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Cheap flights from Knoxville to La Crosse from $381

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to La Crosse departing on 9/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Knoxville to La Crosse

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:00 am - 11:22 am
TYS
-
LSE
4h 22m
1 stop
American Airlines Logo
5:22 pm - 10:42 pm
LSE
-
TYS
4h 20m
1 stop
$381American Airlines
Thu, Sep 24 - Sat, Sep 26
American Airlines Logo
8:15 pm - 12:20 am
TYS
-
LSE
5h 05m
1 stop
American Airlines Logo
12:26 pm - 11:07 pm
LSE
-
TYS
9h 41m
2 stops
$423American Airlines
Thu, Sep 24 - Sat, Sep 26
American Airlines Logo
6:32 pm - 11:59 pm
TYS
-
LSE
6h 27m
1 stop
American Airlines Logo
12:01 pm - 9:33 pm
LSE
-
TYS
8h 32m
2 stops
$442American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
4:07 pm - 11:59 pm
TYS
-
LSE
8h 52m
2 stops
American Airlines Logo
12:01 pm - 9:33 pm
LSE
-
TYS
8h 32m
2 stops
$447American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
7:02 am - 11:31 am
TYS
-
LSE
5h 29m
1 stop
American Airlines Logo
12:01 pm - 9:33 pm
LSE
-
TYS
8h 32m
2 stops
$459American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
6:07 pm - 11:59 pm
TYS
-
LSE
6h 52m
2 stops
American Airlines Logo
12:01 pm - 9:33 pm
LSE
-
TYS
8h 32m
2 stops
$464American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
6:32 pm - 11:59 pm
TYS
-
LSE
6h 27m
1 stop
American Airlines Logo
12:01 pm - 5:49 pm
LSE
-
TYS
4h 48m
1 stop
$472American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
2:00 pm - 12:20 am
TYS
-
LSE
11h 20m
2 stops
American Airlines Logo
12:26 pm - 11:07 pm
LSE
-
TYS
9h 41m
2 stops
$483American Airlines
Thu, Sep 24 - Sat, Sep 26
American Airlines Logo
6:32 pm - 11:59 pm
TYS
-
LSE
6h 27m
1 stop
American Airlines Logo
12:01 pm - 5:49 pm
LSE
-
TYS
4h 48m
1 stop
$492American Airlines
Mon, Jul 27 - Sat, Aug 1
American Airlines Logo
7:02 am - 11:31 am
TYS
-
LSE
5h 29m
1 stop
American Airlines Logo
6:00 am - 10:51 am
LSE
-
TYS
3h 51m
1 stop
$575American Airlines
Mon, Jul 27 - Sat, Aug 1

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American Airlines flights from Knoxville to La Crosse

Our best American Airlines deals on Knoxville to La Crosse flight tickets
American Airlines
Sep 24
TYS8:00 amKnoxville McGhee Tyson
4h 22m
1 stop
LSE11:22 amLa Crosse
Sep 26
LSE5:22 pmLa Crosse
4h 20m
1 stop
TYS10:42 pmKnoxville McGhee Tyson
$381
American Airlines
Sep 24
TYS8:15 pmKnoxville McGhee Tyson
5h 05m
1 stop
LSE12:20 amLa Crosse
Sep 26
LSE12:26 pmLa Crosse
9h 41m
2 stops
TYS11:07 pmKnoxville McGhee Tyson
$423
American Airlines
Jul 27
TYS6:32 pmKnoxville McGhee Tyson
6h 27m
1 stop
LSE11:59 pmLa Crosse
Aug 1
LSE12:01 pmLa Crosse
8h 32m
2 stops
TYS9:33 pmKnoxville McGhee Tyson
$442

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 8, 2026.
Use the filters below to find and compare flights from Knoxville to La Crosse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 9/24

8:00 am-11:22 am

1 stop4h 22m

La Crosse

Sat 9/26

5:22 pm-10:42 pm

1 stop4h 20m

$381

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 9/24

8:15 pm-12:20 am

1 stop5h 05m

La Crosse

Sat 9/26

12:26 pm-11:07 pm

2 stops9h 41m

$423

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

6:32 pm-11:59 pm

1 stop6h 27m

La Crosse

Sat 8/1

12:01 pm-9:33 pm

2 stops8h 32m

$442

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

4:07 pm-11:59 pm

2 stops8h 52m

La Crosse

Sat 8/1

12:01 pm-9:33 pm

2 stops8h 32m

$447

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

7:02 am-11:31 am

1 stop5h 29m

La Crosse

Sat 8/1

12:01 pm-9:33 pm

2 stops8h 32m

$459

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

6:07 pm-11:59 pm

2 stops6h 52m

La Crosse

Sat 8/1

12:01 pm-9:33 pm

2 stops8h 32m

$464

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

6:32 pm-11:59 pm

1 stop6h 27m

La Crosse

Sat 8/1

12:01 pm-5:49 pm

1 stop4h 48m

$472

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Thu 9/24

2:00 pm-12:20 am

2 stops11h 20m

La Crosse

Sat 9/26

12:26 pm-11:07 pm

2 stops9h 41m

$483

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

6:32 pm-11:59 pm

1 stop6h 27m

La Crosse

Sat 8/1

12:01 pm-5:49 pm

1 stop4h 48m

$492

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Mon 7/27

7:02 am-11:31 am

1 stop5h 29m

La Crosse

Sat 8/1

6:00 am-10:51 am

1 stop3h 51m

$575

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to La Crosse from

How to get the cheapest flight ticket from Knoxville to La Crosse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to La Crosse flights?

You could potentially save up to 66% on your flight if you consider stops on a Knoxville to La Crosse flight.

When to book flights from Knoxville to La Crosse

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to La Crosse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to La Crosse (TYS to LSE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to La Crosse

Fastest flight time

4h 22m

Direct flights

None
The fastest flight from Knoxville to La Crosse takes 4h 22m
There are no direct flights from Knoxville to La Crosse. There are no popular flight routes from Knoxville to La Crosse.
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Frequently asked questions about flying from Knoxville to La Crosse

  • How far is Knoxville McGhee Tyson to La Crosse by plane?

    There are 665.3 mi between Knoxville McGhee Tyson and La Crosse. 4h 22m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to La Crosse Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to La Crosse Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to La Crosse Airport.

  • What documentation or ID do you need to fly to La Crosse Airport?

    The required travel and health documents for your La Crosse Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at La Crosse Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near La Crosse?

Book flights to La Crosse if you plan to visit one of these locations
Onalaska
Winona
Decorah
Harpers Ferry
Lansing

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to La Crosse?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to La Crosse for you.

Can I find flights from Knoxville to La Crosse with flexible booking policies on momondo?

All flight searches from Knoxville to La Crosse on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to La Crosse?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to La Crosse from Knoxville.

I’m not ready to book a flight from Knoxville to La Crosse right now. Can momondo alert me if prices change?

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