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Cheap flights from Knoxville to Columbia from $318

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Columbia departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Columbia

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:40 am - 9:25 am
TYS
-
CAE
3h 45m
1 stop
Delta Logo
3:54 pm - 8:14 pm
CAE
-
TYS
4h 20m
1 stop
$367Delta
Thu, Jun 18 - Mon, Jun 22
Delta Logo
7:27 am - 1:14 pm
TYS
-
CAE
5h 47m
1 stop
Delta Logo
6:01 pm - 11:54 pm
CAE
-
TYS
5h 53m
1 stop
$417Delta
Wed, Jun 3 - Wed, Jun 10
Delta Logo
3:30 pm - 9:14 pm
TYS
-
CAE
5h 44m
1 stop
Delta Logo
5:40 am - 9:34 am
CAE
-
TYS
3h 54m
1 stop
$425Delta
Fri, May 29 - Tue, Jun 2
American Airlines Logo
5:00 am - 8:16 am
TYS
-
CAE
3h 16m
1 stop
American Airlines Logo
8:30 pm - 11:47 pm
CAE
-
TYS
3h 17m
1 stop
$497American Airlines
Mon, Jun 15 - Sun, Jun 21
American Airlines Logo
5:00 am - 8:16 am
TYS
-
CAE
3h 16m
1 stop
American Airlines Logo
8:30 pm - 11:47 pm
CAE
-
TYS
3h 17m
1 stop
$667American Airlines
Sun, May 31 - Thu, Jun 4
United Airlines Logo
1:35 pm - 9:56 am
TYS
-
CAE
20h 21m
1 stop
United Airlines Logo
7:45 pm - 8:56 pm
CAE
-
TYS
25h 11m
2 stops
$692United Airlines
Wed, Jun 3 - Wed, Jun 10
American Airlines Logo
6:00 am - 2:05 pm
TYS
-
CAE
8h 05m
2 stops
American Airlines Logo
6:03 pm - 11:47 pm
CAE
-
TYS
5h 44m
1 stop
$696American Airlines
Thu, Jun 18 - Mon, Jun 22
United Airlines Logo
7:19 pm - 9:56 am
TYS
-
CAE
14h 37m
1 stop
United Airlines Logo
5:41 pm - 8:34 pm
CAE
-
TYS
26h 53m
2 stops
$742United Airlines
Fri, May 29 - Tue, Jun 2
United Airlines Logo
6:00 am - 9:56 am
TYS
-
CAE
27h 56m
2 stops
United Airlines Logo
7:45 pm - 8:56 pm
CAE
-
TYS
25h 11m
2 stops
$747United Airlines
Wed, Jun 3 - Wed, Jun 10
United Airlines Logo
7:19 pm - 10:39 am
TYS
-
CAE
15h 20m
2 stops
United Airlines Logo
10:31 am - 11:54 pm
CAE
-
TYS
13h 23m
1 stop
$851United Airlines
Mon, Jun 15 - Sun, Jun 21

Delta flights from Knoxville to Columbia

Our best Delta deals on Knoxville to Columbia flight tickets
Delta
Jun 18
TYS5:40 amKnoxville McGhee Tyson
3h 45m
1 stop
CAE9:25 amColumbia Metropolitan
Jun 22
CAE3:54 pmColumbia Metropolitan
4h 20m
1 stop
TYS8:14 pmKnoxville McGhee Tyson
$367
Delta
Jun 3
TYS11:56 amKnoxville McGhee Tyson
3h 11m
1 stop
CAE3:07 pmColumbia Metropolitan
Jun 10
CAE6:01 pmColumbia Metropolitan
5h 53m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
$417
Delta
May 29
TYS3:30 pmKnoxville McGhee Tyson
5h 44m
1 stop
CAE9:14 pmColumbia Metropolitan
Jun 2
CAE5:40 amColumbia Metropolitan
3h 54m
1 stop
TYS9:34 amKnoxville McGhee Tyson
$425

