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Cheap flights from Key West to South Carolina from $74

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to South Carolina departing on 1/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Key West to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:06 pm - 9:00 am
EYW
-
CLT
19h 54m1 stop
Multiple Airlines Logo
7:00 am - 1:30 pm
CLT
-
EYW
6h 30m1 stop
$282Multiple Airlines
Fri, Feb 13 - Mon, Feb 16
Multiple Airlines Logo
1:06 pm - 9:00 am
EYW
-
CLT
19h 54m1 stop
Multiple Airlines Logo
6:47 pm - 12:21 pm
CLT
-
EYW
17h 34m2 stops
$283Multiple Airlines
Fri, Feb 13 - Mon, Feb 16
Breeze Airways Logo
10:59 am - 2:28 pm
EYW
-
CHS
3h 29m1 stop
Breeze Airways Logo
8:53 pm - 9:17 am
CHS
-
EYW
12h 24m1 stop
$285Breeze Airways
Thu, Jan 1 - Thu, Jan 1
Breeze Airways Logo
9:49 am - 1:22 pm
EYW
-
CHS
3h 33m1 stop
Breeze Airways Logo
3:01 pm - 12:26 pm
CHS
-
EYW
21h 25m1 stop
$314Breeze Airways
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
12:00 pm - 6:40 pm
EYW
-
CHS
6h 40m1 stop
American Airlines Logo
6:10 am - 1:03 pm
CHS
-
EYW
6h 53m2 stops
$358American Airlines
Fri, Jan 16 - Sun, Jan 18
Multiple Airlines Logo
10:59 am - 2:28 pm
EYW
-
CHS
3h 29m1 stop
Multiple Airlines Logo
10:18 pm - 9:45 pm
CHS
-
EYW
23h 27m2 stops
$359Multiple Airlines
Thu, Jan 1 - Thu, Jan 1
American Airlines Logo
1:33 pm - 9:11 pm
EYW
-
CHS
7h 38m2 stops
American Airlines Logo
6:10 am - 1:03 pm
CHS
-
EYW
6h 53m2 stops
$363American Airlines
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
8:03 am - 10:25 am
EYW
-
CLT
2h 22mnonstop
American Airlines Logo
8:41 am - 11:02 am
CLT
-
EYW
2h 21mnonstop
$387American Airlines
Fri, Feb 13 - Mon, Feb 16
United Airlines Logo
6:05 pm - 2:48 pm
EYW
-
CHS
20h 43m1 stop
United Airlines Logo
7:45 pm - 4:22 pm
CHS
-
EYW
20h 37m1 stop
$538United Airlines
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
2:25 pm - 2:48 pm
EYW
-
CHS
24h 23m2 stops
United Airlines Logo
7:45 pm - 4:22 pm
CHS
-
EYW
20h 37m1 stop
$543United Airlines
Fri, Jan 23 - Sun, Jan 25

United Airlines flights from Key West to South Carolina

Our best United Airlines deals on Key West to South Carolina flight tickets
United Airlines
Jan 23
EYW6:05 pmKey West
20h 43m
1 stop
CHS2:48 pmCharleston
Jan 25
CHS7:45 pmCharleston
20h 37m
1 stop
EYW4:22 pmKey West
$538
Find similar
United Airlines
Jan 23
EYW2:25 pmKey West
24h 23m
2 stops
CHS2:48 pmCharleston
Jan 25
CHS7:45 pmCharleston
20h 37m
1 stop
EYW4:22 pmKey West
$543
Find similar
United Airlines
Jan 22
EYW6:05 pmKey West
20h 08m
1 stop
CLT2:13 pmCharlotte Douglas
Jan 25
CLT7:44 pmCharlotte Douglas
20h 38m
1 stop
EYW4:22 pmKey West
$547
Find similar

American Airlines flights from Key West to South Carolina

Our best American Airlines deals on Key West to South Carolina flight tickets
American Airlines
Jan 16
EYW12:00 pmKey West
6h 40m
1 stop
CHS6:40 pmCharleston
Jan 18
CHS6:10 amCharleston
6h 53m
2 stops
EYW1:03 pmKey West
$358
Find similar
American Airlines
Jan 16
EYW1:33 pmKey West
7h 38m
2 stops
CHS9:11 pmCharleston
Jan 18
CHS6:10 amCharleston
6h 53m
2 stops
EYW1:03 pmKey West
$363
Find similar
American Airlines
Feb 13
EYW8:03 amKey West
2h 22m
CLT10:25 amCharlotte Douglas
Feb 16
CLT8:41 amCharlotte Douglas
2h 21m
EYW11:02 amKey West
$387
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/13

1:06 pm-9:00 am

1 stop19h 54m

Charlotte Douglas

Mon 2/16

7:00 am-1:30 pm

1 stop6h 30m

$282

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/13

1:06 pm-9:00 am

1 stop19h 54m

Charlotte Douglas

Mon 2/16

6:47 pm-12:21 pm

2 stops17h 34m

$283

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 1/1

10:59 am-2:28 pm

1 stop3h 29m

Charleston

Thu 1/1

8:53 pm-9:17 am

1 stop12h 24m

$285

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 1/16

9:49 am-1:22 pm

1 stop3h 33m

Charleston

Sun 1/18

3:01 pm-12:26 pm

1 stop21h 25m

$314

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 1/16

12:00 pm-6:40 pm

1 stop6h 40m

Charleston

Sun 1/18

6:10 am-1:03 pm

2 stops6h 53m

$358

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Thu 1/1

10:59 am-2:28 pm

1 stop3h 29m

Charleston

Thu 1/1

10:18 pm-9:45 pm

2 stops23h 27m

$359

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 1/16

1:33 pm-9:11 pm

2 stops7h 38m

Charleston

Sun 1/18

6:10 am-1:03 pm

2 stops6h 53m

$363

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 2/13

8:03 am-10:25 am

Nonstop2h 22m

Charlotte Douglas

Mon 2/16

8:41 am-11:02 am

Nonstop2h 21m

$387

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 1/23

6:05 pm-2:48 pm

1 stop20h 43m

Charleston

Sun 1/25

7:45 pm-4:22 pm

1 stop20h 37m

$538

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 1/23

2:25 pm-2:48 pm

2 stops24h 23m

Charleston

Sun 1/25

7:45 pm-4:22 pm

1 stop20h 37m

$543

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Key West to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $538. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $616.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Key West to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $518. Try not to purchase tickets in the morning because they tend to be around $571. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Key West to South Carolina flights?

You could potentially save up to 56% on your flight if you consider stops on a Key West to South Carolina flight.

Cheap Key West to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to South Carolina

Fastest flight time

2h 20m

Direct flights

Mon, Tue, Thu, Sat and Sun

Airports in South Carolina

57 airports
The fastest flight from Key West to South Carolina takes 2h 20m
Direct flights go from Key West to South Carolina on Monday, Tuesday, Thursday, Saturday and Sunday. There are no airlines offering direct flights.
There are 57 airports in South Carolina. From Key West there are direct flights to Charlotte Douglas (CLT).
Search flight deals

  • When did momondo last update prices for flights from Key West Airport to South Carolina?

    Prices for flights from Key West Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to South Carolina?

  • How old do you have to be to fly from Key West Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Key West to South Carolina

Compare and see reviews for airlines that fly from Key West to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $387Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Key West to South Carolina?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to South Carolina from Key West.

Can I find flights from Key West to South Carolina with flexible booking policies on momondo?

momondo does allow users to show only those flights to South Carolina from Key West which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Key West to South Carolina?

momondo helps you find the best flight between Key West and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Key West to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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