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Cheap flights from Knoxville to Syracuse from $232

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Syracuse departing on 6/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Syracuse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:44 pm - 11:59 pm
TYS
-
SYR
3h 15m1 stop
American Airlines Logo
5:28 pm - 9:39 pm
SYR
-
TYS
4h 11m1 stop
$269American Airlines
Thu, Apr 16 - Mon, Apr 20
Delta Logo
7:07 pm - 11:59 pm
TYS
-
SYR
4h 52m1 stop
Delta Logo
6:00 am - 10:11 am
SYR
-
TYS
4h 11m1 stop
$274Delta
Fri, Mar 13 - Mon, Mar 16
Allegiant Air Logo
8:35 am - 2:53 pm
TYS
-
SYR
6h 18m1 stop
Allegiant Air Logo
7:24 pm - 8:03 am
SYR
-
TYS
12h 39m1 stop
$314Allegiant Air
Wed, Dec 31 - Sun, Jan 4
United Airlines Logo
11:07 am - 11:25 pm
TYS
-
SYR
12h 18m2 stops
United Airlines Logo
5:48 am - 10:57 am
SYR
-
TYS
5h 09m1 stop
$344United Airlines
Thu, Jan 8 - Mon, Jan 12
United Airlines Logo
11:07 am - 11:25 pm
TYS
-
SYR
12h 18m2 stops
United Airlines Logo
7:03 am - 8:52 pm
SYR
-
TYS
13h 49m2 stops
$349United Airlines
Thu, Jan 8 - Mon, Jan 12
American Airlines Logo
7:35 am - 3:11 pm
TYS
-
SYR
7h 36m2 stops
American Airlines Logo
6:26 pm - 11:47 pm
SYR
-
TYS
5h 21m1 stop
$360American Airlines
Wed, Dec 31 - Sun, Jan 4
United Airlines Logo
11:07 am - 4:15 pm
TYS
-
SYR
5h 08m1 stop
United Airlines Logo
5:48 am - 10:57 am
SYR
-
TYS
5h 09m1 stop
$374United Airlines
Thu, Jan 8 - Mon, Jan 12
United Airlines Logo
11:07 am - 4:15 pm
TYS
-
SYR
5h 08m1 stop
United Airlines Logo
7:03 am - 8:52 pm
SYR
-
TYS
13h 49m2 stops
$379United Airlines
Thu, Jan 8 - Mon, Jan 12
United Airlines Logo
11:07 am - 11:25 pm
TYS
-
SYR
12h 18m2 stops
United Airlines Logo
7:03 am - 8:52 pm
SYR
-
TYS
13h 49m2 stops
$384United Airlines
Thu, Jan 8 - Mon, Jan 12
United Airlines Logo
11:07 am - 4:15 pm
TYS
-
SYR
5h 08m1 stop
United Airlines Logo
5:48 am - 10:57 am
SYR
-
TYS
5h 09m1 stop
$398United Airlines
Thu, Jan 8 - Mon, Jan 12

American Airlines flights from Knoxville to Syracuse

Our best American Airlines deals on Knoxville to Syracuse flight tickets
American Airlines
Apr 16
TYS8:44 pmKnoxville McGhee Tyson
3h 15m
1 stop
SYR11:59 pmSyracuse Hancock Intl
Apr 20
SYR5:28 pmSyracuse Hancock Intl
4h 11m
1 stop
TYS9:39 pmKnoxville McGhee Tyson
$269
Find similar
American Airlines
Dec 31
TYS7:35 amKnoxville McGhee Tyson
7h 36m
2 stops
SYR3:11 pmSyracuse Hancock Intl
Jan 4
SYR6:26 pmSyracuse Hancock Intl
5h 21m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$360
Find similar
American Airlines
Mar 13
TYS5:00 amKnoxville McGhee Tyson
6h 39m
2 stops
SYR11:39 amSyracuse Hancock Intl
Mar 16
SYR5:32 amSyracuse Hancock Intl
5h 21m
1 stop
TYS10:53 amKnoxville McGhee Tyson
$475
Find similar