American Airlines flights from Knoxville to Columbia

Our best American Airlines deals on Knoxville to Columbia flight tickets
American Airlines
Jun 15
TYS5:00 amKnoxville McGhee Tyson
3h 16m
1 stop
CAE8:16 amColumbia Metropolitan
Jun 21
CAE8:30 pmColumbia Metropolitan
3h 17m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$497
American Airlines
May 31
TYS5:00 amKnoxville McGhee Tyson
3h 16m
1 stop
CAE8:16 amColumbia Metropolitan
Jun 4
CAE8:30 pmColumbia Metropolitan
3h 17m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$667
American Airlines
Jun 18
TYS6:00 amKnoxville McGhee Tyson
8h 05m
2 stops
CAE2:05 pmColumbia Metropolitan
Jun 22
CAE6:03 pmColumbia Metropolitan
5h 44m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$696

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Knoxville to Columbia that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Thu 6/18

5:40 am-9:25 am

1 stop3h 45m

Columbia Metropolitan

Mon 6/22

3:54 pm-8:14 pm

1 stop4h 20m

$367

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 6/3

7:27 am-1:14 pm

1 stop5h 47m

Columbia Metropolitan

Wed 6/10

6:01 pm-11:54 pm

1 stop5h 53m

$417

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Fri 5/29

3:30 pm-9:14 pm

1 stop5h 44m

Columbia Metropolitan

Tue 6/2

5:40 am-9:34 am

1 stop3h 54m

$425
Quickest round-trip

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Mon 6/15

5:00 am-8:16 am

1 stop3h 16m

Columbia Metropolitan

Sun 6/21

8:30 pm-11:47 pm

1 stop3h 17m

$497

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Sun 5/31

5:00 am-8:16 am

1 stop3h 16m

Columbia Metropolitan

Thu 6/4

8:30 pm-11:47 pm

1 stop3h 17m

$667

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 6/3

1:35 pm-9:56 am

1 stop20h 21m

Columbia Metropolitan

Wed 6/10

7:45 pm-8:56 pm

2 stops25h 11m

$692

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Thu 6/18

6:00 am-2:05 pm

2 stops8h 05m

Columbia Metropolitan

Mon 6/22

6:03 pm-11:47 pm

1 stop5h 44m

$696

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Fri 5/29

7:19 pm-9:56 am

1 stop14h 37m

Columbia Metropolitan

Tue 6/2

5:41 pm-8:34 pm

2 stops26h 53m

$742

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 6/3

6:00 am-9:56 am

2 stops27h 56m

Columbia Metropolitan

Wed 6/10

7:45 pm-8:56 pm

2 stops25h 11m

$747

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Mon 6/15

7:19 pm-10:39 am

2 stops15h 20m

Columbia Metropolitan

Sun 6/21

10:31 am-11:54 pm

1 stop13h 23m

$851

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Columbia from

How to get the cheapest flight ticket from Knoxville to Columbia

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to Columbia Metropolitan?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Columbia Metropolitan

When to book flights from Knoxville to Columbia

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Columbia according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Columbia (TYS to CAE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Columbia

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Knoxville to Columbia takes 3h 45m
There are no direct flights from Knoxville to Columbia. There are no popular flight routes from Knoxville to Columbia.
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Frequently asked questions about flying from Knoxville to Columbia

  • How far is Knoxville McGhee Tyson to Columbia Metropolitan by plane?

    A flight from Knoxville McGhee Tyson to Columbia Metropolitan will travel around 212.0 mi. 3h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Columbia Metropolitan Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Columbia Metropolitan Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Columbia Metropolitan Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Columbia Metropolitan Airport.

  • What documentation or ID do you need to fly to Columbia Metropolitan Airport?

    The travel and health documents you'll need for your trip to Columbia Metropolitan Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Columbia Metropolitan Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Orangeburg
Lexington
West Columbia
Irmo
Swansea

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Columbia?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Columbia for you.

Can I find flights from Knoxville to Columbia with flexible booking policies on momondo?

Flights from Knoxville to Columbia with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Columbia?

Once all potential Knoxville to Columbia flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Columbia right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Columbia, momondo offers a useful price alert feature which will track prices for flights to Columbia from Knoxville and alert you when they change.

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