Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Knoxville to La Crosse from $342

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 6/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:02 pm - 12:19 am
TYS
-
LSE
6h 17m
1 stop
American Airlines Logo
5:25 pm - 11:53 pm
LSE
-
TYS
5h 28m
1 stop
$342American Airlines
Sat, Jun 6 - Wed, Jun 10
American Airlines Logo
7:07 am - 5:03 pm
TYS
-
LSE
10h 56m
2 stops
American Airlines Logo
5:25 pm - 11:53 pm
LSE
-
TYS
5h 28m
1 stop
$348American Airlines
Sat, Jun 6 - Wed, Jun 10
American Airlines Logo
6:07 pm - 12:19 am
TYS
-
LSE
7h 12m
2 stops
American Airlines Logo
6:00 am - 10:58 am
LSE
-
TYS
3h 58m
1 stop
$387American Airlines
Sat, Jun 27 - Mon, Jun 29
American Airlines Logo
6:07 pm - 12:19 am
TYS
-
LSE
7h 12m
2 stops
American Airlines Logo
6:00 am - 3:15 pm
LSE
-
TYS
8h 15m
2 stops
$392American Airlines
Sat, Jun 27 - Mon, Jun 29
American Airlines Logo
4:13 pm - 12:19 am
TYS
-
LSE
9h 06m
2 stops
American Airlines Logo
6:00 am - 3:15 pm
LSE
-
TYS
8h 15m
2 stops
$409American Airlines
Sat, Jun 6 - Wed, Jun 10
American Airlines Logo
6:07 pm - 12:19 am
TYS
-
LSE
7h 12m
2 stops
American Airlines Logo
11:52 am - 6:13 pm
LSE
-
TYS
5h 21m
1 stop
$426American Airlines
Fri, Jun 26 - Mon, Jun 29
American Airlines Logo
3:40 pm - 12:19 am
TYS
-
LSE
9h 39m
2 stops
American Airlines Logo
6:00 am - 5:37 pm
LSE
-
TYS
10h 37m
2 stops
$431American Airlines
Fri, Jun 26 - Mon, Jun 29
American Airlines Logo
7:02 pm - 12:19 am
TYS
-
LSE
6h 17m
1 stop
American Airlines Logo
6:00 am - 12:43 pm
LSE
-
TYS
5h 43m
1 stop
$437American Airlines
Sat, Jun 27 - Mon, Jun 29
American Airlines Logo
6:43 pm - 12:19 am
TYS
-
LSE
6h 36m
1 stop
American Airlines Logo
5:25 pm - 11:53 pm
LSE
-
TYS
5h 28m
1 stop
$475American Airlines
Fri, Jun 26 - Mon, Jun 29
American Airlines Logo
6:07 pm - 12:19 am
TYS
-
LSE
7h 12m
2 stops
American Airlines Logo
11:52 am - 9:31 pm
LSE
-
TYS
8h 39m
2 stops
$486American Airlines
Fri, Jun 26 - Mon, Jun 29

American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Jun 6
TYS7:02 pmKnoxville McGhee Tyson
6h 17m
1 stop
LSE12:19 amLa Crosse
Jun 10
LSE5:25 pmLa Crosse
5h 28m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
$342
American Airlines
Jun 6
TYS7:07 amKnoxville McGhee Tyson
10h 56m
2 stops
LSE5:03 pmLa Crosse
Jun 10
LSE5:25 pmLa Crosse
5h 28m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
$348
American Airlines
Jun 27
TYS6:07 pmKnoxville McGhee Tyson
7h 12m
2 stops
LSE12:19 amLa Crosse
Jun 29
LSE6:00 amLa Crosse
3h 58m
1 stop
TYS10:58 amKnoxville McGhee Tyson
$387

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 6/6

7:02 pm-12:19 am

1 stop6h 17m

La Crosse

Wed 6/10

5:25 pm-11:53 pm

1 stop5h 28m

$342

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 6/6

7:07 am-5:03 pm

2 stops10h 56m

La Crosse

Wed 6/10

5:25 pm-11:53 pm

1 stop5h 28m

$348
Quickest round-trip

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 6/27

6:07 pm-12:19 am

2 stops7h 12m

La Crosse

Mon 6/29

6:00 am-10:58 am

1 stop3h 58m

$387

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 6/27

6:07 pm-12:19 am

2 stops7h 12m

La Crosse

Mon 6/29

6:00 am-3:15 pm

2 stops8h 15m

$392

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 6/6

4:13 pm-12:19 am

2 stops9h 06m

La Crosse

Wed 6/10

6:00 am-3:15 pm

2 stops8h 15m

$409

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 6/26

6:07 pm-12:19 am

2 stops7h 12m

La Crosse

Mon 6/29

11:52 am-6:13 pm

1 stop5h 21m

$426

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 6/26

3:40 pm-12:19 am

2 stops9h 39m

La Crosse

Mon 6/29

6:00 am-5:37 pm

2 stops10h 37m

$431

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 6/27

7:02 pm-12:19 am

1 stop6h 17m

La Crosse

Mon 6/29

6:00 am-12:43 pm

1 stop5h 43m

$437

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 6/26

6:43 pm-12:19 am

1 stop6h 36m

La Crosse

Mon 6/29

5:25 pm-11:53 pm

1 stop5h 28m

$475

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 6/26

6:07 pm-12:19 am

2 stops7h 12m

La Crosse

Mon 6/29

11:52 am-9:31 pm

2 stops8h 39m

$486

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to La Crosse from

How to get the cheapest flight ticket from Knoxville to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to La Crosse flights?

You could potentially save up to 7% on your flight if you consider stops on a Knoxville to La Crosse flight.

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Fastest flight time

6h 17m

Direct flights

None
The fastest flight from Knoxville to La Crosse takes 6h 17m
There are no direct flights from Knoxville to La Crosse. There are no popular flight routes from Knoxville to La Crosse.
Search flight deals

Frequently asked questions about flying from Knoxville to La Crosse

  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 6h 17m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to La Crosse?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to La Crosse for you.

Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

I’m not ready to book a flight from Knoxville to La Crosse right now. Can momondo alert me if prices change?

Price alerts on flights to La Crosse from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your La Crosse trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 6/23
Tue 6/30
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States