United Airlines flights from Knoxville to Syracuse

Our best United Airlines deals on Knoxville to Syracuse flight tickets
United Airlines
Jan 8
TYS11:07 amKnoxville McGhee Tyson
12h 18m
2 stops
SYR11:25 pmSyracuse Hancock Intl
Jan 12
SYR5:48 amSyracuse Hancock Intl
5h 09m
1 stop
TYS10:57 amKnoxville McGhee Tyson
$344
Find similar
United Airlines
Jan 8
TYS11:07 amKnoxville McGhee Tyson
12h 18m
2 stops
SYR11:25 pmSyracuse Hancock Intl
Jan 12
SYR7:03 amSyracuse Hancock Intl
13h 49m
2 stops
TYS8:52 pmKnoxville McGhee Tyson
$349
Find similar
United Airlines
Jan 8
TYS11:07 amKnoxville McGhee Tyson
5h 08m
1 stop
SYR4:15 pmSyracuse Hancock Intl
Jan 12
SYR5:48 amSyracuse Hancock Intl
5h 09m
1 stop
TYS10:57 amKnoxville McGhee Tyson
$374
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 4/16

8:44 pm-11:59 pm

1 stop3h 15m

Syracuse Hancock Intl

Mon 4/20

5:28 pm-9:39 pm

1 stop4h 11m

$269

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 3/13

7:07 pm-11:59 pm

1 stop4h 52m

Syracuse Hancock Intl

Mon 3/16

6:00 am-10:11 am

1 stop4h 11m

$274

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 12/31

8:35 am-2:53 pm

1 stop6h 18m

Syracuse Hancock Intl

Sun 1/4

7:24 pm-8:03 am

1 stop12h 39m

$314

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/8

11:07 am-11:25 pm

2 stops12h 18m

Syracuse Hancock Intl

Mon 1/12

5:48 am-10:57 am

1 stop5h 09m

$344

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/8

11:07 am-11:25 pm

2 stops12h 18m

Syracuse Hancock Intl

Mon 1/12

7:03 am-8:52 pm

2 stops13h 49m

$349

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 12/31

7:35 am-3:11 pm

2 stops7h 36m

Syracuse Hancock Intl

Sun 1/4

6:26 pm-11:47 pm

1 stop5h 21m

$360

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/8

11:07 am-4:15 pm

1 stop5h 08m

Syracuse Hancock Intl

Mon 1/12

5:48 am-10:57 am

1 stop5h 09m

$374

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/8

11:07 am-4:15 pm

1 stop5h 08m

Syracuse Hancock Intl

Mon 1/12

7:03 am-8:52 pm

2 stops13h 49m

$379

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/8

11:07 am-11:25 pm

2 stops12h 18m

Syracuse Hancock Intl

Mon 1/12

7:03 am-8:52 pm

2 stops13h 49m

$384

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/8

11:07 am-4:15 pm

1 stop5h 08m

Syracuse Hancock Intl

Mon 1/12

5:48 am-10:57 am

1 stop5h 09m

$398

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Syracuse from

How to get the cheapest flight ticket from Knoxville to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Syracuse?

The month of April is, on average, the cheapest month to fly to Syracuse from Knoxville, with most prices found around $238. If you aren’t able to travel to Syracuse during the month of April, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $248.

What is the cheapest day to depart on your flight to Syracuse?

The cheapest day to depart from Knoxville to Syracuse is on a Wednesday. Travelers who choose to depart for Syracuse on a Wednesday will often find tickets for as low as $267. The most expensive day to fly to Syracuse is Sunday, with ticket prices averaging around $643.

What is the cheapest time of day to depart on your flight to Syracuse?

Our most recent data shows that the best time of day to fly to Syracuse is in the morning. Flights from Knoxville to Syracuse during this time can be as low as $315. Flights to Syracuse are more costly at noon, with an average ticket price of $411. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Knoxville to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Syracuse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Syracuse (TYS to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Syracuse

Fastest flight time

4h 52m

Direct flights

None
The fastest flight from Knoxville to Syracuse takes 4h 52m
There are no direct flights from Knoxville to Syracuse. There are no popular flight routes from Knoxville to Syracuse.
Search flight deals

  • How far is Knoxville McGhee Tyson to Syracuse Hancock Intl by plane?

    The distance between Knoxville McGhee Tyson and Syracuse Hancock Intl is about 640.5 mi. Flights usually cover this in 4h 52m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport.

  • What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

    The required travel and health documents for your Syracuse Hancock Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Syracuse Hancock Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Syracuse?

Best airlines flying from Knoxville to Syracuse

Compare and see reviews for airlines that fly from Knoxville to Syracuse with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $238Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
United AirlinesPriceFrom $253Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Skaneateles
Oswego
Liverpool
Auburn
East Syracuse
Seneca Falls
Waterloo
Cicero
Bridgeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Syracuse?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Syracuse. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Syracuse with flexible booking policies on momondo?

Flights from Knoxville to Syracuse with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Syracuse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Syracuse from Knoxville.

I’m not ready to book a flight from Knoxville to Syracuse right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Syracuse now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Syracuse and let you know when they change.

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