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Cheap flights from Key West to South Carolina from $90

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to South Carolina departing on 2/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:06 pm - 8:33 am
EYW
-
CLT
19h 27m
1 stop
Multiple Airlines Logo
1:07 pm - 12:26 pm
CLT
-
EYW
23h 19m
1 stop
$174Multiple Airlines
Fri, Feb 20 - Sun, Feb 22
Multiple Airlines Logo
1:06 pm - 8:33 am
EYW
-
CLT
19h 27m
1 stop
Multiple Airlines Logo
7:13 pm - 12:26 pm
CLT
-
EYW
17h 13m
2 stops
$216Multiple Airlines
Fri, Feb 20 - Sun, Feb 22
Multiple Airlines Logo
1:01 pm - 11:56 pm
EYW
-
CLT
10h 55m
2 stops
Multiple Airlines Logo
5:49 pm - 9:06 am
CLT
-
EYW
15h 17m
1 stop
$221Multiple Airlines
Tue, Feb 17 - Sat, Feb 21
Spirit Airlines Logo
2:35 pm - 8:17 pm
EYW
-
CLT
5h 42m
1 stop
Spirit Airlines Logo
6:00 am - 11:30 am
CLT
-
EYW
5h 30m
1 stop
$235Spirit Airlines
Fri, Mar 20 - Sun, Mar 22
Spirit Airlines Logo
2:25 pm - 11:56 pm
EYW
-
CLT
9h 31m
1 stop
Spirit Airlines Logo
7:00 am - 1:30 pm
CLT
-
EYW
30h 30m
3 stops
$340Spirit Airlines
Fri, Feb 20 - Sun, Feb 22
American Airlines Logo
4:40 pm - 11:57 pm
EYW
-
SAV
7h 17m
1 stop
American Airlines Logo
5:00 am - 11:11 am
SAV
-
EYW
6h 11m
1 stop
$383American Airlines
Fri, Mar 6 - Wed, Mar 18
American Airlines Logo
7:45 pm - 11:59 pm
EYW
-
SAV
4h 14m
1 stop
American Airlines Logo
5:00 am - 11:11 am
SAV
-
EYW
6h 11m
1 stop
$387American Airlines
Wed, Feb 25 - Sun, Mar 1
United Airlines Logo
6:35 pm - 10:09 am
EYW
-
CHS
15h 34m
1 stop
United Airlines Logo
5:05 pm - 3:00 pm
CHS
-
EYW
21h 55m
1 stop
$650United Airlines
Thu, Feb 26 - Sun, Mar 1
United Airlines Logo
6:35 pm - 10:09 am
EYW
-
CHS
15h 34m
1 stop
United Airlines Logo
5:05 pm - 5:44 pm
CHS
-
EYW
24h 39m
2 stops
$655United Airlines
Thu, Feb 26 - Sun, Mar 1
Delta Logo
2:46 pm - 7:56 pm
EYW
-
CHS
5h 10m
1 stop
Delta Logo
3:07 pm - 7:42 pm
CHS
-
EYW
4h 35m
1 stop
$695Delta
Mon, Feb 16 - Fri, Feb 20

Spirit Airlines flights from Key West to South Carolina

Our best Spirit Airlines deals on Key West to South Carolina flight tickets
Spirit Airlines
Mar 20
EYW2:35 pmKey West
5h 42m
1 stop
CLT8:17 pmCharlotte Douglas
Mar 22
CLT6:00 amCharlotte Douglas
5h 30m
1 stop
EYW11:30 amKey West
$235
Spirit Airlines
Feb 20
EYW2:25 pmKey West
9h 31m
1 stop
CLT11:56 pmCharlotte Douglas
Feb 22
CLT7:00 amCharlotte Douglas
30h 30m
3 stops
EYW1:30 pmKey West
$340
Spirit Airlines
Mar 20
EYW2:35 pmKey West
23h 17m
3 stops
CLT1:52 pmCharlotte Douglas
Mar 22
CLT6:00 amCharlotte Douglas
5h 30m
1 stop
EYW11:30 amKey West
$350

American Airlines flights from Key West to South Carolina

Our best American Airlines deals on Key West to South Carolina flight tickets
American Airlines
Feb 25
EYW7:45 pmKey West
4h 14m
1 stop
SAV11:59 pmSavannah/Hilton Head
Mar 1
SAV5:00 amSavannah/Hilton Head
6h 11m
1 stop
EYW11:11 amKey West
$387
American Airlines
Feb 25
EYW1:55 pmKey West
8h 59m
2 stops
SAV10:54 pmSavannah/Hilton Head
Mar 1
SAV5:00 amSavannah/Hilton Head
6h 11m
1 stop
EYW11:11 amKey West
$392
American Airlines
Feb 18
EYW3:20 pmKey West
6h 02m
1 stop
CHS9:22 pmCharleston
Feb 22
CHS5:10 amCharleston
6h 01m
1 stop
EYW11:11 amKey West
$447

momondo Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/20

1:06 pm-8:33 am

1 stop19h 27m

Charlotte Douglas

Sun 2/22

1:07 pm-12:26 pm

1 stop23h 19m

$174

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/20

1:06 pm-8:33 am

1 stop19h 27m

Charlotte Douglas

Sun 2/22

7:13 pm-12:26 pm

2 stops17h 13m

$216

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 2/17

1:01 pm-11:56 pm

2 stops10h 55m

Charlotte Douglas

Sat 2/21

5:49 pm-9:06 am

1 stop15h 17m

$221

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 3/20

2:35 pm-8:17 pm

1 stop5h 42m

Charlotte Douglas

Sun 3/22

6:00 am-11:30 am

1 stop5h 30m

$235

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/20

2:25 pm-11:56 pm

1 stop9h 31m

Charlotte Douglas

Sun 2/22

7:00 am-1:30 pm

3 stops30h 30m

$340

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 3/6

4:40 pm-11:57 pm

1 stop7h 17m

Savannah/Hilton Head

Wed 3/18

5:00 am-11:11 am

1 stop6h 11m

$383

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Wed 2/25

7:45 pm-11:59 pm

1 stop4h 14m

Savannah/Hilton Head

Sun 3/1

5:00 am-11:11 am

1 stop6h 11m

$387

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 2/26

6:35 pm-10:09 am

1 stop15h 34m

Charleston

Sun 3/1

5:05 pm-3:00 pm

1 stop21h 55m

$650

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 2/26

6:35 pm-10:09 am

1 stop15h 34m

Charleston

Sun 3/1

5:05 pm-5:44 pm

2 stops24h 39m

$655

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Mon 2/16

2:46 pm-7:56 pm

1 stop5h 10m

Charleston

Fri 2/20

3:07 pm-7:42 pm

1 stop4h 35m

$695

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Key West to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Key West to South Carolina flights?

You could potentially save up to 61% on your flight if you consider stops on a Key West to South Carolina flight.

Cheap Key West to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to South Carolina

Fastest flight time

5h 42m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in South Carolina

57 airports
The fastest flight from Key West to South Carolina takes 5h 42m
Direct flights go from Key West to South Carolina on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There are 57 airports in South Carolina. From Key West there are direct flights to Charlotte Douglas (CLT).
Search flight deals

  • When did momondo last update prices for flights from Key West Airport to South Carolina?

    Prices for flights from Key West Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to South Carolina?

  • How old do you have to be to fly from Key West Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Why use momondo?

Why should I use momondo to find a flight deal from Key West to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Key West.

Can I find flights from Key West to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to South Carolina?

momondo helps you find the best flight between Key West and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Key West to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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