Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Knoxville to La Crosse from $373

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 4/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:48 pm - 11:54 pm
TYS
-
LSE
4h 06m
1 stop
American Airlines Logo
5:40 am - 11:18 am
LSE
-
TYS
4h 38m
1 stop
$373American Airlines
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
2:06 pm - 11:54 pm
TYS
-
LSE
10h 48m
2 stops
American Airlines Logo
5:40 am - 11:18 am
LSE
-
TYS
4h 38m
1 stop
$379American Airlines
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
4:09 pm - 11:54 pm
TYS
-
LSE
8h 45m
2 stops
American Airlines Logo
10:05 am - 9:57 pm
LSE
-
TYS
10h 52m
2 stops
$384American Airlines
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
8:48 pm - 11:54 pm
TYS
-
LSE
4h 06m
1 stop
American Airlines Logo
6:37 pm - 11:18 am
LSE
-
TYS
15h 41m
1 stop
$581American Airlines
Thu, Apr 30 - Fri, May 1
American Airlines Logo
7:06 am - 11:15 am
TYS
-
LSE
5h 09m
1 stop
American Airlines Logo
11:45 am - 6:57 pm
LSE
-
TYS
6h 12m
1 stop
$676American Airlines
Sun, Jul 5 - Sun, Jul 19
American Airlines Logo
8:48 pm - 11:54 pm
TYS
-
LSE
4h 06m
1 stop
American Airlines Logo
10:05 am - 4:40 pm
LSE
-
TYS
5h 35m
1 stop
$680American Airlines
Mon, Apr 13 - Thu, Apr 16
American Airlines Logo
5:03 am - 11:15 am
TYS
-
LSE
7h 12m
2 stops
American Airlines Logo
6:00 am - 12:49 pm
LSE
-
TYS
5h 49m
1 stop
$682American Airlines
Sun, Jul 5 - Sun, Jul 19
American Airlines Logo
3:58 pm - 11:54 pm
TYS
-
LSE
8h 56m
2 stops
American Airlines Logo
5:40 am - 11:18 am
LSE
-
TYS
4h 38m
1 stop
$686American Airlines
Mon, Apr 13 - Thu, Apr 16
American Airlines Logo
2:49 pm - 11:54 pm
TYS
-
LSE
10h 05m
2 stops
American Airlines Logo
5:40 am - 2:24 pm
LSE
-
TYS
7h 44m
2 stops
$691American Airlines
Mon, Apr 13 - Thu, Apr 16
American Airlines Logo
8:48 pm - 11:54 pm
TYS
-
LSE
4h 06m
1 stop
American Airlines Logo
10:05 am - 10:24 pm
LSE
-
TYS
11h 19m
2 stops
$692American Airlines
Thu, Apr 30 - Fri, May 1

American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Apr 11
TYS8:48 pmKnoxville McGhee Tyson
4h 06m
1 stop
LSE11:54 pmLa Crosse
Apr 15
LSE5:40 amLa Crosse
4h 38m
1 stop
TYS11:18 amKnoxville McGhee Tyson
$373
American Airlines
Apr 11
TYS2:06 pmKnoxville McGhee Tyson
10h 48m
2 stops
LSE11:54 pmLa Crosse
Apr 15
LSE5:40 amLa Crosse
4h 38m
1 stop
TYS11:18 amKnoxville McGhee Tyson
$379
American Airlines
Apr 11
TYS4:09 pmKnoxville McGhee Tyson
8h 45m
2 stops
LSE11:54 pmLa Crosse
Apr 15
LSE10:05 amLa Crosse
10h 52m
2 stops
TYS9:57 pmKnoxville McGhee Tyson
$384

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 4/11

8:48 pm-11:54 pm

1 stop4h 06m

La Crosse

Wed 4/15

5:40 am-11:18 am

1 stop4h 38m

$373

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 4/11

2:06 pm-11:54 pm

2 stops10h 48m

La Crosse

Wed 4/15

5:40 am-11:18 am

1 stop4h 38m

$379

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sat 4/11

4:09 pm-11:54 pm

2 stops8h 45m

La Crosse

Wed 4/15

10:05 am-9:57 pm

2 stops10h 52m

$384

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 4/30

8:48 pm-11:54 pm

1 stop4h 06m

La Crosse

Fri 5/1

6:37 pm-11:18 am

1 stop15h 41m

$581

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sun 7/5

7:06 am-11:15 am

1 stop5h 09m

La Crosse

Sun 7/19

11:45 am-6:57 pm

1 stop6h 12m

$676

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 4/13

8:48 pm-11:54 pm

1 stop4h 06m

La Crosse

Thu 4/16

10:05 am-4:40 pm

1 stop5h 35m

$680

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Sun 7/5

5:03 am-11:15 am

2 stops7h 12m

La Crosse

Sun 7/19

6:00 am-12:49 pm

1 stop5h 49m

$682

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 4/13

3:58 pm-11:54 pm

2 stops8h 56m

La Crosse

Thu 4/16

5:40 am-11:18 am

1 stop4h 38m

$686

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 4/13

2:49 pm-11:54 pm

2 stops10h 05m

La Crosse

Thu 4/16

5:40 am-2:24 pm

2 stops7h 44m

$691

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 4/30

8:48 pm-11:54 pm

1 stop4h 06m

La Crosse

Fri 5/1

10:05 am-10:24 pm

2 stops11h 19m

$692

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to La Crosse from

How to get the cheapest flight ticket from Knoxville to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to La Crosse flights?

You could potentially save up to 7% on your flight if you consider stops on a Knoxville to La Crosse flight.

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Knoxville to La Crosse takes 4h 06m
There are no direct flights from Knoxville to La Crosse. There are no popular flight routes from Knoxville to La Crosse.
Search flight deals

  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 4h 06m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to La Crosse?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to La Crosse for you.

Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

I’m not ready to book a flight from Knoxville to La Crosse right now. Can momondo alert me if prices change?

Price alerts on flights to La Crosse from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your La Crosse trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 4/29
Wed 5/6
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States