT5:17 pmLafayette Regional
5h 38m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Sep 26
TYS5:40 amKnoxville McGhee Tyson
6h 01m
1 stop
LFT10:41 amLafayette Regional
$310
Delta
Jan 7
LFT11:00 amLafayette Regional
6h 13m
1 stop
TYS6:13 pmKnoxville McGhee Tyson
Jan 15
TYS5:30 amKnoxville McGhee Tyson
6h 03m
1 stop
LFT10:33 amLafayette Regional
$319
Delta
Aug 27
LFT5:10 pmLafayette Regional
5h 42m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Aug 31
TYS6:12 pmKnoxville McGhee Tyson
4h 29m
1 stop
LFT9:41 pmLafayette Regional
$349

momondo Fare Finder

 
Customize your flight search to find flights from Lafayette to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Lafayette to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Wed 9/9

5:01 pm-11:22 pm

1 stop5h 21m

Knoxville McGhee Tyson

Wed 9/16

6:00 am-10:10 am

1 stop5h 10m

$271

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Sat 11/14

2:04 pm-9:57 pm

1 stop6h 53m

Knoxville McGhee Tyson

Tue 11/17

3:45 pm-7:33 pm

1 stop4h 48m

$271
Quickest round-trip

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Sun 9/13

5:27 pm-11:22 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sat 9/19

6:00 am-10:10 am

1 stop5h 10m

$295

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Wed 9/23

5:17 pm-11:55 pm

1 stop5h 38m

Knoxville McGhee Tyson

Sat 9/26

5:40 am-10:41 am

1 stop6h 01m

$310

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Thu 1/7

11:00 am-6:13 pm

1 stop6h 13m

Knoxville McGhee Tyson

Fri 1/15

5:30 am-10:33 am

1 stop6h 03m

$319

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Sat 11/14

10:35 am-8:43 pm

2 stops9h 08m

Knoxville McGhee Tyson

Tue 11/17

5:19 pm-9:13 pm

1 stop4h 54m

$319

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Thu 1/7

5:45 am-4:49 pm

2 stops10h 04m

Knoxville McGhee Tyson

Fri 1/15

5:25 pm-10:56 pm

1 stop6h 31m

$324

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Thu 8/27

5:10 pm-11:52 pm

1 stop5h 42m

Knoxville McGhee Tyson

Mon 8/31

6:12 pm-9:41 pm

1 stop4h 29m

$349

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Tue 9/1

4:04 pm-9:45 pm

1 stop4h 41m

Knoxville McGhee Tyson

Sat 9/5

2:21 pm-7:32 pm

1 stop6h 11m

$349

LafayetteKnoxville

LFT Lafayette Regional - TYS Knoxville McGhee Tyson

LFTTYS

Lafayette Regional

Wed 1/6

2:00 pm-7:34 pm

1 stop4h 34m

Knoxville McGhee Tyson

Sat 1/9

7:00 am-1:21 pm

1 stop7h 21m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Lafayette to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Lafayette, with most prices found around $308. If you aren’t able to travel during the month of August, then book flights to Knoxville from Lafayette during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $323.

When to book flights from Lafayette to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Lafayette to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Lafayette to Knoxville (LFT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Lafayette to Knoxville

Best Price Found

$274

Fastest flight time

4h 14m

Direct flights

None
The best one-way flight to Knoxville from Lafayette in the past 72 hours is $274. The best round-trip flight deal from Lafayette to Knoxville found on momondo in the last 72 hours is $271.
The fastest flight from Lafayette to Knoxville takes 4h 14m
There are no direct flights from Lafayette to Knoxville. There are no popular flight routes from Lafayette to Knoxville.
Search flight deals

Frequently asked questions about flying from Lafayette to Knoxville

  • How far is Lafayette Regional to Knoxville McGhee Tyson by plane?

    There are 613.1 mi between Lafayette Regional and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 4h 14m.

  • When did momondo last update prices for flights from Lafayette Regional Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lafayette Regional Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lafayette Regional Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lafayette Regional Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lafayette Regional Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Lafayette to Knoxville?

Best airlines flying from Lafayette to Knoxville

Compare and see reviews for airlines that fly from Lafayette to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $268Free CancellationRating
7.8
8,503 reviews
Search Delta flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Lafayette to Knoxville?

It is quick and easy to find Lafayette to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Lafayette to Knoxville with flexible booking policies on momondo?

Flights from Lafayette to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Lafayette to Knoxville?

Once you have performed a search for Lafayette to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Lafayette to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Lafayette and alert you when they change.

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