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Cheap flights from Knoxville to La Crosse from $476

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

American Airlines Logo
1:01 pm - 5:58 pmTYS-LSE
5h 57m1 stop
American Airlines Logo
9:50 am - 5:46 pmLSE-TYS
6h 56m1 stop
$476American Airlines
Find Deal
Tue, Oct 28 - Sun, Nov 9
American Airlines Logo
1:01 pm - 5:58 pmTYS-LSE
5h 57m1 stop
American Airlines Logo
6:00 am - 3:48 pmLSE-TYS
8h 48m2 stops
$482American Airlines
Find Deal
Tue, Oct 28 - Sun, Nov 9
American Airlines Logo
11:40 am - 5:58 pmTYS-LSE
7h 18m2 stops
American Airlines Logo
6:00 am - 3:48 pmLSE-TYS
8h 48m2 stops
$487American Airlines
Find Deal
Tue, Oct 28 - Sun, Nov 9
American Airlines Logo
8:15 am - 2:18 pmTYS-LSE
7h 03m1 stop
American Airlines Logo
4:46 pm - 9:14 pmLSE-TYS
3h 28m1 stop
$583American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
8:02 am - 2:18 pmTYS-LSE
7h 16m2 stops
American Airlines Logo
4:46 pm - 9:14 pmLSE-TYS
3h 28m1 stop
$589American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
8:02 am - 2:18 pmTYS-LSE
7h 16m2 stops
American Airlines Logo
1:03 pm - 9:43 pmLSE-TYS
7h 40m2 stops
$594American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28

American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Oct 28
TYS1:01 pmKnoxville McGhee Tyson
5h 57m
1 stop
LSE5:58 pmLa Crosse
Nov 9
LSE9:50 amLa Crosse
6h 56m
1 stop
TYS5:46 pmKnoxville McGhee Tyson
$476
Find similar
American Airlines
Oct 28
TYS1:01 pmKnoxville McGhee Tyson
5h 57m
1 stop
LSE5:58 pmLa Crosse
Nov 9
LSE6:00 amLa Crosse
8h 48m
2 stops
TYS3:48 pmKnoxville McGhee Tyson
$482
Find similar
American Airlines
Oct 28
TYS11:40 amKnoxville McGhee Tyson
7h 18m
2 stops
LSE5:58 pmLa Crosse
Nov 9
LSE6:00 amLa Crosse
8h 48m
2 stops
TYS3:48 pmKnoxville McGhee Tyson
$487
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 29, 2025.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Tue 10/28

1:01 pm-5:58 pm

1 stop5h 57m

La Crosse

Sun 11/9

9:50 am-5:46 pm

1 stop6h 56m

$476

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Tue 10/28

1:01 pm-5:58 pm

1 stop5h 57m

La Crosse

Sun 11/9

6:00 am-3:48 pm

2 stops8h 48m

$482

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Tue 10/28

11:40 am-5:58 pm

2 stops7h 18m

La Crosse

Sun 11/9

6:00 am-3:48 pm

2 stops8h 48m

$487

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 3/25

8:15 am-2:18 pm

1 stop7h 03m

La Crosse

Sat 3/28

4:46 pm-9:14 pm

1 stop3h 28m

$583

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 3/25

8:02 am-2:18 pm

2 stops7h 16m

La Crosse

Sat 3/28

4:46 pm-9:14 pm

1 stop3h 28m

$589

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 3/25

8:02 am-2:18 pm

2 stops7h 16m

La Crosse

Sat 3/28

1:03 pm-9:43 pm

2 stops7h 40m

$594

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Direct flights

None
There are no direct flights from Knoxville to La Crosse. There are no popular flight routes from Knoxville to La Crosse.
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  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 5h 57m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to La Crosse?

Best airlines flying from Knoxville to La Crosse

Compare and see reviews for airlines that fly from Knoxville to La Crosse with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $400Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

  • How do I get Price Alerts for flights from Knoxville to La Crosse?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Knoxville from La Crosse. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Knoxville to La Crosse with momondo?

    Plan your trips smart with the “Price Forecast” feature, which uses flight data to help you pick the best days to fly for the lowest fares. Our “Price Calendar” helps you get the most for your money by showing you when it’s most advantageous to fly. Curate your own travel experiences for less with “Explore”. Expert travel hacks to fuel your next adventure are a click away with “Discover” by momondo. Set up our “Price Alerts” to track fare changes and book when prices are at their lowest point.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Winona
Onalaska
Decorah
Lansing
Harpers Ferry

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to La Crosse?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to La Crosse for you.

Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

I’m not ready to book a flight from Knoxville to La Crosse right now. Can momondo alert me if prices change?

Price alerts on flights to La Crosse from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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