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Cheap flights from Key West to South Carolina from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to South Carolina departing on 11/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Key West to South Carolina

Cheap round-trip flights

Breeze Airways Logo
8:55 am - 8:57 amEYW-CHS
24h 02m1 stop
Breeze Airways Logo
9:23 pm - 11:05 amCHS-EYW
13h 42m1 stop
$213Breeze Airways
Find Deal
Thu, Oct 9 - Mon, Oct 13
Multiple Airlines Logo
10:59 am - 9:06 amEYW-CHS
22h 07m2 stops
Multiple Airlines Logo
9:23 pm - 11:05 amCHS-EYW
13h 42m1 stop
$245Multiple Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
Multiple Airlines Logo
11:45 am - 1:21 pmEYW-CLT
25h 36m1 stop
Multiple Airlines Logo
2:16 pm - 10:19 amCLT-EYW
20h 03m1 stop
$257Multiple Airlines
Find Deal
Tue, Dec 16 - Mon, Dec 22
Multiple Airlines Logo
11:45 am - 11:28 pmEYW-CLT
35h 43m2 stops
Multiple Airlines Logo
10:06 pm - 8:15 amCLT-EYW
10h 09m1 stop
$284Multiple Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11
Delta Logo
2:35 pm - 6:44 pmEYW-SAV
4h 09m1 stop
Delta Logo
10:20 am - 5:13 pmSAV-EYW
6h 53m1 stop
$387Delta
Find Deal
Fri, Feb 6 - Mon, Feb 9
American Airlines Logo
6:31 am - 2:16 pmEYW-SAV
7h 45m2 stops
American Airlines Logo
9:44 am - 1:06 pmSAV-EYW
3h 22m1 stop
$392American Airlines
Find Deal
Fri, Feb 6 - Mon, Feb 9
American Airlines Logo
6:31 am - 2:16 pmEYW-SAV
7h 45m2 stops
American Airlines Logo
6:58 am - 1:06 pmSAV-EYW
6h 08m2 stops
$397American Airlines
Find Deal
Fri, Feb 6 - Mon, Feb 9
Delta Logo
1:57 pm - 7:31 pmEYW-SAV
5h 34m1 stop
Delta Logo
12:14 pm - 5:21 pmSAV-EYW
5h 07m1 stop
$407Delta
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Tue, Oct 14 - Sat, Oct 18
United Airlines Logo
3:12 pm - 2:10 pmEYW-CLT
22h 58m2 stops
United Airlines Logo
6:00 am - 1:52 pmCLT-EYW
31h 52m2 stops
$558United Airlines
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Tue, Oct 21 - Tue, Oct 28
United Airlines Logo
3:12 pm - 2:10 pmEYW-CLT
22h 58m2 stops
United Airlines Logo
7:00 am - 1:52 pmCLT-EYW
6h 52m1 stop
$563United Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28

American Airlines flights from Key West to South Carolina

Our best American Airlines deals on Key West to South Carolina flight tickets
American Airlines
Feb 6
EYW6:31 amKey West
7h 45m
2 stops
SAV2:16 pmSavannah/Hilton Head
Feb 9
SAV9:44 amSavannah/Hilton Head
3h 22m
1 stop
EYW1:06 pmKey West
$392
Find similar
American Airlines
Oct 30
EYW7:52 pmKey West
3h 58m
1 stop
CLT11:50 pmCharlotte Douglas
Nov 2
CLT7:33 pmCharlotte Douglas
2h 14m
EYW9:47 pmKey West
$397
Find similar
American Airlines
Oct 9
EYW11:22 amKey West
10h 17m
2 stops
CHS9:39 pmCharleston
Oct 13
CHS5:00 amCharleston
7h 55m
2 stops
EYW12:55 pmKey West
$473
Find similar

United Airlines flights from Key West to South Carolina

Our best United Airlines deals on Key West to South Carolina flight tickets
United Airlines
Oct 21
EYW3:12 pmKey West
22h 58m
2 stops
CLT2:10 pmCharlotte Douglas
Oct 28
CLT6:00 amCharlotte Douglas
31h 52m
2 stops
EYW1:52 pmKey West
$558
Find similar
United Airlines
Oct 21
EYW3:12 pmKey West
22h 58m
2 stops
CLT2:10 pmCharlotte Douglas
Oct 28
CLT7:00 amCharlotte Douglas
6h 52m
1 stop
EYW1:52 pmKey West
$563
Find similar
United Airlines
Mar 10
EYW1:30 pmKey West
7h 28m
1 stop
CLT8:58 pmCharlotte Douglas
Mar 11
CLT6:30 amCharlotte Douglas
8h 36m
1 stop
EYW3:06 pmKey West
$569
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 10/9

8:55 am-8:57 am

1 stop24h 02m

Charleston

Mon 10/13

9:23 pm-11:05 am

1 stop13h 42m

$213

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 10/9

10:59 am-9:06 am

2 stops22h 07m

Charleston

Mon 10/13

9:23 pm-11:05 am

1 stop13h 42m

$245

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 12/16

11:45 am-1:21 pm

1 stop25h 36m

Charlotte Douglas

Mon 12/22

2:16 pm-10:19 am

1 stop20h 03m

$257

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 10/7

11:45 am-11:28 pm

2 stops35h 43m

Charlotte Douglas

Sat 10/11

10:06 pm-8:15 am

1 stop10h 09m

$284

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 2/6

2:35 pm-6:44 pm

1 stop4h 09m

Savannah/Hilton Head

Mon 2/9

10:20 am-5:13 pm

1 stop6h 53m

$387

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 2/6

6:31 am-2:16 pm

2 stops7h 45m

Savannah/Hilton Head

Mon 2/9

9:44 am-1:06 pm

1 stop3h 22m

$392

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Fri 2/6

6:31 am-2:16 pm

2 stops7h 45m

Savannah/Hilton Head

Mon 2/9

6:58 am-1:06 pm

2 stops6h 08m

$397

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Tue 10/14

1:57 pm-7:31 pm

1 stop5h 34m

Savannah/Hilton Head

Sat 10/18

12:14 pm-5:21 pm

1 stop5h 07m

$407

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 10/21

3:12 pm-2:10 pm

2 stops22h 58m

Charlotte Douglas

Tue 10/28

6:00 am-1:52 pm

2 stops31h 52m

$558

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Tue 10/21

3:12 pm-2:10 pm

2 stops22h 58m

Charlotte Douglas

Tue 10/28

7:00 am-1:52 pm

1 stop6h 52m

$563

Flights are sorted by cheapest round-trip flights first.

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See travel insights to South Carolina from

How to get the cheapest flight ticket from Key West to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $538. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $616.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Key West to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $518. Try not to purchase tickets in the morning because they tend to be around $571. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Key West to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to South Carolina

Fastest flight time

2h 14m

Direct flights

Every day

Airports in South Carolina

1 airport
The fastest flight from Key West to South Carolina takes 2h 14m
Direct flights go from Key West to South Carolina every day.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Key West Airport to South Carolina?

    Prices for flights from Key West Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to South Carolina?

  • How old do you have to be to fly from Key West Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Key West to South Carolina

Compare and see reviews for airlines that fly from Key West to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.9
7,973 reviews
Search Delta flights
American AirlinesPriceFrom $293Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Key West to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Key West.

Can I find flights from Key West to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to South Carolina?

momondo helps you find the best flight between Key West and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Key West to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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