What airlines fly to Syracuse?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Syracuse from Knoxville according to our data. American Airlines is the first choice among our users, with 64% of people opting to fly with this airline when traveling to Syracuse. Keep in mind that there are 3 different airlines that fly to Syracuse on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between Knoxville and Syracuse?

Philadelphia (PHL) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Syracuse Hancock Intl?

American Airlines, United Airlines, and Allegiant Air are the most popular carriers operating from Knoxville McGhee Tyson to Syracuse Hancock Intl

Which layover airport has the shortest travel time from Knoxville to Syracuse?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 4h 07m.

Which layover airport has the shortest connection time from Knoxville to Syracuse?

Atlanta (ATL) has the shortest average layover time for this route: 1h 04m.

Which layover airport offers the lowest fares from Knoxville to Syracuse?

Flights via New York (LGA) offer the lowest average round-trip price of $293.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

Prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport as of October 2025.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport.

What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

The required travel and health documents for your Syracuse Hancock Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Syracuse Hancock Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$126 Cheap Flights from Knoxville to Syracuse in 2025/26

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10:17 am - 10:12 amTYS-SYR

23h 55m1 stop

7:50 pm - 1:57 pmSYR-TYS

18h 07m1 stop

$243Multiple Airlines

Find Deal

Sat, Nov 8 - Sun, Nov 9

7:30 am - 12:04 pmTYS-SYR

4h 34m1 stop

5:10 pm - 9:32 pmSYR-TYS

4h 22m1 stop

$249Delta

Find Deal

Wed, Feb 18 - Sat, Feb 21

1:52 pm - 11:13 pmTYS-SYR

9h 21m2 stops

6:15 am - 1:17 pmSYR-TYS

7h 02m1 stop

$254United Airlines

Find Deal

Fri, Oct 31 - Wed, Nov 5

5:45 am - 9:43 amTYS-SYR

3h 58m1 stop

7:50 pm - 11:59 pmSYR-TYS

4h 09m1 stop

$259United Airlines

Find Deal

Tue, Oct 28 - Sat, Nov 1

1:52 pm - 11:13 pmTYS-SYR

9h 21m2 stops

7:50 pm - 11:59 pmSYR-TYS

4h 09m1 stop

$264United Airlines

Find Deal

Tue, Oct 28 - Sat, Nov 1

1:52 pm - 11:13 pmTYS-SYR

9h 21m2 stops

11:05 am - 10:55 pmSYR-TYS

11h 50m2 stops

$269United Airlines

Find Deal

Tue, Oct 28 - Sat, Nov 1

6:12 pm - 10:12 amTYS-SYR

16h 00m1 stop

9:12 pm - 1:57 pmSYR-TYS

16h 45m2 stops

$285Multiple Airlines

Find Deal

Sat, Nov 8 - Sun, Nov 9

5:42 pm - 9:43 amTYS-SYR

16h 01m1 stop

6:50 pm - 8:16 pmSYR-TYS

25h 26m1 stop

$404Allegiant Air

Find Deal

Sun, Dec 14 - Fri, Dec 19

8:07 am - 2:58 pmTYS-SYR

6h 51m2 stops

5:28 pm - 11:51 pmSYR-TYS

6h 23m2 stops

$488American Airlines

Find Deal

Fri, Nov 7 - Sat, Nov 8

5:05 am - 11:33 amTYS-SYR

6h 28m2 stops

3:22 pm - 9:58 pmSYR-TYS

6h 36m2 stops

$683American Airlines

Find Deal

Sun, Dec 14 - Fri, Dec 19

United Airlines flights from Knoxville to Syracuse

Our best United Airlines deals on Knoxville to Syracuse flight tickets

United Airlines

Oct 31

TYS1:52 pmKnoxville McGhee Tyson

9h 21m

2 stops

SYR11:13 pmSyracuse Hancock Intl

Nov 5

SYR6:15 amSyracuse Hancock Intl

7h 02m

1 stop

TYS1:17 pmKnoxville McGhee Tyson

$254

Find similar

United Airlines

Oct 28

TYS5:45 amKnoxville McGhee Tyson

3h 58m

1 stop

SYR9:43 amSyracuse Hancock Intl

