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Cheap flights from Knoxville to Syracuse from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Syracuse departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:30 pm - 11:16 pm
TYS
-
SYR
5h 46m
1 stop
Delta Logo
6:30 am - 11:50 am
SYR
-
TYS
5h 20m
1 stop
$315Delta
Wed, Apr 15 - Wed, Apr 22
Allegiant Air Logo
5:02 pm - 3:08 pm
TYS
-
SYR
22h 06m
1 stop
Allegiant Air Logo
7:26 pm - 6:32 pm
SYR
-
TYS
23h 06m
1 stop
$319Allegiant Air
Tue, Jun 23 - Sun, Jun 28
Delta Logo
6:00 am - 11:42 am
TYS
-
SYR
5h 42m
1 stop
Delta Logo
6:00 am - 11:01 am
SYR
-
TYS
5h 01m
1 stop
$329Delta
Wed, Jun 10 - Mon, Jun 15
American Airlines Logo
11:31 am - 6:34 pm
TYS
-
SYR
7h 03m
1 stop
American Airlines Logo
6:15 pm - 11:55 pm
SYR
-
TYS
5h 40m
1 stop
$330American Airlines
Sat, May 9 - Mon, May 11
Delta Logo
6:05 pm - 12:01 am
TYS
-
SYR
5h 56m
1 stop
Delta Logo
6:00 am - 10:51 am
SYR
-
TYS
4h 51m
1 stop
$334Delta
Tue, Jun 23 - Sat, Jun 27
American Airlines Logo
6:38 pm - 11:10 pm
TYS
-
SYR
4h 32m
1 stop
American Airlines Logo
5:30 am - 11:01 am
SYR
-
TYS
5h 31m
1 stop
$339American Airlines
Thu, Apr 9 - Mon, Apr 13
Allegiant Air Logo
8:30 am - 12:56 pm
TYS
-
SYR
28h 26m
1 stop
Allegiant Air Logo
7:39 pm - 9:40 am
SYR
-
TYS
14h 01m
1 stop
$352Allegiant Air
Fri, May 8 - Mon, May 11
Allegiant Air Logo
3:06 pm - 10:22 am
TYS
-
SYR
19h 16m
1 stop
Allegiant Air Logo
7:31 pm - 10:01 pm
SYR
-
TYS
26h 30m
1 stop
$353Allegiant Air
Fri, Jul 10 - Fri, Jul 17
Allegiant Air Logo
6:34 pm - 2:45 pm
TYS
-
SYR
20h 11m
1 stop
Allegiant Air Logo
7:26 pm - 6:32 pm
SYR
-
TYS
23h 06m
1 stop
$358Allegiant Air
Mon, Jun 22 - Sun, Jun 28
United Airlines Logo
6:30 am - 2:15 pm
TYS
-
SYR
7h 45m
2 stops
United Airlines Logo
5:44 pm - 12:30 am
SYR
-
TYS
6h 46m
1 stop
$360United Airlines
Tue, Jun 16 - Sat, Jun 20

American Airlines flights from Knoxville to Syracuse

Our best American Airlines deals on Knoxville to Syracuse flight tickets
American Airlines
May 9
TYS11:31 amKnoxville McGhee Tyson
7h 03m
1 stop
SYR6:34 pmSyracuse Hancock Intl
May 11
SYR6:15 pmSyracuse Hancock Intl
5h 40m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$330
American Airlines
Apr 9
TYS6:38 pmKnoxville McGhee Tyson
4h 32m
1 stop
SYR11:10 pmSyracuse Hancock Intl
Apr 13
SYR5:30 amSyracuse Hancock Intl
5h 31m
1 stop
TYS11:01 amKnoxville McGhee Tyson
$339
American Airlines
Apr 1
TYS5:00 amKnoxville McGhee Tyson
6h 39m
2 stops
SYR11:39 amSyracuse Hancock Intl
Apr 22
SYR6:15 pmSyracuse Hancock Intl
4h 09m
1 stop
TYS10:24 pmKnoxville McGhee Tyson
$369

