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Cheap flights from Knoxville to La Crosse from $378

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 10/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

American Airlines Logo
12:51 pm - 5:51 pmTYS-LSE
6h 00m1 stop
American Airlines Logo
6:00 am - 12:21 pmLSE-TYS
5h 21m1 stop
$464American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
2:07 pm - 10:08 pmTYS-LSE
9h 01m2 stops
American Airlines Logo
6:00 am - 12:21 pmLSE-TYS
5h 21m1 stop
$470American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28
American Airlines Logo
3:09 pm - 10:08 pmTYS-LSE
7h 59m2 stops
American Airlines Logo
6:00 am - 1:54 pmLSE-TYS
6h 54m2 stops
$475American Airlines
Find Deal
Fri, Sep 26 - Sun, Sep 28

American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Sep 26
TYS12:51 pmKnoxville McGhee Tyson
6h 00m
1 stop
LSE5:51 pmLa Crosse
Sep 28
LSE6:00 amLa Crosse
5h 21m
1 stop
TYS12:21 pmKnoxville McGhee Tyson
$464
Find similar
American Airlines
Sep 26
TYS2:07 pmKnoxville McGhee Tyson
9h 01m
2 stops
LSE10:08 pmLa Crosse
Sep 28
LSE6:00 amLa Crosse
5h 21m
1 stop
TYS12:21 pmKnoxville McGhee Tyson
$470
Find similar
American Airlines
Sep 26
TYS3:09 pmKnoxville McGhee Tyson
7h 59m
2 stops
LSE10:08 pmLa Crosse
Sep 28
LSE6:00 amLa Crosse
6h 54m
2 stops
TYS1:54 pmKnoxville McGhee Tyson
$475
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2025.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 9/26

12:51 pm-5:51 pm

1 stop6h 00m

La Crosse

Sun 9/28

6:00 am-12:21 pm

1 stop5h 21m

$464

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 9/26

2:07 pm-10:08 pm

2 stops9h 01m

La Crosse

Sun 9/28

6:00 am-12:21 pm

1 stop5h 21m

$470

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 9/26

3:09 pm-10:08 pm

2 stops7h 59m

La Crosse

Sun 9/28

6:00 am-1:54 pm

2 stops6h 54m

$475

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 10/25

5:35 pm-10:05 pm

1 stop5h 30m

$378

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 10/25

2:52 pm-10:05 pm

2 stops8h 13m

$384

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to La Crosse from

How to get the cheapest flight ticket from Knoxville to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to La Crosse?

American Airlines is the most popular carrier operating from Knoxville McGhee Tyson to La Crosse

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Best Price Found

$378

Fastest flight time

5h 30m

Direct flights

None

Airports in La Crosse

1 airport
The best one-way flight to La Crosse from Knoxville in the past 72 hours is $378. The best round-trip flight deal from Knoxville to La Crosse found on momondo in the last 72 hours is $464.
The fastest flight from Knoxville to La Crosse takes 5h 30m
There are no direct flights from Knoxville to La Crosse. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - La Crosse Airport.
There is 1 airport near La Crosse: La Crosse (LSE)
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  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 6h 00m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to La Crosse?

Best airlines flying from Knoxville to La Crosse

Compare and see reviews for airlines that fly from Knoxville to La Crosse with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $400Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Winona
Onalaska
Decorah
Harpers Ferry
Lansing

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Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

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Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

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