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Cheap flights from Knoxville to La Crosse from $355

1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:55 pm - 11:59 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
6h 04m1 stop Chicago O'Hare Intl
American Airlines Logo
12:23 pm - 6:20 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
4h 57m1 stop Chicago O'Hare Intl
$355American Airlines
Wed, Oct 21 - Mon, Oct 26
American Airlines Logo
6:05 pm - 11:59 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
6h 54m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
American Airlines Logo
12:23 pm - 6:20 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
4h 57m1 stop Chicago O'Hare Intl
$414American Airlines
Wed, Oct 21 - Mon, Oct 26
American Airlines Logo
7:30 am - 11:53 amTYS  Knoxville McGhee Tyson-LSE La Crosse
5h 23m1 stop Chicago O'Hare Intl
American Airlines Logo
6:01 am - 11:01 amLSE  La Crosse-TYS Knoxville McGhee Tyson
4h 00m1 stop Chicago O'Hare Intl
$430American Airlines
Thu, Oct 29 - Sun, Nov 1
American Airlines Logo
10:00 am - 6:20 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
9h 20m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:01 am - 11:01 amLSE  La Crosse-TYS Knoxville McGhee Tyson
4h 00m1 stop Chicago O'Hare Intl
$436American Airlines
Thu, Oct 29 - Sun, Nov 1
American Airlines Logo
10:48 am - 6:20 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
8h 32m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:01 am - 4:48 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
9h 47m2 stops Chicago O'Hare Intl Charlotte Douglas
$441American Airlines
Fri, Oct 30 - Mon, Nov 2
American Airlines Logo
2:56 pm - 11:59 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
10h 03m2 stops New York LaGuardia Chicago O'Hare Intl
American Airlines Logo
12:23 pm - 11:55 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
10h 32m2 stops Chicago O'Hare Intl Charlotte Douglas
$474American Airlines
Wed, Oct 21 - Mon, Oct 26
American Airlines Logo
10:00 am - 6:20 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
9h 20m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
6:01 am - 5:41 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
10h 40m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
$496American Airlines
Thu, Oct 29 - Sun, Nov 1
American Airlines Logo
6:55 pm - 11:59 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
6h 04m1 stop Chicago O'Hare Intl
American Airlines Logo
12:23 pm - 10:59 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
9h 36m2 stops Chicago O'Hare Intl Miami
$568American Airlines
Fri, Oct 9 - Sun, Oct 11
American Airlines Logo
10:00 am - 6:20 pmTYS  Knoxville McGhee Tyson-LSE La Crosse
9h 20m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
12:23 pm - 10:59 pmLSE  La Crosse-TYS Knoxville McGhee Tyson
9h 36m2 stops Chicago O'Hare Intl Miami
$747American Airlines
Fri, Oct 9 - Sun, Oct 11

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American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Oct 21
TYS6:55 pmKnoxville McGhee Tyson
6h 04m
1 stop
LSE11:59 pmLa Crosse
Oct 26
LSE12:23 pmLa Crosse
4h 57m
1 stop
TYS6:20 pmKnoxville McGhee Tyson
$355
American Airlines
Oct 21
TYS6:05 pmKnoxville McGhee Tyson
6h 54m
2 stops
LSE11:59 pmLa Crosse
Oct 26
LSE12:23 pmLa Crosse
4h 57m
1 stop
TYS6:20 pmKnoxville McGhee Tyson
$414
American Airlines
Oct 29
TYS7:30 amKnoxville McGhee Tyson
5h 23m
1 stop
LSE11:53 amLa Crosse
Nov 1
LSE6:01 amLa Crosse
4h 00m
1 stop
TYS11:01 amKnoxville McGhee Tyson
$430

momondo Fare Finder

 
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

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Cheapest round-trip

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Wed 10/21

6:55 pm-11:59 pm

1 stop6h 04m

La Crosse

Mon 10/26

12:23 pm-6:20 pm

1 stop4h 57m

$355

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Wed 10/21

6:05 pm-11:59 pm

2 stops6h 54m

La Crosse

Mon 10/26

12:23 pm-6:20 pm

1 stop4h 57m

$414
Quickest round-trip

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Thu 10/29

7:30 am-11:53 am

1 stop5h 23m

La Crosse

Sun 11/1

6:01 am-11:01 am

1 stop4h 00m

$430

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Thu 10/29

10:00 am-6:20 pm

2 stops9h 20m

La Crosse

Sun 11/1

6:01 am-11:01 am

1 stop4h 00m

$436

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Fri 10/30

10:48 am-6:20 pm

2 stops8h 32m

La Crosse

Mon 11/2

6:01 am-4:48 pm

2 stops9h 47m

$441

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Wed 10/21

2:56 pm-11:59 pm

2 stops10h 03m

La Crosse

Mon 10/26

12:23 pm-11:55 pm

2 stops10h 32m

$474

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Thu 10/29

10:00 am-6:20 pm

2 stops9h 20m

La Crosse

Sun 11/1

6:01 am-5:41 pm

2 stops10h 40m

$496

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Fri 10/9

6:55 pm-11:59 pm

1 stop6h 04m

La Crosse

Sun 10/11

12:23 pm-10:59 pm

2 stops9h 36m

$568

KnoxvilleLa Crosse

TYS Knoxville McGhee Tyson - LSE La Crosse

TYSLSE

Knoxville McGhee Tyson

Fri 10/9

10:00 am-6:20 pm

2 stops9h 20m

La Crosse

Sun 10/11

12:23 pm-10:59 pm

2 stops9h 36m

$747

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to La Crosse from

How to get the cheapest flight ticket from Knoxville to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to La Crosse flights?

You could potentially save up to 66% on your flight if you consider stops on a Knoxville to La Crosse flight.

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Best Price Found

$355

Fastest flight time

6h 04m

Direct flights

None
The best flight deal from Knoxville to La Crosse found on momondo in the last 72 hours is $355
The fastest flight from Knoxville to La Crosse takes 6h 04m
There are no direct flights from Knoxville to La Crosse. There are no popular flight routes from Knoxville to La Crosse.
Search flight deals

Frequently asked questions about flying from Knoxville to La Crosse

  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 6h 04m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to La Crosse?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to La Crosse for you.

Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

I’m not ready to book a flight from Knoxville to La Crosse right now. Can momondo alert me if prices change?

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