Nov 1

SYR7:50 pmSyracuse Hancock Intl

4h 09m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

$259

Find similar

United Airlines

Oct 28

TYS1:52 pmKnoxville McGhee Tyson

9h 21m

2 stops

SYR11:13 pmSyracuse Hancock Intl

Nov 1

SYR7:50 pmSyracuse Hancock Intl

4h 09m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

$264

Find similar

American Airlines flights from Knoxville to Syracuse

Our best American Airlines deals on Knoxville to Syracuse flight tickets

American Airlines

Oct 16

TYS7:00 amKnoxville McGhee Tyson

3h 48m

1 stop

SYR10:48 amSyracuse Hancock Intl

Oct 19

SYR6:00 amSyracuse Hancock Intl

4h 13m

1 stop

TYS10:13 amKnoxville McGhee Tyson

$338

Find similar

American Airlines

Nov 7

TYS8:07 amKnoxville McGhee Tyson

6h 51m

2 stops

SYR2:58 pmSyracuse Hancock Intl

Nov 8

SYR5:28 pmSyracuse Hancock Intl

6h 23m

2 stops

TYS11:51 pmKnoxville McGhee Tyson

$488

Find similar

American Airlines

Dec 14

TYS5:05 amKnoxville McGhee Tyson

6h 28m

2 stops

SYR11:33 amSyracuse Hancock Intl

Dec 19

SYR3:22 pmSyracuse Hancock Intl

6h 36m

2 stops

TYS9:58 pmKnoxville McGhee Tyson

$683

Find similar

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 11/8

10:17 am-10:12 am

1 stop23h 55m

Syracuse Hancock Intl

Sun 11/9

7:50 pm-1:57 pm

1 stop18h 07m

$243

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 2/18

7:30 am-12:04 pm

1 stop4h 34m

Syracuse Hancock Intl

Sat 2/21

5:10 pm-9:32 pm

1 stop4h 22m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 10/31

1:52 pm-11:13 pm

2 stops9h 21m

Syracuse Hancock Intl

Wed 11/5

6:15 am-1:17 pm

1 stop7h 02m

$254

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 10/28

5:45 am-9:43 am

1 stop3h 58m

Syracuse Hancock Intl

Sat 11/1

7:50 pm-11:59 pm

1 stop4h 09m

$259

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 10/28

1:52 pm-11:13 pm

2 stops9h 21m

Syracuse Hancock Intl

Sat 11/1

7:50 pm-11:59 pm

1 stop4h 09m

$264

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 10/28

1:52 pm-11:13 pm

2 stops9h 21m

Syracuse Hancock Intl

Sat 11/1

11:05 am-10:55 pm

2 stops11h 50m

$269

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 11/8

6:12 pm-10:12 am

1 stop16h 00m

Syracuse Hancock Intl

Sun 11/9

9:12 pm-1:57 pm

2 stops16h 45m

$285

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sun 12/14

5:42 pm-9:43 am

1 stop16h 01m

Syracuse Hancock Intl

Fri 12/19

6:50 pm-8:16 pm

1 stop25h 26m

$404

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 11/7

8:07 am-2:58 pm

2 stops6h 51m

Syracuse Hancock Intl

Sat 11/8

5:28 pm-11:51 pm

2 stops6h 23m

$488

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sun 12/14

5:05 am-11:33 am

2 stops6h 28m

Syracuse Hancock Intl

Fri 12/19

3:22 pm-9:58 pm

2 stops6h 36m

$683

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Knoxville to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Syracuse?

The month of April is, on average, the cheapest month to fly to Syracuse from Knoxville, with most prices found around $238. If you aren’t able to travel to Syracuse during the month of April, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $248.

What is the cheapest day to depart on your flight to Syracuse?

The cheapest day to depart from Knoxville to Syracuse is on a Wednesday. Travelers who choose to depart for Syracuse on a Wednesday will often find tickets for as low as $267. The most expensive day to fly to Syracuse is Sunday, with ticket prices averaging around $643.