United Airlines flights from Knoxville to Syracuse

Our best United Airlines deals on Knoxville to Syracuse flight tickets
United Airlines
Jun 16
TYS6:30 amKnoxville McGhee Tyson
7h 45m
2 stops
SYR2:15 pmSyracuse Hancock Intl
Jun 20
SYR5:44 pmSyracuse Hancock Intl
6h 46m
1 stop
TYS12:30 amKnoxville McGhee Tyson
$360
United Airlines
Apr 11
TYS7:20 pmKnoxville McGhee Tyson
4h 30m
1 stop
SYR11:50 pmSyracuse Hancock Intl
Apr 15
SYR6:00 amSyracuse Hancock Intl
4h 50m
1 stop
TYS10:50 amKnoxville McGhee Tyson
$398
United Airlines
Apr 15
TYS7:00 amKnoxville McGhee Tyson
13h 20m
2 stops
SYR8:20 pmSyracuse Hancock Intl
Apr 22
SYR6:30 amSyracuse Hancock Intl
6h 44m
1 stop
TYS1:14 pmKnoxville McGhee Tyson
$400

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 4/15

5:30 pm-11:16 pm

1 stop5h 46m

Syracuse Hancock Intl

Wed 4/22

6:30 am-11:50 am

1 stop5h 20m

$315

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 6/23

5:02 pm-3:08 pm

1 stop22h 06m

Syracuse Hancock Intl

Sun 6/28

7:26 pm-6:32 pm

1 stop23h 06m

$319

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 6/10

6:00 am-11:42 am

1 stop5h 42m

Syracuse Hancock Intl

Mon 6/15

6:00 am-11:01 am

1 stop5h 01m

$329

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 5/9

11:31 am-6:34 pm

1 stop7h 03m

Syracuse Hancock Intl

Mon 5/11

6:15 pm-11:55 pm

1 stop5h 40m

$330

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 6/23

6:05 pm-12:01 am

1 stop5h 56m

Syracuse Hancock Intl

Sat 6/27

6:00 am-10:51 am

1 stop4h 51m

$334
Quickest round-trip

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 4/9

6:38 pm-11:10 pm

1 stop4h 32m

Syracuse Hancock Intl

Mon 4/13

5:30 am-11:01 am

1 stop5h 31m

$339

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 5/8

8:30 am-12:56 pm

1 stop28h 26m

Syracuse Hancock Intl

Mon 5/11

7:39 pm-9:40 am

1 stop14h 01m

$352

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 7/10

3:06 pm-10:22 am

1 stop19h 16m

Syracuse Hancock Intl

Fri 7/17

7:31 pm-10:01 pm

1 stop26h 30m

$353

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Mon 6/22

6:34 pm-2:45 pm

1 stop20h 11m

Syracuse Hancock Intl

Sun 6/28

7:26 pm-6:32 pm

1 stop23h 06m

$358

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 6/16

6:30 am-2:15 pm

2 stops7h 45m

Syracuse Hancock Intl

Sat 6/20

5:44 pm-12:30 am

1 stop6h 46m

$360

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Syracuse from

How to get the cheapest flight ticket from Knoxville to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Syracuse?

What is the cheapest month to fly to Syracuse?

The month of April is, on average, the cheapest month to fly to Syracuse from Knoxville, with most prices found around $238. If you aren’t able to travel to Syracuse during the month of April, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $248.

When to book flights from Knoxville to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Syracuse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Syracuse (TYS to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Syracuse

Fastest flight time

5h 33m

Direct flights

None
The fastest flight from Knoxville to Syracuse takes 5h 33m
There are no direct flights from Knoxville to Syracuse. There are no popular flight routes from Knoxville to Syracuse.
Search flight deals

  • How far is Knoxville McGhee Tyson to Syracuse Hancock Intl by plane?

    The distance between Knoxville McGhee Tyson and Syracuse Hancock Intl is about 640.5 mi. Flights usually cover this in 5h 33m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Syracuse Hancock Intl Airport.

  • What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

    The required travel and health documents for your Syracuse Hancock Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Syracuse Hancock Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Syracuse?

Best airlines flying from Knoxville to Syracuse

Compare and see reviews for airlines that fly from Knoxville to Syracuse with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
8,359 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,521 reviews
Search American Airlines flights

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Skaneateles
Liverpool
Oswego
East Syracuse
Waterloo
Auburn
Seneca Falls
Cicero
Bridgeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Syracuse?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Syracuse. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Syracuse with flexible booking policies on momondo?

Flights from Knoxville to Syracuse with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Syracuse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Syracuse from Knoxville.

I’m not ready to book a flight from Knoxville to Syracuse right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Syracuse now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Syracuse and let you know when they change.

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