Latest deals
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to La Crosse from $346

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 4/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:31 am - 6:07 pm
TYS
-
LSE
7h 36m
1 stop
American Airlines Logo
10:05 am - 9:21 pm
LSE
-
TYS
10h 16m
1 stop
$346American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
11:31 am - 6:07 pm
TYS
-
LSE
7h 36m
1 stop
American Airlines Logo
10:05 am - 10:56 pm
LSE
-
TYS
11h 51m
2 stops
$387American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
6:54 am - 6:07 pm
TYS
-
LSE
12h 13m
2 stops
American Airlines Logo
5:40 am - 4:40 pm
LSE
-
TYS
10h 00m
1 stop
$396American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
4:02 pm - 11:01 am
TYS
-
LSE
19h 59m
1 stop
American Airlines Logo
6:29 pm - 4:31 pm
LSE
-
TYS
21h 02m
1 stop
$406American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
6:54 am - 6:07 pm
TYS
-
LSE
12h 13m
2 stops
American Airlines Logo
10:05 am - 9:26 pm
LSE
-
TYS
10h 21m
2 stops
$436American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
12:22 pm - 11:36 pm
TYS
-
LSE
12h 14m
2 stops
American Airlines Logo
6:29 pm - 4:31 pm
LSE
-
TYS
21h 02m
1 stop
$442American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
6:33 pm - 11:01 am
TYS
-
LSE
17h 28m
1 stop
American Airlines Logo
5:25 pm - 10:56 am
LSE
-
TYS
16h 31m
1 stop
$445American Airlines
Thu, Jul 23 - Mon, Jul 27
American Airlines Logo
7:00 am - 6:07 pm
TYS
-
LSE
12h 07m
2 stops
American Airlines Logo
10:05 am - 9:26 pm
LSE
-
TYS
10h 21m
2 stops
$468American Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
6:33 pm - 11:01 am
TYS
-
LSE
17h 28m
1 stop
American Airlines Logo
5:25 pm - 10:56 am
LSE
-
TYS
16h 31m
1 stop
$469American Airlines
Thu, Jul 23 - Mon, Jul 27
American Airlines Logo
7:40 am - 11:02 am
TYS
-
LSE
4h 22m
1 stop
American Airlines Logo
11:34 am - 4:31 pm
LSE
-
TYS
3h 57m
1 stop
$530American Airlines
Sun, Mar 15 - Thu, Mar 19

American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Apr 24
TYS11:31 amKnoxville McGhee Tyson
7h 36m
1 stop
LSE6:07 pmLa Crosse
Apr 28
LSE10:05 amLa Crosse
10h 16m
1 stop
TYS9:21 pmKnoxville McGhee Tyson
$346
American Airlines
Apr 24
TYS11:31 amKnoxville McGhee Tyson
7h 36m
1 stop
LSE6:07 pmLa Crosse
Apr 28
LSE10:05 amLa Crosse
11h 51m
2 stops
TYS10:56 pmKnoxville McGhee Tyson
$387
American Airlines
Apr 24
TYS6:54 amKnoxville McGhee Tyson
12h 13m
2 stops
LSE6:07 pmLa Crosse
Apr 28
LSE5:40 amLa Crosse
10h 00m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
$396

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 4/24

11:31 am-6:07 pm

1 stop7h 36m

La Crosse

Tue 4/28

10:05 am-9:21 pm

1 stop10h 16m

$346

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 4/24

11:31 am-6:07 pm

1 stop7h 36m

La Crosse

Tue 4/28

10:05 am-10:56 pm

2 stops11h 51m

$387

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 4/24

6:54 am-6:07 pm

2 stops12h 13m

La Crosse

Tue 4/28

5:40 am-4:40 pm

1 stop10h 00m

$396

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 2/25

4:02 pm-11:01 am

1 stop19h 59m

La Crosse

Sun 3/1

6:29 pm-4:31 pm

1 stop21h 02m

$406

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 4/24

6:54 am-6:07 pm

2 stops12h 13m

La Crosse

Tue 4/28

10:05 am-9:26 pm

2 stops10h 21m

$436

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 2/25

12:22 pm-11:36 pm

2 stops12h 14m

La Crosse

Sun 3/1

6:29 pm-4:31 pm

1 stop21h 02m

$442

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 7/23

6:33 pm-11:01 am

1 stop17h 28m

La Crosse

Mon 7/27

5:25 pm-10:56 am

1 stop16h 31m

$445

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Fri 4/24

7:00 am-6:07 pm

2 stops12h 07m

La Crosse

Tue 4/28

10:05 am-9:26 pm

2 stops10h 21m

$468

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 7/23

6:33 pm-11:01 am

1 stop17h 28m

La Crosse

Mon 7/27

5:25 pm-10:56 am

1 stop16h 31m

$469

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sun 3/15

7:40 am-11:02 am

1 stop4h 22m

La Crosse

Thu 3/19

11:34 am-4:31 pm

1 stop3h 57m

$530

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Fastest flight time

4h 22m

Direct flights

None
The fastest flight from Knoxville to La Crosse takes 4h 22m
There are no direct flights from Knoxville to La Crosse. There are no popular flight routes from Knoxville to La Crosse.
Search flight deals

  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 4h 22m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to La Crosse?

Best airlines flying from Knoxville to La Crosse

Compare and see reviews for airlines that fly from Knoxville to La Crosse with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $420Free CancellationRating
7.2
11,275 reviews
Search American Airlines flights

  • How do I get Price Alerts for flights from Knoxville to La Crosse?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Knoxville from La Crosse. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Knoxville to La Crosse with momondo?

    Plan your trips smart with the “Price Forecast” feature, which uses flight data to help you pick the best days to fly for the lowest fares. Our “Price Calendar” helps you get the most for your money by showing you when it’s most advantageous to fly. Curate your own travel experiences for less with “Explore”. Expert travel hacks to fuel your next adventure are a click away with “Discover” by momondo. Set up our “Price Alerts” to track fare changes and book when prices are at their lowest point.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to La Crosse?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to La Crosse for you.

Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

I’m not ready to book a flight from Knoxville to La Crosse right now. Can momondo alert me if prices change?

Price alerts on flights to La Crosse from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your La Crosse trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 3/15
Sun 3/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States