What is the cheapest time of day to depart on your flight to Syracuse?

Our most recent data shows that the best time of day to fly to Syracuse is in the morning. Flights from Knoxville to Syracuse during this time can be as low as $315. Flights to Syracuse are more costly at noon, with an average ticket price of $411. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Knoxville to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Syracuse according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Syracuse (TYS to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Syracuse

Direct flights	None

There are no direct flights from Knoxville to Syracuse. There are no popular flight routes from Knoxville to Syracuse.

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How far is Knoxville McGhee Tyson to Syracuse Hancock Intl by plane?
The distance between Knoxville McGhee Tyson and Syracuse Hancock Intl is about 640.5 mi. Flights usually cover this in 3h 58m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport as of October 2025.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport.
What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?
The required travel and health documents for your Syracuse Hancock Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Syracuse Hancock Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from Knoxville to Syracuse?
Based on momondo bookings for flights between Knoxville and Syracuse, the leading airline is American Airlines, making up 56% of the total bookings. Other popular airlines include Delta with 32% and United Airlines with 12%.

Best airlines flying from Knoxville to Syracuse

Compare and see reviews for airlines that fly from Knoxville to Syracuse with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $216	Free Cancellation	Rating 7.9 7,977 reviews	Search Delta flights
American Airlines	PriceFrom $246	Free Cancellation	Rating 7.2 11,045 reviews	Search American Airlines flights
United Airlines	PriceFrom $253	Free Cancellation	Rating 7.4 8,978 reviews	Search United Airlines flights

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Oswego

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East Syracuse

Seneca Falls

Waterloo

Cicero

Bridgeport

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Why should I use momondo to find a flight deal from Knoxville to Syracuse?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Syracuse. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Syracuse with flexible booking policies on momondo?

Flights from Knoxville to Syracuse with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Syracuse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Syracuse from Knoxville.

I’m not ready to book a flight from Knoxville to Syracuse right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Syracuse now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Syracuse and let you know when they change.

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Cheap flights from Knoxville to Syracuse from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Syracuse departing on 11/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Knoxville to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Syracuse?

The month of April is, on average, the cheapest month to fly to Syracuse from Knoxville, with most prices found around $238. If you aren’t able to travel to Syracuse during the month of April, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $248.

What is the cheapest day to depart on your flight to Syracuse?

The cheapest day to depart from Knoxville to Syracuse is on a Wednesday. Travelers who choose to depart for Syracuse on a Wednesday will often find tickets for as low as $267. The most expensive day to fly to Syracuse is Sunday, with ticket prices averaging around $643.

What is the cheapest time of day to depart on your flight to Syracuse?

What is the cheapest airline that flies from Knoxville McGhee Tyson to Syracuse Hancock Intl?

American Airlines, United Airlines, and Allegiant Air are the most popular carriers operating from Knoxville McGhee Tyson to Syracuse Hancock Intl

What airlines fly to Syracuse?

Which airport is the most popular layover for flights between Knoxville and Syracuse?

Philadelphia (PHL) was the most common stop: 33% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Knoxville to Syracuse?

Flights via New York (LGA) offer the lowest average round-trip price of $293.

Which layover airport has the shortest travel time from Knoxville to Syracuse?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 4h 07m.

Which layover airport has the shortest connection time from Knoxville to Syracuse?

Atlanta (ATL) has the shortest average layover time for this route: 1h 04m.

When to book flights from Knoxville to Syracuse

Cheap Knoxville to Syracuse (TYS to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Syracuse

Direct flights

How far is Knoxville McGhee Tyson to Syracuse Hancock Intl by plane?

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

What is the most popular airline from Knoxville to Syracuse?

Best airlines flying from Knoxville to Syracuse

Compare and see reviews for airlines that fly from Knoxville to Syracuse with momondo

Traveling to a place near Syracuse?

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Syracuse?

Can I find flights from Knoxville to Syracuse with flexible booking policies on momondo?

How can momondo help me find flights from Knoxville to Syracuse?

I’m not ready to book a flight from Knoxville to Syracuse right now. Can momondo alert me if prices change?

An easier way to manage your Syracuse trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing New York